Abstracts tagged "SLE"

Abstract Number: 672 • 2019 ACR/ARP Annual Meeting
Mouse SLE Studies Do Not Describe Human SLE
Ecem Sevim¹, Linjia Jia ², David Fernandez ³ and Michael Lockshin ⁴, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY, ⁴Hospital for Special Surgery, Barbara Volcker Center for Women and Rheumatic Diseases, New York, NY
Background/Purpose: Although mouse models of systemic lupus erythematosus (SLE) are useful proxies for human illness, they are heterogeneous, and publications about mouse SLE may not…
Abstract Number: 1024 • 2019 ACR/ARP Annual Meeting
Lysosome Defects in SLE Promote the Accumulation of Nuclear Antigens on the Surface of Hematopoietic Cells
Sun Ah Kang¹, Jennifer Rogers ², Saira Sheikh ³, Megan Clowse ², Lisa Criscione-Schreiber ² and Barb Vilen ⁴, ¹University of NOrth Carolina at Chapel Hlil, Chapel Hill, NC, ²Duke University, Durham, ³University of North Carolina, Chapel Hill, NC, ⁴University of North Carolina CHapel Hill, Chapel Hill, NC
Background/Purpose: Impaired clearance of cell debris allows nuclear self-antigens such as DNA to accumulate, bind autoreactive IgG and form immune complexes (IgG-ICs) in SLE. We…
Abstract Number: 1579 • 2019 ACR/ARP Annual Meeting
Presence of Antiphospholipid Antibodies in Patients with SLE and Venous Thromboembolic Events of African American and Caucasian Race
Elena Gkrouzman¹, Julia Davis-Porada ¹, Mary Peng ² and Kyriakos Kirou ², ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Risk of thrombosis is elevated in patients with systemic lupus erythematosus (SLE) compared to healthy individuals, especially during the first year after diagnosis. The…
Abstract Number: 2034 • 2019 ACR/ARP Annual Meeting
Identification of IL-17+ and IL-10+ TCRαβ+ CD4- CD8- Double Negative (DN) T Cell Subsets in Lupus-prone Mice and Patients with SLE and Their Significance in Predicting Renal Involvement
Yi Li¹, Hao Li ², Shui Lian Yu ³, Vasileios Kyttaris ⁴ and George Tsokos ⁴, ¹BIDMC, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ³The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (People's Republic), ⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: We have previously shown that DN T cells are expanded in both lupus-prone mice and patients with SLE and we have demonstrated that this…
Abstract Number: 64 • 2019 ACR/ARP Annual Meeting
Rab4A Controls mTOR Pathway Activation, Pro-inflammatory Lineage Development, and Disease Pathogenesis in Lupus-prone Mice
Nick Huang¹, Zhiwei Lai ², Brandon Wyman ², Thomas Winans ², Manuel Duarte ², Joshua Lewis ², Mark Haas ³, Laurence Morel ⁴ and Andras Perl ⁵, ¹Upstate Medical University, Syracuse, NY, ²Upstate Medical University, Syracuse, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Florida, Gainesville, FL, ⁵SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Mouse models of SLE have been indispensable tools for studying disease pathogenesis; however, each model only recapitulates limited aspects of lupus. SLE1.2.3. (TC) mice…
Abstract Number: 673 • 2019 ACR/ARP Annual Meeting
Clinical Characteristics of Lymphadenopathy in Systemic Lupus Erythematous: A Case Control Study from a Tertiary Care Center
Elizabeth Graef¹, Daniel Magliulo ¹, Norris Hollie ¹, Chelsea Marcus ² and Vasileios Kyttaris ³, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: While lymphadenopathy and/or lymphadenitis (LAD) is considered a relatively common clinical finding in SLE patients, its clinical significance is poorly understood. Previous studies described…
Abstract Number: 1025 • 2019 ACR/ARP Annual Meeting
Dynamic Changes During SLE Flare Implicate Age-Associated B Cells and Altered T Follicular and Peripheral Helper Cell Responses in Disease Activity
Kieran Manion¹, Zahi Touma ², Dennisse Bonilla ², Dafna Gladman ³, Murray Urowitz ² and Joan Wither ⁴, ¹Krembil Research Institute, Toronto, ON, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Krembil Research Institute, U of Toronto, Toronto, ON, Canada, ⁴University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: SLE is a chronic autoimmune disorder in which periods of relative disease inactivity are punctuated by flares that present with increased inflammation and tissue…
Abstract Number: 1586 • 2019 ACR/ARP Annual Meeting
All-cause Hospitalizations and Mortality in Systemic Lupus Erythematosus in the US- results from a National Inpatient Database
Rashmi Dhital¹, Dilli Ram Poudel ², Ramesh Kumar Pandey ³ and Paras Karmacharya ⁴, ¹Reading Hospital ,PA, Shillington, PA, ²University of Pennsylvania, Philadelphia, ³Fox Chase Hospital, Philadelphia, ⁴Reading Hospital, Mayo Clinic, Rochester
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disorder with variable presentation. While several studies have outlined the risk factors for hospitalization and…
Abstract Number: 2036 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus
Jie An¹, Bhargavi Duvvuri ¹, Xizhang Sun ¹, Lena Tanaka ¹, Christian Lood ¹ and Keith Elkon ¹, ¹University of Washington, Seattle
Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some…
Abstract Number: 65 • 2019 ACR/ARP Annual Meeting
CD6 Modulation Ameliorates Skin and Kidney Disease in a Spontaneous Murine Model of SLE
Samantha Chalmers¹, Sayra Garcia ¹, Rajalakshmy Ayilam Ramachandran ², Chandra Mohan ², Jeanette Ampudia ³, Cherie Ng ³, Stephen Connelly ³ and Chaim Putterman ⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Houston, Houston, ³Equillium, Inc, San Diego, CA, ⁴Albert Einstein College of Medicine, New York, NY
Background/Purpose: T cells are an important contributor the pathogenesis of SLE and its various end organ manifestations. Thus, they present themselves as potential therapeutic targets;…
Abstract Number: 678 • 2019 ACR/ARP Annual Meeting
Performance of the EULAR/ACR 2019 Classification Criteria for Systemic Lupus Erythematosus in Men, Diverse Ethnicities, and Early Disease
Martin Aringer¹, Ralph Brinks ², Karen Costenbader ³, David Daikh ⁴, Dimitrios Boumpas ⁵, David Jayne ⁶, Diane Kamen ⁷, Marta Mosca ⁸, Rosalind Ramsey-Goldman ⁹, Josef Smolen ¹⁰, David Wofsy ¹¹, Betty Diamond ¹², Søren Jacobsen ¹³, W Joseph McCune ¹⁴, Guillermo Ruiz-Irastorza ¹⁵, Matthias Schneider ¹⁶, Murray Urowitz ¹⁷, George Bertsias ¹⁸, Bimba Hoyer ¹⁹, Nicolai Leuchten ²⁰, Chiara Tani ²¹, Sara K. Tedeschi ²², Zahi Touma ¹⁷, Branimir Anic ²³, Florence Assan ²⁴, Daniel TM Chan ²⁵, Ann E Clarke ²⁶, Mary Crow ²⁷, László Czirják ²⁸, Andrea Doria ²⁹, Winfried Graninger ³⁰, Bernadette Halda-Kiss ³¹, Sarfaraz Hasni ³², Peter Izmirly ³³, Michelle Jung ²⁶, Gabor Kumanovics ³¹, Xavier Mariette ³⁴, Ivan Padjen ²³, Jose Maria Pego-Reigosa ³⁵, Juanita Romero-Diaz ³⁶, Iñigo Rua Figueroa ³⁷, Raphaèle Seror ²⁴, Georg Stummvoll ¹⁰, Yoshiya Tanaka ³⁸, Maria Tektonidou ³⁹, Carlos Vasconcelos ⁴⁰, Edward Vital ⁴¹, Daniel Wallace ⁴², Sule Yavuz ⁴³ Raymond Naden ⁴⁴, Thomas Dörner ⁴⁵ and Sindhu R. Johnson ⁴⁶, ¹Division of Rheumatology, Department of Medicine III, University Medical Center & Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany, ²Department of Rheumatology and Hiller Research Unit of Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany, ³Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴University of California at San Francisco and VA Medical Center, San Francisco, CA, ⁵University of Athens, Athens, Greece, ⁶Vasculitis and Lupus Clinic, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom, ⁷Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁸Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁹Northwestern University, Chicago, IL, ¹⁰Medical University of Vienna, Vienna, Austria, ¹¹UCSF, San Francisco, ¹²Feinstein Institutes for Medical Research, Manhasset, ¹³Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, ¹⁴University of Michigan, Ann Arbor, MI, ¹⁵Autoimmune Diseases Unit, Hospital Universitario Cruces, Barakaldo, Spain, ¹⁶Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany, ¹⁷University Health Network, University of Toronto, Toronto, ON, Canada, ¹⁸University of Crete, Rheumatology, Clinical Immunology and Allergy Unit, Heraklion, Greece, ¹⁹University of Schleswig-Holstein at Kiel, and Charité – Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Kiel, Germany, ²⁰University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, ²¹Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy, ²²Brigham and Women's Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ²³UHC Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia, ²⁴Université Paris Sud, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM UMR 1184, Le Kremlin-Bicêtre, France, ²⁵University of Hong Kong, Hong Kong, Hong Kong, ²⁶University of Calgary, Calgary, AB, Canada, ²⁷Hospital for Special Surgery, New York, NY, ²⁸Dept. of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ²⁹University and Azienda Ospedaliera of Padova, Padova, Italy, ³⁰Medical University of Graz, Graz, Austria, ³¹University of Pécs, Pécs, Hungary, ³²NIAMS, National Institutes of Health, Bethesda, MD, ³³NYU School of Medicine, New York, ³⁴Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, ³⁵Complexo Hospitalario Universitario, Vigo, Spain, ³⁶Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, ³⁷Hospital Doctor Negrin, Las Palmas, ³⁸University of Occupational and Environmental Health Japan, Kitakyushu, Japan, ³⁹First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, ⁴⁰University of Porto, UMIB Abel Salazar Biomedical Sciences Institute, Porto, Portugal, ⁴¹University of Leeds, Leeds, United Kingdom, ⁴²Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, ⁴³Uppsala University, Istanbul, Turkey, ⁴⁴McMaster University, Hamilton, ON, Canada, ⁴⁵Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, ⁴⁶Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada
Background/Purpose: The EULAR/ACR 2019 Classification Criteria for SLE have been validated in an international cohort of 696 SLE patients and 574 non-SLE patients with a…
Abstract Number: 1033 • 2019 ACR/ARP Annual Meeting
Mass Cytometric Immunophenotyping Highlights a Dysregulated T cell-B Cell Axis in Patients with New-onset Lupus
Ye Cao¹, Stephen Alves ², Corine Sinnette ³, Cameron Speyer ³, Gregory Keras ¹, Yujie Qu ², Joshua Keegan ⁴, James Lederer ⁴, Deepak Rao ³ and Karen Costenbader ³, ¹Brigham and Women's Hospital, Boston, ²Merck, boston, ³Brigham and Women's Hospital, Boston, MA, ⁴BWH, Boston
Background/Purpose: The immune cell subsets most altered early in SLE disease course remain unclear. Defining abnormalities in lymphocyte populations in patients with new-onset SLE may…
Abstract Number: 1591 • 2019 ACR/ARP Annual Meeting
Anti-ovarian Antibodies Are Not Associated with Premature Menopause in SLE Treated with Cyclophophosphamide
Martha Tsaliki ¹, Kristi Koelsch ¹, Ambre Chambers ¹, Mitali Talsania ², Eliza Chakravarty ³ and Robert Scofield³, ¹University of Oklahoma health Sciences Center, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoam City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Treatment of systemic lupus erythematosus (SLE) with cyclophosphamide is associated with premature menopause, especially those at an older age of treatment and those receiving…
Abstract Number: 2041 • 2019 ACR/ARP Annual Meeting
Epigenome-wide Association Study Reveals Differential DNA Methylation in Systemic Lupus Erythematosus Patients with a History of Ischemic Heart Disease
Juliana Imgenberg-Kreuz¹, Christopher Sjöwall ², Martina Frodlund ², Iva Gunnarsson ³, Elisabet Svenungsson ⁴ and Dag Leonard ¹, ¹Department of Medical Sciences, Section of Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of ischemic heart disease (IHD). Altered methylation patterns have been reported both in SLE,…
Abstract Number: 66 • 2019 ACR/ARP Annual Meeting
Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation
Samantha Chalmers¹, Sayra Garcia ¹, Jeanette Ampudia ², Cherie Ng ², Stephen Connelly ² and Chaim Putterman ³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Equillium, Inc, San Diego, CA, ³Albert Einstein College of Medicine, New York, NY
Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…

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