Abstracts tagged "SLE"

Abstract Number: 678 • 2019 ACR/ARP Annual Meeting
Performance of the EULAR/ACR 2019 Classification Criteria for Systemic Lupus Erythematosus in Men, Diverse Ethnicities, and Early Disease
Martin Aringer¹, Ralph Brinks ², Karen Costenbader ³, David Daikh ⁴, Dimitrios Boumpas ⁵, David Jayne ⁶, Diane Kamen ⁷, Marta Mosca ⁸, Rosalind Ramsey-Goldman ⁹, Josef Smolen ¹⁰, David Wofsy ¹¹, Betty Diamond ¹², Søren Jacobsen ¹³, W Joseph McCune ¹⁴, Guillermo Ruiz-Irastorza ¹⁵, Matthias Schneider ¹⁶, Murray Urowitz ¹⁷, George Bertsias ¹⁸, Bimba Hoyer ¹⁹, Nicolai Leuchten ²⁰, Chiara Tani ²¹, Sara K. Tedeschi ²², Zahi Touma ¹⁷, Branimir Anic ²³, Florence Assan ²⁴, Daniel TM Chan ²⁵, Ann E Clarke ²⁶, Mary Crow ²⁷, László Czirják ²⁸, Andrea Doria ²⁹, Winfried Graninger ³⁰, Bernadette Halda-Kiss ³¹, Sarfaraz Hasni ³², Peter Izmirly ³³, Michelle Jung ²⁶, Gabor Kumanovics ³¹, Xavier Mariette ³⁴, Ivan Padjen ²³, Jose Maria Pego-Reigosa ³⁵, Juanita Romero-Diaz ³⁶, Iñigo Rua Figueroa ³⁷, Raphaèle Seror ²⁴, Georg Stummvoll ¹⁰, Yoshiya Tanaka ³⁸, Maria Tektonidou ³⁹, Carlos Vasconcelos ⁴⁰, Edward Vital ⁴¹, Daniel Wallace ⁴², Sule Yavuz ⁴³ Raymond Naden ⁴⁴, Thomas Dörner ⁴⁵ and Sindhu R. Johnson ⁴⁶, ¹Division of Rheumatology, Department of Medicine III, University Medical Center & Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany, ²Department of Rheumatology and Hiller Research Unit of Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany, ³Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁴University of California at San Francisco and VA Medical Center, San Francisco, CA, ⁵University of Athens, Athens, Greece, ⁶Vasculitis and Lupus Clinic, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom, ⁷Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁸Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁹Northwestern University, Chicago, IL, ¹⁰Medical University of Vienna, Vienna, Austria, ¹¹UCSF, San Francisco, ¹²Feinstein Institutes for Medical Research, Manhasset, ¹³Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, ¹⁴University of Michigan, Ann Arbor, MI, ¹⁵Autoimmune Diseases Unit, Hospital Universitario Cruces, Barakaldo, Spain, ¹⁶Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany, ¹⁷University Health Network, University of Toronto, Toronto, ON, Canada, ¹⁸University of Crete, Rheumatology, Clinical Immunology and Allergy Unit, Heraklion, Greece, ¹⁹University of Schleswig-Holstein at Kiel, and Charité – Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Kiel, Germany, ²⁰University Medical Center and Faculty of Medicine TU Dresden, Dresden, Germany, ²¹Azienda Ospedaliero Universitaria Pisana, University of Pisa, Pisa, Italy, ²²Brigham and Women's Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ²³UHC Zagreb and University of Zagreb School of Medicine, Zagreb, Croatia, ²⁴Université Paris Sud, Hôpitaux Universitaires Paris-Sud, AP-HP, INSERM UMR 1184, Le Kremlin-Bicêtre, France, ²⁵University of Hong Kong, Hong Kong, Hong Kong, ²⁶University of Calgary, Calgary, AB, Canada, ²⁷Hospital for Special Surgery, New York, NY, ²⁸Dept. of Rheumatology and Immunology, University of Pécs, Pécs, Hungary, ²⁹University and Azienda Ospedaliera of Padova, Padova, Italy, ³⁰Medical University of Graz, Graz, Austria, ³¹University of Pécs, Pécs, Hungary, ³²NIAMS, National Institutes of Health, Bethesda, MD, ³³NYU School of Medicine, New York, ³⁴Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, ³⁵Complexo Hospitalario Universitario, Vigo, Spain, ³⁶Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, ³⁷Hospital Doctor Negrin, Las Palmas, ³⁸University of Occupational and Environmental Health Japan, Kitakyushu, Japan, ³⁹First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, ⁴⁰University of Porto, UMIB Abel Salazar Biomedical Sciences Institute, Porto, Portugal, ⁴¹University of Leeds, Leeds, United Kingdom, ⁴²Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, ⁴³Uppsala University, Istanbul, Turkey, ⁴⁴McMaster University, Hamilton, ON, Canada, ⁴⁵Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, ⁴⁶Toronto Scleroderma Program, Department of Medicine, Toronto Western and Mount Sinai Hospitals, University of Toronto, Toronto, Canada
Background/Purpose: The EULAR/ACR 2019 Classification Criteria for SLE have been validated in an international cohort of 696 SLE patients and 574 non-SLE patients with a…
Abstract Number: 1033 • 2019 ACR/ARP Annual Meeting
Mass Cytometric Immunophenotyping Highlights a Dysregulated T cell-B Cell Axis in Patients with New-onset Lupus
Ye Cao¹, Stephen Alves ², Corine Sinnette ³, Cameron Speyer ³, Gregory Keras ¹, Yujie Qu ², Joshua Keegan ⁴, James Lederer ⁴, Deepak Rao ³ and Karen Costenbader ³, ¹Brigham and Women's Hospital, Boston, ²Merck, boston, ³Brigham and Women's Hospital, Boston, MA, ⁴BWH, Boston
Background/Purpose: The immune cell subsets most altered early in SLE disease course remain unclear. Defining abnormalities in lymphocyte populations in patients with new-onset SLE may…
Abstract Number: 1591 • 2019 ACR/ARP Annual Meeting
Anti-ovarian Antibodies Are Not Associated with Premature Menopause in SLE Treated with Cyclophophosphamide
Martha Tsaliki ¹, Kristi Koelsch ¹, Ambre Chambers ¹, Mitali Talsania ², Eliza Chakravarty ³ and Robert Scofield³, ¹University of Oklahoma health Sciences Center, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoam City, OK, ³Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Treatment of systemic lupus erythematosus (SLE) with cyclophosphamide is associated with premature menopause, especially those at an older age of treatment and those receiving…
Abstract Number: 2041 • 2019 ACR/ARP Annual Meeting
Epigenome-wide Association Study Reveals Differential DNA Methylation in Systemic Lupus Erythematosus Patients with a History of Ischemic Heart Disease
Juliana Imgenberg-Kreuz¹, Christopher Sjöwall ², Martina Frodlund ², Iva Gunnarsson ³, Elisabet Svenungsson ⁴ and Dag Leonard ¹, ¹Department of Medical Sciences, Section of Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden, ³Department of Medicine Solna, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have an increased risk of ischemic heart disease (IHD). Altered methylation patterns have been reported both in SLE,…
Abstract Number: 66 • 2019 ACR/ARP Annual Meeting
Amelioration of Immune Complex-Mediated Glomerulonephritis by CD6 Modulation
Samantha Chalmers¹, Sayra Garcia ¹, Jeanette Ampudia ², Cherie Ng ², Stephen Connelly ² and Chaim Putterman ³, ¹Albert Einstein College of Medicine, Bronx, NY, ²Equillium, Inc, San Diego, CA, ³Albert Einstein College of Medicine, New York, NY
Background/Purpose: CD6 is a co-stimulatory receptor on T cells, that binds to activated leukocyte cell adhesion molecule (ALCAM), a ligand expressed on antigen presentation cells…
Abstract Number: 687 • 2019 ACR/ARP Annual Meeting
CCP Autoantibody Positive SLE Patients Show Unique Enrichments in SLE Criteria and Autoantibody Biomarkers That Vary by Race
John Goetzinger¹, Carla J. Guthridge ², Wade DeJager ², Eliza F. Chakravarty ³, Cristina Arriens ³, Teresa Aberle ², Aikaterini Thanou ², Joan T. Merrill ⁴ and Judith James ³, ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Okalahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are a hallmark of RA but are widely distributed in other autoimmune diseases. Although SLE is well characterized as…
Abstract Number: 1039 • 2019 ACR/ARP Annual Meeting
Molecular Profiling Identifies Immunologic Subgroups and Informs Mechanism of Action of Baricitinib in SLE
Thomas Dörner¹, Yoshiya Tanaka ², Michelle Petri ³, Josef Smolen ⁴, Daniel Wallace ⁵, Ernst Dow ⁶, Damiano Fantini ⁶, Richard Higgs ⁶, Guilherme Rocha ⁶, Brenda Crowe ⁶, Robert Benschop ⁶, Adam Abel ⁶, Nicole Byers ⁶, Maria Silk ⁶, Stephanie de Bono ⁶ and Robert Hoffman ⁶, ¹Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany, ²University of Occupational and Environmental Health Japan, Kitakyushu, Japan, ³Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Medical University of Vienna, Vienna, Austria, ⁵Cedars-Sinai Medical Center/University California at Los Angeles, Los Angeles, CA, ⁶Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Baricitinib is an oral selective Janus kinase (JAK) 1 and JAK2 inhibitor. In the Phase II, 24-week, randomized, placebo-controlled, double-blind study JAHH (NCT02708095), once-daily…
Abstract Number: 1593 • 2019 ACR/ARP Annual Meeting
Heart Rate Visit-to-Visit Variability in Patients with Systemic Lupus Erythematosus Is Associated with Increased Mortality
Tyler Reese¹, Alyson Dickson ¹, Jocelyn Gandelman ¹, Sarah Bayefsky ¹, April Barnado ¹, Katherine Barker ¹, C. Michael Stein ¹, Vivian Kawai ¹ and Cecilia Chung ¹, ¹Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have increased mortality compared to the general population. Heart rate visit-to-visit variability (HRVVV) has emerged as an adverse…
Abstract Number: 2042 • 2019 ACR/ARP Annual Meeting
Intestinal Microbiota Alters Th1/Th17 Balance but Is Dispensable for the Development of Systemic Autoimmune Disease in BXD2 Mice
Huixian Hong¹, Qi Wu ¹, PingAr Yang ¹, Bao Luo ², Alex Essman ², Oluwagbemiga Ojo ², Michael R. Crowley ³, David K. Crossman ³, Casey D. Morrow ⁴, Jeremy B. Foote ⁵, Trenton R. Schoeb ⁶, Charles O. Elson ⁷, Hui-Chen Hsu ⁸ and John D. Mountz ⁹, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ³Department of Genetics, University of Alabama at Birmingham, Birmingham, ⁴Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, ⁵Department of Microbiology, University of Alabama at Birmingham, Birmingham, ⁶Department of Genetics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁸1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham & University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham
Background/Purpose: Intestinal microbiota dysbiosis has been implicated in the pathogenesis of autoimmune disease. How the microbiota affects the peripheral immune system leading to the development…
Abstract Number: 80 • 2019 ACR/ARP Annual Meeting
The Role of Adopter Protein SH3BP2 in a Murine Systemic Lupus Erythematosus Model
Kyoko Kawahara¹, Tomoyuki Mukai ², Akiko Nagasu ¹, Masanori Iseki ³, Hajime Nagasu ⁴, Shoko Tshuji ¹, Takahiko Akagi ¹, Yasuyoshi Ueki ⁵ and Yoshitaka Morita ¹, ¹Department of Rheumatology, Kawasaki medical School, Kurashiki, Okayama, Japan, ²Department of Rheumatology, Kawasaki medical School, Kurashiki, Okayama, Okayama, Japan, ³Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, ⁴Department of Nephrology and Hypertension, Kawasaki medical School, Kurashiki, Okayama, Japan, ⁵Department of Biomedical Sciences and Comprehensive Care Indiana University School of Dentistry, Indianapolis, IN
Background/Purpose: An adaptor protein SH3BP2 (Src homology 3 domain-binding protein 2) is widely expressed in immune cells and controls intracellular signaling pathways, such as Syk,…
Abstract Number: 690 • 2019 ACR/ARP Annual Meeting
Urinary MRP8/14, an Endogenous Toll-Like Receptor 4 Ligand, Reflects Renal Disease Activity in Lupus Nephritis: A Cross-Sectional and Longitudinal Assessment
Ranjan Gupta¹, Dipendra Kumar Mitra ¹ and Sonam Rani ¹, ¹All India Institute of Medical Sciences, New Delhi, India
Background/Purpose: Monocytes/macrophages are the most abundant cells infiltrating the glomeruli and in the active urinary sediment of patients with Lupus Nephritis (LN).1 These cells also…
Abstract Number: 1075 • 2019 ACR/ARP Annual Meeting
The Impact of Race on Birth Outcomes Among Women with Autoimmune Rheumatic Diseases
Lena Sabih¹, Jennifer Strouse ¹, Nichole Nidey ², Gretchen Bandoli ³, Rebecca Baer ⁴, Sky Feuer ⁵, Laura Jelliffe-Pawlowski ⁵, Christina Chambers ⁶, Kelli Ryckman ² and Namrata Singh ⁷, ¹University of Iowa Hospitals and Clinics, Iowa City, ²UIOWA, Iowa City, ³University of California, San Diego, La Jolla, ⁴UCSD, La Jolla, ⁵UCSF, San Francisco, ⁶UCSD, San Diego, ⁷University of Iowa, Iowa City
Background/Purpose: Autoimmune rheumatic diseases (ARDs) are associated with adverse pregnancy outcomes (APOs). There are only a small number of studies that have looked at the…
Abstract Number: 1600 • 2019 ACR/ARP Annual Meeting
Frailty and Sarcopenia in Women with Systemic Lupus Erythematosus
Sarah Lieber¹, Stephen Paget ², Jessica Berman ¹, Medha Barbhaiya ³, Lisa Sammaritano ², Kyriakos Kirou ², John Carrino ², Dina Sheira ⁴, Jackie Finik ⁴ and Lisa Mandl ⁵, ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁴Hospital for Special Surgery, New York, NY, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Frailty is a clinical phenotype that increases with age. However, frailty can occur in younger patients with chronic disease, including SLE. Based on few…
Abstract Number: 2275 • 2019 ACR/ARP Annual Meeting
Effect of Race and Lupus Nephritis on Pregnancy Outcomes in Systemic Lupus Erythematosus: An Individual Participant Meta-analysis
Ravyn Njagu¹, Amanda Eudy ², Stephen Balevic ³, Michelle Petri ⁴, Dafna Gladman ⁵, Murray Urowitz ⁶ and Megan Clowse ², ¹Duke University, Durham, NC, ²Duke University, Durham, ³Duke University, Hillsborough, NC, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ⁶University Health Network, University of Toronto, Toronto, ON, Canada
Background/Purpose: Individual cohort studies have found that Black and Hispanic women have worse pregnancy outcomes compared to their white counterparts. Additionally, this population of women…
Abstract Number: 84 • 2019 ACR/ARP Annual Meeting
Cenerimod, a Potent and Selective Sphingosine-1-Phosphate Receptor 1 Modulator, Controls Systemic Autoimmunity and Organ Pathology in Mouse Models of Systemic Lupus Erythematosus and Sjögren’s Syndrome
Estelle Gerossier ¹, Saba Nayar ², Charlotte Smith ², Sylvie Froidevaux ³, Francesca Barone ² and Marianne Martinic¹, ¹Idorsia Pharmaceuticals Ltd., Allschwil, Basel-Landschaft, Switzerland, ²Rheumatology Research Group, University of Birmingham, Birmingham, United Kingdom, ³Idorsia Pharmaceuticals Ltd., Allschwil, Switzerland
Background/Purpose: Autoimmune diseases including SLE and SS are characterized by aberrant lymphocyte activation and autoantibody production. This results in systemic manifestations and the formation of…