ACR Meeting Abstracts

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Abstracts tagged "SLE"

  • Abstract Number: 668 • 2019 ACR/ARP Annual Meeting

    Lack of Uptake of Prophylactic Human Papilloma Virus (HPV) Vaccination Among Women with Systemic Lupus Erythematosus (SLE) in the Detroit, MI Area, a High Risk Population

    J. Patricia Dhar1, Louis Saravolatz 2 and Susan Szpunar 3, 1Wayne State University, Bloomfield Hills, MI, 2Ascension St. John Hospital and Wayne State University, Grosse Pointe Woods, MI, 3Ascension St. John Hospital Hospital, Grosse Pointe Woods, MI

    Background/Purpose: Women with SLE are at increased risk for cervical neoplasia likely because of infection with high risk (HR) HPV and thus should be considered…
  • Abstract Number: 1016 • 2019 ACR/ARP Annual Meeting

    Identification of Differentially Expressed Genes and Signaling Pathways in Systemic Lupus Erythematosus by Integrated Bioinformatics Analysis

    Wei Liu1, Yuanhao Wu 1 and Wenjia Zhao 1, 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China (People's Republic)

    Background/Purpose: Systemic lupus erythematosus (SLE) is a common autoimmune disease. The occurrence and development of SLE is a result of multiple factors, but its exact…
  • Abstract Number: 1576 • 2019 ACR/ARP Annual Meeting

    Prevalence and Outcome of Thrombocytopenia in Systemic Lupus Erythematosus – Single Centre Cohort Analysis

    Tatiana Costa Pires1, Raquel Caparrós-Ruiz 2 and David A Isenberg 3, 1Serviço de Medicina 1, Centro Hospitalar de Leiria, Leiria, Portugal, 2UGC de Reumatologia, Instituto de Investigación Biomédica de Málaga, Hospital Universitario de Málaga, Universidad de Málaga, Málaga, Spain, 3Centre for Rheumatology, London, United Kingdom

    Background/Purpose: To characterize the frequency of thrombocytopenia in SLE and determine its time of onset during the course of the disease, severity and impact on mortality.Methods: This…
  • Abstract Number: 2022 • 2019 ACR/ARP Annual Meeting

    Analysis of Gene Expression from Systemic Lupus Erythematosus Synovium Reveals Unique Pathogenic Mechanisms

    Erika Hubbard1, Michelle Catalina 2, Sarah Heuer 1, Prathyusha Bachali 2, Nicholas Geraci 3, Peter Lipsky 3 and Amrie Grammer 1, 1AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, 2AMPEL BioSolutions and the RILITE Research Institute, Charlottesville, VA, 3AMPEL BioSolutions, LLC, Charlottesville, VA

    Background/Purpose: Arthritis is a common manifestation of SLE and the ability of a new lupus therapy often depends on its ability to suppress joint inflammation.…
  • Abstract Number: 2784 • 2019 ACR/ARP Annual Meeting

    Alterations in Inflammatory, TNF-Superfamily, and IFN-Associated Chemokines Precede Clinical Changes in SLEDAI After Methylprednisolone Treatment of SLE Patients

    Melissa E. Munroe1, Carla J. Guthridge 1, Sarah Kleckner 1, Ly Tran 2, Joel Guthridge 3, Debra J. Zack 4, Judith James 3 and Joan T. Merrill 5, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, 3Oklahoma Medical Research Foundation, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 4Xencor, Inc., San Diego, CA, 5Okalahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: SLE is typified by a wide spectrum of clinical manifestations and immune dysregulation. Corticosteroids are almost universally effective, but marked by unacceptable side effects.…
  • Abstract Number: 671 • 2019 ACR/ARP Annual Meeting

    Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study

    John G Hanly1, Qiuju Li 2, Li Su 3, Murray Urowitz 4, Caroline Gordon 5, Sang-Cheol Bae 6, Juanita Romero-Diaz 7, Jorge Sanchez-Guerrero 8, Sasha Bernatsky 9, Ann E Clarke 10, Daniel J Wallace 11, David A Isenberg 12, Anisur Rahman 13, Joan Merrill 14, Paul Fortin 15, Dafna Gladman 16, Ian Bruce 17, Michelle Petri 18, Ellen M Ginzler 19, MA Dooley 20, Kristjan Steinsson 21, Rosalind Ramsey-Goldman 22, Asad A Zoma 23, Susan Manzi 24, Ola Nived 25, Andreas Jönsen 25, Munther A Khamashta 26, Graciela Alarcón 27, Elisabet Svenungsson 28, Ronald F Van Vollenhoven 29, Cynthia Aranow 30, Meggan Mackay 31, Guillermo Ruiz-Irastorza 32, Manuel Ramos-Casals 33, S Sam Lim 34, Murat Inanc 35, Kenneth C Kalunian 36, Soren Jacobsen 37, Christine Peschken 38, Diane Kamen 39, Anca Askanase 40, Chris Theriault 1 and Vernon Farewell 2, 1Dalhousie University, Halifax, NS, Canada, 2University of Cambridge, Cambridge, United Kingdom, 3Universidy of Cambridge, Cambridge, United Kingdom, 4University Health Network, University of Toronto, Toronto, ON, Canada, 5University of Birmingham, Birmingham, United Kingdom, 6Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 7Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, 8Toronto Western Hospital, Toronto, ON, Canada, 9Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 10University of Calgary, Calgary, AB, Canada, 11Cedars-Sinai Medical Centre, Beverly Hills, CA, 12Centre for Rheumatology, London, United Kingdom, 13University College London, London, United Kingdom, 14Oklahoma Medical Research Foundation, Oklahoma City, 15Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, 16Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, 17University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, 18Johns Hopkins University School of Medicine, Baltimore, MD, 19State University of New York Downstate Medical Center, Brooklyn, NY, 20UnC Kidney Centre, Chapel Hill, NC, 21Landspitali, University Hospital, Reykjavik, Iceland, 22Northwestern University, Chicago, IL, 23University of Glasgow, East Kilbride, United Kingdom, 24Allegheny Health Network, Pittsburg, PA, 25Lund University, Lund, Sweden, 26King's College London School of Medicine, London, United Kingdom, 27University of Alabama at Birmingham, Birmingham, 28Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, 29Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, 30Feinstein Institute for Medical Research, Manhasset, NY, 31Feinstein Institute for Medical Research, New York, 32Unidad de Enfermedades Autoinmunes, BioCruces Health Research Institute, Barakaldo, Spain, 33Department of Autoimmune Diseases, ICMiD. Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX. Department of Medicine, University of Barcelona, Hospital Clínic, Barcelona, Spain., Barcelona, Spain, 34Emory University, Atlanta, GA, 35Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 36UC San Diego School of Medicine, LaJolla, CA, 37Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, 38University of Manitoba, Winnipeg, Canada, 39Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, 40Columbia University Medical Center, New York, NY

    Background/Purpose: Although there is a large body of work on central nervous system (CNS) disease in SLE patients, involvement of the peripheral nervous system (PNS)…
  • Abstract Number: 1017 • 2019 ACR/ARP Annual Meeting

    The Integration of Genetic Data, Molecular Pathway Analysis and Differential Expression to Delineate the Impact of Ancestral Differences on Lupus

    Katherine Owen1, Bryce Aidukaitis 1, Adam Labonte 1, Michelle Catalina 1, Prathyusha Bachali 1, Nicholas Geraci 2, Miranda Marion 3, Hannah Ainsworth 4, kip Zimmerman 3, Timothy Howard 4, Carl Langefeld 4, Peter Lipsky 2 and Amrie Grammer 5, 1AMPEL Biosolutions and the RILITE research institute, Charlottesville, VA, 2AMPEL BioSolutions, LLC, Charlottesville, VA, 3Wake Forest School of Medicine, Winston-Salem, NC, 4Wake Forest School of Medicine, Winston-Salem, 5AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Evidence has shown that individuals of African-Ancestry (AA) experience the…
  • Abstract Number: 1578 • 2019 ACR/ARP Annual Meeting

    Factors Implicated in the Development of Early Osteonecrosis in Systemic Lupus Erythematosus

    Konstantinos Tselios1, Dafna Gladman 2, Jiandong Su 3 and Murray Urowitz 3, 1University Health Network, University of Toronto, Toronto, 2Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, 3University Health Network, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Osteonecrosis (ON) complicates approximately 15-20% of patients with systemic lupus erythematosus (SLE) on an average of six years after diagnosis. However, a small subgroup…
  • Abstract Number: 2023 • 2019 ACR/ARP Annual Meeting

    Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways

    MIKHAIL OLFERIEV1, David Fernandez 2, Dina Greenman 1, Mary Peng 1, Kyriakos Kirou 1 and Mary Crow 1, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY

    Background/Purpose: The female predisposition for development of multiple autoimmune diseases is well recognized. The female to male ratio reaches a maximum during the reproductive years…
  • Abstract Number: 2820 • 2019 ACR/ARP Annual Meeting

    Calcium/ Calmodulin – Dependent Protein Kinase IV Associates with Phosphofructokinase to Promote Glycolysis and Limit IL-2 Production

    Milena Vukelic1, Nobuya Yoshida 2, Masataka Umeda 3, Seo Yeon Orite 3, Rhea Bhargava 3, Michihito Kono 4, Irina Gavanescu-Stockton 3, Ryo Hisada 3 and George Tsokos 2, 1Beth Israel Deaconess Medical Center, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, 4Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Background/Purpose: Systemic lupus erythematosus (SLE) is disease characterized by an imbalance between pro-inflammatory (such as Th1 and Th17) and regulatory cells (Tregs). Th1 and Th17…
  • Abstract Number: 672 • 2019 ACR/ARP Annual Meeting

    Mouse SLE Studies Do Not Describe Human SLE

    Ecem Sevim1, Linjia Jia 2, David Fernandez 3 and Michael Lockshin 4, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, NY, 3Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY, 4Hospital for Special Surgery, Barbara Volcker Center for Women and Rheumatic Diseases, New York, NY

    Background/Purpose: Although mouse models of systemic lupus erythematosus (SLE) are useful proxies for human illness, they are heterogeneous, and publications about mouse SLE may not…
  • Abstract Number: 1024 • 2019 ACR/ARP Annual Meeting

    Lysosome Defects in SLE Promote the Accumulation of Nuclear Antigens on the Surface of Hematopoietic Cells

    Sun Ah Kang1, Jennifer Rogers 2, Saira Sheikh 3, Megan Clowse 2, Lisa Criscione-Schreiber 2 and Barb Vilen 4, 1University of NOrth Carolina at Chapel Hlil, Chapel Hill, NC, 2Duke University, Durham, 3University of North Carolina, Chapel Hill, NC, 4University of North Carolina CHapel Hill, Chapel Hill, NC

    Background/Purpose:   Impaired clearance of cell debris allows nuclear self-antigens such as DNA to accumulate, bind autoreactive IgG and form immune complexes (IgG-ICs) in SLE.  We…
  • Abstract Number: 1579 • 2019 ACR/ARP Annual Meeting

    Presence of Antiphospholipid Antibodies in Patients with SLE and Venous Thromboembolic Events of African American and Caucasian Race

    Elena Gkrouzman1, Julia Davis-Porada 1, Mary Peng 2 and Kyriakos Kirou 2, 1Hospital for Special Surgery, New York, 2Hospital for Special Surgery, New York, NY

    Background/Purpose: Risk of thrombosis is elevated in patients with systemic lupus erythematosus (SLE) compared to healthy individuals, especially during the first year after diagnosis. The…
  • Abstract Number: 2034 • 2019 ACR/ARP Annual Meeting

    Identification of IL-17+ and IL-10+ TCRαβ+ CD4- CD8- Double Negative (DN) T Cell Subsets in Lupus-prone Mice and Patients with SLE and Their Significance in Predicting Renal Involvement

    Yi Li1, Hao Li 2, Shui Lian Yu 3, Vasileios Kyttaris 4 and George Tsokos 4, 1BIDMC, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 3The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (People's Republic), 4Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

    Background/Purpose: We have previously shown that DN T cells are expanded in both lupus-prone mice and patients with SLE and we have demonstrated that this…
  • Abstract Number: 64 • 2019 ACR/ARP Annual Meeting

    Rab4A Controls mTOR Pathway Activation, Pro-inflammatory Lineage Development, and Disease Pathogenesis in Lupus-prone Mice

    Nick Huang1, Zhiwei Lai 2, Brandon Wyman 2, Thomas Winans 2, Manuel Duarte 2, Joshua Lewis 2, Mark Haas 3, Laurence Morel 4 and Andras Perl 5, 1Upstate Medical University, Syracuse, NY, 2Upstate Medical University, Syracuse, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4University of Florida, Gainesville, FL, 5SUNY Upstate Medical University, Syracuse, NY

    Background/Purpose: Mouse models of SLE have been indispensable tools for studying disease pathogenesis; however, each model only recapitulates limited aspects of lupus. SLE1.2.3. (TC) mice…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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