Abstracts tagged "Osteoarthritis"

Abstract Number: 0051 • ACR Convergence 2021
Identification of Biomarkers and Deregulated Pathways in Psoriatic Arthritis Through Proteomic Analysis of Synovial Fluid
Jacqueline Lai¹, Sara Rahmati², Raam Sivakumar², Katerina Oikonomopoulou³, Fatima Abji⁴ and Vinod Chandran⁵, ¹McMaster University, Hamilton, ON, Canada, ²University Health Network, Toronto, ON, Canada, ³Krembil Research Institute, Toronto, ON, Canada, ⁴University of Toronto, University Health Network, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose: Psoriatic arthritis (PsA) is an inflammatory arthritis that currently lacks diagnostic biomarkers. We hypothesized that there are differences in the protein intensities in the…
Abstract Number: 0465 • ACR Convergence 2021
Cost-effectiveness of Treatment Strategies Involving Arthroscopic Partial Meniscectomy and Physical Therapy for Degenerative Meniscal Tear
Emma Williams¹, Valia Leifer¹, Jamie Collins², Tuhina Neogi³, Lisa Suter⁴, Jeffrey Katz⁵ and Elena Losina², ¹The Orthopaedic and Arthritis Center for Outcomes Research (OrACORe) at Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Yale School of Medicine, New Haven, CT, ⁵Brigham and Women's Hospital, Brookline, MA
Background/Purpose: Knee osteoarthritis (KOA) and meniscal tear (MT) are highly prevalent and often concomitant. Treatments for MT in the presence of KOA include physical therapy…
Abstract Number: 0728 • ACR Convergence 2021
Intra-articular Canakinumab (anti-interleukin-1β) for Treatment of Symptomatic Knee Osteoarthritis: A Randomized, Double-blind, Placebo and Naproxen-controlled Phase II Study
Philip Conaghan¹, Xavier Chevalier², Linda Mindeholm³, Ursula Schramm³, Jens Praestgaard³, Abdelkader Seroutou³, Ronenn Roubenoff³ and Matthias Schieker³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Henri Mondor University Hospital and Paris University XII, UPEC, Créteil, France, Créteil, France, ³Novartis Institutes for Biomedical Research, Basel, Switzerland, Basel, Switzerland
Background/Purpose: Knee osteoarthritis (OA) is a common musculoskeletal disease associated with pain and functional impairment. There are few effective therapies, often limited by side-effects.1 This…
Abstract Number: 1035 • ACR Convergence 2021
The ELSA-Brasil Musculoskeletal Cohort (ELSA-Brasil MSK): Design, Implementation and Prevalence of Chronic Musculoskeletal Pain and Radiographic Knee Osteoarthritis at Baseline
Rosa Weiss Telles¹, Luciana Machado², Luciana Costa-Silva³ and Sandhi Maria Barreto¹, ¹Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ²Clinical Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, ³Instituto Hermes Pardini. Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
Background/Purpose: Musculoskeletal (MSK) disorders, including low back pain and osteoarthritis (OA), are ranked among the top causes of years lived with disability and increased risk-attributable…
Abstract Number: 1125 • ACR Convergence 2021
Synovial Perivascular Edema Is Associated with Altered Knee Loading Patterns During Gait in Patients with Medial Compartment-Dominant Knee Osteoarthritis
McKenzie Carter¹, Holly Philpott¹, Trevor Birmingham², Ryan Pinto³, Codie Primeau¹, J. Robert Giffin¹, Brent Lanting² and Tom Appleton², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³Western University, Kitchener, ON, Canada
Background/Purpose: Synovial inflammation and aberrant joint loads are independent risk factors for knee osteoarthritis (OA) incidence and progression. Perivascular edema, the accumulation of fluid around…
Abstract Number: 1471 • ACR Convergence 2021
Oral Administration of Berberine Limits Post-traumatic Osteoarthritis Development and Associated Pain via AMP-activated Protein Kinase (AMPK) in Mice
Jun Li¹, Yun Wang², Di Chen³ and Ru Liu Bryan⁴, ¹Rush University Medical Center, Chicago, IL, ²Valo Health, Lexington, MA, ³Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (People's Republic), ⁴University of California San Diego and VASDHS, San Diego, CA
Background/Purpose: AMP-activated protein kinase (AMPK), a master regulator of energy balance and metabolism, is implicated to play an important role in cartilage homeostasis. Berberine is…
Abstract Number: 0153 • ACR Convergence 2021
Echogenic and Hypervascular Synovium Detected on Ultrasound Are Predictive of a Favorable Response After Intra-articular Corticosteroid Injection in Patients with Knee Osteoarthritis
Robert Dima¹, Trevor Birmingham², Ryan Pinto³, Holly Philpott¹, McKenzie Carter¹ and Tom Appleton², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³Western University, Kitchener, ON, Canada
Background/Purpose: Intra-articular corticosteroids (IACS) are commonly used for symptom management in knee osteoarthritis (KOA) patients, despite the fact that many patients do not respond to…
Abstract Number: 0478 • ACR Convergence 2021
Identification of Clinical Phenotypes of Hand Osteoarthritis Using Hierarchical Clustering Method
Marie Binvignat¹, Gabriel Pires¹, Nicolas Tchitchek¹, Alice Courties², Felicie Costantino³, David Klatzmann¹, Bernard Combe⁴, Maxime Dougados⁵, Pascal Richette⁶, Encarnita Mariotti-Ferrandiz¹, Francis Berenbaum⁷ and Jeremie Sellam⁸, ¹Sorbonne Universite, Paris, France, ²Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, ³Inserm, Boulogne Billancourt, France, ⁴CHU Montpellier Montpellier University, Montpellier, France, ⁵Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, ⁶Lariboisiere Hospital, Paris, France, ⁷Sorbonne Universit - hopital Saint-Antoine, Paris, France, ⁸INSERM UMRS_938, Sorbonne Université, St-Antoine Hospital, Paris, France, Paris, France
Background/Purpose: Hand osteoarthritis (OA) is an heterogenous disease in terms of risk factors, localization and severity. This heterogeneity also applies to the clinical presentation and…
Abstract Number: 0731 • ACR Convergence 2021
An Open-Label Study to Evaluate the Effect of Intra-articular Triamcinolone Acetonide Extended Release on Patients with Baseline Synovitis and Osteoarthritis of the Knee
Kim Huffman¹, Alan Kivitz², Philip Conaghan³, Michael Bowes⁴, Alan Brett⁴, Virginia Kraus¹, William Maloney⁵, Javad Parvizi⁶, Amy Cinar⁷, Neil Bodick⁷ and Scott Kelley⁷, ¹Duke University School of Medicine, Durham, NC, ²Altoona Center for Clinical Research, Duncansville, PA, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Imorphics Ltd, Manchester, United Kingdom, ⁵Stanford University School of Medicine, Stanford, CA, ⁶Thomas Jefferson University Hospital, Philadelphia, PA, ⁷Flexion Therapeutics Inc., Burlington, MA
Background/Purpose: Synovial inflammation is common in knee osteoarthritis (OA) and is associated with pain and disease severity. Previous studies have suggested short-term (approximately 2 weeks)…
Abstract Number: 1037 • ACR Convergence 2021
Variations in Total Knee Replacement Utilization and Outcomes in USA and Canada: The Role of Geography and Socioeconomic Factors
Bella Mehta¹, Kaylee Ho², Vicki Ling³, Susan Goodman⁴, Michael Parks⁴, Bheeshma Ravi⁵, Samprit Banerjee², Said Ibrahim⁶ and Peter Cram⁷, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Institute for Clinical Evaluative Sciences, Toronto, ON, Canada, ⁴Hospital for Special Surgery, New York, NY, ⁵Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Weill Cornell Medicine, Cleveland, OH, ⁷Sinai Health System and University Health Network, Toronto, ON, Canada
Background/Purpose: Total Knee Arthroplasty (TKA) is an effective treatment option for end-stage knee osteoarthritis. The US is well known for having striking wealth-based disparities in…
Abstract Number: 1126 • ACR Convergence 2021
Synovial Cell Dysfunction in Obese Patients May Contribute to Poor Outcomes in Knee Osteoarthritis
Holly Philpott¹, Trevor Birmingham², Nicole Aye², Benoit Fiset³, Logan Walsh³, Brent Lanting² and Tom Appleton², ¹Western University, London, ON, Canada, ²University of Western Ontario, London, ON, Canada, ³McGill University, Montréal, QC, Canada
Background/Purpose: Obesity is a major risk factor for poor outcomes in knee osteoarthritis (OA) and may involve both mechanical and physiological stresses on joint tissues.…
Abstract Number: 1473 • ACR Convergence 2021
Chaperone-mediated Autophagy Is a Hallmark of Joint Damage in Osteoarthritic Patients
Irene Lorenzo-Gómez¹, Uxía Nogueira-Recalde¹, Natividad Oreiro², José A. pinto³, Francisco Blanco-García⁴ and Beatriz Caramés¹, ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain, ⁴Unidad de Proteómica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). C/ As Xubias de Arriba 84, 15006, A Coruña, España.Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S). Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, 15008, A Coruña, España., A Coruña, Spain
Background/Purpose: In osteoarthritis (OA), defects in Autophagy are evident and precede joint damage. Therefore, identifying hallmarks associated with specific autophagy subtypes could shed light to…
Abstract Number: 0210 • ACR Convergence 2021
Using Machine Learning to Predict Medial Knee Cartilage Worsening over 2 Years Using Gait and Physical Activity: The MOST Study
Kerry Costello¹, David Felson¹, S. Reza Jafarzadeh², Neil Segal³, Cora Lewis⁴, Michael Nevitt⁵, Cara Lewis⁶, Vijay Kolachalama² and Deepak Kumar¹, ¹Boston University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³University of Kansas Medical Center, Iowa City, IA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of California San Francisco, Orinda, CA, ⁶Boston University, Brookline, MA
Background/Purpose: Identifying knees at risk of worsening osteoarthritis (OA) could help to identify individuals in need of interventions. While gait and physical activity are considered…
Abstract Number: 0479 • ACR Convergence 2021
A Novel Semi-automated Classifier of Radiographic Hip Osteoarthritis on DXA Scans Is Strongly Predictive of Pain, Clinical Diagnosis and Joint Replacement: Findings from 40,000 Participants in UK Biobank
Benjamin Faber¹, Raja Ebsim², Fiona Saunders³, Monika Frysz¹, Claudia Lindner², Jennifer Gregory³, Richard Aspden³, Nicholas Harvey⁴, George Davey Smith¹, Timothy Cootes² and Jon Tobias¹, ¹University of Bristol, Bristol, United Kingdom, ²University of Manchester, Manchester, United Kingdom, ³University of Aberdeen, Aberdeen, United Kingdom, ⁴University of Southampton, Southampton, United Kingdom
Background/Purpose: Radiographic hip osteoarthritis (rHOA) is traditionally defined on hip or pelvic radiographs, using subjective methods such as Kellgren-Lawrence scoring. Associations between subjective rHOA measures…
Abstract Number: 0732 • ACR Convergence 2021
Topical Rofecoxib for OA of the Knee
Bruce Register¹, Nancy Lane², Lee Simon³, John Newsam⁴, Edward Kisak⁴, Jed Pheneger⁵, John Galvin⁵, Jeffrey Klein⁶ and Marc Hochberg⁷, ¹BriOri BioTech, Inc., Newport Beach, CA, ²University of California Davis, Hillsborough, CA, ³SDG LLC, West Newton, MA, ⁴Tioga Research, Inc, San Diego, CA, ⁵Inotiv, Boulder, CO, ⁶Sinclair Research Center, Auxvasse, MO, Canada, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Osteoarthritis remains a highly prevalent disease in the elderly, and there are currently no approved treatments that can modify the disease course. Currently, both…

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