ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1130

Osteoarthritis Patients Feel Their Tissue Remodeling

Anne-Christine Bay-Jensen1, Yi He2, Christian Thudium1 and Morten Karsdal3, 1Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience A/S, Herlev, Denmark, 3Nordic Bioscience, Herlev

Meeting: ACR Convergence 2021

Keywords: Biomarkers, Osteoarthritis, Patient reported outcomes, WOMAC

  • Tweet
  • Email
  • Print
Session Information

Date: Monday, November 8, 2021

Session Title: Osteoarthritis – Clinical Poster III (1118–1134)

Session Type: Poster Session C

Session Time: 8:30AM-10:30AM

Background/Purpose: Osteoarthritis (OA) is a chronic disease characterized by pain and disability. Central to the revised FDA guidelines for the approval of a disease modifying OA drug are patient reported outcomes (PROs). There is a need in drug development to understand how biomarkers of tissue remodeling objectively relate to PROs, or even predict changes in PROs. Recently, it was shown that levels of the CRP metabolite (CRPM), but not CRP, with concentrations of above 9 ng/mL were prognostic of knee OA progression assessed by X-ray. Moreover, that 1/3 of OA patients had levels of CRPM like that of RA patients. While several biomarkers of tissue modeling correlate to disease activity score in RA, this information is missing in OA. The joint comprises of multiple connective tissues which consist of collagen such as type I, II, III and IV. Biomarkers have been developed which measures the remodeling of collagens. We hypothesis that such markers may provide the missing link between OA pathology and PROs. We differentiated an OA population in high and low CRPM and investigate the relationship to PROS to serological biomarker of tissue turnover.

Methods: 111 knee OA patients, 62% women, from the placebo arm of a phase III study with knee OA were included: mean (SD) age, 32(10); mean (SD) BMI, 27(4); NSAID users, 32%; and radiographic OA (KL≥2) 68%. PROs were: VASpain and WOMAC total, pain, stiffness, and function at baseline (BL). 19 healthy individuals were included as reference. Median (IQR) were 39 (13-69) and 37 (13-52) for BL VASpain and WOMACpain. Eight serum biomarkers of type I, II, III and IV collagen degradation (C1M, C2M, C3M, C4M) and formation (PRO-C1, PRO-C2, PRO-C3 and PRO-C4) as well as two inflammatory biomarkers CRPM and hsCRP, were assessed. Log2 transformed data was adjusted for race, gender, age, and BMI.

Results: None of the collagen formation or degradation markers were on average higher or lower in OA than healthy controls (adjusted for age, gender, race, and BMI). No correlations between collagen markers and PROs were observed. We confirmed the previous identified cut-off and found an AUC of 0.61 (p=0.078, cut-off of 8.7). In patients with low CRPM: PRO-C2 was positively correlated with VASpain (r=0.53) WOMAC total and pain (r=0.22) and PRO-C4 negatively with WOMACpain (r=-0.26). In patients with high CRPM: PRO-C4 was positively correlated with VASpain (r=0.29), WOMACtotal, pain and stiffness (r=0.28, 0.3 and 0.22). C1M was correlated with VASpain (r=0.20), WOMACtotal, pain, stiffness and function (r=0.32, 0.24, 0.29, 0.30). C2M was negatively correlated with VASpain (r=-0.28), WOMACtotal, pain, stiffness and function (r=-0.49, -0.43, 0.44, -0.43). C3M was also negatively correlated with VASpain (r=-0.44), WOMACtotal, pain, stiffness and function (r=-0.51, -0.42, -0.55, -0.49).

Conclusion: Biomarkers of tissue remodeling did not correlate to PROs in the undifferentiated OA population. In contrast, the two distinct subpopulations of ether low or high CRPM had multiple correlation between tissue turnover and PROs. The data provide the first insights into objective tissue turnover biomarkers and PROs, which is essential for successful drug development, and in the understanding of the processes in the OA joint causing pain.


Disclosures: A. Bay-Jensen, Nordic Biosciences, 3, 11; Y. He, None; C. Thudium, Nordic Bioscience, 3; M. Karsdal, Nordic Bioscience, 3, 11.

To cite this abstract in AMA style:

Bay-Jensen A, He Y, Thudium C, Karsdal M. Osteoarthritis Patients Feel Their Tissue Remodeling [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/osteoarthritis-patients-feel-their-tissue-remodeling/. Accessed February 4, 2023.
  • Tweet
  • Email
  • Print

« Back to ACR Convergence 2021

ACR Meeting Abstracts - https://acrabstracts.org/abstract/osteoarthritis-patients-feel-their-tissue-remodeling/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences