Abstracts tagged "Osteoarthritis"

Abstract Number: L05 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics, and Clinical Outcomes Following Single-Dose IA Administration of UBX0101, a Senolytic MDM2/p53 Interaction Inhibitor, in Patients with Knee OA
Benjamin Hsu¹, Jennifer Visich ², Mark Genovese ³, Kimberly Walter ², Mahru An ⁴, Remi-Martin Laberge ⁴ and Jamie Dananberg ⁴, ¹Unity Biotechnology, Brisbane, ²Unity Biotechnology, Brisbane, California, ³Stanford University, Stanford, CA, ⁴Unity Biotechnology, Brisbane, CA
Background/Purpose: A non-drug biomarker study showed senescent cell (SnC) burden in OA synovial tissue to correlate with disease severity, inflammation, and knee pain (C. Yohn,…
Abstract Number: 1129 • 2019 ACR/ARP Annual Meeting
Direct Medical and Societal Cost of Opioid Use in Symptomatic Knee Osteoarthritis Patients in the United States
Jamie Huizinga¹, Elizabeth Stanley ¹, Shuang Song ¹, James Sullivan ², Jeffrey Katz ³ and Elena Losina ⁴, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital/Harvard Medical School, Boston, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Symptomatic knee OA affects 14 million adults in the US. Recent estimates suggest that about 40% of people with knee OA are taking prescription…
Abstract Number: 1317 • 2019 ACR/ARP Annual Meeting
Frail Patients Have Worse Function After Total Knee Replacement
Lisa Mandl¹, Charles Cornell ¹, Michael Cross ¹, Alejandro Gonzalez Della Valle ¹, Mark Figgie ¹, Seth Jerabek ¹, Marianna Frey ², John Roberts IV ³, Justin Do ³, Mayu Sasaki ³, Nathaniel Hupert ⁴, Jackie Finik ³ and Steven Magid ¹, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY, ²Hospital for Special Surgery, New York, NY, New York, ³Hospital for Special Surgery, New York, NY, New York, NY, ⁴Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: To determine whether frailty is associated with patient outcomes 1 year after total knee replacement (TKR).Methods: Patients ≥65yo scheduled for elective primary TKR for…
Abstract Number: 1968 • 2019 ACR/ARP Annual Meeting
A Drug Repurposing Story: New Therapeutic Tools Ready to Block Innate Immune Responses in Osteoarthritis
Eloi Franco-Trepat¹, Ana Alonso-Pérez ¹, Maria Guillán-Fresco ¹, Alberto Jorge-Mora ², Ana Lois Iglesias ³, Oreste Gualillo ⁴ and Rodolfo Gómez ¹, ¹Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Spain, ²Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, ³Institute IDIS - Musculoskeletal Pathology Group, Santiago de Compostela, Galicia, Spain, ⁴Institute IDIS - NEIRID Lab - SERGAS, Santiago de Compostela, Spain
Background/Purpose: Rheumatic diseases, also known as musculoskeletal pathologies, are steadily rising their prevalence. This worldwide phenomenon is depriving our society of their life quality and…
Abstract Number: 2057 • 2019 ACR/ARP Annual Meeting
Cross-sectional Associations of Multiple Joint Osteoarthritis in the Osteoarthritis Initiative
Charles Eaton¹, Mary Roberts ², Jeffrey Driban ³, Michael Nevitt ⁴, Jeffrey Duryea ⁵ and Timothy McAlindon ⁶, ¹Warren Alpert Medical School of Brown University, Pawtucket, RI, ²Center for Primary Care and Prevention, Pawtucket, ³Tufts Medical Center, Boston, ⁴University of California at San Francisco, San Francisco, CA, ⁵Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA, ⁶Tufts Medical Center, Boston, MA
Background/Purpose: Multiple joint osteoarthritis (MJOA) may represent a unique phenotype of osteoarthritis related to systemic factors associated with pathologic aging. We tested the hypothesis that metabolic…
Abstract Number: 2189 • 2019 ACR/ARP Annual Meeting
Reference Curves for the Knee Injury and Osteoarthritis Outcome Score in the Middle-aged Dutch Population
Marieke Loef¹, Féline PB Kroon ¹, Stephan Böhringer ¹, Frits R Rosendaal ¹ and Margreet Kloppenburg ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background/Purpose: The Knee injury and Osteoarthritis Outcome Score (KOOS) questionnaire is a widely used patient-reported outcome tool, developed to evaluate short- and long-term knee symptoms…
Abstract Number: 2762 • 2019 ACR/ARP Annual Meeting
The Preparation and Recovery Experience from Total Knee Replacement of Patients with Osteoarthritis: A Qualitative Study
Iris Navarro-Millan¹, Sarah Young ², Geyanne Lui ¹, Marianna Frey ³, Janey Peterson ¹, Susan Goodman ⁴, Monika Safford ¹ and Lisa Mandl ⁵, ¹Weill Cornell Medicine, New York, ²Binghamton University, Binghamton, ³Hospital for Special Surgery, New York, NY, New York, ⁴Hospital For Special Surgery/Weill Cornell Medicine, New York, NY, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, New York, NY
Background/Purpose: Up to 30% of patients may have persistent pain post-total knee arthroplasty (TKA). One possible approach to improve these outcomes is to optimize muscle…
Abstract Number: 1139 • 2019 ACR/ARP Annual Meeting
Lifetime Direct Medical and Indirect Cost of Knee Osteoarthritis: Impact of Pain and Structural Severity
Elizabeth Stanley¹, James Sullivan ², Jamie Huizinga ¹, Jamie Collins ³, Jeffrey Katz ⁴ and Elena Losina ⁵, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women's Hospital, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, ⁴Brigham and Women's Hospital/Harvard Medical School, Boston, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Symptomatic knee OA is a debilitating condition that affects 14 million adults in the US. We estimated the variability of lifetime OA-related direct and…
Abstract Number: 1319 • 2019 ACR/ARP Annual Meeting
Impact of ACL Injury Management on the Development of Knee Osteoarthritis: A Meta-analysis
stéphanie Ferrero¹, marion louvois ¹, Thomas Barnetche ², Thao Pham ³, Véronique Breuil ¹ and christian roux ⁴, ¹University of Nice, nice, France, ²FHU ACRONIM, Department of Rheumatology, Centre Hospitalier Universitaire, Bordeaux, France, Bordeaux, France, ³Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, ⁴CHU Pasteur Nice, Nice, France
Background/Purpose: Background: The development of knee's osteoarthritis after anterior cruciate ligament ACL injury is now widely recognized. The impact of surgical or rehabilitative management on…
Abstract Number: 1970 • 2019 ACR/ARP Annual Meeting
Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe¹, Nobunori Takahashi ¹, Yoshifumi Ohashi ², Toshihisa Kojima ¹, Naoki Ishiguro ¹, Cheryl Knudson ² and Warren Knudson ², ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²East Carolina University, Greenville
Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic…
Abstract Number: 2083 • 2019 ACR/ARP Annual Meeting
Understanding Knee Function and Symptom Management in Individuals with Risk Factors for Knee Osteoarthritis
Jason Jakiela¹, Daniel White ², Hiral Master ², Meredith Christiansen ¹, Dana Voinier ¹, Lauren Neely ¹ and Louise Thoma ³, ¹University of Delaware, Newark, ²University of Delaware, Newark, DE, ³University of North Carolina at Chapel Hill, Newark
Background/Purpose: Worse knee function and frequent use of knee symptom management strategies are common in people with symptomatic knee osteoarthritis (SxOA). There are several risk…
Abstract Number: 2191 • 2019 ACR/ARP Annual Meeting
Construct Validity of OMERACT Ultrasound Knee Scores with Pain, Other Symptoms, Radiographic and MRI Findings
Win Min Oo¹, James Linklater ², Kimberly Bennell ³, Shirley Yu ¹, Xia Wang ¹, Vicky Duong ¹ and David Hunter ¹, ¹Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia, Sydney, New South Wales, Australia, ²Department of Musculoskeletal Imaging, Castlereagh Sports Imaging Center, St. Leonards, Sydney, Australia, Sydney, New South Wales, Australia, ³Centre for Health, Exercise and Sports Medicine, Department of Physiotherapy, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, VIC, Australia., Parkville, Victoria, Australia
Background/Purpose: To investigate the construct validity of Outcome Measures in Rheumatology (OMERACT) ultrasound scores for knee osteoarthritis (OA) with pain, other symptoms, and OA severity…
Abstract Number: 2794 • 2019 ACR/ARP Annual Meeting
Predictors of Incident and Worsening Lumbar Spine Degeneration: The Johnston County Osteoarthritis Project
Adam Goode¹, Rebecca Cleveland ², David Hu ³, Steven George ⁴, Virginia Byers Kraus ⁵, Todd Schwartz ⁶, Richard Gracely ⁷, Louis DeFrate ⁸, Joanne Jordan ⁹ and Yvonne Golightly ¹⁰, ¹Duke University, Department of Orthopedic Surgery, Duke Clinical Research Institute, and Department of Population Health Sciences, Durham, NC, ²Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Center, University of North Carolina - Chapel Hill, Chapel Hill, NC, ⁴Duke University, Department of Orthopedic Surgery and Duke Clinical Research Institute, Durham, NC, ⁵Duke University, Department of Orthopedic Surgery, Duke Molecular Physiology Laboratory, Durham, NC, ⁶University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁷Department of Endodontics, Adams School of Dentistry, University of North Carolina, Chapel Hill, Chapel Hill, NC, ⁸Duke University, Department of Orthopedic Surgery, Department of Mechanical Engineering and Materials Science and Department of Biomedical Engineering, Durhham, NC, ⁹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ¹⁰University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC
Background/Purpose: Our aim was to determine whether demographics, clinical characteristics or appendicular joint osteoarthritis predict the incidence and worsening of lumbar spine disc space narrowing…
Abstract Number: 1162 • 2019 ACR/ARP Annual Meeting
Changes in Novel Composite Scores of Disease Activity and Cumulative Damage Are Prognostic of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Matthew Harkey¹, Julie Davis ², Bing Lu ³, Lori Lyn Price ⁴, Robert Ward ⁵, James MacKay ⁶, Charles Eaton ⁷, Grace Lo ⁸, Mary Barbe ⁹, Ming Zhang ⁵, Jincheng Pang ¹⁰, Alina Stout ¹¹, Lavalley Michael ¹², Timothy McAlindon ¹³ and Jeffrey Driban ¹³, ¹University of Massachusetts Medical School, Worcester, ²George Washington University, Washington DC, ³Brigham and Women's Hospital, Boston, MA, ⁴Tufts Medical Center, Tufts University, Boston, MA, ⁵Tufts Medical Center, Boston, ⁶University of Cambridge, Cambridge, United Kingdom, ⁷Brown University Center for Primary Care and Prevention, Pawtucket, ⁸Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁹Temple University, Philadelphia, ¹⁰Pfizer, Inc., Cambridge, MA, ¹¹Northeastern University, Boston, ¹²Boston University, Boston, ¹³Tufts Medical Center, Boston, MA
Background/Purpose: Composite imaging scores that reflect cartilage damage, bone marrow lesions (BMLs), and effusion-synovitis may enable us to conceptualize knee osteoarthritis (KOA) disease progression as…
Abstract Number: 1320 • 2019 ACR/ARP Annual Meeting
Individual Socio-economic Status and Symptomatic Hip and Knee Osteoarthritis: A Longitudinal Study, Results from the KHOALA Cohort
Pauline Baudart¹, Anne-Christine Rat ², Christian Marcelli ¹ and Joséphine Bryère ³, ¹CHU Caen, rheumatology department, Caen Normandie University, Caen, France, ²CHU Caen, rheumatology department, Caen Normandie University, Université de Lorraine, EA 4360 APEMAC, Caen, France, ³Inserm, university of Caen research U1086 Anticipe, Caen, France
Background/Purpose: We analyzed the association between individual socio-economic status (SES) variables and clinical symptoms (function, pain and quality of life) in patients with symptomatic knee…

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