Abstracts tagged "Osteoarthritis"

Abstract Number: LB07 • ACR Convergence 2025
Adipose-Tissue Derived Mesenchymal Stem Cells vs Hyaluronic Acid in Refractory Knee Osteoarthritis in a low-resource setting: A Phase IIb RCT
Moshiur Rahman Khasru¹, Mohammad Tariqul Islam², AGM Zakaria Nazimuddin Jubery³, Mahbuba Shirin⁴, Fazle Rabbi Chowdhury⁵, Tangila Marzen⁶, Nafi Uzzaman⁷, Md Abu Bakar Siddiq⁸, Md Ashraful Hoque⁹, Masuda Begum¹⁰, Md Moniruzzaman Khan² and Abul Salek¹¹, ¹Musculoskeletal Medicine and Interventional Physiatry Division, Bagladesh Medcial University, Dhaka, Bangladesh, ²Department of Physical Medicine and Rehabilitation, Bangladesh Medical University, Dhaka, Bangladesh, ³Department of Burn and Plastic Surgery, Dhaka Medcial College and Hospital, Dhaka, Bangladesh, ⁴Department of Radiology and Imaging, Bangladesh Medical University, Dhaka, Bangladesh, ⁵Department of Internal Medicine, Bangladesh Medical University, Dhaka, Bangladesh, ⁶Department of Anatomy, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh, ⁷Stem Cell Rearch Group, Department of Physical Medicine and Rehabilitation, Bangladesh Medical University, Dhaka, Bangladesh, ⁸Department of Rheumatology, Royal North Shore Hospital, Faculty of Medicine, University of Sydney, New South Wales, Australia, ⁹Department of Transfusion Medicine, Cumilla Medical College, Cumilla, Bangladesh, ¹⁰Department of Haematology, Banglabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, ¹¹Department of Physical Medicine and Rehabilittaion, Bangladesh Medical University, Dhaka, Bangladesh
Background/Purpose: Knee osteoarthritis (KOA) is a leading cause of disability, with no available disease-modifying treatments. While Hyaluronic Acid (HA) remains widely used, there is little…
Abstract Number: LB12 • ACR Convergence 2025
Randomized, Double-Blind, Placebo-Controlled Phase IIa Trial of an Innovative Intra-Articular Apoptotic Cell Therapy in Knee Osteoarthritis (OA): 3-Month Positive Outcomes and Identification of Responder Population (NCT06233474)
Philip Conaghan¹, Bernt Husøy², Cecilie Rovsing³, Sidsel L Boll⁴, Liliana Groppa⁵, Amir Oron⁶, Asger Bihlet⁷, Ali Mobasheri⁸, Tobias Winkler⁹, Dror Mevorach¹⁰, Einat Galamidi¹¹, Lital Weinfeld-Bergman¹², Lior Binder¹² and Oren Hershkovitz¹¹, ¹University of Leeds, Leeds, United Kingdom, ²Sanos Clinic, Herlev, Denmark, ³Sanos Clinic, Gandrup, Denmark, ⁴Sanos Clinic, Vejle, Denmark, ⁵T. Mosneaga Republican Clinical Hospital, Chisinau, Moldova, ⁶Kaplan MC, Rehovot, Israel, ⁷NBCD A/S, Soeborg, Denmark, ⁸University of Oulu, Oulu, Finland, ⁹Charité - Universitätsmedizin Berlin, Berlin, Germany, ¹⁰Hadassah-University Hospital, Jerusalem, Israel, ¹¹Enlivex Therapeutics, Ness Ziona, Israel, ¹²Enlivex Therapeutics, Nes Ziona, Israel
Background/Purpose: OA is a prevalent disabling disease growing globally due to aging populations and rising obesity. In primary OA, the effects of joint tissue damage accumulate with age,…
Abstract Number: 0165 • ACR Convergence 2025
Per-Protocol Analysis of the Effectiveness of GLP1 Agonists Against SGLT2 Inhibitors on Osteoarthritis Outcomes
Nene Ukonu¹, David Felson², Michael LaValley³ and S. Reza Jafarzadeh⁴, ¹Boston University School of Public Health, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Public Health, Arlington, MA, ⁴Boston University Chobanian & Avedisian School of Medicine, Boston, MA
Background/Purpose: Anti-diabetic medications often have effects on other conditions. GLP1 agonists (GLP1a) have shown protective effects on OA outcomes in trials and short-term trial emulations,…
Abstract Number: 0322 • ACR Convergence 2025
Metabolites Reflective of the Gut Microbiome Relate to Future Incident Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Shike Xu², Timothy McAlindon³, John Haran⁴, Julieann Patarini⁴ and Bing Lu⁵, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²University of Connecticut Health Center, Farmington, CT, ³UMass Chan School of Medicine, Arlington, MA, ⁴UMass Chan Medical School, Worcester, MA, ⁵UConn Health Center, Newton, MA

Background/Purpose: Numerous cross-sectional and animal studies have linked an altered gut microbiome to osteoarthritis (OA). Human studies are needed to explore the association between the…
Abstract Number: 0765 • ACR Convergence 2025
Rural Access to Physical Therapy for Osteoarthritis Rehabilitation (RAPTOR): A Pilot Feasibility Study
Allyn Bove, Emma Zavacky, Hallie Zeleznik, Christopher Bise, Charity Patterson, Bambang Parmanto and G Kelley Fitzgerald, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Individuals who live in rural areas are more likely to experience knee osteoarthritis-related disability and less likely to be referred to physical therapy for…
Abstract Number: 1647 • ACR Convergence 2025
Clinical Phenotypes of Participants with Radiographic Osteoarthritis Attaining Patient Acceptable Symptom State in the Multicenter Osteoarthritis Study
Sarah Tilley¹, Michael LaValley², Brooke McGinley³, Cora Lewis⁴, James Torner⁵, David Felson³ and Tuhina Neogi⁶, ¹Boston University School of Medicine, Somerville, MA, ²Boston University School of Public Health, Arlington, MA, ³Boston University, Boston, MA, ⁴The University of Alabama at Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶Boston University School of Medicine, Boston, MA
Background/Purpose: Osteoarthritis (OA) is a leading cause of pain and disability in older adults marked by progressive joint degeneration. Symptom trajectories vary: some experience persistent…
Abstract Number: 1791 • ACR Convergence 2025
Determining the Effect of CD14 Deficiency on Osteoblastogenesis and Subchondral Bone Remodeling In Mice
Kate Sharp¹, Lance Murphy², Vu Nguyen³, Baofeng Hu⁴ and Carla Scanzello⁵, ¹University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ³University of Pennsylvania, Phildealphia, ⁴University of Pennsylvania, Wynnewood, PA, ⁵University of Pennsylvania, Philadelphia
Background/Purpose: Osteoarthritis (OA) is a debilitating disease affecting ~54% of US adults 75 and older. Toll-like receptor 4 (TLR4), and its co-receptor CD14, have been…
Abstract Number: 1937 • ACR Convergence 2025
Does Combining Standard MRI-Based Scores with Radiographic Trabecular Bone Texture Biomarkers Improve Predictive Performance for Radiographic Knee Osteoarthritis Progression?
Ahmad Almhdie-Imjabbar¹, Saida Daroussi², Daniela Herrera³, Hechmi Toumi² and Eric Lespessailles⁴, ¹University Hospital Center of Orleans, Orleans, France, ²PRIMMO- University Hospital Center of Orleans, Orleans, France, ³PRIMMO- University Hospital Center of Orleans, Olreans, France, ⁴CHU Orléans, Orléans, France
Background/Purpose: Knee osteoarthritis (KOA) is a major cause of disability worldwide, particularly impacting the elderly and obese population. Radiographic trabecular bone texture (TBT) is demonstrated…
Abstract Number: 2091 • ACR Convergence 2025
Multiplanar MRI Quantification of Effusion-Synovitis: Reliability and Potential Investigative Utility for Inflammation-Mediated Knee Conditions
Greg Gilles¹, Dagoberto Robles², Luke Grawer³, Nathaniel H. Christiansen⁴, Karim Jayyusi³, Ali Shaikh³, Rongrong Tang⁵, Mihra S. Taljanovic³, Jeffrey Duryea⁶, Edward J. Bedrick⁵ and C. Kent Kwoh⁷, ¹University of Arizona Arthritis Center, The University of Arizona College of Medicine, Tucson, AZ, ²University of Arizona, Tucson, AZ, ³University of Arizona, Tucson, ⁴University of Arizona, Stockton, NJ, ⁵The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: Effusion-synovitis (ES) is often seen in knee osteoarthritis (KOA), and MRI-detected ES may serve as a potential imaging biomarker of disease activity, progression, and…
Abstract Number: 2603 • ACR Convergence 2025
Evaluating the Feasibility, Acceptability, and Behavioral Impact of Brief Action Planning (BAP) Coaching for Physical Activity in Adults with Chronic Knee Symptoms: A Qualitative Study
Moath Alshahrani¹, Kristin Haglund², Miranda McIlheran², Rowland Chang³, Pamela Semanik⁴, Sheikh Iqbal Ahamed² and Daniel Pinto⁵, ¹Marquette University/ King Khalid University, Milwaukee, WI, ²Marquette University, Milwaukee, WI, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Rush uUniversity, Chicago, IL, ⁵Marquette University, Wauwatosa, WI
Background/Purpose: Physical activity (PA) improves chronic knee symptoms (CKS) by decreasing pain and improving function, yet many interventions to increase PA are resource-intensive or poorly…
Abstract Number: 0306 • ACR Convergence 2025
Direct Assessment of Intestinal Permeability as a Risk Factor for Multiple Joint Osteoarthritis in Community Cohorts of Humans and Pet Dogs
Liubov Arbeeva¹, Virginia Kraus², Richard Loeser³, Yvonne Golightly⁴, Hiroko Enomoto⁵, Masataka Enomoto⁵, Duncan Lascelles⁵ and Amanda Nelson⁶, ¹University of North Carolina, Chapel Hill, Carrboro, NC, ²Duke University, Durham, NC, ³University of North Carolina, Chapel Hill, NC, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵North Carolina State University, Raleigh, NC, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Increased intestinal permeability (IP) is common in chronic inflammatory diseases, and can be measured indirectly (e.g., with blood markers such as lipopolysaccharide, LPS), or…
Abstract Number: 0323 • ACR Convergence 2025
Automated Effusion-Synovitis Volume is Prognostic and Responsive to Knee Osteoarthritis Progression: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Kate Lapane², Shao-Hsien Liu², Jonggyu Baek², Grace Lo³, Matthew Harkey⁴, Charles Eaton⁵, James Mackay⁶, Timothy McAlindon⁷, Mohammad Chowdhury⁸, Zhen Cao⁹, Juan Shan¹⁰ and Ming Zhang¹¹, ¹University of Massachusetts Chan Medical School, Marlborough, NH, ²UMass Chan Medical School, Worcester, MA, ³Baylor College of Medicine / MEDVAMC, Houston, TX, ⁴Michigan State University, East Lansing, MI, ⁵Brown University, Pawtucket, RI, ⁶University of Cambridge; Norwich Medical School, San Diego, CA, ⁷UMass Chan School of Medicine, Arlington, MA, ⁸Pace University, New York City, NY, ⁹Boston University, Boston, MA, ¹⁰Pace University, New York, NY, ¹¹Boston University, Westford, MA

Background/Purpose: Semi-quantitative and semi-automated quantitative measurements of effusion-synovitis (ES) are prognostic for knee OA progression. Changes in these metrics relate to changes in knee pain.…
Abstract Number: 0768 • ACR Convergence 2025
Veteran Rehabilitation, Physical Therapy Care Delivery, and Outcomes after Total Knee Arthroplasty
Nina Carson¹, Jeremy Graber², Shane O'Malley³, Dennis Hanse⁴, Amy Peters⁵, Jennifer Stevens-Lapsley⁶ and Michael Bade⁶, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²University of Colorado Anschutz Medical Campus & the VA Denver-Seattle Center of Innovation, Aurora, CO, ³Eastern Colorado Health Care System, Aurora, CO, ⁴Eastern Colorado Health Care System & University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Eastern Colorado Health Care System and University of Colorado Anschutz Medical Campus, Aurora, CO, ⁶University of Colorado Anschutz Medical Campus & Eastern Colorado Health Care System, Aurora, CO
Background/Purpose: Compared to the general population, Veterans have higher prevalence of knee osteoarthritis, comorbidities, activities of daily living limitations, and healthcare utilization following total knee…
Abstract Number: 1649 • ACR Convergence 2025
Does Physical Activity Differ Among those with Autoimmune vs Non-Autoimmune Rheumatic Diseases?
Sydney Liles¹, Jennifer Copson², Yvonne Lee³ and Daniel K. White¹, ¹University of Delaware, Newark, DE, ²University of Delaware, Wilmington, DE, ³Northwestern University, Chicago, IL
Background/Purpose: Individuals with rheumatic conditions, such as Rheumatoid Arthritis (RA) and Osteoarthritis (OA), often experience low physical activity levels. Physical activity may vary by autoimmune…
Abstract Number: 1792 • ACR Convergence 2025
OA protection in African spiny (Acomys) mice is partially mediated by the gut microbiome and is transferrable to wild-type mice via microbiome transplantation
Gabriella Dyson¹, Montana Barrett¹, Nicholas Hanebutt¹, Aleksander Szymczak², Cindy Miranda Brawner¹, Pratibha Dube³, Padmaja Mehta-d'Souza¹, Ashley Siefert⁴ and Matlock Jeffries², ¹Oklahoma Medical Research Foundation, Oklahoma City, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation, Edmond, OK, ⁴University of Kentucky, Lexington, KY
Background/Purpose: Mounting evidence suggests that gut microbiome shifts may be associated with knee osteoarthritis (OA) development. We have previously shown that gut microbiome transplantation from…

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