Abstract Number: L04 • ACR Convergence 2023
EP-104IAR (Extended-Release Fluticasone Propionate for Injectable Suspension): Topline and Key Secondary Results from a Phase 2 Randomized, Double-blind, Vehicle-Controlled Trial in Subjects with Knee Osteoarthritis
Background/Purpose: EP-104IAR is being developed to treat OA symptoms. Previous results from non-clinical studies evaluating local joint safety in beagle dogs, in contrast to other…Abstract Number: L05 • ACR Convergence 2023
DICKENS: A Multicentre Randomised Controlled Trial of Diacerein for Knee Osteoarthritis with Effusion-Synovitis
Background/Purpose: There is an unmet need for treatments of knee OA. Diacerein is recommended for alleviating pain in OA patients for its anti-inflammatory effect by…Abstract Number: L19 • ACR Convergence 2023
A Phase 3 Study of Repeat Injection of TLC599 in Osteoarthritis of the Knee: Benefits to 52 Weeks
Background/Purpose: In osteoarthritis (OA) of the knee, intraarticular injections of corticosteroids can relieve pain, reduce inflammation, and improve mobility, but the effect is not predictable,…Abstract Number: 0311 • ACR Convergence 2023
Heterogeneity and Natural History of Medial Fixed Joint Space Width in Healthy Knees Among Women and Men: Data from Three Large Cohort Studies
Background/Purpose: Radiographic joint space width (JSW) is commonly used to assess structural progression in randomized controlled trials and observational studies of knee osteoarthritis (KOA). No…Abstract Number: 0756 • ACR Convergence 2023
Validation of Quantitative Effusion-synovitis Volume Measured by Deep-learning: Data from the Osteoarthritis Initiative
Background/Purpose: Knee effusion-synovitis (ES) is an attractive target for therapeutic interventions in arthritis, since it is associated with stiffness, pain, and disease progression to arthroplasty.…Abstract Number: 0869 • ACR Convergence 2023
Clinical Impact of PTEN as a Marker for Diabetes-Associated Osteoarthritis
Background/Purpose: Defects in homeostatic mechanisms, such as autophagy, contribute to joint aging and Osteoarthritis (OA) and precede joint damage (1). OA is a complex and…Abstract Number: 0885 • ACR Convergence 2023
Mice Fed a Well-formulated Ketogenic Diet After OA Induction Develop Worse OA Outcomes and Increased Pain Sensitivity
Background/Purpose: A ketogenic diet (KD) has beneficial effects in preclinical models of a variety of systemic autoimmune diseases. In this study, we set out to…Abstract Number: 1195 • ACR Convergence 2023
Relationship of Depth-Specific Subchondral Bone Mineral Density to MRI Cartilage Worsening: The Multicenter Osteoarthritis Study
Background/Purpose: While OA has been considered a disease of cartilage, early subchondral bone changes may precede cartilage abnormalities. Although higher systemic BMD has a known…Abstract Number: 1798 • ACR Convergence 2023
Association Between Knee Osteoarthritis and Mortality: A Serial Propensity Score-matched Cohort Study
Background/Purpose: The association between symptomatic knee osteoarthritis (OA) and higher cardiovascular disease (CVD) mortality is well established; however, findings from previous studies that utilized regression…Abstract Number: 1982 • ACR Convergence 2023
Effect of Denosumab on Knee Pain and Bone Marrow Lesions in Symptomatic Knee Osteoarthritis
Background/Purpose: There are currently no licensed therapies which reduce progression of knee OA. Current therapies focus on reducing pain, have limited effect, and some have…Abstract Number: 2467 • ACR Convergence 2023
Quadriceps Muscle Fat Composition but Not Muscle Energetics Is Associated with Knee Osteoarthritis: Initial Results from the Study of Muscle, Mobility, and Aging
Background/Purpose: Osteoarthritis (OA) remains the most common cause of joint pain and disability with age, and to date, effective treatments to reduce pain and slow…Abstract Number: 0312 • ACR Convergence 2023
Frontal Lobe Activation and Gait Alterations During Single- and Dual-task Walking in People with Knee Osteoarthritis: A Functional Near-infrared Spectroscopy Study
Background/Purpose: Altered gait patterns, including high variability or muscular co-contraction, can increase fall risk and worsen disease progression in people with knee osteoarthritis (OA). However,…Abstract Number: 0817 • ACR Convergence 2023
Comparative Effectiveness of Yoga and Strengthening Exercise for Treating Knee OsteoArthritis: A Randomised Controlled Trial (YOGA Trial)
Background/Purpose: There is uncertainty about the best type of exercise to optimise outcomes for people with knee osteoarthritis (OA). Strengthening exercise is commonly recommended. However,…Abstract Number: 0870 • ACR Convergence 2023
Targeting Peroxisome Proliferator-Activated Receptor α Is a Disease-Modifying Therapy for Osteoarthritis
Background/Purpose: Disease-modifying therapeutic agents to prevent progression of Osteoarthritis (OA) are an urgent clinical need. Targeting senescence and autophagy in chondrocytes with small molecules is…Abstract Number: 1006 • ACR Convergence 2023
Use of Implementation Strategies to Promote Adherence of Knee Osteoarthritis Guidelines and Improve Patient Outcomes: A Systematic Review
Background/Purpose: Despite the development of care models and practice guidelines the translation of knee osteoarthritis guidelines to practice remains suboptimal. Theoretically informed implementation strategies may…
- 1
- 2
- 3
- …
- 54
- Next Page »