Abstract Number: 0153 • ACR Convergence 2020
Counseling on Safe Driving Strategies in Patients with Osteoarthritis and Rheumatoid Arthritis
Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) cause functional impairments that impact daily life activities, including automobile driving. Radiographic presence of OA on knee and…Abstract Number: 0701 • ACR Convergence 2020
miRNome Sequencing Identifies a Unique Profile of Circulating MicroRNAs in Early Knee Osteoarthritis
Background/Purpose: MicroRNAs have been shown to contribute to osteoarthritis (OA) pathophysiology, yet little is known about the circulating miRNome in OA. The circulating miRNome (e.g.…Abstract Number: 1101 • ACR Convergence 2020
Effect of Transcutaneous Vagal Nerve Stimulation in Erosive Hand Osteoarthritis: Results from an Open-label Non-randomized Pilot Trial
Background/Purpose: Beyond classical effect on vegetative functions, the activation of the vagus nerve inhibits inflammation and reduces the pain signal. Vagus nerve stimulation (VNS) can…Abstract Number: 1117 • ACR Convergence 2020
Prediction Model for Progression to Different Find-Grained MRI-Based Osteoarthritis Severity States: The Vancouver Longitudinal Study of Early Knee Osteoarthritis (VALSEKO)
Background/Purpose: To develop a novel, fine-grained MRI osteoarthritis (OA) severity score, based on cartilage, osteophytes and meniscus (OA-COM) scores and to predict the progression to…Abstract Number: 1483 • ACR Convergence 2020
A Randomised Controlled Trial Evaluating the Efficacy of Internet-based Exercises Aimed at Treating Knee Osteoarthritis (iBEAT-OA)
Background/Purpose: Osteoarthritis (OA) is the commonest cause of pain and disability in the general population and is usually managed by family doctors and physiotherapists. This…Abstract Number: 1643 • ACR Convergence 2020
Evaluating Analgesic Response to Subcutaneous Tanezumab in Patients with Inadequate Treatment Response to Other Analgesics Based on Daily E-pain Diaries: A Pooled Analysis of 2 Randomized, Placebo-controlled Studies
Background/Purpose: Tanezumab is a monoclonal antibody against nerve growth factor being investigated for treatment of the signs and symptoms of osteoarthritis (OA). Subcutaneous tanezumab was…Abstract Number: 1659 • ACR Convergence 2020
Synergistic Effect of Quadriceps Weakness and Obesity in Women at Risk of Knee Osteoarthritis
Background/Purpose: Quadriceps weakness is associated with an increased risk of incident symptomatic and radiographic knee osteoarthritis (OA), particularly in women. Stronger quadriceps muscles may confer…Abstract Number: 0192 • ACR Convergence 2020
Influence of Inflammatory and Non-inflammatory Rheumatic Disorders on the Clinical and Biological Profile of Adult-onset Diabetes
Background/Purpose: To compare the profile of adult-onset diabetes in patients with rheumatoid arthritis (RA) or osteoarthritis (OA), two chronic diseases leading to disability differing by…Abstract Number: 0702 • ACR Convergence 2020
Distinct Murine Cartilage Microbial DNA Signatures Are Seen in High Fat Diet-Induced Obesity and Aging
Background/Purpose: The strongest nongenetic risk factors for primary knee OA are advanced age and obesity. We have previously shown a human cartilage microbial DNA signature…Abstract Number: 1102 • ACR Convergence 2020
Neuropathic Pain in Inflammatory Hand Osteoarthritis(OA) Lowers Quality of Life and May Require Another Approach Than Anti-inflammatory Treatment
Background/Purpose: To investigate whether neuropathic pain is present in patients with inflammatory hand OA, to investigate characteristics of those patients and the impact of neuropathic…Abstract Number: 1118 • ACR Convergence 2020
Bone Marrow Lesion Scores in Patients with Knee Osteoarthritis Undergoing Tibial Osteotomy: Reliability and Concurrent Validity of the Knee Inflammation MRI Scoring System (KIMRISS)
Background/Purpose: Bone marrow lesions (BMLs) commonly occur in knee osteoarthritis (OA) and are associated with increased risk of cartilage damage and pain. The Knee Inflammation…Abstract Number: 1484 • ACR Convergence 2020
Efficacy of Tocilizumab in Patients with Hand Osteoarthritis: Double Blind, Randomized, Placebo Controlled, Multicenter Trial
Background/Purpose: To evaluate the efficacy of tocilizumab, an antibody against interleukin-6 receptor (IL-6R), in patients with hand osteoarthritis.Methods: This was a multicenter, 12-week, randomized, double-blind,…Abstract Number: 1644 • ACR Convergence 2020
Radiographic Exclusionary Findings During Screening for Three Phase III Trials of Subcutaneous Tanezumab in Patients with Moderate to Severe Hip or Knee Osteoarthritis
Background/Purpose: Tanezumab is a nerve growth factor monoclonal antibody in development for osteoarthritis (OA). Following a clinical hold due to concerns around adverse joint events,…Abstract Number: 1660 • ACR Convergence 2020
Sleep Disturbance and Pain Severity and Multi-site Pain: A Prospective 10.7-year Follow-up Study
Background/Purpose: Sleep disturbance is often comorbid with chronic pain disorders, with emerging evidence suggesting a stronger effect of sleep disturbance on pain than vice versa;…Abstract Number: 0537 • ACR Convergence 2020
Hip Abductor Strength and Its Association with New or Worsening Knee Pain: The MOST Study
Background/Purpose: Hip abductors are important for controlling pelvic orientation and rotation of the femur during gait, both of which affect knee mechanics. Thus hip abductor…
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