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Abstracts tagged "Osteoarthritis"

  • Abstract Number: 0153 • ACR Convergence 2020

    Counseling on Safe Driving Strategies in Patients with Osteoarthritis and Rheumatoid Arthritis

    Anna Falls1, Peta-Gay Ricketts1, John Elliott1 and Kim Jordan1, 1OhioHealth Riverside Methodist Hospital, Columbus, OH

    Background/Purpose: Osteoarthritis (OA) and rheumatoid arthritis (RA) cause functional impairments that impact daily life activities, including automobile driving. Radiographic presence of OA on knee and…
  • Abstract Number: 0701 • ACR Convergence 2020

    miRNome Sequencing Identifies a Unique Profile of Circulating MicroRNAs in Early Knee Osteoarthritis

    S. Amanda Ali1, Rajiv Gandhi2, Pratibha Potla2, Sareh Keshavarzi2, Osvaldo Espin-Garcia2, Konstantin Shestopaloff2, Chiara Pastrello3, Dylan Bethune-Waddell2, Starlee Lively2, Anthony Perruccio4, Raj Rampersaud2, Christian Veillette2, Jason Rockel2, Igor Jurisica2, Tom Appleton5 and Mohit Kapoor6, 1Henry Ford Health System, Detroit, MI, 2Krembil RI, Toronto, Canada, 3University Health Network, Toronto, ON, Canada, 4Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, 5The University of Western Ontario, LONDON, ON, Canada, 6Krembil RI, Toronto, ON, Canada

    Background/Purpose: MicroRNAs have been shown to contribute to osteoarthritis (OA) pathophysiology, yet little is known about the circulating miRNome in OA. The circulating miRNome (e.g.…
  • Abstract Number: 1101 • ACR Convergence 2020

    Effect of Transcutaneous Vagal Nerve Stimulation in Erosive Hand Osteoarthritis: Results from an Open-label Non-randomized Pilot Trial

    Alice Courties1, Camille Deprouw2, Emmanuel Maheu3, Eric Gibert4, Jacques-Eric Gottenberg5, Julien Champey6, Béatrice Banneville7, Camille Chesnel8, Gerard Amarenco8, Alexandra Rousseau9, Francis Berenbaum1 and Jeremie Sellam1, 1AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 21. AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012, France, Paris, France, 3AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012, Paris, France, 4Cabinet de Rhumatologie, 94200 Ivry sur Seine, Paris, France, 5Service de Rhumatologie, Centre national de référence pour les maladies auto-immunes systémiques, Hôpital universitaire de Strasbourg, Université de Strasbourg, Strasbourg,, Strasbourg, France, 6AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012,, paris, France, 7AP-HP, Hôpital Pitié-Salpêtrière, Service de Rhumatologie, Paris, 75013, Paris, France, 8Sorbonne Université, GRC 001, GREEN Groupe de Recherche Clinique en Neuro-Urologie, AP-HP, Hôpital Tenon, F-75020 Paris,, Paris, France, 9AP-HP, Hôpital Saint-Antoine, Unité de Recherche Clinique de l'Est Parisien (URC-Est), Paris, 75012,, Paris, France

    Background/Purpose: Beyond classical effect on vegetative functions, the activation of the vagus nerve inhibits inflammation and reduces the pain signal. Vagus nerve stimulation (VNS) can…
  • Abstract Number: 1117 • ACR Convergence 2020

    Prediction Model for Progression to Different Find-Grained MRI-Based Osteoarthritis Severity States: The Vancouver Longitudinal Study of Early Knee Osteoarthritis (VALSEKO)

    Jolanda Cibere1, Ali Guermazi2, Savvas Nicolaou3, Jacek Kopec4, John Esdaile5, Hubert Wong6, Joel Singer6, Anona Thorne6 and Eric Sayre7, 1Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada, 2Boston University School of Medicine, Boston, MA, 3University of British Columbia, Vancouver, BC, Canada, 4University of British Columbia, Arthritis Research Canada, Richmond, BC, Canada, 5Arthritis Research Canada, Vancouver, BC, Canada, 6University of British Columbia, Vancouver, Canada, 7Arthritis Research Canada, Richmond, BC, Canada

    Background/Purpose: To develop a novel, fine-grained MRI osteoarthritis (OA) severity score, based on cartilage, osteophytes and meniscus (OA-COM) scores and to predict the progression to…
  • Abstract Number: 1483 • ACR Convergence 2020

    A Randomised Controlled Trial Evaluating the Efficacy of Internet-based Exercises Aimed at Treating Knee Osteoarthritis (iBEAT-OA)

    Sameer Gohir1, Abhishek Abhishek2, Anthony Kelly2 and Ana M Valdes3, 1NIHR Nottingham Biomedical Research Centre, GRAYS ESSEX, England, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom, 3NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom

    Background/Purpose: Osteoarthritis (OA) is the commonest cause of pain and disability in the general population and is usually managed by family doctors and physiotherapists. This…
  • Abstract Number: 1643 • ACR Convergence 2020

    Evaluating Analgesic Response to Subcutaneous Tanezumab in Patients with Inadequate Treatment Response to Other Analgesics Based on Daily E-pain Diaries: A Pooled Analysis of 2 Randomized, Placebo-controlled Studies

    Thomas Schnitzer1, Francis Berenbaum2, Isabelle Davignon3, Ruoyong Yang4, Lars Viktrup5, Christine West3 and Kenneth Verburg6, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 3Pfizer Inc, Groton, CT, 4Pfizer Inc.,, New York, 5Eli Lilly and Company, Indianapolis, IN, 6Pfizer Inc, Groton

    Background/Purpose: Tanezumab is a monoclonal antibody against nerve growth factor being investigated for treatment of the signs and symptoms of osteoarthritis (OA). Subcutaneous tanezumab was…
  • Abstract Number: 1659 • ACR Convergence 2020

    Synergistic Effect of Quadriceps Weakness and Obesity in Women at Risk of Knee Osteoarthritis

    Jose Rubio1, David Felson2, Xiaoyang Chen3, Kathy Bacon4, Neil Segal5, Michael Nevitt6, Cora Lewis7, Tuhina Neogi2 and Devyani Misra8, 1Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University, Boston, MA, 4Boston University School of Medicine, Boston, 5University of Kansas Medical Center, Kansas City, 6University of California San Fransisco, Orinda, CA, 7University of Alabama Birmingham, Birmingham, AL, 8Beth Israel Deaconess Medical Center, Boston, MA

    Background/Purpose: Quadriceps weakness is associated with an increased risk of incident symptomatic and radiographic knee osteoarthritis (OA), particularly in women. Stronger quadriceps muscles may confer…
  • Abstract Number: 0192 • ACR Convergence 2020

    Influence of Inflammatory and Non-inflammatory Rheumatic Disorders on the Clinical and Biological Profile of Adult-onset Diabetes

    Jerome Avouac1, Muriel Elhai2, Marine Forien3, Jeremie Sellam4, Florent Eymard5, Anna Molto6, Frederic Banal7, Joel Damiano8, Philippe Dieude3, Etienne Larger9 and Yannick Allanore1, 1Service de Rhumatologie, Hôpital Cochin, AP-HP.CUP, Paris, France, 2Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland., Schlieren, Switzerland, 3Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France, 4AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 5APHP Henri Mondor Hospital, Creteil, France, 6Rheumatology Department, Cochin Hospital, APHP, Paris, France, Paris, France, 7Service de Rhumatologie Hôpital d'instruction des armées Bégin, Saint Mande, France, 8Service de Rhumatologie Hôpital Sainte Camille, Bry-Sur-Marne, Ile-de-France, France, 9Université de Paris, Service de Diabétologie, Hôpital Cochin, AP-HP.CUP, Paris, Ile-de-France, France

    Background/Purpose: To compare the profile of adult-onset diabetes in patients with rheumatoid arthritis (RA) or osteoarthritis (OA), two chronic diseases leading to disability differing by…
  • Abstract Number: 0702 • ACR Convergence 2020

    Distinct Murine Cartilage Microbial DNA Signatures Are Seen in High Fat Diet-Induced Obesity and Aging

    Christopher Dunn1, Cassandra Garman2, Jake Martin2, Vladislav Izda2, Cassandra Velasco2 and Matlock Jeffries2, 1University of Oklahoma Health Sciences Center, Oklahoma Cityq, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: The strongest nongenetic risk factors for primary knee OA are advanced age and obesity. We have previously shown a human cartilage microbial DNA signature…
  • Abstract Number: 1102 • ACR Convergence 2020

    Neuropathic Pain in Inflammatory Hand Osteoarthritis(OA) Lowers Quality of Life and May Require Another Approach Than Anti-inflammatory Treatment

    Coen van der Meulen1, Lotte van de Stadt1, Féline Kroon2, Marion Kortekaas1, Annelies Boonen3, Stefan Böhringer4, Monique Reijnierse2, Frits Rosendaal2, Naghmeh Riyazi5, Mirian Starmans6, Franktien Turkstra7, Jende Van Zeben8, CF Allaart2 and Margreet Kloppenburg2, 1LUMC, Leiden, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Maastricht University Medical Center, Maastricht, Netherlands, 4LUMC, Leiden, 5HAGA ziekenhuis, the hague, Netherlands, 6Zuyderland MC, Heerlen, Netherlands, 7Reade, Amsterdam, Netherlands, 8Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands

    Background/Purpose: To investigate whether neuropathic pain is present in patients with inflammatory hand OA, to investigate characteristics of those patients and the impact of neuropathic…
  • Abstract Number: 1118 • ACR Convergence 2020

    Bone Marrow Lesion Scores in Patients with Knee Osteoarthritis Undergoing Tibial Osteotomy: Reliability and Concurrent Validity of the Knee Inflammation MRI Scoring System (KIMRISS)

    Jenna Schulz1, Trevor Birmingham1, Walter Maksymowych2, Robert G Lambert3, Stephany Pritchett4, Frank Beier1, J. Robert Giffin5 and Tom Appleton6, 1Western University, London, Canada, 2University of Alberta, Edmonton, AB, Canada, 3University of Alberta and CARE Arthritis, Edmonton, AB, Canada, 4London Health Sciences Centre, London, Canada, 5Western University and London Health Sciences Centre, London, Canada, 6The University of Western Ontario, LONDON, ON, Canada

    Background/Purpose: Bone marrow lesions (BMLs) commonly occur in knee osteoarthritis (OA) and are associated with increased risk of cartilage damage and pain. The Knee Inflammation…
  • Abstract Number: 1484 • ACR Convergence 2020

    Efficacy of Tocilizumab in Patients with Hand Osteoarthritis: Double Blind, Randomized, Placebo Controlled, Multicenter Trial

    Pascal Richette1, Augustin Latourte2, Jeremie Sellam3, Daniel Wendling4, Muriel Piperno5, Philippe Goupille6, Yves-Marie Pers7, Florent Eymard8, Sebastien Ottaviani9, Paul Ornetti10, Rene-Marc Flipo11, Bruno Fautrel12, Jean-Pierre Bertola13, Eric Vicaut14 and Xavier Chevalier15, 1Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, 2Department of Rheumatology, Lariboisière Hospital, AP-HP Université de Paris, INSERM U1132, Paris, France, 3AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 4CHU Besançon, department of rheumatology, Besancon, France, 5Rheumatology Department, Lyon University Hospital, Lyon, France, 6CHU Tours, department of rheumatology, Tours, France, 7IRMB, University of Montpellier, Inserm U1183, University Hospital of Montpellier, Montpellier, France, 8APHP Henri Mondor Hospital, Creteil, France, 9Rheumatology Department, Bichat hospital, APHP, Paris, France, 10CHU Dijon, INSERM CAPS 1093, plateforme d’investigation technologique CIC1432, Dijon, France, 11Lille University Hospital, Lille, France, 12Sorbonne University, INSERM, IPLES; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, 13CHUGAI PHARMA FRANCE, Paris, France, 14Clinical Research Unit, Paris, 15AP-HP, UPEC, Créteil

    Background/Purpose: To evaluate the efficacy of tocilizumab, an antibody against interleukin-6 receptor (IL-6R), in patients with hand osteoarthritis.Methods: This was a multicenter, 12-week, randomized, double-blind,…
  • Abstract Number: 1644 • ACR Convergence 2020

    Radiographic Exclusionary Findings During Screening for Three Phase III Trials of Subcutaneous Tanezumab in Patients with Moderate to Severe Hip or Knee Osteoarthritis

    Ali Guermazi1, Frank Roemer2, Andrew Kompel1, Luis Diaz3, Michel Crema4, Mark Brown5, Anne Hickman5, Glenn Pixton6, Lars Viktrup7, Robert Fountaine5, Aimee Burr5, Sarah Sherlock5 and Christine West8, 1Boston University School of Medicine, Boston, MA, 2Boston University School of Medicine, Boston, MA, and Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany, 3Boston Veteran Affairs Healthcare System, Boston, MA, 4Boston University School of Medicine, Paris, France, 5Pfizer Inc., Groton, CT, 6Pfizer Inc., Morrisville, NC, 7Eli Lilly and Company, Indianapolis, IN, 8Pfizer Inc, Groton, CT

    Background/Purpose: Tanezumab is a nerve growth factor monoclonal antibody in development for osteoarthritis (OA). Following a clinical hold due to concerns around adverse joint events,…
  • Abstract Number: 1660 • ACR Convergence 2020

    Sleep Disturbance and Pain Severity and Multi-site Pain: A Prospective 10.7-year Follow-up Study

    Feng Pan1, Jing Tian1, Flavia Cicuttini2 and Graeme Jones1, 1University of Tasmania Menzies Institute for Medical Research, Hobart, Tasmania, Australia, 2Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia

    Background/Purpose: Sleep disturbance is often comorbid with chronic pain disorders, with emerging evidence suggesting a stronger effect of sleep disturbance on pain than vice versa;…
  • Abstract Number: 0537 • ACR Convergence 2020

    Hip Abductor Strength and Its Association with New or Worsening Knee Pain: The MOST Study

    Cara Lewis1, Neil Segal2, Joshua Stefanik3, Xiaoyang Chen4, Glenn Williams5, Michael Nevitt6, Cora Lewis7 and David Felson8, 1Boston University, Brookline, MA, 2University of Kansas Medical Center, Iowa City, IA, 3Northeastern University, Boston, MA, 4Boston University, Boston, MA, 5Drexel University, Philadelphia, PA, 6Department of Epidemiology and Biostatistics, University of California San Francisco, Orinda, CA, 7University of Alabama Birmingham, Birmingham, AL, 8Boston University School of Medicine, Boston, MA

    Background/Purpose: Hip abductors are important for controlling pelvic orientation and rotation of the femur during gait, both of which affect knee mechanics. Thus hip abductor…
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ACR Pediatric Rheumatology Symposium 2020

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