Abstract Number: 0513 • ACR Convergence 2021
Spirulina Activates IFNγ via TLR4 in Dermatomyositis Skin and Peripheral Blood
Background/Purpose: Our group has previously shown that Spirulina, a popular herbal supplement with purported immune boosting effects, is temporally associated with dermatomyositis (DM) onset and…Abstract Number: 0942 • ACR Convergence 2021
Transcriptional Regulation of Synovial Macrophages in the Aging Joint
Background/Purpose: Macrophages are critical in maintaining tissue homeostasis, as well as in inflammation and immune response, but their function deteriorates with age increasing susceptibility to…Abstract Number: 1002 • ACR Convergence 2021
Nerve and Airway-associated Tissue Resident Pulmonary Macrophages Limit Infiltration and Alter Phenotype of Infiltrating Monocytes and Fibrocytes to Reduce Pulmonary Fibrosis
Background/Purpose: Macrophages and monocytes are increasingly implicated in the pathogenesis of autoimmune induced pulmonary fibrosis. In addition to the well-recognized classes of tissue resident macrophages…Abstract Number: 1422 • ACR Convergence 2021
Urinary CD163 Predicts Proliferative Lupus Nephritis in SLE Patients with Proteinuria: A Practical Liquid Biopsy Approach
Background/Purpose: Diagnosis of lupus nephritis (LN) relies on a kidney biopsy obtained in SLE with proteinuria. Delayed access to kidney biopsies may delay diagnosis and…Abstract Number: 1490 • ACR Convergence 2021
Myeloid and B Cell Transcriptional Phenotypes Reveal Race Dependent Differences in Early Autoimmunity
Background/Purpose: Early immune events leading to clinical autoimmune disease are complex and the pathways involved remain incompletely defined. Anti-nuclear antibody (ANA) positivity is a feature…Abstract Number: 1860 • ACR Convergence 2021
Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients
Background/Purpose: Patients with SSc display a complex clinical phenotype.Our group has made important contributions to an emerging understanding of monocytes and macrophages as central to…Abstract Number: 0788 • ACR Convergence 2020
Rigorous Plasma Microbiome Analysis Method Enables Disease Association Discovery
Background/Purpose: The mucosal microbiome contributes to disease pathogenesis via local and systemic interaction with the host. The hallmark of this interaction in the physiological condition…Abstract Number: 0949 • ACR Convergence 2020
SLAMF7 Engagement Drives Monocyte Super-Activation in Acute and Chronic Inflammation
Background/Purpose: Monocytes orchestrate immune responses that protect against microbes but can also drive pathological inflammation and autoimmune disease. Monocytes are thought to be activated primarily…Abstract Number: 1037 • ACR Convergence 2020
Relationship Between Air Quality and Sarcoidosis Inflammatory Activity
Background/Purpose: African Americans [AA] and minorities in the lower socioeconomic strata of Chicago are disproportionately affected by pulmonary sarcoidosis, and regularly exposed to poorer air…Abstract Number: 1067 • ACR Convergence 2020
Anti-Viral Proinflammatory Phenotype in Circulating Monocytes from Patients with Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Associated Interstitial Lung Disease
Background/Purpose: Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is associated with interstitial lung disease (ILD), which often represents rapidly progressive course and fatal outcomes. Circulating levels…Abstract Number: 0039 • ACR Convergence 2020
Identification of a Regulatory Pathway Governing Expression of TRAF1 via a JIA-associated Non-coding Variant
Background/Purpose: Over the past decade, genome-wide association studies (GWAS) have identified TRAF1/C5 locus as a risk locus for rheumatoid diseases including RA and JIA(Plenge, Seielstad…Abstract Number: 1156 • ACR Convergence 2020
Comparison of Immunological Biomarkers and Lung Histology in Patients with Elevated IL18 – Pulmonary Alveolar Proteinosis and Recurrent Macrophage Activation Syndrome (IL-18PAP-MAS) and Other Inflammatory Lung Diseases
Background/Purpose: Recently, pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS) have been reported in rare patients (pts) with systemic juvenile idiopathic arthritis (SJIA)…Abstract Number: 0065 • ACR Convergence 2020
The Energy-dependent Hierarchy of Immune Functions in Human Monocytes
Background/Purpose: At sites of inflammation, monocytes carry out specific immunological functions while facing challenging bioenergetic restrictions. Here, we investigated the potential of human monocytes to…Abstract Number: 1951 • ACR Convergence 2020
Possible Involvement of Fractalkine/CX3CR1 Axis in Peripheral CD14++CD16+ Monocytes in Disease Development of Patients with Systemic Lupus Erythematosus
Background/Purpose: Fractalkine (FKN) binds its receptor, CX3CR1 and accelerates chemotaxis of immune cells by inducing cell surface molecules and mediating adhesion of the cells to…Abstract Number: 0066 • ACR Convergence 2020
AMP Deaminase 2 Is Expressed on the Surface of Human Immune Cells as a Novel Regulator of Extracellular Adenosine Metabolism
Background/Purpose: Adenosine and its nucleotides represent crucial immunomodulators in the extracellular environment. ATP and ADP are released from stressed cells in states of inflammation, whereas…
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