ACR Meeting Abstracts

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Abstracts tagged "Monocytes/macrophages"

  • Abstract Number: 037 • 2023 Pediatric Rheumatology Symposium

    Transcriptional Analysis of CD14+ Monocytes During Macrophage Activation Syndrome Highlights Role for Interferons and RNA Sensing in Monocytes

    Susan Canny1, Hannah DeBerg2, Griffin Gessay2, Ailing Lu3, Mary Eckert1, Andrea La Bella4, Susan Shenoi5, Joyce Hui-Yuen6, Betsy Barnes7 and Jessica Hamerman2, 1Seattle Children's Hospital, Seattle, WA, 2Benaroya Research Institute, Seattle, WA, 3Feinstein Institutes for Medical Research, Manhasset, NY, 4Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY, 5Seattle Children's Hospital, Seattle, WA, 6Cohen Children's Medical Center, Northwell Health, Lake Success, New York; Center for Autoimmune, Musculoskeletal, and Hematopoietic Diseases Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, 7Center for Autoimmune, Musculoskeletal, and Hematopoietic Diseases Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY

    Background/Purpose: Macrophage activation syndrome (MAS), a form of secondary hemophagocytic lymphohistiocytosis (HLH), is a potentially fatal complication of rheumatic diseases. MAS is a dysfunctional hyperinflammatory…
  • Abstract Number: 0557 • ACR Convergence 2022

    VEXAS Syndrome Is Characterized by Blood and Tissues Inflammasome Pathway Activation and Monocyte Dysregulation

    Benjamin Terrier1, Celine Posseme2, Marie Temple3, Aurélien Corneau4, Francesco Carbone5, Eugénie Duroyon3, camille Gobeaux3, Estibaliz Lazaro6, Roderau Outh7, Guillaume Le Guenno8, Francois Lifermann9, Marie Berleur10, Thierry Weitten11, Vivien Guillotin12, Cédric Lenormand13, Hang-Korng Ea14, Mickael Ménager5, Darragh Duffy2 and Olivier Kosmider3, 1National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 2Institut Pasteur, Paris, France, 3Cochin Hospital, Paris, France, 4Pitié Salpêtrière Hospital, Paris, France, 5Institut Imagine, Paris, France, 6Bordeaux Hospital University, Bordeaux, France, 7CH, Perpignan, France, 8CHU, Clermont-Ferrand, France, 9Dax Hospital, Dax, France, 10CH, Versailles, France, 11CHIGAS, Gap, France, 12CHU Bordeaux, Bordeaux, France, 13CHRU, Strasbourg, France, 14Lariboisière Hospital, Paris, France

    Background/Purpose: Acquired mutations in the UBA1 gene, occurring in myeloid cells and resulting in expression of a catalytically impaired isoform of the enzyme E1, were…
  • Abstract Number: 0568 • ACR Convergence 2022

    The Absence of Blk Leads to Increased Inflammation in a Murine Model of Kawasaki Disease

    Melissa Kleinau1, Mohammed Massumi2, Lysa Langevin2, Paul Tsoukas2, Harper Cheng2, Suzanne Tam2, Trang Duong2 and Rae Yeung3, 1University of Toronto, Toronto, ON, Canada, 2Peter Gilgan Centre for Research and Learning, Toronto, ON, Canada, 3The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Kawasaki Disease (KD) is the leading cause of acquired heart disease in children in developed countries characterized by inflammation of the coronary arteries leading…
  • Abstract Number: 0599 • ACR Convergence 2022

    Expansion of HLA-DR+CD45RAhi Non-lymphoid Cells in Patients with Rheumatoid Arthritis

    Christian Geier1, Andras Perl2 and Robert Winchester3, 1SUNY Upstate Medical University, Syracuse, NY, 2SUNY, Syracuse, NY, 3Columbia University, New York, NY

    Background/Purpose: In RA, aberrant lymphocytes can damage synovial joints and other organs. Antigen-presenting cells (APC) can activate lymphocytes and are considered critical to initiate immune…
  • Abstract Number: 0604 • ACR Convergence 2022

    Altered Metabolic State in Myeloid Precursors and Mature Cells Within Rheumatoid Arthritis

    Patricia Riedlova1, Luís Almeida2, Cecilia Ansalone3, Shatakshi Sood1, Bart Everts2 and Carl Goodyear1, 1University of Glasgow, Glasgow, Scotland, United Kingdom, 2Leiden University Medical Center, Leiden, Netherlands, 3UCSD and University of Glasgow, Glasgow, Scotland, United Kingdom

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterised by synovial inflammation and joint destruction. Prior research has revealed perturbation in the myeloid compartment of…
  • Abstract Number: 0652 • ACR Convergence 2022

    Serum from Patients with SLE and Anti-MDA5 Antibody-Positive Dermatomyositis Induce Shared Monocyte Cytokine Signature Through Type 1 Interferon Pathway

    Shohei Nakamura, Yuko okamoto, Yasuhiro Katsumata and Masayoshi Harigai, Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    Background/Purpose: Although type 1 interferon (IFN) plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE) and polymyositis/dermatomyositis (PM/DM) [1] as typically evidenced…
  • Abstract Number: 0654 • ACR Convergence 2022

    Lymphatic Dysfunction and Immune Activation in Lupus

    william ambler1, Madhavi Somaraju1, JiHyun Sim1, Ethan Seltzer1, Noa Schwartz2, Ecem Sevim3, Doruk Erkan1, Jinyeon Shin4, Rahgu Kataru4, Babak Mehrara5 and theresa Lu1, 1Hospital for Special Surgery, New York, NY, 2Albert Einstein College of Medicine, New York, NY, 3Montefiore Medical Center - Wakefield Campus, New York, NY, 4Memorial Sloan Kettering, New York, NY, 5Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering, New York, NY

    Background/Purpose: Systemic lupus erythematosus is a prototypic autoimmune disease in which patients frequently have photosensitivity. Exposure to ultraviolet radiation (UVR) causes the eruption of cutaneous…
  • Abstract Number: 0663 • ACR Convergence 2022

    Anti-Erythrocyte Antibodies in Childhood Onset Systemic Lupus Erythematosus

    Lauren Robinson1, Zurong Wan2, Preetha Balasubramanian3, Juan Rodriguez Alcazar3, Lynnette Walters4, Jeanine Baisch2, karen onel5, Tracey Wright6, Virginia Pascual3 and Simone Caielli3, 1Hospital for Special Surgery/New York Presbyterian-Weill Cornell, New York, NY, 2Weill Cornell Medicine, New York, NY, 3Weill Cornell Medical College, New York, NY, 4Scottish Rite Hospital for Children, Allen, TX, 5Hospital for Special Surgery, New York, NY, 6UT Southwestern, Plano, TX

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is a disease characterized by the presence of auto-antibodies, immune complex deposition, and a robust type 1 interferon signature. It…
  • Abstract Number: 1167 • ACR Convergence 2022

    Towards an Autologous 3D Skin-like Tissue Harboring Patient-Derived Fibroblasts, Keratinocytes, T-cells and Macrophages

    Sasha Shenk1, Jonathan Garlick1, Lev Brown2, Jamie Riesenberg2, Christian Evans2, Julia Jaffe Zweifach2, Andrew Macklin2, Tamar Abel3, Noelle Kosarek4, Mengqi Huang5, Avi Smith1, Tammara Wood3, Gretel Torres6, Patricia pioli6 and Michael Whitfield7, 1Tufts University School of Dental Medicine, Boston, MA, 2Tufts University, Boston, MA, 3Dartmouth College, Hanover, NH, 4Dartmouth Geisel School of Medicine, Lebanon, NH, 5University of Pittsburgh, Pittsburgh, PN, 6Geisel School of Medicine at Dartmouth, Lebanon, NH, 7Dartmouth Geisel School of Medicine, Department of Biomedical Data Science, Lebanon, NH

    Background/Purpose: Scleroderma (Systemic Sclerosis; SSc) is an autoimmune disease of unknown etiology that is characterized by vascular dysfunction, fibrosis, and inflammation. A lack of human…
  • Abstract Number: 1169 • ACR Convergence 2022

    Downregulated Fli1 in Systemic Sclerosis Myeloid Cells Contributes to Enhanced Transendothelial Migration

    Pablo Weilg Espejo1, Taha Dinc2, Fatima El Adili3, Maria Trojanowska4 and Andreea Bujor4, 1Boston Medical Center, Chelsea, MA, 2Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Revere, MA, 4Boston University, Boston, MA

    Background/Purpose: The mononuclear phagocytic system in Systemic Sclerosis (SSc) is central to fibrogenesis and may contribute to fibrosis via enhanced monocyte migration into injured tissues…
  • Abstract Number: 1565 • ACR Convergence 2022

    Dissection of Ocular and Peripheral Blood Immune Phenotypes Suggests Preferential Transmigration of CD16+ Monocytes to Effector Sites in Behçet’s Disease

    Yesim Ozguler1, Ziyan Lin2, Ann Cavers3, gulen Hatemi4, Olivier Manches5 and Johannes Nowatzky3, 1Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, New York, NY, 2NYU Grossman School of Medicine, NYU Langone Applied Informatics Laboratories, New York, NY, 3NYU Grossman School of Medicine, New York, NY, 4Istanbul University-Cerrahpaşa, Cerrahpasa Medical Faculty, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, 5Recherche et Développement, Immunobiology and Immunotherapy in Chronic Diseases, Institute for Advanced Biosciences, Inserm U 1209, CNRS UMR 5309, Université Grenoble Alpes Etablissement Français du Sang Auvergne-Rhône-Alpes, Grenoble, France

    Background/Purpose: Cellular immunity of Behçet's Disease (BD) remains poorly understood. Previous work has provided clues pointing to most innate and adaptive immune cell types in…
  • Abstract Number: 1699 • ACR Convergence 2022

    Arthritis-associated Synovial CD64-Ly6c- myeloid Cells Comprise 2 Subpopulations

    Yidan Wang1, Miranda Gurra1, Carla Cuda1, Hadijat Makinde1, Shangyang Chen1, Gaurav Gadhvi1, Salina Dominguez1, Caroline Shah1, Deborah Winter2 and Harris Perlman1, 1Northwestern University, Chicago, IL, 2Northwestern University, Skokie, IL

    Background/Purpose: Monocytes are critical for the pathogenesis of rheumatoid arthritis (RA). However, depletion of circulating monocytes – either classical or non-classical monocytes – is not…
  • Abstract Number: 1710 • ACR Convergence 2022

    CCL2 Drives Interferon-enhanced Monocytosis in UV-mediated Skin Injury in Murine Lupus

    Mitra Maz1, Hong Shi2, Sonya Wolf-Fortune3, Shannon Estadt3, Alayka Reddy3, Rachael Wasikowski3, Alex Tsoi3, Celine Berthier3 and J. Michelle Kahlenberg3, 1University of Michigan Medical School, Ann Arbor, MI, 2Department of Internal Medicine/Division of Rheumatology, Vascular Biology Center, Augusta, GA, 3University of Michigan, Ann Arbor, MI

    Background/Purpose: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by overproduction of type I interferons (IFNs) and sensitivity to ultraviolet (UV) light. Though…
  • Abstract Number: 2003 • ACR Convergence 2022

    Anti-rheumatic Treatment Modulates Expression of the Glycolytic Enzyme PFKFB3 in CD14+ Monocytes of Patients with Rheumatoid Arthritis, Which Contributes to Dissimilarities of the IFN Signature

    Malin Erlandsson1, Karin Andersson1, Sofia Töyrä Silfverswärd2, Rille pullerits2 and Maria Bokarewa2, 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden, 2Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden

    Background/Purpose: Combination of IFN-stimulated genes known as IFN signature, helps to predict disease activity and treatment response in several autoimmune diseases, including rheumatoid arthritis (RA).…
  • Abstract Number: 0004 • ACR Convergence 2022

    mTORC1 Drives the Spectrum of Pathology in Systemic JIA and Macrophage Activation Syndrome

    zhengping huang1, xiaomeng You2, Liang Chen3, Yan Du3, Kailey Brodeur3, Qiang Wang3, David Sykes4, Margaret Chang5, Julia Charles2, Peter Nigrovic5 and Pui Lee5, 1Guangdong Second Provincial Hospital, Guangzhou, China, 2Brigham and Women's Hospital, Boston, MA, 3Boston Children's Hospital, Boston, MA, 4Massachusetts General Hospital, Boston, MA, 5Division of Immunology, Boston Children's Hospital, Boston, MA

    Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is a severe inflammatory syndrome characterized by fever, skin rash and arthritis. A subset of patients with sJIA develop…
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