ACR Meeting Abstracts

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Abstracts tagged "Monocytes/macrophages"

  • Abstract Number: 1765 • ACR Convergence 2024

    CD8+ T Cells and Monocytes from Children with Macrophage Activation Syndrome Demonstrate Specific Transcriptional Changes Consistent with T Cell Activation and Expansion of Monocytes Shaped by Interferon and TLR Signaling

    Susan Canny1, Hannah DeBerg2, Griffin Gessay2, Ailing Lu3, Mary Eckert4, Andrea La Bella5, Hayley Waterman2, Danish Nadeem2, Susan Shenoi6, Joyce Hui-Yuen7, Daniel Campbell2, Betsy Barnes8 and Jessica Hamerman2, 1University of Washington, Seattle, WA, 2Benaroya Research Institute, Seattle, WA, 3Northwell Health, Manhasset, NY, 4Seattle Children's Hospital, Seattle, WA, 5Cohen Children's Medical Center, Queens, NY, 6Seattle Children's Hospital and Research Center, Mercer Island, WA, WA, 7North Shore LIJ Health System, Great Neck, NY, 8Feinstein Institutes for Medical Science, Manhasset, NY

    Background/Purpose: Macrophage activation syndrome (MAS), a form of secondary hemophagocytic lymphohistiocytosis (sHLH), is a potentially fatal complication of rheumatic diseases. MAS is characterized by a…
  • Abstract Number: 1789 • ACR Convergence 2024

    Multi-omic Profiling Identifies Pathogenic Pro-inflammatory Human Monocytes/Macrophages in Systemic Lupus Erythematosus

    Lais Osmani1, Min Shin2, Sang Jin Lee3, Helen Cai4, Won Jae Seong2, Hyoungsu Kim2, Jongjin Yoo2, Angela Mirabella2, William Bracamonte2, Mario Felix5, Jong Gyun Ahn2, Hong-Jai Park2, Juan Young6, Junghee Shin2, Serhan Unlu7, Noelle Yoo2, Edward Doherty2, Jiaye Chen2, Chenxi Li2, Gabriela Sanchez-Zuno2, Caroline Valdez4, Thuy Tran8, Mei Dong2, Sang Kim2, Christine Ko9, Sungyong You10, Jose Gomez11, Richard Bucala12 and Insoo Kang2, 1Yale, New Haven, CT, 2Yale University School of Medicine, Internal Medicine (Rheumatology, Allergy & Immunology), New Haven, CT, 3Division of Rheumatology, Kyungpook National University Hospital, Dae gu, Republic of Korea, 4Yale University School of Medicine, New Haven, CT, 5Yale, Hamden, CT, 6Yale University School of Medicine, Psychiatry, New Haven, CT, 7Cleveland Clinic, Internal Medicine, Cleveland, OH, 8Yale University School of Medicine, Internal Medicine (Medical Oncology), New Haven, CT, 9Yale University School of Medicine, Dermatology and Pathology, New Haven, CT, 10Cedars-Sinai Medical Center, Surgery and Computational Biomedicine, Los Angeles, CA, 11Yale University School of Medicine, Internal Medicine (Pulmonary, Critical Care & Sleep), New Haven, CT, 12Yale University School of Medicine, Internal Medicine (Rheumatology, Allergy & Immunology) and Pathology, New Haven, CT

    Background/Purpose: Systemic lupus erythematosus (SLE or lupus) is a clinically heterogeneous autoimmune disease, in which emerging evidence implicates the innate immune system, particularly monocytes and…
  • Abstract Number: 0004 • ACR Convergence 2024

    Beyond Antibodies and CAR-T: Topologically Engineered, Superdimeric Antibody NK Engagers and T Cell Engagers for B Cell Depletion Demonstrating Cooperative Binding to Target and Effector Cells

    Daniel Capon, Larisa Troitskaya, Marina Fomin, Brendon Frank, Ursula Edman, Benjamin Capon, Brian Law, Steven Chapin, Gavin Lewis, Malcolm Gefter, Juha Punnonen and Nelson Chan, Hinge Bio, Inc., Burlingame, CA

    Background/Purpose: The dramatic demonstration of CD19 CAR-T efficacy in systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis by Georg Schett and colleagues (F.…
  • Abstract Number: 1782.5 • ACR Convergence 2024

    Monocytes from HLA B27 Positive Enthesitis Related Arthritis Patients Are More Activated Than HLA B27 Negative Patients

    Shivika Guleria1, Anu Balakrishnan1, Able Lawrence1 and Amita Aggarwal2, 1SGPGIMS, Lucknow, Lucknow, Uttar Pradesh, India, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

    Background/Purpose: Enthesitis related arthritis (ERA) is a chronic immune-inflammatory disease with unknown etiology. HLA-B27 is the strongest risk factor predisposing to ERA similar to Spondylarthritis…
  • Abstract Number: 0014 • ACR Convergence 2024

    Phenotypic Validation of Humanized IgA1 and CD89 Transgenic Mice as a Model for IgA Nephropathy-Like Autoimmune Disease

    Kaiyuan Zi and Juan Liang, GemPharmatech, San Diego

    Background/Purpose: The etiology of IgA nephropathy (IgAN) remains only partly understood, but the presence of IgA antibodies together with the myeloid IgA-receptor FcαRI/CD89 complexes in…
  • Abstract Number: 1808 • ACR Convergence 2024

    Not Only Type-I Interferon Regulated Genes Are Differentially Expressed in Circulating Monocytes from Active Lupus Nephritis Patients

    Paula Losada Vanegas1, Juan Antonio Villatoro-García2, Daniel Rodriguez3, Juan Camilo Diaz3, Ricardo Pineda4, Pedro Carmona-Saez5, Mauricio Rojas6 and Gloria Vasquez7, 1Universidad de Antioquia, Medellin, Antioquia, Colombia, 2GENYO (Centre for Genomics and Oncological Research: Pfizer, University of Granada, Granada, Andalucia, Spain, 3ARTMEDICA, Medellín, Antioquia, Colombia, 4ARTMEDICA, Medellin, Antioquia, Colombia, 5GENYO (Centre for Genomics and Oncological Research: Pfizer, University of Granada, Granada, Asturias, Spain, 6Grupo de Inmunología Celular e Inmunogenética, Sede de Investigación Universitaria. Facultad de Medicina. Universidad de Antioquia, Medellin, Antioquia, Colombia, 7Grupo de Inmunología Celular e Inmunogenética, Sede de Investigación Universitaria. Facultad de Medicina.Universidad de Antioquia, Medellin, Colombia

    Background/Purpose: Monocytes play an important role in organ damage, such as in Lupus Nephritis (LN). Although monocytes are typically considered inflammatory cells, evidence shows they…
  • Abstract Number: 0058 • ACR Convergence 2024

    Bradykinin Receptor B1 Blockade Suppresses Soluble CD13-Induced Differentiation of Osteoclasts from Monocytes

    Sei Muraoka1, Qi Wu2, Mikel Gurrea-Rubio3, Camila Amarista2, William Brodie2, Megan Mattichak2, Yuzo Ikari4, Caroline Foster2, Phillip Campbell2, David Fox5 and Pei-Suen Tsou2, 1University of Michigan, Toyko, Japan, 2University of Michigan, Ann Arbor, MI, 3University of Michigan - Ann Arbor, Ann Arbor, MI, 4Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 5University of Michigan, Dexter, MI

    Background/Purpose: CD13 is an ectopeptidase expressed on myeloid cells, endothelial cells, and rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). Soluble (s) CD13 is generated by matrix…
  • Abstract Number: 1862 • ACR Convergence 2024

    Folate Receptor β CAR-Tregs Induce Monocyte Apoptosis and Immune Polarization: Potential for Therapeutic Application in Rheumatoid Arthritis

    Xiangni Wu1, Pin-I Chen2, Magdiel Pérez Cruz3, Kent Jensen3 and Everett Meyer3, 1UMKC, KANSAS CITY, MO, 2Department of Medicine, Division of Blood and Bone Marrow Transplantation and Cell Therapy, Stanford University School of Medicine, Stanford, CA, USA., Sunnyvale, CA, 3Department of Medicine, Division of Blood and Bone Marrow Transplantation and Cell Therapy, Stanford University School of Medicine, Stanford, CA, USA., Stanford

    Background/Purpose: Rheumatoid arthritis (RA) affects approximately 1.3 million adults in the United States, causing significant morbidity and economic burden. Current treatments reduce inflammation and slow…
  • Abstract Number: 0073 • ACR Convergence 2024

    Self or Bacteria-reactive Th17 Expand from Conventional and Regulatory T Cells in Parabacteroides Goldsteinii Gnotobiotic Arthritic SKG Mice, in Context of Interferon-driven Synovial Inflammatory Macrophages and Reduced Bacterial Immune Regulation

    Benjamin Cai1, Zewen Kelvin Tuong2, Mark Morrison1, Anne-Sophie Bergot1 and Ranjeny Thomas3, 1Frazer Institute, University of Queensland, Brisbane, Australia, 2Child Health Research Centre, University of Queensland, South Brisbane, Queensland, Australia, 3University of Queensland, Brisbane, Australia

    Background/Purpose: In ankylosing spondylitis, spondyloarthritis (SpA) is often associated with gut inflammation. The strong genetic association with HLA-B27 and expanded CD8 TCR public clonotypes implicate…
  • Abstract Number: 2247 • ACR Convergence 2024

    Pro-inflammatory Monocytes and CD11c Expression in ACPA Positive Individuals with Arthralgia and Their Associations with Subclinical Synovitis Preceding the Onset of Arthritis

    Klára Prajzlerová1, Olga Kryštufková2, Petra Hánová1, Nora Růžičková2, Hana Hulejová1, Jiří Vencovský2, Ladislav Šenolt2 and Mária Filková2, 1Institute of Rheumatology, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Background/Purpose: Autoantibodies, e.g., against citrullinated proteins (ACPA), increase the risk of clinical arthritis and can be detected years before rheumatoid arthritis (RA) onset. EULAR's definition…
  • Abstract Number: 0890 • ACR Convergence 2024

    Pervasive Inflammation Poisons Hematopoiesis and Drives Clonal Dominance in VEXAS Syndrome

    Corrado Campochiaro1, Molteni raffaella2, Martina Fiumara3, Alessandro Tomelleri4, Elisa Diral5, Davide Stefanoni6, Angelica Varesi6, Alessandra Weber7, Roberta Alfieri8, Luisa Albano7, Maddalena Panigada6, Eleonora Cantoni6, Daniele Canarutto9, Luca Basso-Ricci10, Pamela Quaranta7, Angelo D’Alessandro11, Gregorio Bergonzi12, Marco Matucci-Cerinic13, Raffaella Di Micco3, Alessandro Aiuti3, Fabio Ciceri12, Ivan Merelli3, Lorenzo Dagna14, Serena Scala3, Simone Cenci6, Luigi Naldini3, Samuele Ferrari3 and Giulio Cavalli15, 1IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 2Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy, Milan, Italy, 3San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy, Milan, Italy, 4Unit of Immunology, Allergology and Rare Diseases, IRCCS Ospedale San Raffaele, Milano, Italy, 5Unit of Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Hospital, Milan, Italy, Milan, Lombardia, Italy, 6Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy, Milan, Lombardia, Italy, 7San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy, 8Institute for Biomedical Technologies, National Research Council, Segrate, Italy, 9Pediatric Immunohematology Unit and BMT Program, IRCCS San Raffaele Scientific Institute, Milan, Italy, 10San Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milano, Italy, 11Department of Biochemistry and Molecular Genetics, University of Colorado Denver - Anschutz Medical Campus, Autora, CO, 12Unit of Haematology and Bone Marrow Transplantation, IRCCS San Raffaele Hospital, Milan, Italy, Milan, Italy, 13University San Raffaele Milano, Milano, Milan, Italy, 14Ospedale San Raffaele, Milano, Italy, 15Vita-Salute San Raffaele University, Milan, Italy

    Background/Purpose: VEXAS syndrome is an adult-onset, X-linked, life-threatening, autoinflammatory and hematological disease caused by somatic mutation in UBA1 gene. Our study aims at uncovering pathophysiology…
  • Abstract Number: 2290 • ACR Convergence 2024

    Umbilical Cord-derived Mesenchymal Stem Cells Suppress Sjogren’s Syndrome Pathology

    Yukitomo Hagiwara1, Goh Murayama2, Taiga Kuga2, Yujin Nishioka2, Takumi Saito2, Yu Yamaji2, Tomoko Miyashita2, Makio Kusaoi3, Ken Yamaji2 and Naoto Tamura2, 1Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, 2Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, 3Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan

    Background/Purpose: Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the salivary and lacrimal glands, leading to functional loss and gradually causing dry mouth…
  • Abstract Number: 0925 • ACR Convergence 2024

    Macrophages Produce Bone Anabolic Factors in Settings of Inflammation-Induced Bone Formation

    Jia (Sijia) Chen1, Megan Hanlon2, Catherine Manning3, Susan MacLauchlan1, Paul Hoover4, Christian Jacome-Galarza5 and Ellen Gravallese6, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women’s Hospital, Boston, MA, 3Brigham and Women's Hospital, Dedham, MA, 4Brigham and Women's Hospital, SWAMPSCOTT, MA, 5Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 6Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA

    Background/Purpose: Understanding the pathogenesis of inflammation-induced pathologic bone formation remains a significant challenge in spondyloarthritis patients. We thought to uncover the pivotal events driving the…
  • Abstract Number: 2327 • ACR Convergence 2024

    Differential Quantitative Profile of Myeloid Derived Suppressor Cells and Monocyte Subsets Relate to Clinical Phenotype and Disease Activity in Psoriatic Arthritis Patients

    Jennifer Balderas Miranda1, Jiram Torres Ruiz2, Guillermo Guaracha Basañez3, Virginia Pascual Ramos4, Beatriz Alcalá-Carmona5, Yatzil Reyna-Juárez5, María José Ostos-prado5, Nancy R Mejía-Domínguez5, Guillermo Juarez-Vega6 and Diana Gomez-martin7, 1Universidad Nacional Autónoma de México, Ciudad de México, Mexico, 2INCMNSZ, Mexico, Federal District, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirón", Mexico City, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Federal District, Mexico, 5Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Distrito Federal, Mexico, 6Red de Apoyo a la Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán and Universidad Nacional Autónoma de México, Mexico City, Distrito Federal, Mexico, 7INCMNSZ, Mexico City, Federal District, Mexico

    Background/Purpose: The innate immune system not only participates in PsA pathogenesis but may also counteract with immunomodulatory elements. Proinflammatory and repairing roles according to monocyte…
  • Abstract Number: 0944 • ACR Convergence 2024

    Targeting Defective Macrophages to Restore Resolution of Inflammation in Rheumatoid Arthritis -Perspectives for an Autologous Secretome Therapy

    Melanie Couturier1, Francis Bonnefoy2, emilie Gaiffe3, Charline Vauchy4, Suzanne Behlke2, ERIC TOUSSIROT5 and Sylvain Perruche2, 11MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, 2MED’INN’Pharma, F-25000 Besançon, France, Besançon, France, 3INSERM CIC -1431 CHU Besançon, France, Besançon, France, 4INSERM CIC-1431, CHU de Besançon, Besancon, France, Besançon, France, 5university hospital of BESANCON, besancon, France

    Background/Purpose: Impaired macrophage efferocytosis, a key hallmark of failed inflammation resolution, is reported in many immune-mediated inflammatory diseases, including in Rheumatoid Arthritis (RA). Hence the…
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