Monocytes/macrophages Archives - ACR Meeting Abstracts

Abstract Number: 1101 • ACR Convergence 2026
CBX-663, a First-in-class TCR-mimetic T-Cell Engager Targeting a Telomerase Reverse Transcriptase-derived Peptide-HLA Complex, Depletes B Cells and Monocytes In Vitro and In Vivo and Alleviates SLE Severity in a Preclinical Mouse Model
Ricard Masia¹, Yu Huang², Jessica Jimenez², Qunyan Yu², Jennifer Helble², Tanzila Rahman², Bhupal Ban², Michi Schebesta², Benjamin Lee¹ and Dmitri Wiederschain² Affiliations: ¹Crossbow Therapeutics, Inc., Cambridge, ²Crossbow Therapeutics, Inc., Cambridge, MA
Background/Purpose: T-cell redirecting therapies against pathogenic B cells have revolutionized the therapeutic landscape in autoimmunity by showing proof-of-concept clinical benefit in a broad range of…
Abstract Number: 1909 • ACR Convergence 2026
SAT1 loss-of-function drives lupus-like autoimmunity through polyamine depletion and macrophage mitochondrial reprogramming
Lu Liu¹, Yulu Qiu¹, Jian Zhao², Chenyu Xu¹, Lei Wang³, Fang Wang⁴, Betty P Tsao⁵, Wenfeng Tan⁶ and lingxiao Xu¹ Affiliations: ¹Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (People's Republic), ²Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, ³The First Affiliated Hospital of Nanjing Medical University, Nanjing, China (People's Republic), ⁴Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (People's Republic), ⁵Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ⁶Jiangsu province hospital, Nanjing, China (People's Republic)
Background/Purpose: Spermidine/spermine N1-acetyltransferase 1 (SAT1) is a key regulator of polyamine catabolism and has been implicated in systemic lupus erythematosus (SLE). We previously identified a…
Abstract Number: 0028 • ACR Convergence 2026
Divergent Roles for Classical and Non-Classical Monocytes in the Development of a Multi-Organ Murine Model of Systemic Sclerosis
Kainat Mian¹, Vanessa Manada De Lobos², Meghan Mayer¹, Harris Perlman¹ and Hadijat Makinde¹ Affiliations: ¹Northwestern University, Chicago, IL, ²Northwestern University, Chicago
Background/Purpose: Systemic sclerosis (SSc)/scleroderma is a complex autoimmune disease that results in multi-organ fibrosis and is associated with the highest mortality among autoimmune connective tissue…
Abstract Number: 1928 • ACR Convergence 2026
Spatial and Functional Characterization of SPP1+ Macrophages in Pre-RA and RA Synovium
Megan Hanlon¹, Raghav Sharma¹, Ursula Fearon², Kevin Wei³ and Ellen Gravallese⁴ Affiliations: ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Trinity College Dublin, Dublin, Dublin, Ireland, ³Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: We have reported an enrichment of secreted phosphoprotein-1 synovial tissue macrophages (SPP1+ STM) in rheumatoid arthritis (RA) synovium compared to control, correlating significantly with…
Abstract Number: 0087 • ACR Convergence 2026
Reduction of Emergency Myelopoiesis Represents a Mechanism of Action of TNF Blockade and IL-6 Deficiency in an Arthritis Model
Brianna Williams, Richard Bell, Claire Wingert, Toolika Singh and Lionel Ivashkiv Affiliations: Hospital For Special Surgery, New York, NY
Background/Purpose: Bone marrow abnormalities in rheumatoid arthritis (RA) have been long appreciated but implication of emergency myelopoiesis and myeloid skewing in pathogenesis is an exciting…
Abstract Number: 1967 • ACR Convergence 2026
Macrophage/DC subpopulations correlate with esophagus dysmotility in SSc patients.
Hadijat Makinde¹, Matthew Dapas¹, Margaret Clevenger², Salina Dominguez¹, Miranda Gurra¹, Carla Cuda¹, Tyler Therron³, Kathleen Aren⁴, Alexandra Soriano¹, Mary Carns¹, Jane Dematte⁵, Dustin Carlson¹, John Pandolfino⁶, Darren Brenner¹, Lutfiyya Mohammed⁷, Deborah Winter⁸, Monique Hinchcliff⁹, Marie-Pier Tetreault¹ and Harris Perlman¹ Affiliations: ¹Northwestern University, Chicago, IL, ²University of Chicago, Chicago, ³Northwestern Feinberg School of Medicine, Chicago, IL, ⁴Northwestern University Division of Rheumatology, Chicago, IL, ⁵Northwestern University, Elmhurst, IL, ⁶Northwestern University, Feinberg School of Medicine, Wilmette, IL, ⁷Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Northwestern University, Skokie, IL, ⁹Yale School of Medicine, Westport, CT
Background/Purpose: Systemic sclerosis/scleroderma (SSc) is a complex, systemic autoimmune rheumatic disease characterized by widespread vascular damage, chronic inflammation, and fibrosis. Gastrointestinal (GI) dysmotility, the most…
Abstract Number: 0092 • ACR Convergence 2026
β-Dominant Type I Interferon Stimulation Produces Coordinated TYK2/MX1/STAT2/PKR/MCSF Signaling in Rheumatoid Arthritis Fibroblast-Like Synoviocyte and Macrophage Cocultures, Implicating Distinct Chronic Inflammation in Patients with High Circulating IFN-β/α Activity
Jod Prado¹, Carolyn Harris², Timothy Niewold² and Theresa Wampler Muskardin³ Affiliations: ¹Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery and Weill Cornell Medicine, New York, NY
Background/Purpose: Despite advances in therapy including biologic and targeted synthetic treatments, up to 40% of rheumatoid arthritis (RA) patients fail to achieve adequate response to…
Abstract Number: 1996 • ACR Convergence 2026
Compartment-Specific RABGAP1L Expression Pathways and Differential Correlation with Systemic Inflammatory Mediators in Patients Across Preclinical and Clinical Systemic Lupus Erythematosus Categories
Caleb Marlin¹, Aleksandra Bylinska¹, Alexandre Cammarata-Mouchtouris¹, Miles Smith¹, Cristina Arriens¹, Joan Merrill², Teresa Aberle¹, Joel Guthridge³ and Judith James³ Affiliations: ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Oklahoma Medical Research Foundation and University of Oklahoma Health Campus, Oklahoma City, OK
Background/Purpose: RabGAP1L encodes a GTPase-activating protein regulating endocytic trafficking and vesicle-mediated antigen presentation1. Although genetic variations in RABGAP1L link to systemic lupus erythematosus (SLE) susceptibility2,…
Abstract Number: 0097 • ACR Convergence 2026
Fibrin deposits and SPP1hi macrophages mark active tissue remodeling niches from early to established RA
Ian Mantel¹, Annabelle Small², Yakir Reshef³, Melanie Smith¹, Edward Dicarlo⁴, Brendan Boyce⁵, Michael Clay⁶, Lakshay Sood⁷, Philip Blazar⁸, David Boyle⁹, Mary Buchanan¹⁰, Yoshimi Endo⁴, Melissa Griffith¹¹, Paul Hsu¹², Laith Jazrawi¹³, Susan Lee⁹, Ogonna Nwawka¹⁴, Meghan Sahr¹, Darren Tabechian¹⁵, Nida Meednu⁵, Tyler Cavin¹⁶, Angelica Cornelison¹⁶, Caleb Marlin¹⁷, Accelerating Medicines Partnership: Autoimmune & Immune Mediated Diseases consortium¹⁸, Joan Bathon¹⁹, Rebecca Blank¹³, S. Louis Bridges, Jr.²⁰, Andrew Filer²¹, Gary Firestein²², Ellen Gravallese²³, Michael Holers²⁴, Katherine Liao²⁵, Kenneth Saag²⁶, Susan Goodman¹, Michael Brenner²⁷, Ranjeny Thomas²⁸, Kevin Wei²⁹, Soumya Raychaduhuri³, Larry Moreland³⁰, Jennifer Anolik³¹, Mihir Wechalekar³² and Laura Donlin¹ Affiliations: ¹Hospital for Special Surgery, New York, NY, ²Flinders University, Bedford Park, South Australia, Australia, ³Brigham and Women's Hospital, Boston, ⁴Hospital for Special Surgery, New York, ⁵University of Rochester, Rochester, NY, ⁶Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, ⁷Brigham and Women's Hospital, Boston, MA, ⁸Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁹University of California San Diego, San Diego, CA, ¹⁰University of Colorado Denver, Aurora, ¹¹University of Colorado, Aurora, CO, ¹²University of California San Diego, San Diego, ¹³NYU Grossman School of Medicine, New York, NY, ¹⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ¹⁵University of Rochester Medicine, Rochester, ¹⁶University of Rochester, Rochester, ¹⁷Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, ¹⁹Columbia University Medical Center, New York, NY, ²⁰Self, Birmingham, AL, ²¹The University of Birmingham, Birmingham, United Kingdom, ²²University of California, San Diego, San Diego, CA, ²³Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA, ²⁴University of Colorado School of Medicine, Aurora, CO, ²⁵Mass General Brigham/Harvard Medical School, Boston, MA, ²⁶The University of Alabama at Birmingham, Birmingham, AL, ²⁷Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²⁸University of Queensland, Brisbane, Queensland, Australia, ²⁹Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³⁰University of Colorado, Denver, CO, ³¹University of Rochester Medical Center, Rochester, NY, ³²Rheumatology Synovial Tissue Translational Research Group, Flinders University, and Rheumatology Unit, Flinders Medical Centre, Adelaide, Australia
Background/Purpose: Chronic inflammation frequently drives tissue remodeling, where fibrin accumulation is common. In rheumatoid arthritis (RA), excessive fibrin deposits in synovial tissue associate with clinical…
Abstract Number: 2017 • ACR Convergence 2026
CX3CR1 and MHCII define four synovial macrophage populations with conserved inflammatory response across rheumatoid arthritis mouse models.
Shang-Yang Chen¹, Yidan Wang¹, Philip Homan¹, Anna Montgomery¹, Tyler Therron², Meghan Mayer¹, Kainat Mian¹, Hadijat Makinde¹, Carla Cuda¹, Harris Perlman¹ and Deborah Winter³ Affiliations: ¹Northwestern University, Chicago, IL, ²Northwestern Feinberg School of Medicine, Chicago, IL, ³Northwestern University, Skokie, IL
Background/Purpose: Macrophages in the synovial lining of the joint are critical for the maintenance of the healthy tissue while also contributing to the pathogenesis of…
Abstract Number: 0103 • ACR Convergence 2026
Single-Cell Transcriptomics Identifies Monocyte Antigen Presentation and Adiposity-Associated Costimulatory Programs in Rheumatoid Arthritis
Shalini Swamy¹, Hua Zhong², Kylie Williams², Joan T. Merrill², Kurt Zimmerman² and Beatriz Hanaoka² Affiliations: ¹University of Oklahoma Health Sciences, Oklahoma City, OK, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Obesity is associated with higher disease activity, reduced treatment response, and worse clinical outcomes in rheumatoid arthritis (RA), yet the mechanisms linking adiposity to…
Abstract Number: 2018 • ACR Convergence 2026
Development of a Patient-Derived 3D Synovial Organoid Platform for Personalized Drug Testing in Rheumatoid Arthritis
Amber Dassen¹, Eva Philippon², Aziza Elmesmari³, Domenico Somma⁴, Lisanne van Rooijen¹, Aldo jongejan¹, Anne-Marieke van Stalborch¹, Jaap van Buul¹, Stefano Alivernini⁵, Jan Piet van Hamburg², Mariola Kurowska-Stolarska⁶ and Sander Tas² Affiliations: ¹Amsterdam University Medical Center, Amsterdam, Netherlands, ²Amsterdam UMC, Amsterdam, Netherlands, ³University of Glasgow, Glasgow, United Kingdom, ⁴School of infection and immunity, Glasgow, United Kingdom, ⁵Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Rome, Italy, ⁶Research into Inflammatory Arthritis Centre Versus Arthritis (RACE), University of Glasgow, Glasgow, United Kingdom
Background/Purpose: To evaluate the utility of 3D synovial organoids (SOs) for therapeutic profiling in rheumatoid arthritis (RA) and advance their development toward a scalable, fully…
Abstract Number: 0115 • ACR Convergence 2026
Single-cell metabolic modeling identifies inositol phosphate and lysophosphatidic acid metabolic pathways associated with synovial inflammation in osteoarthritis
Marta Sala-Climent¹, Jessica Murillo-Saich², Chris Mahony³, Shahrzad Alimohammadi⁴, Nathan Argel¹, Valentina Pucino⁵, Adam P Croft⁵ and Monica Guma⁶ Affiliations: ¹University of California San Diego, San Diego, ²UCSD, San Diego, ³University of Glasgow, Glasgow, ⁴UCSD, san diego, CA, ⁵University of Birmingham, Birmingham, ⁶University of California San Diego, La JOlla, CA
Background/Purpose: Metabolic dysregulation contributes to osteoarthritis (OA) pathogenesis, yet the specific pathways driving synovial inflammation remain incompletely understood. We applied single-cell metabolic modeling to identify…
Abstract Number: 2068 • ACR Convergence 2026
A RUNX1-Bound Enhancer Variant at IRF8 Amplifies cGAS-STING-Induced Type I Interferon Responses in SLE Monocytes
Zhaorui Cheng¹, Guojun Hou¹, Xinyi Zhu¹, Yutong Zhang¹, Weiwen Shi¹ and Nan Shen² Affiliations: ¹Shanghai Institute of Rheumatology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Shanghai, Shanghai, China (People's Republic), ²Shanghai Institute of Rheumatology, Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (People's Republic)
Background/Purpose: Type I interferon (IFN-I) is a central driver of systemic lupus erythematosus (SLE), and the DNA-sensing cGAS-STING pathway is an important upstream inducer of…
Abstract Number: 0125 • ACR Convergence 2026
Subclinical inflammation in patients with Familial Mediterranean Fever with well-controlled disease
Alba Maria Torrat Noves¹, Jose Ivorra Cortes², Elena Grau García³, Sheyla Velasco⁴, Isabel Campillo⁵, Regina Rodrigo⁶, Pablo Muñoz Martínez⁷, Daniel Ramos Castro⁷, Iago Alcántara Álvarez⁷, Belén Villanueva Mañes⁷, Miguel Simeó Vinaixa⁷, Andres Perez Hurtado⁷, patricia anton Enguidanos⁷, Belen diaz Mora⁷, Lucia Lacruz-Perez⁸ and Jose Andres Roman Ivorra⁹ Affiliations: ¹1.Rheumatology Department. HUP La Fe; 2.Doctoral School. Catholic University of Valencia San Vicente Mártir, Valencia, Spain, ²1.Rheumatology Department.HUP La Fe; 2.Doctoral School. Catholic University of Valencia San Vicente Mártir, Valencia, Spain, ³HUP La Fe, Valencia, Spain, ⁴Group of Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Comunidad Valenciana, Spain, ⁵Group of Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF), Valencia, Spain, ⁶1.Group of Pathophysiology and Therapies for Vision Disorders, Principe Felipe Research Center (CIPF) Valencia,Spain; 2.Catholic University of Valencia (UCV), Facutlty of Healtch Sciences, Valencia, Spain; 3.Biomedical Research Networking Center in Rare Diseases (CIBER-ER) Institute of Health Carlos III, Madrid, Spain, Valencia, Spain, ⁷Rheumatology Department. HUP La Fe, Valencia, Spain, ⁸Paediatric Rheumatology Department. HUP La Fe, Valencia, Spain, ⁹Hospital Universitari i Politècnic La Fe, Valencia, Spain
Background/Purpose: Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disease driven by abnormal inflammasome activation, increased IL-1β, IL-18 and IL-6 production, and subsequent innate immune…

Abstracts tagged "Monocytes/macrophages"