ACR Meeting Abstracts

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Abstracts tagged "Monocytes/macrophages"

  • Abstract Number: 0039 • ACR Convergence 2020

    Identification of a Regulatory Pathway Governing Expression of TRAF1 via a JIA-associated Non-coding Variant

    Qiang Wang1, Marta Martínez2, Matthew Weirauch3 and Peter Nigrovic4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, 3Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, 4Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA, Boston

    Background/Purpose: Over the past decade, genome-wide association studies (GWAS) have identified TRAF1/C5 locus as a risk locus for rheumatoid diseases including RA and JIA(Plenge, Seielstad…
  • Abstract Number: 1156 • ACR Convergence 2020

    Comparison of Immunological Biomarkers and Lung Histology in Patients with Elevated IL18 – Pulmonary Alveolar Proteinosis and Recurrent Macrophage Activation Syndrome (IL-18PAP-MAS) and Other Inflammatory Lung Diseases

    Alhanouf Alsaleem1, Adriana de Jesus2, Sofia Torreggiani3, Chyi-Chia Lee4, Les Folio5, Huy Do6, Andrew Oler7, Caroline Kim3, Stewart Levine8, Anthony Suffredini9, Cem Gabay10, Joseph Fontana11, Scott Canna12 and Raphaela Goldbach-Mansky13, 1Division of Pediatric Rheumatology, Department of pediatrics, King Faisal specialist hospital and research center, Riyadh, Saudi Arabia, RiYADH, Saudi Arabia, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 3Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 4Pathology Department/NCI/NIH, Bethesda, MD, 5Radiology and Imaging Services/NIH, Bethesda, MD, 6Radiology and Imaging Sciences, Bethesda, MD, 7Bioinformatics and Computational Biosciences Branch/NIAID/NIH, Bethesda, MD, 8Laboratory of Asthma and Lung Inflammation, Division of Intramural Research, NHLBI, NIH,, Bethesda, MD, 9Critical Care Medicine Department, Clinical Center, NIH, Bethesda, MD, 10University Hospitals of Geneva, Geneva, Switzerland, 11NHLBI/NIH, Bethesda, MD, 12University of PIttsburgh, Pittsburgh, PA, 13Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: Recently, pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS) have been reported in rare patients (pts) with systemic juvenile idiopathic arthritis (SJIA)…
  • Abstract Number: 0065 • ACR Convergence 2020

    The Energy-dependent Hierarchy of Immune Functions in Human Monocytes

    Pierre-Louis Krauß1, Thomas Buttgereit2, Yuling Chen1, Moritz Pfeiffenberger1, Timo Gaber1 and Frank Buttgereit3, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology, Venerology, and Allergology, Berlin, Germany, 3Charité University Medicine, Berlin, Germany

    Background/Purpose: At sites of inflammation, monocytes carry out specific immunological functions while facing challenging bioenergetic restrictions. Here, we investigated the potential of human monocytes to…
  • Abstract Number: 1951 • ACR Convergence 2020

    Possible Involvement of Fractalkine/CX3CR1 Axis in Peripheral CD14++CD16+ Monocytes in Disease Development of Patients with Systemic Lupus Erythematosus

    Keiko Yoshimoto1, Katsuya Suzuki1, Noriyasu Seki2, Shuntaro Saito3, Jun Kikuchi1 and Tsutomu Takeuchi4, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 3Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, 4Division of Rheumatology, Department of internal Medicine, School of Medicine, Keio University, Tokyo, Japan

    Background/Purpose: Fractalkine (FKN) binds its receptor, CX3CR1 and accelerates chemotaxis of immune cells by inducing cell surface molecules and mediating adhesion of the cells to…
  • Abstract Number: 0066 • ACR Convergence 2020

    AMP Deaminase 2 Is Expressed on the Surface of Human Immune Cells as a Novel Regulator of Extracellular Adenosine Metabolism

    Lisa Ehlers1, Aditi Kuppe1, Marieluise Kirchner2, Alexandra Damerau1, Cindy Strehl1, Frank Buttgereit3 and Timo Gaber1, 1Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Germany, 2Max Delbrück Center for Molecular Medicine, BIH Core Facility Proteomics, Berlin, Germany, 3Charité University Medicine, Berlin, Germany

    Background/Purpose: Adenosine and its nucleotides represent crucial immunomodulators in the extracellular environment. ATP and ADP are released from stressed cells in states of inflammation, whereas…
  • Abstract Number: 0068 • ACR Convergence 2020

    Single Cell RNA-seq to Characterize Monocyte Subtypes in the Autoinflammatory Interferonopathy, SAVI and the Inflammasomopathy, NOMID

    Ying Zhang1, Bernadette Marrero2, Adriana de Jesus3, Sara Alehashemi4, Jinguo Chen5, Rongye Shi6, Huizhi Zhou6, Clifton Dalgard7, Manfred Boehm8 and Raphaela Goldbach-Mansky9, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 2Computational Systems Biology Section/NIAID/NIH, Bethesda, MD, 3Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 5Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD, 6Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, 7Department of Anatomy, Physiology and Genetics, Uniformed Services University of Health Sciences, Bethesda, 8Center for Molecular Medicine, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 9Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: Monocytes are pivotal producers of key inflammatory cytokines that drive autoinflammatory diseases. In SAVI, constitutive STING activation causes chronic activation with increased type-I IFN…
  • Abstract Number: 0294 • ACR Convergence 2020

    Tired T-Cells and Monocytes with Malaise: Investigating the Links Between Cellular Iron Deficiency and Mitochondrial Dysfunction in Systemic Lupus Erythematosus

    Chris Wincup1, Thomas McDonnell1, George Robinson2, Filipa Farinha1, Anna Radziszewska1 and Anisur Rahman1, 1University College London, London, United Kingdom, 2University College London, Hertford, United Kingdom

    Background/Purpose: Iron is vital for many physiological processes and is found within respiratory complexes of the mitochondrial electron transport chain, the key site of oxidative phosphorylation…
  • Abstract Number: 0450 • ACR Convergence 2020

    In Vitro Characterization of Inflammatory Arthritis Associated with Immune Check Point Inhibition

    Anne Sofie Sørensen1, Morten Nørgaard Andersen1, Kristian Juul-Madsen2, Cæcilie Deisting Skejø1, Henrik Schmidt1, Thomas Vorup-Jensen1 and Tue Wenzel Kragstrup1, 1Aarhus University, Aarhus, Denmark, 2Aarhus University, Aarhus, Midtjylland, Denmark

    Background/Purpose: During treatment with immune checkpoint inhibitors (ICI) such as the anti-PD-1 antibody pembrolizumab, 2-4% of cancer patients develop inflammatory arthritis as an immune-related adverse…
  • Abstract Number: 0496 • ACR Convergence 2020

    A Role of Lipid-Peroxidation in Systemic Lupus Erythematosus-Associated Cardiovascular Disease

    David Patrick1, Justin van Beusecum1, Michelle Ormseth2, Leslie J. Crofford2, Sean Davies3, Sergey Dikalov1 and David Harrison1, 1Vanderbilt University Medical Center, Nashville, 2Vanderbilt University Medical Center, Nashville, TN, 3Vanderbilt University, Nashville

    Background/Purpose: In SLE, cardiovascular complications are a significant contributor to morbidity and death. Importantly, there is an increased prevalence of hypertension in SLE patients compared…
  • Abstract Number: 0772 • ACR Convergence 2020

    Modification of THP-1 Cells with Malondialdehyde-Acetaldehyde Increases Cellular Calcium Load Rendering Cells Susceptible to Citrullination of Self-Proteins

    Nozima Aripova1, Michael Duryee1, Xiarepati Tieliwaerdi1, Xiaoting Jiang1, Lynell Klassen2, James O'Dell1, Bryant England1, Ted Mikuls1 and Geoffrey Thiele1, 1University of Nebraska Medical Center, Omaha, NE, 2Univerisity of Nebraska Medical Center, Omaha, NE

    Background/Purpose: The post translational modification of self-proteins with malondialdehyde-acetaldehyde (MAA) has been shown to alter protein function and antibodies to MAA are increased in both…
  • Abstract Number: 0777 • ACR Convergence 2020

    CLEC12A Expression as a Potential Predictor of Disease Activity in Early Rheumatoid Arthritis

    Myriam Vaillancourt1, Philippe Desaulniers1, Guillaume Paré1, Nathalie Pagé1, Asmaa Lachaab1, Anthony Kerever1, Anne-Sophie Julien1, Nathalie Amiable1, Martin Pelletier1, Philippe Tessier1, Louis Bessette2, Paul Fortin3, Laetitia Michou1 and Maria Fernandes1, 1Université Laval, Québec, QC, Canada, 2Laval University, Quebec, Canada, 3CHU de Quebec - Universite Laval, Quebec, Canada

    Background/Purpose: Rheumatoid arthritis (RA) develops as a result of the dysregulation of immune activating and inhibitory pathways. Several lines of evidence indicate that inhibitory receptors…
  • Abstract Number: 0784 • ACR Convergence 2020

    Upregulation of Tyro3TK on CD14+CD16- Monocytes Promotes Osteoclast Formation in Rheumatoid Arthritis

    Jimeng Xue1, Liling Xu1, Fanlei Hu1 and Yin Su2, 1Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing Key Laboratory for Rheumatism Mechanism and Immune Diagnosis (BZ0135), Beijing, China, Beijing, China (People's Republic), 2Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China (People's Republic)

    Background/Purpose: The study aimed to investigate the expression and clinical significance of Tyro3TK on CD14+CD16+ and CD14+CD16- monocyte subsets and explore the effect of Tyro3TK…
  • Abstract Number: 0785 • ACR Convergence 2020

    Identification of Recruited CCR2+ Inflammatory Monocytes in a Mouse Model of RA-associated Lung Disease with Potential Role for resolvin-D1 in Reducing Monocyte Inflammatory Responses

    Austin Barry1, Geoffrey Thiele1, Ted Mikuls1, Michael Duryee1, Amy Nelson1, Rohit Gaurav1, Bryant England1 and Jill Poole1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Patients with rheumatoid arthritis (RA) are at an increased risk for comorbid chronic lung disease, with premature mortality. Therapies for RA-associated lung disease are…
  • Abstract Number: 0786 • ACR Convergence 2020

    A Combination of Dimensionality Reduction Techniques Reveals Novel HLA-DR+ ‘Candidate’ Antigen-Presenting Cell Subsets (cAPC) in Patients with Rheumatoid Arthritis (RA)

    Christian Geier1, Jon Giles1, Samantha Gaines2, Christopher Depender1, Joan Bathon1 and Robert Winchester1, 1Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 2Division of Rheumatology, Columbia University Vagelos College of Physicians and Surgeons, New York

    Background/Purpose: The presentation of MHC-peptide complexes to T lymphocytes via antigen-presenting cells (APC) is a crucial step in the initiation of immune responses. Dendritic cells…
  • Abstract Number: 0788 • ACR Convergence 2020

    Rigorous Plasma Microbiome Analysis Method Enables Disease Association Discovery

    Wei Jiang1, Alexander Alekseyenko2, Gary Gilkeson3, Jim Oates4, Elizabeth Ogunrind5, Quan Li6, Diane Kamen2, Betty Tsao5 and Zhenwu Luo5, 1MUSC, Charleston, SC, 2Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology, Medical University of South Carolina, Charleston, SC, 4Medical University of South Carolina, Charleston, SC, Charleston, SC, 5Medical University of South Carolina, Charleston, 6UT South Western Medical Center, Texas

    Background/Purpose: The mucosal microbiome contributes to disease pathogenesis via local and systemic interaction with the host. The hallmark of this interaction in the physiological condition…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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