Abstracts tagged "microbiome"

Abstract Number: 0012 • ACR Convergence 2021
A Novel Mechanism Linking Mucosal Bacteria with Autoantibody Responses in RA: Acetylated Bacterial Lysate as a Model Antigen
Mikhail Volkov, Arieke Kampstra, Karin van Schie, Joanneke Kwekkeboom, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly…
Abstract Number: 0788 • ACR Convergence 2020
Rigorous Plasma Microbiome Analysis Method Enables Disease Association Discovery
Wei Jiang¹, Alexander Alekseyenko², Gary Gilkeson³, Jim Oates⁴, Elizabeth Ogunrind⁵, Quan Li⁶, Diane Kamen², Betty Tsao⁵ and Zhenwu Luo⁵, ¹MUSC, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC, Charleston, SC, ⁵Medical University of South Carolina, Charleston, ⁶UT South Western Medical Center, Texas
Background/Purpose: The mucosal microbiome contributes to disease pathogenesis via local and systemic interaction with the host. The hallmark of this interaction in the physiological condition…
Abstract Number: 0795 • ACR Convergence 2020
Minimum Clinically Important Improvement in Patients with Rheumatoid Arthritis Associates with Gut Microbiome
Vinod Gupta¹, Kevin Cunningham², Benjamin Hur¹, John Davis¹ and Jaeyun Sung¹, ¹Mayo Clinic, Rochester, MN, ²University of Minnesota, Minneapolis, MN
Background/Purpose: Within the past decade, there have been several major discoveries in cross-sectional gut microbiome studies suggesting that dysbiosis of the gut microbiota is a…
Abstract Number: 0959 • ACR Convergence 2020
Altered Gut Microbiome in Dermatomyositis
Sangmee Bae¹, Tien Dong², Venu Lagishetty³, William Katzka⁴, Jonathan Jacobs³ and Christina Charles-Schoeman⁵, ¹University of California Los Angeles, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, ³University of California, Los Angeles, Los Angeles, ⁴UCLA, Los Angeles, ⁵University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Dermatomyositis (DM) is an autoimmune myopathy associated with marked microvascular dysfunction and high morbidity and mortality. The gut microbiome has been implicated in the…
Abstract Number: 1310 • ACR Convergence 2020
Gut Microbiome Changes Are Different Between Ankylosing Spondylitis and Inflammatory Bowel Disease, and Correlate with Disease Activity in Both Diseases
Peter Sternes¹, Laurel Brett², Julie Phipps³, Francesco Ciccia⁴, Erika de Guzman³, Mark Morrison⁵, Gerald Holtmann⁶, Eva Klingberg⁷, Carolyn McIvor², Helena Forsblad-d'Elia⁸ and Matthew Brown⁹, ¹Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, Brisbane, Queensland, Australia, ²Department of Gastroenterology, Logan Hospital, Brisbane, Queensland, Australia, ³Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, ⁴Dipartimento di Medicina di Precisione, Università della Campania L. Vanvitelli, Naples, Naples, Campania, Italy, ⁵University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, ⁶Department of Gastrenterology, Princess Alexandra Hospital, Brisbane, Queensland, Australia, ⁷Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Vastra Gotaland, Sweden, ⁸Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Vasterbottens Lan, Sweden, ⁹Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom
Background/Purpose: Multiple studies have confirmed that the gut and stool microbiome in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are distinct from healthy controls,…
Abstract Number: 1491 • ACR Convergence 2020
Association of a Leaky Gut but Not Microbial Dysbiosis with Obesity-related OA: A Translational Study
Richard Loeser¹, Liubov Arbeeva¹, Kathryn Kelley², Anthony Fodor³, Shan Sun³, Veronica Ulici⁴, Lara Longobardi², Yang Cui², Susan Sumner², Andrea Azcarate-Peril², Balfour Sartor², Ian Carrol² and Amanda Nelson¹, ¹University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ²University of North Carolina, Chapel Hill, NC, ³University of North Carolina-Charlotte, Charlotte, NC, ⁴Brown University, Providence, RI
Background/Purpose: To test the hypothesis that an altered gut microbiota (dysbiosis) plays a causal role in the obese OA phenotype (obesity with both hand and…
Abstract Number: 1517 • ACR Convergence 2020
Metabolic Regulation of Type 3 Innate Lymphoid Cells by Intestinal Bacteria-Derived Indoles in Ankylosing Spondylitis
Adam Berlinberg¹, Adam Lefferts², Emilie Regner³, Andrew Stahly⁴ and Kristine Kuhn⁴, ¹University of Colorado, Denver, CO, ²University of Colorado, Anschutz Medical Campus, Denver, CO, ³University of California San Francisco, San Francisco, CA, ⁴University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Intestinal microbial dysbiosis, intestinal inflammation, and Th17 immunity are all linked to the pathophysiology of ankylosing spondylitis (AS); however, the mechanisms linking them remain…
Abstract Number: 1815 • ACR Convergence 2020
Dynamic Changes in Microbiota Representation of a Gut Pathobiont and Clinical Disease Activity in Patients with Lupus Nephritis
Doua Azzouz¹, Ze Chen², Zhi Li³, Peter Izmirly⁴, Jing Deng¹, David Fenyo³, Jill Buyon¹, Alexander Alekseyenko⁵ and Gregg Silverman⁶, ¹Department of Medicine, NYU School of Medicine, New York, NY, ²Department of Microbiology, NYU School of Medicine, New York, NY, ³Institute for Systems Genetics, NYU School of Medicine, New York, NY, ⁴Department of Medicine, New York University School of Medicine, New York, NY, ⁵Medical University of South Carolina, Charleston, SC, ⁶Laboratory of B cell immunobiology, Department of Medicine, NYU School of Medicine, New York, NY
Background/Purpose: From a cross-sectional cohort, we have recently identified a candidate human gut pathobiont, Ruminococcus gnavus (RG) of the Lachnospiraceae family and Blautia genus that…
Abstract Number: 1849 • ACR Convergence 2020
Identification of New Associations Between Psoriatic Arthritis and the Gut Microbiota. the Mi-PART, a Phenomic Study
Jesus Miguens Blanco¹, Uma Selvarajah¹, Zhigang Lui¹, Benjamin Mullish¹, James Alexander¹, Julie McDonald², Sonya Abraham¹ and Julian Marchesi¹, ¹Imperial College London, London, United Kingdom, ²Imperial College London, London
Background/Purpose: Perturbations of the gut microbiota have been associated with Psoriatic Arthritis (PsA), a chronic inflammatory disease. We aim to test the microbiome-metabolic interface of…
Abstract Number: 1853 • ACR Convergence 2020
Association of Gut Dysbiosis with Radiographic and Enthesis Involvement, Disease Activity and Duration in Axial Spondyloarthritis. Data from CASTRO Registry
Ignacio Gómez-García¹, Isabel Moreno-Indias², María-Carmen Abalos-Aguilera¹, Clementina Lopez-Medina³, Lourdes Ladehesa-Pineda⁴, Concepción Aranda-Valera⁴, Carolina Gutierrez-Repiso², Yolanda Jimenez-Gomez⁵, Nuria Barbarroja¹, Chary Lopez-Pedrera¹, Francisco-Jose Tinahones², Eduardo Collantes-Estévez⁴, Alejandro Escudero-Contreras⁴ and Patricia Ruiz-Limon⁶, ¹Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ²Biomedical Research Institute of Malaga (IBIMA)/ Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Malaga, Spain/ CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain, Malaga, Spain, ³Rheumatology Department, Cochin Hospital, Paris, Paris, France, ⁴Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, ⁵Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ⁶Biomedical Research Institute of Málaga (IBIMA)/ Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Malaga, Spain, Malaga, Spain
Background/Purpose: The etiopathogenesis of axial spondyloarthritis (AxSpA) is multifactorial. The possible role of alteration in gut microbiome (dysbiosis) has been recently suggested. However, the association…
Abstract Number: 1859 • ACR Convergence 2020
Curdlan-induced Villous Permeability, Luminal Pathobiont Translocation to the Ileal Crypts, Ileitis and Arthritis Are Mitigated by Clostridia in Colonised Germ-free SKG Mice
Anne-Sophie Bergot¹, Rabina Giri², Amy Cameron¹, Emily Duggan³, Jeimy Jimenez Loayza¹, Mark Morrison⁴, Linda Rehaume³, Jakob Begun² and Ranjeny Thomas⁵, ¹University of Queensland, Brisbane, Australia, ²Mater Research Institute UQ, Brisbane, Australia, ³University of Queensland, Brisbane, Queensland, Australia, ⁴University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, ⁵University of Queensland Diamantina Institute and Rheumatology Department, Princess Alexandra Hospital, Brisbane – Australia., Brisbane, Australia
Background/Purpose: IL-23 dependent spondylitis, arthritis and inflammatory bowel disease (IBD) recapitulate human spondyloarthropathy (SpA) in 1,3 beta glucan (curdlan)-treated SKG mice. Human SpA and SKG…
Abstract Number: 1971 • ACR Convergence 2020
Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice
Matlock Jeffries¹, Jake Martin¹, Vladislav Izda¹, Cassandra Garman¹, Cassandra Velasco¹ and Christopher Dunn², ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²University of Oklahoma HSC, Edmond, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 1994 • ACR Convergence 2020
Rheumatoid Arthritis Improvement After Exposure to an Anti-Inflammatory “ITIS” Diet Is Associated with Changes of Gut Microbiome and Systemic Metabolome
Roxana Coras¹, Cameron Martino², Julia Gauglitz³, Anupriya Tripathi³, Alan Jarmusch⁴, Francesca Cedola⁵, Marta Fernandez Bustamante⁶, Meritxall Agustín-Perez⁷, Maram Alharthi⁸, Susan Lee⁸, Abha Singh⁸, Soo In Choi⁸, Tania Rivera⁸, Katherine Nguyen⁸, Tatyana Shekhtman⁹, Tiffany Holt¹⁰, Shahrokh Golshan¹¹, Rob Knight³, Pieter Dorrestein¹² and Monica Guma¹³, ¹University of California San Diego, La Jolla, CA, ²Bioinformatics and Systems Biology, University of California San Diego, San Diego, ³University of California San Diego, San Diego, ⁴Univesity of California San Diego, San Diego, ⁵Hospital Policlinico Tor Vergata, Rome, Italy, ⁶Departement of Medicine, Division of Rheumatology, University of California San Diego, San Diego, ⁷Department of Medicine, University of California San Diego, San Diego, San Diego, ⁸Department of Medicine, Division of Rheumatology, University of California San Diego, San Diego, ⁹Department of Psychiatry, University of California, San Diego, San Diego, ¹⁰Center for Integrative Nutrition, University of California San Diego, San Diego, ¹¹Department of Psychiatry, University of California San Diego, San Diego, CA, USA, San Diego, ¹²Department of Pharmacology and Pediatrics, University of California San Deigo, San Diego, ¹³Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: A new dimension has been added to the link between diet and health, the gut microbiome. Of particular interest is the influence of diet…
Abstract Number: 0293 • ACR Convergence 2020
Contraction of the Stool Taxa Clostridia Is Associated with the Development of Clinical Disease Among Anti-Ro+ Mothers of Children with Neonatal Lupus
Robert Clancy¹, Miranda Marion², Peter Izmirly³, Mala Masson⁴, Hannah Ainsworth², Timothy Howard⁵, Jill Buyon⁶ and Carl Langefeld⁷, ¹NYU School of Medicine, New York, ²Wake Forest School of Medicine, Winston-Salem, ³Department of Medicine, New York University School of Medicine, New York, NY, ⁴New York University School of Medicine, New York, ⁵Wake Forest School of Medicine, Winston-Salem, NC, ⁶Department of Medicine, NYU School of Medicine, New York, NY, ⁷Wake Forest School of Medicine, Winston Salem, NC
Background/Purpose: Anti-Ro autoantibody production often precedes the development of systemic lupus erythematosus (SLE) or Sjögren’s syndrome (SS) by years. Anti-Ro+ mothers of children with manifestations…
Abstract Number: 2041 • ACR Convergence 2020
Disease Features of Systemic Sclerosis Are Associated with Alterations in Gastrointestinal Microbial Composition in Two Independent Cohorts
Kristofer Andréasson¹, Sungeun Lee², Venu Lagishetty², Meifang Wu², Natalie Howlett², James English², Roger Hesselstrand¹, Jonathan Jacobs² and Elizabeth Volkmann³, ¹Lund University, Lund, Sweden, ²University of California, Los Angeles, Los Angeles, ³University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Previous studies have demonstrated alterations in GI microbiota of patients with systemic sclerosis (SSc) compared with healthy controls [1]. However, these prior studies did…

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