ACR Meeting Abstracts

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Abstracts tagged "microbiome"

  • Abstract Number: 0639 • ACR Convergence 2022

    Association of Gut Microbiome Streptococcus, Health Status, Cytokines, and HLA Class in Anti-Ro+ Mothers of Children with Neonatal Lupus: Insights into Progression of Clinical Autoimmunity

    Robert Clancy1, Joel Guthridge2, Miranda Marion3, Hannah Ainsworth4, Marci Beel2, Christina Firl5, Nicola Fraser6, Nour Hachemian5, Timothy Howard4, Peter Izmirly1, Mala Masson7, Melissa Munroe2, Jill Buyon1, Judith James2 and Carl Langefeld8, 1NYU Grossman School of Medicine, New York, NY, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Wake Forest University, Winston-Salem, NC, 4Wake Forest School of Medicine, Winston-Salem, NC, 5NYU Langone Health, New York, NY, 6NYU School of Medicine, New York, NY, 7NYU Langone Medical Center- Division of Rheumatology, New York, NY, 8Wake Forest School of Medicine, Winston Salem, NC

    Background/Purpose: High titer anti-Ro+ mothers of children with neonatal lupus (NL), often completely asymptomatic, offer a unique opportunity to uncover insights into permissive and protective…
  • Abstract Number: 0868 • ACR Convergence 2022

    Spondyloarthritis and Neonatal Factors Affecting the Gut Microbiome

    Joy Um1, Douglas Einstadter2, Myung-Yong Um3 and Maria Antonelli1, 1Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 2Center for Health Care Research and Policy, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 3Department of Social Welfare, Sungkyunkwan University, Seoul, Republic of Korea

    Background/Purpose: Spondyloarthritis (SpA) consists of clinically and genetically related but phenotypically distinct disorders, including ankylosing spondylitis, enteropathic arthritis, psoriatic arthritis, reactive arthritis, and enthesitis-related arthritis…
  • Abstract Number: 1157 • ACR Convergence 2022

    Bacterial Indole Associated with Spondyloarthritis-Related Dysbiosis Contributes to Enhanced Th17 Immunity

    Brenda Seymour1, Brandon Trent2, Brendan Allen3, Adam Berlinberg1 and Kristi Kuhn3, 1University of Colorado Anschutz Medical Campus, Denver, CO, 2University of Colorado Anschutz Medical Campus, Eugene, OR, 3University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: While intestinal dysbiosis and the Th17 pathway are linked to the pathophysiology of spondyloarthritis (SpA), the mechanisms by which this occurs are unknown. We…
  • Abstract Number: 1162 • ACR Convergence 2022

    Improvement of Gut Microbiota Dysbiosis in Patients with Axial Spondyloarthritis After One Year of Biological Treatment

    valeria Rios-Rodriguez1, Morgan Essex2, Judith Rademacher3, Murat Torgutalp4, Fabian Proft5, Ulrike Löber2, Lajos Marko2, Sofia Forslund2 and Denis Poddubnyy5, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany, 3Charité Universitätsmedizin Berlin, Berlin, Germany, 4Charité - Universitätsmedizin, Berlin, Berlin, Germany, 5Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: There is little evidence about the effect of biological disease-modifying antirheumatic drugs (bDMARD) on gut dysbiosis in patients with axial SpA. Here we investigated…
  • Abstract Number: 1640 • ACR Convergence 2022

    Tryptophan Metabolites Are Associated with Erosion and Symptoms in Hand Osteoarthritis: Results from the DIGICOD Cohort

    Marie Binvignat1, Patrick Emond2, Brenda Miao3, Alice Courties4, Emmanuel Maheu5, Margreet Kloppenburg6, Pascal Richette7, Atul Butte3, Encarnita Mariotti-Ferrandiz1, Francis Berenbaum8, Harry Sokol9 and Jérémie SELLAM10, 1Sorbonne Universite, Paris, France, 2Tours University, Tours, France, 3UCSF, San Francisco, CA, 4Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, 5Hopital Paris Saint Antoine, Moirans, Auvergne-Rhone-Alpes, France, 6Leiden University Medical Center, Leiden, Netherlands, 7Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, 8Sorbonne University - Saint-Antoine hospital, Paris, France, 9Sorbonne Universite Saint Antoine Hospital, Paris, France, 10Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France

    Background/Purpose: Tryptophan (Trp) and its metabolites have been linked to inflammatory processes and associated with gut dysbiosis. However, their role in osteoarthritis (OA) is unknown.…
  • Abstract Number: 1713 • ACR Convergence 2022

    Bank1 Signaling Shapes the Gut Microbiota Composition by Controlling the Gut Mucosal B-cell Response in Lupus

    Georgina Galicia-Rosas, María Botía Sánchez, Daniel Toro-Domínguez, Lorena Albadalejo and Marta Alarcon-Riquelme, Center for Genomics and Oncological Research (GENYO), Granada, Spain

    Background/Purpose: Mucosa-associated commensal bacteria have been shown to be involved in the pathogenesis of systemic lupus erythematosus (SLE). However, its exact role remains to be…
  • Abstract Number: 1997 • ACR Convergence 2022

    Effects of Short Chain Fatty Acid Supplementation in Modulation of Gut Microbiome and T-Regulatory Cells in Health and New Onset Rheumatoid Arthritis

    Rebecca Blank1, Alba Boix-Amoros2, Renuka Nayak3, Anthony Jimenez Hernandez1, Sydney Catron4, Zakwan Uddin4, Erin Reilly5, Andrew Patterson5, Peter Turnbaugh6, Jose Clemente2 and Jose Scher7, 1NYU School of Medicine, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3University of California San Francisco, San Francisco, CA, 4NYU Langone Health, New York, NY, 5Pennsylvania State University, College Park, PA, 6UCSF, San Francisco, 7New York University School of Medicine, New York, NY

    Background/Purpose: The gut microbiome and its metabolites are dysregulated in rheumatoid arthritis. Short chain fatty acids (SCFAs), microbial fermentation byproducts of certain gut microbes, induce…
  • Abstract Number: 0944 • ACR Convergence 2021

    A Characterization of the Gut and Cutaneous Microbiome of Monozygotic Twins Discordant for Psoriatic Disease

    Julia Manasson1, Matthew Stapylton2, Rhina Medina1, Rochelle Castillo3, Parvathy Vasudevanpillai Girija1, Adriana Heguy1, Carles Ubeda4, Mid-Atlantic Twin Registry (MATR)5, Jose Clemente2 and Jose Scher1, 1New York University School of Medicine, New York, NY, 2Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 3NYU Langone Health, New York, NY, 4La Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Valencia, Spain; CIBERESP, Madrid, Spain, 5Virginia Commonwealth University, Richmond, VA

    Background/Purpose: Psoriasis (PsO) is an inflammatory, immune-mediated skin disorder affecting ~3% of the population worldwide. It is associated with multiple comorbidities, including psoriatic arthritis (PsA),…
  • Abstract Number: 1470 • ACR Convergence 2021

    Cartilage Epigenetic Changes Induced by Microbial DNA Amplified from Human OA Samples

    Vladislav Izda1, Christopher Dunn2, Cassandra Sturdy1, Jake Martin1, Cassandra Velasco2, Paul Jacob3 and Matlock Jeffries1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Oklahoma Joint Reconstruction Institute, Oklahoma City, OK

    Background/Purpose: Strong links between epigenetic changes, particularly alterations in DNA methylation, have been linked with the onset and progression of knee osteoarthritis (OA); however, the…
  • Abstract Number: 1492 • ACR Convergence 2021

    A Permissive Factor of Anti-Ro+ Mothers of Neonatal Lupus Children Is Linked to Overt SLE Associated with Immunity to a Gut Commensal

    Robert Clancy1, Miranda Marion2, Hannah Ainsworth2, Miao Chang1, Timothy Howard3, Peter Izmirly4, Mala Masson5, Jill Buyon6 and Carl Langefeld7, 1NYU Grossman School of Medicine, New York, NY, 2Wake Forest University, Winston-Salem, NC, 3Wake Forest University, Quakertown, NC, 4New York University School of Medicine, New York, NY, 5NYU Grossman School Medicine, New York, NY, 6NYU School of Medicine, New York, NY, 7Wake Forest University, Winston Salem, NC

    Background/Purpose: Unknown factors trigger the transition of anti-Ro+ mothers of neonatal lupus (NL) children from preclinical autoimmunity to clinical disease. One candidate may be the…
  • Abstract Number: 1699 • ACR Convergence 2021

    The “ITIS” Diet Improves Fatigue in Patients with Rheumatoid Arthritis and Is Associated with Changes in Metabolome and Fecal Microbiome

    Roxana Coras1, Cameron Martino1, Julia Gauglitz1, Alan Jarmusch1, Anupriya Tripathi1, Francesca Cedola2, Marta Fernandez-Bustamante1, Meritxall Agustín-Perez1, Maram Alharthi1, Susan Lee1, Abha Singh1, Soo In Choi1, Tania Rivera1, Katherine Nguyen3, Tatyana Shekhtman1, Tiffany Holt1, Shahrokh Golshan1, Rob Knight1, Pieter C Dorrestein1 and Monica Guma1, 1University of California San Diego, La Jolla, CA, 2University of California San Diego, Rome, CA, Italy, 3University of California San Diego, San Diego, CA

    Background/Purpose: Fatigue is common symptom in rheumatoid arthritis (RA), associated with decreased quality of life and productivity. Fatigue mechanisms have not been well studied, hence,…
  • Abstract Number: 0012 • ACR Convergence 2021

    A Novel Mechanism Linking Mucosal Bacteria with Autoantibody Responses in RA: Acetylated Bacterial Lysate as a Model Antigen

    Mikhail Volkov, Arieke Kampstra, Karin van Schie, Joanneke Kwekkeboom, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly…
  • Abstract Number: 0062 • ACR Convergence 2021

    Axial Spondyloarthritis and Its Related Immune-Mediated Diseases Share a Gut Microbiome Signature Besides Their Own Distinctive Profile

    Valeria Rios Rodriguez1, Morgan Essex2, Judith Rademacher1, Fabian Proft1, Ulrike Löber2, Lajos marko2, Uwe Pleyer3, Britta Siegmund4, Denis Poddubnyy5 and Sofia Forslund6, 1Charité University Medicine Berlin, Berlin, Germany, 2Experimental and Clinical Research Center of the MDC and Charité Berlin, Berlin, Germany, 3Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin; Department of Ophthalmology, Berlin, Germany, 4Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin. Department of Gastroenterology, Infectious Diseases and Rheumatology (including Nutrition Medicine), Berlin, Germany, 5Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 6Experimental an dclinical Research Center of the MDC and Charité Berlin, Berlin, Germany

    Background/Purpose: Deep profiling of gut microbiota may reveal new pathways of how SpA and its related diseases such as Crohn’s disease (CD) and acute anterior…
  • Abstract Number: 0068 • ACR Convergence 2021

    Gut Bacteria Causing Ankylosing Spondylitis Identified Through Mendelian Randomization Studies

    Nicholas Harvey1, Jose Garrido-Mesa2, Zhixiu Li3, David Evans4, Peter Sternes5 and Matthew Brown2, 1Molecular Genetics, London, United Kingdom, 2King's College London, London, United Kingdom, 3Queensland University of Technology, Brisbane, Australia, 4University of Queensland, Brisbane, Australia, 5Queensland University of Technology, Bisbane, Australia

    Background/Purpose: There is strong evidence from animal models, human microbiome profiling studies, genetic analyses, and from the model of reactive arthritis, that AS is caused…
  • Abstract Number: 0524 • ACR Convergence 2021

    Development of Biomarker Models to Identify HLA-related Microbiome Associations in Anti-Ro+ Mothers of Children with Neonatal Lupus

    Robert Clancy1, Miranda Marion2, Hannah Ainsworth2, Marci Beel3, Miao Chang1, Carla Guthridge3, Joel Guthridge3, Timothy Howard4, Peter Izmirly5, Joseph Kheir3, Mala Masson1, Miles Smith3, Judith James3, Jill Buyon6 and Carl Langefeld7, 1NYU Grossman School of Medicine, New York, NY, 2Wake Forest University, Winston-Salem, NC, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Wake Forest University, Quakertown, NC, 5New York University School of Medicine, New York, NY, 6NYU School of Medicine, New York, NY, 7Wake Forest University, Winston Salem, NC

    Background/Purpose: Anti-Ro autoantibody production often precedes the development of Systemic Lupus Erythematosus (SLE) or Sjogren’s syndrome (SS) by years. For anti-Ro+ mothers enrolled in the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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