Abstracts tagged "microbiome"

Abstract Number: 621 • 2019 ACR/ARP Annual Meeting
The Use of Microbial Flow Cytometry to Analyze the Intestinal and Oral Microbiota
Patrick Stauffer¹, Mark Klick ¹, Tammy Martin ¹, James T. Rosenbaum ² and Mark Asquith ¹, ¹Oregon Health and Science University, Portland, OR, ²Devers Eye Institute and Oregon Health & Science University, Portland, OR
Background/Purpose: The role of the microbiome in the pathogenesis of autoimmune disorders such as axial spondyloarthritis (SpA) has been well-established through means of describing gross…
Abstract Number: 983 • 2019 ACR/ARP Annual Meeting
Fecal Transfer from Mice on High or Low Magnesium Diets Confers Arthritis Protection
Teresina Laragione¹, Carolyn Harris ¹ and Percio Gulko ¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Magnesium (Mg) plays a key role in the immune response. We have previously demonstrated that alterations in the Mg balance by increasing or decreasing…
Abstract Number: 1464 • 2019 ACR/ARP Annual Meeting
The Oral Microbiome as a Risk Factor for Benign or Pathologic Autoimmunity Associated with Anti-SSA/Ro Positivity and Mimicry for Von Willebrand Factor Type a Domain Protein (vWFA) of L. Mirabilis
Robert Clancy¹, Miranda Marion ², Peter Izmirly ¹, Hannah Ainsworth ³, Timothy Howard ³, Mala Masson ¹, Jill Buyon ¹ and Carl Langefeld ³, ¹NYU School of Medicine, New York, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Wake Forest School of Medicine, Winston-Salem
Background/Purpose: Autoantibody production precedes SLE or SS by years, including anti-Ro. Anti-Ro+ mothers of children with congenital heart block (CHB) are a unique population at…
Abstract Number: 1780 • 2019 ACR/ARP Annual Meeting
Microbiome in Offspring of Ankylosing Spondylitis Patients
Matthew Stoll¹, Kimberly DeQuattro ², Zhixiu Li ³, Henna Sawhney ⁴, Maria Castillo ⁴, Pamela F. Weiss ⁵, Peter Nigrovic ⁶, Lynn Punaro ⁷, Kenneth Schikler ⁸, Barbara Edelheit ⁹, John Reveille ¹⁰, Matthew Brown ³ and Lianne Gensler ¹¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of California, San Francisco, San Francisco, CA, ³Queensland University of Technology, Queensland, Australia, ⁴University of California in San Francisco, San Francisco, CA, ⁵Children's Hospital of Philadelphia, Philadelphia, PA, ⁶Boston Children's Hospital, Boston, MA, ⁷Texas Scottish Rite Hospital, Dallas, TX, ⁸University of Kentucky, Louisville, KY, ⁹Connecticut Children's Medical Center, Hartford, CT, ¹⁰University of Texas McGovern Medical School, Houston, ¹¹University San Francisco California, San Francisco, CA
Background/Purpose: Spondyloarthritis (SpA) results from the interplay between genetic and environmental factors. An emerging factor is the human intestinal microbiota, which multiple studies in children…
Abstract Number: 1908 • 2019 ACR/ARP Annual Meeting
Preliminary Identification of Arthritis-Associated Microbiota in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran ², Stephen Brooks ³ and Robert Colbert ⁴, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: Gut microbiota are strongly implicated in the pathogenesis of spondyloarthritis (SpA). Previous studies from our lab have documented extensive gut microbial dysbiosis in rats…
Abstract Number: 2042 • 2019 ACR/ARP Annual Meeting
Intestinal Microbiota Alters Th1/Th17 Balance but Is Dispensable for the Development of Systemic Autoimmune Disease in BXD2 Mice
Huixian Hong¹, Qi Wu ¹, PingAr Yang ¹, Bao Luo ², Alex Essman ², Oluwagbemiga Ojo ², Michael R. Crowley ³, David K. Crossman ³, Casey D. Morrow ⁴, Jeremy B. Foote ⁵, Trenton R. Schoeb ⁶, Charles O. Elson ⁷, Hui-Chen Hsu ⁸ and John D. Mountz ⁹, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ³Department of Genetics, University of Alabama at Birmingham, Birmingham, ⁴Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, ⁵Department of Microbiology, University of Alabama at Birmingham, Birmingham, ⁶Department of Genetics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁸1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham & University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham
Background/Purpose: Intestinal microbiota dysbiosis has been implicated in the pathogenesis of autoimmune disease. How the microbiota affects the peripheral immune system leading to the development…
Abstract Number: 2317 • 2019 ACR/ARP Annual Meeting
Gut Dysbiosis Is Associated with Measures of Early Vascular Dysfunction in Patients with Rheumatoid Arthritis
Michelle Ormseth¹, Joseph Solus ¹, Annette Oeser ¹ and C. Michael Stein ¹, ¹Vanderbilt University Medical Center, Nashville
Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated cardiovascular disease independent of traditional risk factors. Previous studies demonstrate that the gut microbiome is altered in…
Abstract Number: 2490 • 2019 ACR/ARP Annual Meeting
The Cutaneous Microbiome of Psoriatic Disease Is Influenced by Disease Susceptibility HLA Alleles but Not Clinical Phenotype
Meital Yerushalmi¹, Osvaldo Espin-Garcia ², Justine (Yang) Ye ³, Remy Pollock ⁴, Sara Rahmati ³, Lihi Eder ⁵, Mark Silverberg ⁶ and Vinod Chandran ⁷, ¹University of Toronto, University Health Network, Toronto, ON, Canada, ²Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, ON, Canada, ⁴Krembil Research Institute, University Health Network, Toronto, Canada, ⁵Women’s College Hospital and the Department of Medicine, University of Toronto, Toronto, Canada, ⁶Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷University Health Network, University of Toronto, Toronto, Canada
Background/Purpose: Psoriasis is an inflammatory skin disease. Psoriatic arthritis (PsA) is an inflammatory arthritis that affects 30% of psoriasis patients. The heterogeneity of psoriatic disease…
Abstract Number: 2550 • 2019 ACR/ARP Annual Meeting
Impact of Pathogenic and Protective Environmental Exposures on Autoimmune Disease—The Microbiome Effects on Lupus (MEL) Study
Hayley Walter¹, Trevor Faith ², Alexander Alekseyenko ³, Ali Bakhtiari ³, Paula Ramos ² and Diane Kamen ⁴, ¹Division of Rheumatology/Medical University South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Medical University South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic and often severe multi-organ autoimmune disease characterized by the production of autoantibodies and heterogeneous clinical manifestations. African…
Abstract Number: 2769 • 2019 ACR/ARP Annual Meeting
The Pre-Treatment Gut Microbiome Predicts Early Response to Methotrexate in Rheumatoid Arthritis
Sandrine Isaac ¹, Alejandro Artacho ¹, Renuka Nayak ², Steven B. Abramson ³, Margaret Alexander ², Imhoi Koo ⁴, Pamela Rosenthal ⁵, Peter Izmirly ⁶, Andrew Patterson ⁷, Antonio Pineda ⁸, Leonor Puchades-Carrasco ⁸, Peter Turnbaugh ², Carles Ubeda ⁹ and Jose Scher¹⁰, ¹FISABIO, Valencia, Spain, ²UCSF, San Francisco, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Pennsylvania State University; Penn State · Huck Institutes of Life Sciences, University Park, PA, ⁵NYU Langone Orhopedic Hospital, New York, ⁶NYU School of Medicine, New York, ⁷Penn State, University Park, PA, ⁸Centro de Investigación Príncipe Felipe/Instituto de Investigación Sanitaria La Fe, Valencia, Spain, ⁹Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain, ¹⁰New York University School of Medicine, New York, NY
Background/Purpose: Early treatment initiation in rheumatoid arthritis (RA) is fundamental to avoid chronic joint destruction and disability. Despite remarkable advances in RA therapeutics, oral methotrexate…
Abstract Number: 2788 • 2019 ACR/ARP Annual Meeting
Longitudinal Changes in the Nasal Microbiome and Disease Activity in Patients with Granulomatosis with Polyangiitis
Rennie Rhee¹, Antoine Sreih ², Jung-Jin Lee ³, Kyle Bittinger ³, Lisa Mattei ³, Ronald Collman ⁴ and Peter Merkel ², ¹University of Pennsylvania, Division of Rheumatology, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Children's Hospital of Philadelphia, Philadelphia, ⁴University of Pennsylvania, Philadelphia
Background/Purpose: Microbial organisms have been theorized to contribute to disease activity in granulomatosis with polyangiitis (GPA) but little is known about what changes occur in…
Abstract Number: 2860 • 2019 ACR/ARP Annual Meeting
Perturbation of the Human Gut Microbiome by Methotrexate Contributes to the Resolution of Inflammation and Autoimmune Disease
Renuka Nayak¹, Margaret Alexander ¹, Kye Stapleton-Grey ², Carles Ubeda ³, Jose Scher ⁴ and Peter Turnbaugh ¹, ¹UCSF, San Francisco, ²Carnegie Mellon, Pittsburg, ³Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain, ⁴Division of Rheumatology, New York University School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: The trillions of microorganisms (microbiota) found within the human gut play a critical role in shaping the immune system, yet these complex microbial communities…
Abstract Number: 1829 • 2018 ACR/ARHP Annual Meeting
Perturbations of the Gut Fungal and Bacterial Microbiome with Biologic Therapy in Spondyloarthritis
Julia Manasson¹, Lu Yang², Gary E. Solomon¹, Soumya M. Reddy¹, Parvathy V. Girija¹, Andrea L. Neimann³, Leopoldo N. Segal⁴, Carles Ubeda⁵, Jose C. Clemente⁶ and Jose U. Scher⁷, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Department of Dermatology, New York University School of Medicine, New York, NY, ⁴Department of Medicine, Division of Pulmonary and Critical Care, New York University School of Medicine, New York City, NY, ⁵Institute for Research in Public Health (FISABIO), Valencia, Spain, ⁶Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, ⁷New York University School of Medicine, New York, NY
Background/Purpose: The microbiome serves a number of important functions, including modulation of the immune system and protection from pathogenic microorganisms1. Many autoimmune diseases have been…
Abstract Number: 2017 • 2018 ACR/ARHP Annual Meeting
Oral Microbiota in New-Onset Juvenile Idiopathic Arthritis
Albert Chow^1,2,3, Sriharsha Grevich^1,2,3, Peggy Lee⁴, Jeffrey McLean⁴, Sarah Ringold^1,3,5, Roger Bumgarner⁶ and Anne Stevens^1,2,3, ¹Pediatrics, University of Washington, Seattle, WA, ²Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, ³Pediatric Rheumatology, Seattle Children's Hospital, Seattle, WA, ⁴Dentistry, University of Washington, Seattle, WA, ⁵Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, ⁶Microbiology, University of Washington, Seattle, WA
Background/Purpose: Oral microbial dysbiosis of specific organisms such as Porphyromonas, Aggregatibacter, Tannerella, and Treponema in dental plaque has been implicated in the pathogenesis of adult…
Abstract Number: 2058 • 2018 ACR/ARHP Annual Meeting
Effects of Fatty Acid Supplementation in Modulation of Gut Microbiome and T-Regulatory Cells in Health and Psoriatic Disease
Fardina Malik¹, Julia Manasson¹, Alberto Herrera², Malavika Attur³, Soumya M. Reddy³, Lu Yang⁴, Sergei Koralov⁵ and Jose U. Scher¹, ¹New York University School of Medicine, New York, NY, ²New York University School of Medicine, NEW YORK, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴New York University School of Medicine, New York, NY, ⁵Pathology, New York University School of Medicine, New York, NY
Background/Purpose: Psoriatic Arthritis (PsA) affects up to 30% patients with psoriasis and is characterized by widespread synovio-entheseal inflammation. Physiologically, the human gut microbiota metabolizes dietary…