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Abstracts tagged "microbiome"

  • Abstract Number: 0528 • ACR Convergence 2022

    Nasal Epithelial Gene Expression Profiling Preceding Relapse in Patients with Granulomatosis with Polyangiitis

    Fang R. Zhao1, Rebecca Deek2, James Garifallou3, Jalal Jalaly2, Cailu Lin4, Danielle Reed4, Shubhasree Banerjee2, Naomi Amudala2, Antoine Sreih5, Sherry Chou2, Virginia Livolsi2, Ronald Collman2, Hongzhe Lee2, Peter Merkel2, Peter Grayson6, Noam Cohen2, Jonathan Miner2 and Rennie Rhee2, 1Washington University in St. Louis, St. Louis, MO, 2University of Pennsylvania, Philadelphia, PA, 3Children's Hospital of Philadelphia, Philadelphia, PA, 4Monell Center, Philadelphia, PA, 5Bristol Myers Squibb, Philadelphia, PA, 6National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD

    Background/Purpose: Predicting relapse is a major challenge in granulomatosis with polyangiitis (GPA). We previously demonstrated changes in the nasal microbiota, particularly Corynebacterium tuberculostearicum, prior to…
  • Abstract Number: 0639 • ACR Convergence 2022

    Association of Gut Microbiome Streptococcus, Health Status, Cytokines, and HLA Class in Anti-Ro+ Mothers of Children with Neonatal Lupus: Insights into Progression of Clinical Autoimmunity

    Robert Clancy1, Joel Guthridge2, Miranda Marion3, Hannah Ainsworth4, Marci Beel2, Christina Firl5, Nicola Fraser6, Nour Hachemian5, Timothy Howard4, Peter Izmirly1, Mala Masson7, Melissa Munroe2, Jill Buyon1, Judith James2 and Carl Langefeld8, 1NYU Grossman School of Medicine, New York, NY, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Wake Forest University, Winston-Salem, NC, 4Wake Forest School of Medicine, Winston-Salem, NC, 5NYU Langone Health, New York, NY, 6NYU School of Medicine, New York, NY, 7NYU Langone Medical Center- Division of Rheumatology, New York, NY, 8Wake Forest School of Medicine, Winston Salem, NC

    Background/Purpose: High titer anti-Ro+ mothers of children with neonatal lupus (NL), often completely asymptomatic, offer a unique opportunity to uncover insights into permissive and protective…
  • Abstract Number: 0868 • ACR Convergence 2022

    Spondyloarthritis and Neonatal Factors Affecting the Gut Microbiome

    Joy Um1, Douglas Einstadter2, Myung-Yong Um3 and Maria Antonelli1, 1Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 2Center for Health Care Research and Policy, Case Western Reserve University at MetroHealth Medical Center, Cleveland, OH, 3Department of Social Welfare, Sungkyunkwan University, Seoul, Republic of Korea

    Background/Purpose: Spondyloarthritis (SpA) consists of clinically and genetically related but phenotypically distinct disorders, including ankylosing spondylitis, enteropathic arthritis, psoriatic arthritis, reactive arthritis, and enthesitis-related arthritis…
  • Abstract Number: 1157 • ACR Convergence 2022

    Bacterial Indole Associated with Spondyloarthritis-Related Dysbiosis Contributes to Enhanced Th17 Immunity

    Brenda Seymour1, Brandon Trent2, Brendan Allen3, Adam Berlinberg1 and Kristi Kuhn3, 1University of Colorado Anschutz Medical Campus, Denver, CO, 2University of Colorado Anschutz Medical Campus, Eugene, OR, 3University of Colorado Anschutz Medical Campus, Aurora, CO

    Background/Purpose: While intestinal dysbiosis and the Th17 pathway are linked to the pathophysiology of spondyloarthritis (SpA), the mechanisms by which this occurs are unknown. We…
  • Abstract Number: 1162 • ACR Convergence 2022

    Improvement of Gut Microbiota Dysbiosis in Patients with Axial Spondyloarthritis After One Year of Biological Treatment

    valeria Rios-Rodriguez1, Morgan Essex2, Judith Rademacher3, Murat Torgutalp4, Fabian Proft5, Ulrike Löber2, Lajos Marko2, Sofia Forslund2 and Denis Poddubnyy5, 1Charité-Universitätsmedizin Berlin, Berlin, Germany, 2Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany, 3Charité Universitätsmedizin Berlin, Berlin, Germany, 4Charité - Universitätsmedizin, Berlin, Berlin, Germany, 5Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany

    Background/Purpose: There is little evidence about the effect of biological disease-modifying antirheumatic drugs (bDMARD) on gut dysbiosis in patients with axial SpA. Here we investigated…
  • Abstract Number: 1640 • ACR Convergence 2022

    Tryptophan Metabolites Are Associated with Erosion and Symptoms in Hand Osteoarthritis: Results from the DIGICOD Cohort

    Marie Binvignat1, Patrick Emond2, Brenda Miao3, Alice Courties4, Emmanuel Maheu5, Margreet Kloppenburg6, Pascal Richette7, Atul Butte3, Encarnita Mariotti-Ferrandiz1, Francis Berenbaum8, Harry Sokol9 and Jérémie SELLAM10, 1Sorbonne Universite, Paris, France, 2Tours University, Tours, France, 3UCSF, San Francisco, CA, 4Service de Rhumatologie, AP-HP Hopital Saint-Antoine, Sorbonne Universite, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, 5Hopital Paris Saint Antoine, Moirans, Auvergne-Rhone-Alpes, France, 6Leiden University Medical Center, Leiden, Netherlands, 7Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, 8Sorbonne University - Saint-Antoine hospital, Paris, France, 9Sorbonne Universite Saint Antoine Hospital, Paris, France, 10Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France

    Background/Purpose: Tryptophan (Trp) and its metabolites have been linked to inflammatory processes and associated with gut dysbiosis. However, their role in osteoarthritis (OA) is unknown.…
  • Abstract Number: 1713 • ACR Convergence 2022

    Bank1 Signaling Shapes the Gut Microbiota Composition by Controlling the Gut Mucosal B-cell Response in Lupus

    Georgina Galicia-Rosas, María Botía Sánchez, Daniel Toro-Domínguez, Lorena Albadalejo and Marta Alarcon-Riquelme, Center for Genomics and Oncological Research (GENYO), Granada, Spain

    Background/Purpose: Mucosa-associated commensal bacteria have been shown to be involved in the pathogenesis of systemic lupus erythematosus (SLE). However, its exact role remains to be…
  • Abstract Number: 1997 • ACR Convergence 2022

    Effects of Short Chain Fatty Acid Supplementation in Modulation of Gut Microbiome and T-Regulatory Cells in Health and New Onset Rheumatoid Arthritis

    Rebecca Blank1, Alba Boix-Amoros2, Renuka Nayak3, Anthony Jimenez Hernandez1, Sydney Catron4, Zakwan Uddin4, Erin Reilly5, Andrew Patterson5, Peter Turnbaugh6, Jose Clemente2 and Jose Scher7, 1NYU School of Medicine, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY, 3University of California San Francisco, San Francisco, CA, 4NYU Langone Health, New York, NY, 5Pennsylvania State University, College Park, PA, 6UCSF, San Francisco, 7New York University School of Medicine, New York, NY

    Background/Purpose: The gut microbiome and its metabolites are dysregulated in rheumatoid arthritis. Short chain fatty acids (SCFAs), microbial fermentation byproducts of certain gut microbes, induce…
  • Abstract Number: 2181 • ACR Convergence 2022

    Gut Microbe-derived Short-Chain Fatty Acids Regulate Arthritis and Myositis During Chikungunya Virus Infection

    Fang R. Zhao1, Emma Winkler1, Chun-Jun Guo2, Russell B. Williams3, Leran Wang1, Ana Jung1, Lindsay Droit1, Leah Heath1, Ting-ting Li2, Matthias Mack4, Megan T. Baldridge1, Thaddeus S. Stappenbeck5, Larissa B. Thackray1, Scott A. Handley1, Michael A. Fischbach6 and Michael S. Diamond1, 1Washington University in St. Louis, St. Louis, MO, 2Cornell University, New York, NY, 3Donald Danforth Plant Science Center, St. Louis, MO, 4University Hospital Regensburg, Regensburg, Germany, 5Cleveland Clinic, Cleveland, OH, 6Stanford University, Stanford, CA

    Background/Purpose: The intestinal microbiota regulates musculoskeletal inflammation and antibiotic use increases risk for the development or relapse of inflammatory arthritis. However, the basis for this…
  • Abstract Number: 2222 • ACR Convergence 2022

    Lupus Clinical Flares in Patients with Gut Pathobiont Blooms Share a Novel Peripheral Blood Transcriptomic Immune Activation Profile

    Gregg Silverman1, Macintosh Cornwell1, Peter Izmirly1, Mala Masson1, Jill Buyon1, Doua Azzouz2 and Kelly Ruggles1, 1NYU Grossman School of Medicine, New York, NY, 2NYU Gross School of Medicine, New York, NY

    Background/Purpose: SLE is an inflammatory condition associated with hyperactivation of the immune system, with mounting evidence that imbalances in the gut microbiota communities are common.…
  • Abstract Number: 0019 • ACR Convergence 2022

    Bacterial Peptidoglycan in Synovial Tissue at Time of Total Knee Arthroplasty Is Associated with Inflammatory Synovitis and Younger Patient Age

    Meaghan Holub1, Amanda Wahhab2, Joseph Rouse2, Brandon Jutras3, Klemen Strle4, Adam Edelstein5 and Robert Lochhead6, 1Central Michigan University College of Medicine, Mount Pleasant, MI, 2Medical College of Wisconsin, Milwaukee, WI, 3Virginia Tech, Blacksburg, VA, 4Wadsworth Center, Albany, NY, 5Northwestern Medicine, Chicago, IL, 6Medical College of Wisconsin, Germantown, WI

    Background/Purpose: Peptidoglycan (PG) is a bacterial cell wall component that is known to induce innate immune responses. PG has been identified as a driver of…
  • Abstract Number: 0018 • ACR Convergence 2022

    Longitudinal Development of Cartilage Microbial DNA Profiles Following Oral Microbiome Inoculation

    Emmaline Prinz1, Leoni Schlupp1, Vladislav Izda2, Emily Nguyen1, Christopher Dunn3, Cassandra Sturdy1 and Matlock Jeffries1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, New York, NY, 3University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: Previous studies have associated microbiome changes with human OA and post-traumatic OA mouse models. Our group has previously published a description of cartilage microbial…
  • Abstract Number: 0017 • ACR Convergence 2022

    Intra-articular Injection of Bacterial DNA Amplified from Human OA Patient Cartilage Worsens OA Outcomes in Mice

    Leoni Schlupp1, Emmaline Prinz1, Vladislav Izda2, Emily Nguyen1, Christopher Dunn3 and Matlock Jeffries1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, New York, NY, 3University of Oklahoma Health Sciences Center, Edmond, OK

    Background/Purpose: We have previous demonstrated a bacterial DNA signature within cartilage of humans and mice and shown shifts in this signature with OA development. However,…
  • Abstract Number: 0053 • ACR Convergence 2022

    Natural Microbial Exposure Increases Susceptibility of C57BL/6 Mice to Collagen-induced Arthritis

    Sahar Lotfi-Emran1 and David Masopust2, 1University of Minnesota, Minneapolis, MN, 2University of Minnesota, Department of Microbiology and Immunology, Minneapolis, MN

    Background/Purpose: Mice exposed to natural microbes (NME) develop an appropriately mature immune system, one that resembles that of a non-neonatal human.1,2 Collagen induced arthritis is…
  • Abstract Number: 0012 • ACR Convergence 2021

    A Novel Mechanism Linking Mucosal Bacteria with Autoantibody Responses in RA: Acetylated Bacterial Lysate as a Model Antigen

    Mikhail Volkov, Arieke Kampstra, Karin van Schie, Joanneke Kwekkeboom, Tom WJ Huizinga, René Toes and Diane van der Woude, Leiden University Medical Center, Leiden, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by autoantibodies against post-translationally modified proteins (AMPA) such as citrullinated, carbamylated and acetylated proteins. Importantly, these antibodies are highly…
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ACR Pediatric Rheumatology Symposium 2020

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