Abstracts tagged "Knee"

Abstract Number: 431 • 2018 ACR/ARHP Annual Meeting
Early Pre-Radiographic Structural Pathology Precedes the Onset of Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Matthew Harkey¹, Julie Davis², Bing Lu³, Lori Lyn Price^4,5, Robert J. Ward⁶, James MacKay⁷, Charles B. Eaton⁸, Grace H. Lo⁹, Mary Barbe¹⁰, Ming Zhang¹¹, Jincheng Pang¹², Alina Stout¹, Timothy E. McAlindon¹³ and Jeffrey B. Driban¹⁴, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, BOSTON, MA, ³Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Temple University School of Medicine, Philadelphia, PA, ¹¹Tufts Medical Center, Boston, MA, ¹²Electrical Engineering, Tufts University, Medford, MA, ¹³Division of Rheumatology, Tufts Medical Center, Boston, MA, ¹⁴Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Individuals that develop accelerated knee osteoarthritis (AKOA) have more frequent knee pain, decreased physical function, and are more likely to receive a knee replacement…
Abstract Number: 1167 • 2018 ACR/ARHP Annual Meeting
The Role of Fear-Avoidance Model on Pain and Disability in Knee Osteoarthritis Patients
Leticia Leon^1,2, Marta Redondo², Sara Lopez de Felipe², Daniel Garriguez³, Lydia A Alcazar⁴ and Luis Rodriguez-Rodriguez⁵, ¹Rheumatology Department, Hospital Clínical San Carlos, and IdISSC, Madrid, Spain, ²Health Sciences, Universidad Camilo Jose Cela, Madrid, Spain, ³Orthopedics Unit, Hospital Clinico San Carlos, Madrid, Spain, ⁴Rheumatology Department and Heath Research Institute (IdISSC), Hospital Clinico San Carlos, Madrid, Spain, ⁵Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain
Background/Purpose: The model of Fear-Avoidance of pain (anxiety, catastrophization and hypervigilance) appears when the pain has maladaptive interpretations, being associated with greater pain and limitations…
Abstract Number: 2909 • 2018 ACR/ARHP Annual Meeting
Diagnostic and Prognostic Value of Ultrasound Compared with Plain Radiography in Knee Osteoarthritis
Annie Yang¹, Fernando Bomfim², Kristen Lee², Mukundan Attur³, Steven B. Abramson⁴ and Jonathan Samuels⁵, ¹Department of Medicine, NYU Langone Health, New York, NY, ²NYU Langone Health, New York, NY, ³Rheumatology, NYU Langone Health, New York, NY, ⁴Dept of Medicine, NYU Langone Health, New York, NY, ⁵Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY
Background/Purpose: Plain radiography of knee osteoarthritis (OA) has inherent diagnostic and prognostic limitations, especially in early disease. Ultrasound (US) examination sheds light on disease activity…
Abstract Number: 432 • 2018 ACR/ARHP Annual Meeting
Relation of Patellofemoral Joint Alignment, Morphology, and Radiographic Osteoarthritis to Frequent Anterior Knee Pain
Erin Macri¹, Tuhina Neogi², Irina Tolstykh³, Cora E. Lewis⁴, James Torner⁵, Michael C. Nevitt⁶ and Joshua J. Stefanik⁷, ¹Physical Therapy, University of Delaware, Newark, DE, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Iowa, Iowa City, IA, ⁶Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Radiographic patellofemoral osteoarthritis (OA) is prevalent in approximately 25% of population-based samples and 39% of individuals with knee pain. Discordance between knee OA features…
Abstract Number: 1169 • 2018 ACR/ARHP Annual Meeting
Association between Depressive Symptom Subtypes and Disease Severity in Knee Osteoarthritis
Alan Rathbun¹, Megan Schuler², Elizabeth Stuart³, Michelle Shardell⁴, Michelle S. Yau⁵, Joseph Gallo⁶ and Marc C. Hochberg⁷, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Rand Coportation, Boston, MA, ³Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ⁵Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁶Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Latent and modifiable factors, such as depressive symptoms, may affect the course of knee OA. Depression is clinically heterogeneous, and effects on pain and…
Abstract Number: 441 • 2018 ACR/ARHP Annual Meeting
The Presence of Neuropathic Pain Does Not Influence the Response to Hyaluronic Acid (HA) in Patients with Knee Osteoarthritis but HA Injections Modify Pain Phenotype
Evariste Tiendrebeogo¹, Thierry Conrozier², Xavier Chevalier³ and Florent Eymard⁴, ¹Rheumatology, APHP Henri Mondor Hospital, Creteil, France, ²Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, ³Rheumatology, APHP Henri Mondor Hospital, Créteil, France, ⁴Department of Rheumatology, APHP Henri Mondor Hospital, Creteil, France
Background/Purpose: Twenty to forty percent of patients with symptomatic knee osteoarthritis (OA) described neuropathic pain (NP). Several studies have shown that hyaluronic acid (HA) is…
Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Matthew Fuller², Becki Cleveland³, Todd Schwartz⁴, Joanne M. Jordan¹, Leigh F. Callahan¹, J.S. Marron² and Richard Loeser¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…
Abstract Number: 444 • 2018 ACR/ARHP Annual Meeting
Trajectories of Sport or Recreational Activities over Eight Years and Associated Factors in Persons at Risk for Knee Osteoarthritis
Alison H. Chang¹, Julia (Jungwha) Lee², Orit Almagor¹, Joan S. Chmiel³, Julie Szymaszek¹ and Leena Sharma⁴, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Participation in exercise, sport or recreational activities offers multiple health benefits, promotes wellbeing and weight management, and preserves function and quality of life. Staying…
Abstract Number: 1362 • 2018 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Features Can Classify Adults Who Will Develop Accelerated Knee Osteoarthritis
Lori Lyn Price^1,2, Matthew Harkey³, Robert J. Ward⁴, James MacKay⁵, Ming Zhang⁶, Julie Davis⁷, Timothy E. McAlindon⁸, Grace H. Lo⁹, Mamta Amin¹⁰, Charles B. Eaton¹¹, Bing Lu¹², Jeffrey Duryea¹³, Mary Barbe¹⁴ and Jeffrey B. Driban¹⁵, ¹Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Radiology, Tufts Medical Center, Boston, MA, ⁵Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁶Tufts Medical Center, Boston, MA, ⁷Rheumatology, Tufts Medical Center, BOSTON, MA, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ¹¹Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ¹²Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ¹³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ¹⁴Temple University School of Medicine, Philadelphia, PA, ¹⁵Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a painful disorder and is associated with several risk factors and pre-radiographic structural features. While no single factor can…
Abstract Number: 457 • 2018 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis (Preliminary Report)
Pinar Borman¹, Ferda Kaygisiz² and Aysegul Yaman³, ¹Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, ²Dept of PMR, Ankara Training and Research Hospital, Ankara, Turkey, ³Dept of PMR, University of Hacettepe Faculty of Medicine, Ankara, Turkey
Background/Purpose: There are limited studies in the literature indicating that neuropathic pain occurs in knee osteoarthritis (OA) (1). The aim of this cross sectional study…
Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting
Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor
Jeyanesh Tambiah¹, Sarah Kennedy¹, Heli Ghandehari¹, Christopher Swearingen¹ and Marc C. Hochberg², ¹Samumed, LLC, San Diego, CA, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
Abstract Number: 915 • 2018 ACR/ARHP Annual Meeting
The Association between Structural and Symptomatic Progression in Knee Osteoarthritis
Jamie E. Collins¹, Swastina Shrestha² and Elena Losina³, ¹Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA
Background/Purpose: The link between progression of structure and symptoms in knee osteoarthritis (OA) is not well understood. This uncertainty hinders the effort to develop therapies…
Abstract Number: 1366 • 2018 ACR/ARHP Annual Meeting
Assessment of Health-Related Quality of Life in a 52-Week, Phase 2, Randomized, Controlled Trial of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for Treatment of Knee Osteoarthritis
Vibeke Strand¹, Heli Ghandehari², Christopher Swearingen² and Jeyanesh Tambiah², ¹Stanford University School of Medicine, Palo Alto, CA, ²Samumed, LLC, San Diego, CA
Background/Purpose: SM04690, a small molecule, intra-articular (IA) Wnt pathway inhibitor, is in development for knee OA treatment. A phase 2, 52-week, trial evaluated changes in…
Abstract Number: 930 • 2018 ACR/ARHP Annual Meeting
Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, Amanda Kuhs¹, Rizi Ai², David L. Boyle¹, Wei Wang³ and Gary S. Firestein¹, ¹Medicine, University of California San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: Recent studies suggest that epigenetic marks distinguish FLS isolated from different joints in RA. Hip and knee joint-derived FLS, in particular, have distinctive DNA…
Abstract Number: 1371 • 2018 ACR/ARHP Annual Meeting
Systemic Exposure of Triamcinolone Acetonide Following Bilateral Injection of Extended-Release Triamcinolone Acetonide and Standard Triamcinolone in Patients with Bilateral Knee Osteoarthritis
Alan J. Kivitz¹, Louis Kwong², Tammi Shlotzhauer³, Joelle Lufkin⁴, Teresa Curto⁵ and Scott Kelley⁴, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, ³Rochester Clinical Research, Inc., Rochester, NY, ⁴Flexion Therapeutics, Inc., Burlington, MA, ⁵Cytel Inc., Waltham, MA
Background/Purpose: Current ACR guidelines recommend the use of IACS for short-term acute pain relief in patients (pts) with knee OA.1 Bilateral knee OA can occur…

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