Abstracts tagged "Knee"

Abstract Number: 1366 • 2018 ACR/ARHP Annual Meeting
Assessment of Health-Related Quality of Life in a 52-Week, Phase 2, Randomized, Controlled Trial of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for Treatment of Knee Osteoarthritis
Vibeke Strand¹, Heli Ghandehari², Christopher Swearingen² and Jeyanesh Tambiah², ¹Stanford University School of Medicine, Palo Alto, CA, ²Samumed, LLC, San Diego, CA
Background/Purpose: SM04690, a small molecule, intra-articular (IA) Wnt pathway inhibitor, is in development for knee OA treatment. A phase 2, 52-week, trial evaluated changes in…
Abstract Number: 930 • 2018 ACR/ARHP Annual Meeting
Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, Amanda Kuhs¹, Rizi Ai², David L. Boyle¹, Wei Wang³ and Gary S. Firestein¹, ¹Medicine, University of California San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: Recent studies suggest that epigenetic marks distinguish FLS isolated from different joints in RA. Hip and knee joint-derived FLS, in particular, have distinctive DNA…
Abstract Number: 1371 • 2018 ACR/ARHP Annual Meeting
Systemic Exposure of Triamcinolone Acetonide Following Bilateral Injection of Extended-Release Triamcinolone Acetonide and Standard Triamcinolone in Patients with Bilateral Knee Osteoarthritis
Alan J. Kivitz¹, Louis Kwong², Tammi Shlotzhauer³, Joelle Lufkin⁴, Teresa Curto⁵ and Scott Kelley⁴, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, ³Rochester Clinical Research, Inc., Rochester, NY, ⁴Flexion Therapeutics, Inc., Burlington, MA, ⁵Cytel Inc., Waltham, MA
Background/Purpose: Current ACR guidelines recommend the use of IACS for short-term acute pain relief in patients (pts) with knee OA.1 Bilateral knee OA can occur…
Abstract Number: 263 • 2018 ACR/ARHP Annual Meeting
Racial Disparities in Total Knee Replacement Failure Are Not Explained By Poverty
Anne R. Bass¹, Jackie Szymonifka², Lisa A. Mandl¹, Bella Y. Mehta³, Emily Ying Lai², Stephen Lyman¹, Michael L. Parks¹, Serene Z. Mirza², Shirin A. Dey² and Susan M. Goodman², ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery/Weill Cornell Medicine/Mailman School of Public Health, New York, NY
Background/Purpose: U.S. blacks have a higher risk of revision total knee replacement (TKR) than whites, but whether this is mediated by poverty is unknown. The…
Abstract Number: 952 • 2018 ACR/ARHP Annual Meeting
Effusion-Synovitis and Infrapatellar Fat Pad Edema Differentiate Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Julie Davis¹, Robert J. Ward², James MacKay³, Bing Lu⁴, Lori Lyn Price^5,6, Timothy E. McAlindon⁷, Charles B. Eaton⁸, Mary Barbe⁹, Grace H. Lo¹⁰, Matthew Harkey¹ and Jeffrey B. Driban¹¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Radiology, Tufts Medical Center, Boston, MA, ³Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁴Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Temple University School of Medicine, Philadelphia, PA, ¹⁰Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹¹Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a unique endotype of knee osteoarthritis (KOA) that is characterized by a sudden onset of advance-stage disease and greater…
Abstract Number: 1373 • 2018 ACR/ARHP Annual Meeting
Predictive Probabilities Are Superior in Communicating the Clinical Relevance of Cartilage Thickness As an Imaging Biomarker of Knee Osteoarthritis Progression
C. Kent Kwoh^1,2, Erin L. Ashbeck¹, Edward J. Bedrick³ and Felix Eckstein^4,5, ¹University of Arizona Arthritis Center, Tucson, AZ, ²Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ³Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, ⁴Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁵Chondrometrics GmbH, Ainring, Germany
Background/Purpose: Establishing a threshold of clinically important cartilage loss is of great interest for the design and interpretation of knee OA trials of structure-modifying treatments.…
Abstract Number: 402 • 2018 ACR/ARHP Annual Meeting
Preoperative Physical Function Influences on Stair Climbing Ability 1 Month after Total Knee Arthroplasty
Jinseok Kim¹ and Bo Ryun Kim², ¹Department of Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), ²Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South)
Background/Purpose: This study was undertaken to identify preoperative physical performance factors predictive of stair climbing ability 1 month following total knee arthroplasty. Methods: In this…
Abstract Number: 953 • 2018 ACR/ARHP Annual Meeting
Evaluating MRI-Detected Knee Inflammation Prior to Total Knee Replacement As a Predictive Biomarker of Clinically Important Pain Reduction Two Years Later
Manjinder Kaur¹, Lili Zhou², Erin L. Ashbeck², Ernest Vina³, Frank Roemer⁴, Ali Guermazi⁵, David J. Hunter⁶ and C. Kent Kwoh^1,2, ¹Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, Tucson, AZ, ³University of Arizona School of Medicine, University of Arizona Arthritis Center, Tucson, AZ, ⁴Department of Radiology, Boston University School of Medicine, Boston, MA, USA, Boston, MA, ⁵Boston University School of Medicine, Boston, MA, ⁶University of Sydney, Sydney, Australia
Background/Purpose: Some patients do not experience clinical improvement after total knee replacement (TKR). Presence of structural abnormalities on MRI before surgery may inform pain prognosis…
Abstract Number: 1376 • 2018 ACR/ARHP Annual Meeting
The Omeract-Oarsi Core Set of Outcome Domains to Measure in Clinical Trials for People with Hip and/or Knee Osteoarthritis
Toby O Smith¹, Gillian Hawker², David J. Hunter³, Lyn March⁴, Beverly Shea⁵, Robin Christensen⁶, Francis Guillemin⁷, Caroline Terwee⁸, Paula Williamson⁹, Ewa M. Roos¹⁰, Richard Loeser¹¹, Thomas J. Schnitzer¹², Margreet Kloppenburg¹³, Tuhina Neogi¹⁴, Christoph Ladel¹⁵, Ulrike Kaiser¹⁶, Ali Mobasheri¹⁷, Nigel K Arden¹, Marc C. Hochberg¹⁸, Alan Tennant¹⁹, Maarten de Wit²⁰, Peter Tugwell²¹ and Philip G. Conaghan²², ¹Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, ²University of Toronto, Toronto, ON, Canada, ³University of Sydney, Sydney, Australia, ⁴Department of Rheumatology, Northern Clinical School, Institute of Bone and Joint Research, Kolling Institute, University of Sydney & Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, Australia, ⁵Bruyere Research Institute, Ottawa, ON, Canada, ⁶Department of Rheumatology, Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, & Department of Rheumatology, Odense University Hospital, Copenhagen, Denmark, ⁷University of Lorraine, Nancy, France, Nancy, France, ⁸Dep of Epidemiology and Biostatistics, EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands, ⁹University of Liverpool, Liverpool, United Kingdom, ¹⁰Inst Sports and Biomechanics, University of Southern Denmark, Odense, Denmark, ¹¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ¹²Northwestern University, Chicago, IL, ¹³Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ¹⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ¹⁵Merck KGaA, Darmstadt, Germany, ¹⁶Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Germany, ¹⁷Rheumatology, School of Veterinary Medicine, University of Surrey, Guildford, United Kingdom, ¹⁸University of Maryland School of Medicine, Baltimore, MD, ¹⁹Swiss Paraplegic Research, Nottwil, Switzerland, ²⁰EULAR standing committee of PARE, Zurich, Switzerland, ²¹Center For Global Health, Institute of Population Hlth, Ottawa, ON, Canada, ²²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and National Institute for Health Research (NIHR) Leeds Biomedical Research Centre, Leeds, United Kingdom, Leeds, United Kingdom
Background/Purpose: It has been over 20 years since the OMERACT core outcome set (COS) to measure in clinical trials with people who have hip and/or…
Abstract Number: 406 • 2018 ACR/ARHP Annual Meeting
Limiting the Risk of Osteoarthritis after Anterior Cruciate Ligament Injury: Are We Missing the Opportunity to Intervene?
Aileen Davis¹, Rosalind Wong², Krista Steinhart², Janie Astephen Wilson³, Laura Cruz⁴, David Cudmore³, Tim Dwyer⁵, Linda Li⁶, Peter MacDonald⁷, Paul Marks⁴, Laura Nimmon⁸, Darrell Ogilvie-Harris⁴, Nathan Urquhart³ and Jas Chahal⁵, ¹Health Care and Outcomes Research, Krembil Research Institute, University Health Network, Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada, ²Krembil Research Institute, Health Care and Outcomes Research, Toronto, ON, Canada, ³Dalhousie University, Halifax, NS, Canada, ⁴University of Toronto, Toronto, ON, Canada, ⁵Orthopaedics, University of Toronto, Toronto, ON, Canada, ⁶Arthritis Research Canada, Richmond, BC, Canada, ⁷Pan Am Clinic, Winnipeg, ON, Canada, ⁸University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Fifty percent of people with anterior cruciate (ACL) injury develop knee osteoarthritis (OA) within 6-10 years, even with ligament reconstruction. Despite evidence that targeted…
Abstract Number: 955 • 2018 ACR/ARHP Annual Meeting
Lower Limb Muscle Strength and Protection Against Functional Decline and Structural Worsening in Knee Osteoarthritis
Alison H. Chang¹, Joan S. Chmiel², Orit Almagor¹, Karen W. Hayes¹, Ali Guermazi³, Prasad Pottumarthi⁴, Kirsten C. Moisio¹, Yunhui Zhang¹, Julie Szymaszek¹ and Leena Sharma⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Boston University School of Medicine, Boston, MA, ⁴NorthShore University HealthSystem, Evanston, IL, ⁵Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Lower limb muscle weakness has been proposed as a factor contributing to functional decline and structural progression. Hip abductor strengthening, in addition to quadriceps…
Abstract Number: 1395 • 2018 ACR/ARHP Annual Meeting
Could the Shortening of the Electronic Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) Questionnaire Improve Its Metric Properties?
Maud Wieczorek¹, Christine Rotonda¹, Jonathan Epstein^1,2, Francis Guillemin^1,2 and Anne-Christine Rat^1,3, ¹Université de Lorraine, EA4360, APEMAC, Nancy, France, ²Inserm, CIC-1433 Epidémiologie Clinique, Vandoeuvre-lès-Nancy, France, ³Rheumatology Department, CHRU Nancy, Vandoeuvre-lès-Nancy, France
Background/Purpose: The aim of this study was to assess the validity of a short version of the electronic OAKHQOL questionnaire in a combined analysis with…
Abstract Number: 420 • 2018 ACR/ARHP Annual Meeting
Accelerated Knee Osteoarthritis Is Characterized By Destabilizing Meniscal Tears and Pre-Radiographic Structural Disease Burden
Jeffrey B. Driban¹, Julie Davis², Bing Lu³, Lori Lyn Price^4,5, Robert J. Ward⁶, James MacKay⁷, Charles B. Eaton⁸, Grace H. Lo⁹, Mary Barbe¹⁰, Ming Zhang¹¹, Jincheng Pang¹², Alina Stout¹³, Matthew Harkey¹³ and Timothy E. McAlindon¹⁴, ¹Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Rheumatology, Tufts Medical Center, BOSTON, MA, ³Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁴Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Radiology, Tufts Medical Center, Boston, MA, ⁷Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Temple University School of Medicine, Philadelphia, PA, ¹¹Tufts Medical Center, Boston, MA, ¹²Electrical Engineering, Tufts University, Medford, MA, ¹³Rheumatology, Tufts Medical Center, Boston, MA, ¹⁴Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: A subset of adults who develop knee osteoarthritis (KOA) quickly progress from no radiographic disease to advanced-stage disease often in ≤12 months. Adults with…
Abstract Number: 956 • 2018 ACR/ARHP Annual Meeting
Bone Mineral Density Is a Causal Risk Factor for Knee and Hip Osteoarthritis: A Population-Based and Mendelian Randomization Study in the UK Biobank
Thomas Funck-Brentano¹, Maria Nethander², Sofia Moverare Skrtic¹, Pascal Richette³ and Claes Ohlsson¹, ¹Center for Bone and Arthritis Research, Department of Internal Medicine, Sahlgrensaka Academy, Gothenburg University, Gothenburg, Sweden, ²Bioinformatics Core Facility, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden, ³Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France
Background/Purpose: Osteoarthritis (OA) involves the whole joint, with alterations of cartilage, synovium and bone. Whether bone changes are a cause or consequence of the disease…
Abstract Number: 1947 • 2018 ACR/ARHP Annual Meeting
Do Changes in Pain Sensitization and Depressive Symptoms Mediate the Effect of Extreme Weight Loss on Knee Pain Improvement?
S. Reza Jafarzadeh¹, Tuhina Neogi¹, Joshua J. Stefanik², Margaret M. Clancy¹, Jing-Sheng Li³ and David T. Felson¹, ¹Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ²Department of Physical Therapy, University of Delaware, Newark, DE, ³College of Health and Rehabilitation Sciences: Sargent College, Boston University, Boston, MA
Background/Purpose: We previously showed that the one-year effects of weight loss on knee pain reduction were not mediated by changes in structural features of osteoarthritis…

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