Abstracts tagged "Knee"

Abstract Number: 1169 • 2018 ACR/ARHP Annual Meeting
Association between Depressive Symptom Subtypes and Disease Severity in Knee Osteoarthritis
Alan Rathbun¹, Megan Schuler², Elizabeth Stuart³, Michelle Shardell⁴, Michelle S. Yau⁵, Joseph Gallo⁶ and Marc C. Hochberg⁷, ¹Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, ²Rand Coportation, Boston, MA, ³Mental Health, Biostatistics, and Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁴Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, ⁵Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School, Boston, MA, ⁶Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Latent and modifiable factors, such as depressive symptoms, may affect the course of knee OA. Depression is clinically heterogeneous, and effects on pain and…
Abstract Number: 441 • 2018 ACR/ARHP Annual Meeting
The Presence of Neuropathic Pain Does Not Influence the Response to Hyaluronic Acid (HA) in Patients with Knee Osteoarthritis but HA Injections Modify Pain Phenotype
Evariste Tiendrebeogo¹, Thierry Conrozier², Xavier Chevalier³ and Florent Eymard⁴, ¹Rheumatology, APHP Henri Mondor Hospital, Creteil, France, ²Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, ³Rheumatology, APHP Henri Mondor Hospital, Créteil, France, ⁴Department of Rheumatology, APHP Henri Mondor Hospital, Creteil, France
Background/Purpose: Twenty to forty percent of patients with symptomatic knee osteoarthritis (OA) described neuropathic pain (NP). Several studies have shown that hyaluronic acid (HA) is…
Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Matthew Fuller², Becki Cleveland³, Todd Schwartz⁴, Joanne M. Jordan¹, Leigh F. Callahan¹, J.S. Marron² and Richard Loeser¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…
Abstract Number: 444 • 2018 ACR/ARHP Annual Meeting
Trajectories of Sport or Recreational Activities over Eight Years and Associated Factors in Persons at Risk for Knee Osteoarthritis
Alison H. Chang¹, Julia (Jungwha) Lee², Orit Almagor¹, Joan S. Chmiel³, Julie Szymaszek¹ and Leena Sharma⁴, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Participation in exercise, sport or recreational activities offers multiple health benefits, promotes wellbeing and weight management, and preserves function and quality of life. Staying…
Abstract Number: 1362 • 2018 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Features Can Classify Adults Who Will Develop Accelerated Knee Osteoarthritis
Lori Lyn Price^1,2, Matthew Harkey³, Robert J. Ward⁴, James MacKay⁵, Ming Zhang⁶, Julie Davis⁷, Timothy E. McAlindon⁸, Grace H. Lo⁹, Mamta Amin¹⁰, Charles B. Eaton¹¹, Bing Lu¹², Jeffrey Duryea¹³, Mary Barbe¹⁴ and Jeffrey B. Driban¹⁵, ¹Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Radiology, Tufts Medical Center, Boston, MA, ⁵Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁶Tufts Medical Center, Boston, MA, ⁷Rheumatology, Tufts Medical Center, BOSTON, MA, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ¹¹Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ¹²Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ¹³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ¹⁴Temple University School of Medicine, Philadelphia, PA, ¹⁵Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a painful disorder and is associated with several risk factors and pre-radiographic structural features. While no single factor can…
Abstract Number: 457 • 2018 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis (Preliminary Report)
Pinar Borman¹, Ferda Kaygisiz² and Aysegul Yaman³, ¹Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, ²Dept of PMR, Ankara Training and Research Hospital, Ankara, Turkey, ³Dept of PMR, University of Hacettepe Faculty of Medicine, Ankara, Turkey
Background/Purpose: There are limited studies in the literature indicating that neuropathic pain occurs in knee osteoarthritis (OA) (1). The aim of this cross sectional study…
Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting
Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor
Jeyanesh Tambiah¹, Sarah Kennedy¹, Heli Ghandehari¹, Christopher Swearingen¹ and Marc C. Hochberg², ¹Samumed, LLC, San Diego, CA, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
Abstract Number: 915 • 2018 ACR/ARHP Annual Meeting
The Association between Structural and Symptomatic Progression in Knee Osteoarthritis
Jamie E. Collins¹, Swastina Shrestha² and Elena Losina³, ¹Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA
Background/Purpose: The link between progression of structure and symptoms in knee osteoarthritis (OA) is not well understood. This uncertainty hinders the effort to develop therapies…
Abstract Number: 1366 • 2018 ACR/ARHP Annual Meeting
Assessment of Health-Related Quality of Life in a 52-Week, Phase 2, Randomized, Controlled Trial of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for Treatment of Knee Osteoarthritis
Vibeke Strand¹, Heli Ghandehari², Christopher Swearingen² and Jeyanesh Tambiah², ¹Stanford University School of Medicine, Palo Alto, CA, ²Samumed, LLC, San Diego, CA
Background/Purpose: SM04690, a small molecule, intra-articular (IA) Wnt pathway inhibitor, is in development for knee OA treatment. A phase 2, 52-week, trial evaluated changes in…
Abstract Number: 13L • 2017 ACR/ARHP Annual Meeting
Significant, Sustained Improvement in Knee Function after Intra-Articular TPX-100: A Double-Blind, Randomized, Multi-Center, Placebo-Controlled Phase 2 Trial
Dawn McGuire¹, Nancy E Lane², Neil Segal³, Samy Metyas⁴, Hans Richard Barthel⁵, Meghan Miller¹, David Rosen¹ and Yoshi Kumagai¹, ¹OrthoTrophix, Inc, Oakland, CA, ²UC Davis Medical Center, Sacramento, CA, ³University of Kansas, Shawnee, KS, ⁴Medvin Clinical Research, Covina, CA, ⁵Barthel Clinic, Santa Barbara, CA

Background/Purpose: The current Phase 2 study was designed to evaluate safety, tolerability and preliminary efficacy of TPX-100 by IA administration in subjects with mild to…
Abstract Number: 1L • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: Results of the 2-Year Primary Analysis from a 5-Year Randomised, Placebo-Controlled, Phase II Study
Marc C. Hochberg¹, Ali Guermazi², Hans Guehring³, Aida Aydemir⁴, Stephen Wax⁵, Patricia Fleuranceau-Morel⁴, Asger Reinstrup Bihlet⁶, Inger Byrjalsen⁶, Jeppe Ragnar Andersen⁶ and Felix Eckstein⁷, ¹University of Maryland School of Medicine, Baltimore, MD, ²Boston Imaging Core Lab, LLC, and Boston University School of Medicine, Boston, MA, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria

Background/Purpose: Sprifermin, a novel recombinant human fibroblast growth factor-18 is currently investigated as a potential disease-modifying osteoarthritis (OA) drug. Two-year primary data from a 5-year…
Abstract Number: 1192 • 2017 ACR/ARHP Annual Meeting
Patient Characteristics That Predict the Effect of Laparoscopic Adjustable Gastric Band Weight Loss Surgery on Knee Osteoarthritis Pain
Shannon Chen¹, Fernando Bomfim², Heekoung Youn³, Christine Ren-Fielding⁴ and Jonathan Samuels⁵, ¹Medicine, NYU Langone Medical Center, New York, NY, ²NYU Langone Medical Center, New York, NY, ³Surgery, NYU Langone Medical Center, New York, NY, ⁴Department of Surgery, New York University School of Medicine, New York, NY, ⁵Department of Medicine, NYU School of Medicine, NYU Langone Medical Center, New York, NY
Background/Purpose: Obesity is a modifiable risk factor for knee osteoarthritis (OA), yet diet and exercise often fail to achieve sustained weight loss or knee improvement.…
Abstract Number: 2189 • 2017 ACR/ARHP Annual Meeting
Metabolic Syndrome Influences the Radiographic Progression of Knee Osteoarthritis and Condition the Risk of Erosive Hand OA
Natividad Oreiro¹, Mercedes Fernandez Moreno², Estefanía Cortés-Pereira², Maria Eugenia Vazquez Mosquera³, Sonia Pertega⁴, Sara Relaño-Fernandez⁵, Ana Cecilia Raga⁶, Carlos Fernandez-Lopez⁶, Ignacio Rego-Pérez⁶ and Francisco J Blanco⁶, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruna, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruna, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Unidad de Epidemiología Clínica y Bioestadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁵Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain
Background/Purpose: The contribution of metabolic factors in the development of OA has not been fully elucidated. The aim of this work is to analyze the…
Abstract Number: 1194 • 2017 ACR/ARHP Annual Meeting
Are Bisphosphonates Efficacious in Knee Osteoarthritis? A Meta-Analysis of Randomized Controlled Trials
Mikala C. Osani¹, Elizaveta Vaysbrot¹, Raveendhara R. Bannuru², Mia-Cara Musetti¹ and Timothy E. McAlindon¹, ¹Division of Rheumatology, Tufts Medical Center, Boston, MA, ²Center of Integrative Medicine and Division of Rheumatology, Tufts Medical Center, Boston, MA, Boston, MA
Background/Purpose: One of the key aspects of osteoarthritis (OA) pathogenesis is subchondral bone remodeling. Bisphosphonates have been touted as disease-modifying agents for OA due to…
Abstract Number: 2192 • 2017 ACR/ARHP Annual Meeting
Association between Mitochondrial DNA (mtDNA) Haplogroups and Bone Marrow Lesions at 24 Months in Osteoarthritis Subjects: Subjets from the Osteoarthritis Initiative
Ignacio Rego-Pérez¹, Jean-Pierre Pelletier², François Abram³, Natividad Oreiro⁴, Carlos Fernandez-Lopez¹, Ana Cecilia Raga¹, Francisco J Blanco¹ and Johanne Martel-Pelletier², ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruña, Spain, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ³Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña. España, A Coruna, Spain
Background/Purpose: Bone marrow lesions (BMLs) have been consistently associated with the development of osteoarthritis (OA); however the extent to which they are genetically driven by…

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