Abstracts tagged "Knee"

Abstract Number: L05 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics, and Clinical Outcomes Following Single-Dose IA Administration of UBX0101, a Senolytic MDM2/p53 Interaction Inhibitor, in Patients with Knee OA
Benjamin Hsu¹, Jennifer Visich ², Mark Genovese ³, Kimberly Walter ², Mahru An ⁴, Remi-Martin Laberge ⁴ and Jamie Dananberg ⁴, ¹Unity Biotechnology, Brisbane, ²Unity Biotechnology, Brisbane, California, ³Stanford University, Stanford, CA, ⁴Unity Biotechnology, Brisbane, CA
Background/Purpose: A non-drug biomarker study showed senescent cell (SnC) burden in OA synovial tissue to correlate with disease severity, inflammation, and knee pain (C. Yohn,…
Abstract Number: 281 • 2019 ACR/ARP Annual Meeting
Frequency of Ultrasound Features of Knee Osteoarthritis and Their Association with Radiographic Features and Symptoms in a Community-Based Cohort
Nadiya Yerich¹, Carolina Alvarez ², Todd Schwartz ³, Sue Savage-Guin ², Catherine Bakewell ⁴, Minna Kohler ⁵, Janice Lin ⁶, Jonathan Samuels ⁷ and Amanda Nelson ², ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Biostatistics, Chapel Hill, NC, ⁴Intermountain Medical Center, Salt Lake City, UT, ⁵MGH, Boston, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone Medical Center, New Yort, NY
Background/Purpose: To evaluate the frequency and associations of osteoarthritis (KOA) features on knee ultrasound (KUS) in a community-based cohort study with radiographic and symptomatic data…
Abstract Number: 416 • 2019 ACR/ARP Annual Meeting
Global Management of Patients with Knee Osteoarthritis Begins with Quality of Life Assessment: A Systematic Review
Josep Verges¹, Marianna Vitaloni ¹, Rosa Sciortino ², Maritza Quintero ², Marco Bibas ¹, Jordi Monfort ³, Francisco de Abajo ⁴, Marco Matucci-Cerinic ⁵, Patrick du Souich ⁶, Ingrid Möller ⁷, Guy Eakin ⁸ and Angie Botto-van Bemden ⁸, ¹Osteoarthritis International Foundation, Barcelona, Spain, ²De los Andes University, Merida, Venezuela, ³Hospital del Mar, Barcelona, Spain, ⁴Universidad de Alcalá, Madrid, Spain, ⁵University of Florence, Department of Medicine, Florence, Italy, Florence, Italy, ⁶University of Montreal, Montreal, Canada, ⁷Poal Institute, Barcelona, Spain, ⁸Arthritis Foundation, Atlanta
Background/Purpose: Knee OA (KOA) associates with remarkable functional restrictions due to pain that seriously affect social and emotional well-being, reducing the quality of life (QoL).…
Abstract Number: 1180 • 2019 ACR/ARP Annual Meeting
Confirmation of Manual Cartilage Segmentation Findings by Automated Segmentation: Retrospective Analysis of MRI Images from a Sprifermin Phase II Study
Alan Brett¹, Michael A Bowes ¹, Philip G Conaghan ², Christoph Ladel ³, Jeffrey Kraines ⁴, Hans Guehring ³, Flavie Moreau ⁴ and Felix Eckstein ⁵, ¹Imorphics, Manchester, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono Research and Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵Paracelsus Medical University, Salzburg, Austria
Background/Purpose: Sprifermin is under investigation as a potential disease-modifying osteoarthritis drug (DMOAD). 2-yr results from the FORWARD study showed significant dose-dependent modification of cartilage thickness…
Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting
Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts
C. Kent Kwoh¹, Amanda Nelson ², Yvonne Golightly ³, Erin Ashbeck ⁴, Liubov Arbeeva ⁵, Na Wang ⁶, Jeffrey Duryea ⁷ and Tuhina Neogi ⁶, ¹University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁴The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁵University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
Abstract Number: 1304 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Hylan G-F 20 versus Intra-Articular Corticosteroids in Patients with Knee Osteoarthritis: A Systematic Literature Review, Meta-Analysis, and Network Meta-analysis
Xavier Chevalier ¹, Brendan Sheehan ², Craig Whittington ³, Chunyi Ho ⁴, Wilson Ngai⁵ and Gustavo Campos ⁶, ¹Department of Rheumatology, Hospital henri Mondor, Paris University XII, Creteil, France, ²Department of Medicine, Dalhousie University, Saint John, NB, Canada, ³Doctor Evidence, Santa Monica, CA, ⁴Doctor Evidence, Santa Monica, ⁵Sanofi, U.S. Medical Affairs, Bridgewater, ⁶Universidade Estadual de Campinas, Campinas, Brazil
Background/Purpose: Knee OA is a progressive joint disease which affects more than 250 million people worldwide. Meta-analysis (MA) has demonstrated that IA CS were more…
Abstract Number: 1305 • 2019 ACR/ARP Annual Meeting
Quality Improvement in Diagnostic and Therapeutic Arthrocentesis in the Flexed Knee Using Pneumatic Compression of the Suprapatellar Bursa
Fatemeh Jafari Farshami¹, Jaren Trost ², Wilmer Sibbitt ², Maheswari Muruganandam ², Philip Band ³, Monthida Fangtham ¹, Nicole Emil ¹, William Hayward ⁴, Luke Haseler ⁵ and Arthur Bankhurst ¹, ¹Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, ²Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, ³Department of Orthopaedic Surgery, Biochemistry & Molecular Pharmacology NYU School of Medicine, New York City, New York City, NY, ⁴The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM, ⁵Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia
Background/Purpose: Arthrocentesis is an essential procedure in diagnosing inflammatory and septic arthritis and is a basic procedure for intra-articular therapy, including therapeutic arthrocentesis and intra-articular…
Abstract Number: 1307 • 2019 ACR/ARP Annual Meeting
A Prospective, Multi-center, Randomized, Clinical Trial Comparing the Effectiveness and Safety of Cooled Radiofrequency Ablation versus a Single Injection of Hyaluronic Acid in the Management of OA Knee Pain
Antonia Chen¹, Fred Khalouf ², Michael DePalma ³, Keith Zora ⁴, Lynn Kohan ⁵, Maged Guirguis ⁶, Douglas Beall ⁷, Eric Loudermilk ⁸, Matthew Pingree ⁹, Ignacio Badiola ¹⁰ and Jeffrey Lyman ¹¹, ¹Brigham and Women’s Hospital, Boston, MA, ²University Orthopedics Center, Altoona, PA, ³Virginia iSpine Physicians, Richmond, VA, ⁴University Orthopedics Center, State College, PA, ⁵University of Virginia School of Medicine, Charlottesville, VA, ⁶Ochsner Clinic Foundation, New Orleans, LA, ⁷Clinical Investigations, Edmond, OK, ⁸PCPMG Clinical Research Unit LLC, Anderson, SC, ⁹Mayo Clinic, Rochester, MN, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Institute for Orthopedic Research and Innovation, Coeur d'Alene, IN
Background/Purpose: This prospective, randomized, multi-center study was conducted to compare pain relief, functional improvement, and the safety of cooled radiofrequency ablation (CRFA) to hyaluronic acid…
Abstract Number: 1315 • 2019 ACR/ARP Annual Meeting
Relation of MRI-detected Structural Damage in the Patellofemoral Joint to Pain and Performance Based Function: The MOST Study
Jessica Maxwell¹, Tuhina Neogi ², Kay Crossley ³, Erin Macri ⁴, Daniel White ⁵, Ali Guermazi ⁶, Frank Roemer ⁷, Michael Nevitt ⁸, Beth Lewis ⁹, James Torner ¹⁰ and Joshua Stefanik ¹¹, ¹Northeastern University, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³La Trobe University, Victoria, Australia, ⁴Erasmus MC, Rotterdam, Netherlands, ⁵University of Delaware, Newark, DE, ⁶Boston Medical Center, Boston, ⁷University of Erlangen-Nuremberg, Erlangen, Germany, ⁸University of California at San Francisco, San Francisco, CA, ⁹University of Alabama at Birmingham, Birmingham, AL, ¹⁰University of Iowa at Iowa City, Iowa City, ¹¹Northeastern University, Boston
Background/Purpose: Osteoarthritis (OA) of the knee is one of the most common causes of disability in the U.S. Often overlooked, OA specific to the patellofemoral…
Abstract Number: 1321 • 2019 ACR/ARP Annual Meeting
What Is the Relationship Between the 3 Knee Bones in Osteoarthritis? Baseline and Longitudinal Associations Using a Latent Growth Modelling Approach on 37,583 MR Images from the Osteoarthritis Initiative
Bright Dube¹, Michael Bowes ², Elizabeth Hensor ¹, Sarah Kingsbury ³ and Philip G Conaghan ⁴, ¹University of Leeds, LEEDS, England, United Kingdom, ²Imorphics, Manchester, England, United Kingdom, ³University of Leeds, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: 3D femur bone shape measured by statistical shape modelling (SSM) provides a responsive biomarker of knee OA. However it is unclear how the 3…
Abstract Number: 1322 • 2019 ACR/ARP Annual Meeting
Evaluation of Intra-articular CNTX-4975 in Subjects with Painful Bilateral Knee Osteoarthritis: Effects on Pain with Walking and Patient Impression of Change in Pain
Randall Stevens ¹, Kimberly Guedes ¹, Nilam Mistry ¹, Paul Tiseo ², Duncan Lascelles ³, Mario Mendoza¹ and David Ball ⁴, ¹Centrexion Therapeutics Corp, Boston, MA, ²Centrexion Therapeutics Corp, Boston, ³Translational Research in Pain, North Carolina State University, Raleigh, NC, ⁴MAC Clinical Research, Manchester, United Kingdom
Background/Purpose: A double-blind, randomized, placebo-controlled trial (TRIUMPH; NCT02558439) with a single 1 mg intra-articular (IA) injection of CNTX-4975 (highly purified trans-capsaicin) into one knee for…
Abstract Number: 1961 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Sub-haplogroup H1 Influences the Risk of Rapidly Progressive Osteoarthritis of the Knee: Data from the Osteoarthritis Initiative
Alejandro Duran-Sotuela¹, Mercedes Fernandez-Moreno ², María E. Vázquez-Mosquera ³, Paula Ramos-Louro ¹, Andrea Dalmao-Fernández ³, Sara Relaño ¹, Natividad Oreiro ¹, Francisco J. Blanco ¹ and Ignacio Rego-Pérez ¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, ³Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain
Background/Purpose: There is a need to identify the rapid progressive phenotype of Osteoarthritis (OA). Our aim is to analyze the effect of mitochondrial haplogroups in…
Abstract Number: 2176 • 2019 ACR/ARP Annual Meeting
A Novel Composite Score Reflecting Disease Activity Predicts Future Knee Replacements: Data from the Osteoarthritis Initiative
Jeffrey Driban¹, Matthew Harkey ², Lori Lyn Price ³, Grace Lo ⁴, Jincheng Pang ⁵, Ming Zhang ⁶ and Timothy McAlindon ¹, ¹Tufts Medical Center, Boston, MA, ²Tufts Medical Center, University of Massachusetts Medical School, Boston, MA, ³Tufts Medical Center, Tufts University, Boston, MA, ⁴Center of Excellence Michael E. DeBakey VAMC, Baylor College of Medicine, Houston, TX, ⁵Pfizer, Inc., Cambridge, MA, ⁶Tufts Medical Center, Wentworth Institute of Technology, Boston, MA
Background/Purpose: While knee osteoarthritis (KOA) leads to cumulative damage to a diarthrodial joint there are also more dynamic processes that fluctuate throughout the disease process…
Abstract Number: 2188 • 2019 ACR/ARP Annual Meeting
The Association of Plasma Fatty Acids Levels with Hand and Knee Osteoarthritis
Marieke Loef¹, Andreea Ioan-Facsinay ¹, Dennis O Mook-Kanamori ², Ko Willems van Dijk ¹, Renée de Mutsert ¹, Margreet Kloppenburg ¹ and Frits R Rosendaal ¹, ¹Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Obesity is one of the most important risk factors for osteoarthritis, and is strongly associated with increased levels of circulating fatty acids, which may…
Abstract Number: 2198 • 2019 ACR/ARP Annual Meeting
Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis
Kevin Ong¹, Maria Runa ¹, Wilson Ngai ², Zhimin Xiao ³, Edmund Lau ⁴ and Roy Altman ⁵, ¹Exponent, Inc., Philadelphia, ²Sanofi, U.S. Medical Affairs, Bridgewater, ³Sanofi US, Cambridge, ⁴Exponent, Inc., Menlo Park, ⁵University of California, Los Angeles
Background/Purpose: Some concerns have been raised about subsequent severe acute localized reactions (SALR) (flares, pseudoseptic reactions, etc.) following hyaluronic acid (HA) injections for pain relief…

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