Abstracts tagged "Knee"

Abstract Number: L03 • 2018 ACR/ARHP Annual Meeting
Efficacy and Safety from a Phase 2b Trial of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor for the Treatment of Osteoarthritis of the Knee
Yusuf Yazici¹, Timothy E. McAlindon², Allan Gibofsky³, Nancy Lane⁴, Christian Lattermann⁵, Nebojsa Skrepnik⁶, Christopher Swearingen¹, Anita DiFrancesco¹, Jeymi Tambiah¹ and Marc Hochberg⁷, ¹Samumed, LLC, San Diego, CA, ²Division of Rheumatology, Tufts Medical Center, Boston, MA, ³Rheumatology, Weill Cornell Medicine, and Hospital for Special Surgery, New York, NY, ⁴Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Tucson Orthopaedic Institute, Tucson, AZ, ⁷University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: A previous Phase 2a study of SM04690, a small molecule, intra-articular (IA), Wnt pathway inhibitor, demonstrated positive effects on knee OA pain, physical function,…
Abstract Number: 441 • 2018 ACR/ARHP Annual Meeting
The Presence of Neuropathic Pain Does Not Influence the Response to Hyaluronic Acid (HA) in Patients with Knee Osteoarthritis but HA Injections Modify Pain Phenotype
Evariste Tiendrebeogo¹, Thierry Conrozier², Xavier Chevalier³ and Florent Eymard⁴, ¹Rheumatology, APHP Henri Mondor Hospital, Creteil, France, ²Department of Rheumatology,, Nord Franche-Comté Hospital, Belfort, France, ³Rheumatology, APHP Henri Mondor Hospital, Créteil, France, ⁴Department of Rheumatology, APHP Henri Mondor Hospital, Creteil, France
Background/Purpose: Twenty to forty percent of patients with symptomatic knee osteoarthritis (OA) described neuropathic pain (NP). Several studies have shown that hyaluronic acid (HA) is…
Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Matthew Fuller², Becki Cleveland³, Todd Schwartz⁴, Joanne M. Jordan¹, Leigh F. Callahan¹, J.S. Marron² and Richard Loeser¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…
Abstract Number: 444 • 2018 ACR/ARHP Annual Meeting
Trajectories of Sport or Recreational Activities over Eight Years and Associated Factors in Persons at Risk for Knee Osteoarthritis
Alison H. Chang¹, Julia (Jungwha) Lee², Orit Almagor¹, Joan S. Chmiel³, Julie Szymaszek¹ and Leena Sharma⁴, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Preventive Medicine, Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Participation in exercise, sport or recreational activities offers multiple health benefits, promotes wellbeing and weight management, and preserves function and quality of life. Staying…
Abstract Number: 1362 • 2018 ACR/ARHP Annual Meeting
Magnetic Resonance Imaging Features Can Classify Adults Who Will Develop Accelerated Knee Osteoarthritis
Lori Lyn Price^1,2, Matthew Harkey³, Robert J. Ward⁴, James MacKay⁵, Ming Zhang⁶, Julie Davis⁷, Timothy E. McAlindon⁸, Grace H. Lo⁹, Mamta Amin¹⁰, Charles B. Eaton¹¹, Bing Lu¹², Jeffrey Duryea¹³, Mary Barbe¹⁴ and Jeffrey B. Driban¹⁵, ¹Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ²Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ³Rheumatology, Tufts Medical Center, Boston, MA, ⁴Radiology, Tufts Medical Center, Boston, MA, ⁵Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁶Tufts Medical Center, Boston, MA, ⁷Rheumatology, Tufts Medical Center, BOSTON, MA, ⁸Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁹Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹⁰Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, ¹¹Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ¹²Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ¹³Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, ¹⁴Temple University School of Medicine, Philadelphia, PA, ¹⁵Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a painful disorder and is associated with several risk factors and pre-radiographic structural features. While no single factor can…
Abstract Number: 457 • 2018 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis (Preliminary Report)
Pinar Borman¹, Ferda Kaygisiz² and Aysegul Yaman³, ¹Department of Physical Medicine and Rehabilitation, University of Hacettepe Faculty of Medicine, Ankara, Turkey, ²Dept of PMR, Ankara Training and Research Hospital, Ankara, Turkey, ³Dept of PMR, University of Hacettepe Faculty of Medicine, Ankara, Turkey
Background/Purpose: There are limited studies in the literature indicating that neuropathic pain occurs in knee osteoarthritis (OA) (1). The aim of this cross sectional study…
Abstract Number: 1364 • 2018 ACR/ARHP Annual Meeting
Treatment of Knee Osteoarthritis with SM04690 Improved WOMAC A1 “Pain on Walking” – Results from a 52-Week, Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of a Novel, Intra-Articular, Wnt Pathway Inhibitor
Jeyanesh Tambiah¹, Sarah Kennedy¹, Heli Ghandehari¹, Christopher Swearingen¹ and Marc C. Hochberg², ¹Samumed, LLC, San Diego, CA, ²University of Maryland School of Medicine, Baltimore, MD
Background/Purpose: Knee osteoarthritis (OA) is characterized by pain, functional limitation, and physical disability due to articular cartilage degradation and bone remodeling. Wnt signaling is involved…
Abstract Number: 915 • 2018 ACR/ARHP Annual Meeting
The Association between Structural and Symptomatic Progression in Knee Osteoarthritis
Jamie E. Collins¹, Swastina Shrestha² and Elena Losina³, ¹Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA
Background/Purpose: The link between progression of structure and symptoms in knee osteoarthritis (OA) is not well understood. This uncertainty hinders the effort to develop therapies…
Abstract Number: 1366 • 2018 ACR/ARHP Annual Meeting
Assessment of Health-Related Quality of Life in a 52-Week, Phase 2, Randomized, Controlled Trial of a Novel, Intra-Articular, Wnt Pathway Inhibitor (SM04690) for Treatment of Knee Osteoarthritis
Vibeke Strand¹, Heli Ghandehari², Christopher Swearingen² and Jeyanesh Tambiah², ¹Stanford University School of Medicine, Palo Alto, CA, ²Samumed, LLC, San Diego, CA
Background/Purpose: SM04690, a small molecule, intra-articular (IA) Wnt pathway inhibitor, is in development for knee OA treatment. A phase 2, 52-week, trial evaluated changes in…
Abstract Number: 930 • 2018 ACR/ARHP Annual Meeting
Joint Location-Specific IL6 and JAK-STAT Signaling in Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS)
Deepa Hammaker¹, Gyrid Nygaard¹, Amanda Kuhs¹, Rizi Ai², David L. Boyle¹, Wei Wang³ and Gary S. Firestein¹, ¹Medicine, University of California San Diego, La Jolla, CA, ²University of California San Diego, La Jolla, CA, ³Chemistry and Biochemistry, University of California San Diego, La Jolla, CA
Background/Purpose: Recent studies suggest that epigenetic marks distinguish FLS isolated from different joints in RA. Hip and knee joint-derived FLS, in particular, have distinctive DNA…
Abstract Number: 1371 • 2018 ACR/ARHP Annual Meeting
Systemic Exposure of Triamcinolone Acetonide Following Bilateral Injection of Extended-Release Triamcinolone Acetonide and Standard Triamcinolone in Patients with Bilateral Knee Osteoarthritis
Alan J. Kivitz¹, Louis Kwong², Tammi Shlotzhauer³, Joelle Lufkin⁴, Teresa Curto⁵ and Scott Kelley⁴, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, ³Rochester Clinical Research, Inc., Rochester, NY, ⁴Flexion Therapeutics, Inc., Burlington, MA, ⁵Cytel Inc., Waltham, MA
Background/Purpose: Current ACR guidelines recommend the use of IACS for short-term acute pain relief in patients (pts) with knee OA.1 Bilateral knee OA can occur…
Abstract Number: 263 • 2018 ACR/ARHP Annual Meeting
Racial Disparities in Total Knee Replacement Failure Are Not Explained By Poverty
Anne R. Bass¹, Jackie Szymonifka², Lisa A. Mandl¹, Bella Y. Mehta³, Emily Ying Lai², Stephen Lyman¹, Michael L. Parks¹, Serene Z. Mirza², Shirin A. Dey² and Susan M. Goodman², ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery/Weill Cornell Medicine/Mailman School of Public Health, New York, NY
Background/Purpose: U.S. blacks have a higher risk of revision total knee replacement (TKR) than whites, but whether this is mediated by poverty is unknown. The…
Abstract Number: 952 • 2018 ACR/ARHP Annual Meeting
Effusion-Synovitis and Infrapatellar Fat Pad Edema Differentiate Accelerated Knee Osteoarthritis: Data from the Osteoarthritis Initiative
Julie Davis¹, Robert J. Ward², James MacKay³, Bing Lu⁴, Lori Lyn Price^5,6, Timothy E. McAlindon⁷, Charles B. Eaton⁸, Mary Barbe⁹, Grace H. Lo¹⁰, Matthew Harkey¹ and Jeffrey B. Driban¹¹, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Radiology, Tufts Medical Center, Boston, MA, ³Radiology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ⁴Brigham & Women's Hospital and Harvard Medical School, Boston, MA, ⁵Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, ⁶Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA, ⁸Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, ⁹Temple University School of Medicine, Philadelphia, PA, ¹⁰Michael E. DeBakey Veterans Affairs Medical Center / Baylor College of Medicine, Houston, TX, ¹¹Medicine, Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Accelerated knee osteoarthritis (AKOA) is a unique endotype of knee osteoarthritis (KOA) that is characterized by a sudden onset of advance-stage disease and greater…
Abstract Number: 1373 • 2018 ACR/ARHP Annual Meeting
Predictive Probabilities Are Superior in Communicating the Clinical Relevance of Cartilage Thickness As an Imaging Biomarker of Knee Osteoarthritis Progression
C. Kent Kwoh^1,2, Erin L. Ashbeck¹, Edward J. Bedrick³ and Felix Eckstein^4,5, ¹University of Arizona Arthritis Center, Tucson, AZ, ²Division of Rheumatology, Department of Medicine, The University of Arizona, Tucson, AZ, ³Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, ⁴Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria, ⁵Chondrometrics GmbH, Ainring, Germany
Background/Purpose: Establishing a threshold of clinically important cartilage loss is of great interest for the design and interpretation of knee OA trials of structure-modifying treatments.…
Abstract Number: 402 • 2018 ACR/ARHP Annual Meeting
Preoperative Physical Function Influences on Stair Climbing Ability 1 Month after Total Knee Arthroplasty
Jinseok Kim¹ and Bo Ryun Kim², ¹Department of Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), ²Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South)
Background/Purpose: This study was undertaken to identify preoperative physical performance factors predictive of stair climbing ability 1 month following total knee arthroplasty. Methods: In this…

1
2
3
…
22
Next Page »