Abstracts tagged "Environmental factors"

Abstract Number: 132 • 2017 ACR/ARHP Annual Meeting
Occupational Physical Workload and Development of Anti-Collagen Type II Antibodies in Rheumatoid Arthritis Patients
Pingling Zeng¹, Lars Alfredsson², Lars Klareskog³, Mohammed Mullazehi⁴, Saedis Saevarsdottir⁵, Camilla Bengtsson⁶ and Johan Rönnelid⁷, ¹Institute of Environmental Medicine, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, ²The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ³Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, ⁴Department of Immunology, Genetics and Pathology,Uppsala University, Uppsala, Sweden, Uppsala, Sweden, ⁵Karolinska Institute and Karonlinska University Hospital, Stockholm, Sweden, ⁶Inst of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ⁷Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden
Background/Purpose: We have previously observed an association between exposure to occupational physical workload (PW) and risk of developing rheumatoid arthritis (RA)[1].We posit that PW could…
Abstract Number: 914 • 2017 ACR/ARHP Annual Meeting
Occupational Exposure to Combustion Products and Risk of Developing Rheumatoid Arthritis
Anna Ilar¹, Pernilla Wiebert^1,2, Saedis Saevarsdottir³, Johan Askling^4,5, Per Gustavsson^1,2 and Lars Alfredsson^1,2, ¹The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²Stockholm County Council, Centre for Occupational and Environmental Medicine, Stockholm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, ⁵Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Studies have suggested a potential association between traffic pollutants and rheumatoid arthritis (RA), but findings have been inconclusive. We therefore assessed the risk of…
Abstract Number: 915 • 2017 ACR/ARHP Annual Meeting
Pesticide Exposure and Risk of Systemic Lupus Erythematosus in an Urban Population of Predominantly African-American Women
Jessica Williams¹, Shun-Chiao Chang¹, Corine Sinnette¹, Susan Malspeis², Christine G. Parks³, Elizabeth Karlson¹, Patricia Fraser¹ and Karen H. Costenbader¹, ¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC
Background/Purpose: Several studies have reported an association between exposure to pesticides and the risk of systemic lupus erythematosus (SLE). However, this association has not yet…
Abstract Number: 988 • 2017 ACR/ARHP Annual Meeting
Association of Ultraviolet-B Radiation and Risk of SLE Among Women in the Nurses’ Health Studies
Medha Barbhaiya¹, Jaime Hart^2,3, Susan Malspeis⁴, Sara K. Tedeschi⁵, David J. Kreps⁵, Trang VoPham⁶, Jeffrey A. Sparks⁷, Elizabeth Karlson⁵, Francine Laden^2,3,8 and Karen H. Costenbader⁵, ¹Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, ³Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁶Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, ⁷Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁸Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA
Background/Purpose: Ultraviolet-B radiation (UV-B) exposure may lead to worsened photosensitivity, rashes, and systemic flares among SLE patients. Although UV-B radiation damages keratinocytes and may result…
Abstract Number: 2140 • 2017 ACR/ARHP Annual Meeting
Infections and Medications Associated with Onset of Myositis in Myovision, a National Myositis Patient Registry
Lisa G Rider¹, Payam Noroozi Farhadi¹, Nastaran Bayat¹, Jesse Wilkerson², Abdullah Faiq¹, John McGrath², Hermine I. Brunner³, Bob Goldberg⁴ and Frederick W Miller¹, ¹Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, ²Social and Scientific Systems, Inc., Durham, NC, ³Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴The Myositis Association, Alexandria, VA
Background/Purpose: Myositis is a rare systemic autoimmune disease with suspected environmental and genetic risk factors, but little is known about specific infections and medications that…
Abstract Number: 2825 • 2017 ACR/ARHP Annual Meeting
A Possible Environmental Origin for a Proportion of the Genetic Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus
John B. Harley¹, Xiaoting Chen¹, Mario Pujato², Daniel Miller¹, Avery Maddox¹, Carmy Forney³, Albert Magnusen³, Arthur Lynch¹, Kashish Chetal⁴, Masashi Yukawa⁵, Artem Barski⁶, Nathan Salomonis⁴, Kenneth Kaufman⁷, Leah C. Kottyan⁸ and Matthew Weirauch⁹, ¹Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Divisions of Allergy and Immunology and Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Divisions of Allergy and Immunology and Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁸Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Nearly 150 genetic loci are convincingly associated with lupus (SLE) or rheumatoid arthritis (RA) and underlie their incompletely understood mechanisms of pathogenesis. Since 90%…
Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting
Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis
Asha Mariam Alex^1,2, Gary A. Kunkel³, Jorge Flautero Arcos⁴, Richard Amdur⁵ and Gail S. Kerr⁶, ¹Rheumatology, Veterans Affairs Medical Center, Washington, DC, ²Rheumatology, Georgetown University Hospital, Washington, DC, ³Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, ⁴Rheumatology, Howard University Hospital, Washington, DC, ⁵Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, ⁶Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC
Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
Abstract Number: 1210 • 2015 ACR/ARHP Annual Meeting
Genetic, Environmental, and Serologic Risk Factors for Inflammatory Joint Signs Among First-Degree Relatives without Rheumatoid Arthritis in a Prospective Cohort
Jeffrey A. Sparks¹, Shun-Chiao Chang², Kevin D. Deane³, Ryan W. Gan⁴, Kristen Demoruelle³, Marie L. Feser³, LauraKay Moss³, Jane H. Buckner⁵, Richard M. Keating⁶, Karen H. Costenbader⁷, Peter K. Gregersen⁸, Michael H. Weisman⁹, Ted R. Mikuls¹⁰, James R. O'Dell¹⁰, V. Michael Holers³, Jill M. Norris⁴ and Elizabeth W. Karlson², ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ³Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ⁴Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Benaroya Research Institute at Virginia Mason, Seattle, WA, ⁶Division of Rheumatology, Scripps Health, La Jolla, CA, ⁷Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁸Feinstein Insititute for Medical Research, Manhasset, NY, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Family history of RA in a first-degree relative increases RA risk 4-fold. Determining risk factors for inflammatory joint signs (IJS) in this high risk…
Abstract Number: 46 • 2015 ACR/ARHP Annual Meeting
Feasibility Study of Smartphone Data Collection for Cloudy with a Chance of Pain: Sustained Engagement for Daily Self-Reporting of Disease Severity in Rheumatoid Arthritis over Two Months
Samuel Reade¹, Jamie C Sergeant^2,3, Matthew Sperrin⁴, David M. Schultz⁵, Karen Spencer⁶, Caroline Sanders⁶ and William G Dixon⁷, ¹The University of Manchester, Manchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ³Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, ⁴Institute of Population Health, Health e-Research Centre, The University of Manchester, Manchester, United Kingdom, ⁵Faculty of Engineering and Physical Sciences, School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Manchester, United Kingdom, ⁶Institute of Population Health, Centre for Primary Care, The University of Manchester, Manchester, United Kingdom, ⁷Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Previous research has attempted to study the association between weather and joint pain. Inconclusive results may be due, in part, to infrequent measures of…
Abstract Number: 79 • 2015 ACR/ARHP Annual Meeting
Hypervigilence: Patients with Fibromyalgia Often Appear Very Sensitive to Environmental Stresses
Robert S. Katz¹, Kelli Davis², Lauren Kwan² and Jessica L. Polyak², ¹Rush University Medical Center, Chicago, IL, ²Rheumatology Associates S.C., Chicago, IL
Background/Purpose: We inquired about hypervigilence and hypersensitivity to various environmental stresses in patients with fibromyalgia and in rheumatic disease controls. Methods: 103 fibromyalgia patients with…
Abstract Number: 839 • 2015 ACR/ARHP Annual Meeting
Occupational Exposures in Patients with Systemic Sclerosis Associated with Increased Frequency of Interstitial Lung Disease and Primary Pulmonary Hypertension
Brandi E. Stevens^1,2, Mary Lucas³, Thomas A. Medsger Jr.⁴ and Robyn T. Domsic⁵, ¹Division of Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, ³Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, ⁵Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic sclerosis (SSc) has been linked with environmental and occupational exposures. Silica and solvent exposure have the strongest known correlation with SSc. Other agents,…
Abstract Number: 2058 • 2014 ACR/ARHP Annual Meeting
The Impact of Environmental Stress on Pain in Fibromyalgia Patients
Robert S. Katz¹, Ben J Small² and Susan Shott³, ¹Rush Medical College, Chicago, IL, ²MacNeal Hospital, Berwyn, IL, ³Rush University Medical Center, Chicago, IL
Background/Purpose: Many fibromyalgia syndrome (FMS) report that their illness is significantly affected by environmental stress. We compared FMS and RA patients with respect to the…
Abstract Number: 2008 • 2014 ACR/ARHP Annual Meeting
Personalized Risk Education for Rheumatoid Arthritis Improves Self-Perceived Risk Accuracy and Risk Factor Knowledge in First-Degree Relatives
Jeffrey A. Sparks¹, Maura D. Iversen^1,2,3, Rachel Miller Kroouze^1,4, Nellie A. Triedman¹, Taysir G. Mahmoud¹, Sarah S. Kalia⁴, Michael L. Atkinson⁵, Robert C. Green⁴ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, ³Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden, ⁴Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose Having a first-degree relative (FDR) with RA increases personal RA risk by four-fold. Other RA risk factors include demographics, genetics, auto-antibodies, and behaviors. We…
Abstract Number: 2017 • 2014 ACR/ARHP Annual Meeting
Fish Consumption and Risk of Rheumatoid Arthritis Among Women in Large Prospective Cohorts
Jeffrey A. Sparks¹, Shun-Chiao Chang², Bing Lu¹, Susan Malspeis¹, Karen H. Costenbader¹ and Elizabeth W. Karlson¹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose Prior studies have suggested a protective effect of fish intake on RA. However, these studies were limited by potential recall bias, short follow-up, and…
Abstract Number: 2015 • 2014 ACR/ARHP Annual Meeting
Fine Particulate Air Pollution and Systemic Autoimmune Rheumatic Disease in Two Canadian Provinces
Sasha Bernatsky¹, Audrey Smargiassi², Cheryl Barnabe³, Lawrence W. Svenson⁴, Allan Brand⁵, Marie Hudson⁶, Steven M. Edworthy⁷, Ann E. Clarke³, Paul R. Fortin⁸, Patrick Belisle⁹ and Lawrence Joseph¹⁰, ¹Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ²Département de santé environnementale et santé au travail, Université de Montréal, Montréal, QC, Canada, ³Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁴Community Health Sciences, University of Calgary, Calgary, AB, Canada, ⁵Institut national de santé publique du Québec, Montreal, QC, Canada, ⁶Rheumatology, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁷The University of Calgary, Calgary, AB, Canada, ⁸Rheumatology, Laval University, Division of Rheumatology, Centre de Recherche du CHU de Québec and Department of Medicine, Quebec City, QC, Canada, ⁹Clinical Epidemiology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ¹⁰McGill University, Montreal, QC, Canada
Background/Purpose: To estimate the degree to which fine particulate (PM2.5) air pollution is associated with systemic autoimmune rheumatic diseases (SARDs). Methods: We used population-based administrative…

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