Abstracts tagged "Environmental factors"

Abstract Number: 1447 • ACR Convergence 2020
Vitamin D Deficiency Enhances Antiphospholipid Antibody-Mediated Thrombosis in a Passive Immunization Mouse Model
Rohan Willis¹, Karen Roye-Green², Zurina Romay-Penabad¹, Elizabeth Papalardo¹, Alvaro Schleh³, Vijaya Murthy⁴, Monica Smikle² and Emilio Gonzalez¹, ¹University of Texas Medical Branch, Galveston, TX, ²University of the West Indies, Kingston, Jamaica, ³Antiphospholipid Standardization Laboratory, GALVESTON, TX, ⁴University of Texas Medical Branch, League City, TX
Background/Purpose: Abnormal vitamin D levels occur frequently in antiphospholipid (APS) patients and are correlated with thrombosis. It remains unclear however if vitamin D deficiency observed…
Abstract Number: 1794 • ACR Convergence 2020
Systemic Lupus Erythematosus and Geomagnetic Disturbances: A Time Series Analysis
George Stojan¹, Flavia Giammarino² and Michelle Petri³, ¹Johns Hopkins University, BALTIMORE, MD, ²Deutsche Bank, London, United Kingdom, ³Johns Hopkins University School of Medicine, Baltimore
Background/Purpose: To examine the influence of solar cycle and geomagnetic effects on SLE disease activity.Methods: The data used for the analysis consisted of 327 observations…
Abstract Number: 1800 • ACR Convergence 2020
Association of Air Pollution with Systemic Lupus Erythematosus Disease Activity in the Central Valley of California
Mosaab Mohameden¹, Ali H.Ali², Zi Ying Li², Yabsira Abejie³, Ratnali Jain² and Candice Reyes Yuvienco⁴, ¹University of Cincinnati College of Medicine, Cincinnati, OH, ²University of California San Francisco Fresno, Fresno, CA, ³Floyd B. Buchanan High School, Fresno, CA, ⁴University of California San Francisco Fresno, Clovis, CA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease that affects at least 300,000 people in the United States creating a substantial socioeconomic…
Abstract Number: 1813 • ACR Convergence 2020
A Comprehensive Method to Study Environmental Chemicals in Serum in Patients with SLE
Cristina Lanata¹, Kim Taylor², James Hurst-Hopf¹, Laura Trupin¹, Patricia Katz³, Jinoos Yazdany¹, Maria Dall'Era⁴, Dimitri Abrahamsson¹, Lindsey Criswell⁵ and Roy Gerona¹, ¹UCSF, San Francisco, CA, ²University of California, San Francisco, San Francisco, CA, ³University of California, San Francisco, Novato, CA, ⁴Division of Rheumatology, University of California, San Francisco, CA, ⁵Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA
Background/Purpose: Environmental exposures may play a substantial role in the pathogenesis of Systemic Lupus Erythematosus (SLE), however it has been challenging to measure and capture…
Abstract Number: 2037 • ACR Convergence 2020
Geographic Distribution and Environmental Triggers of Systemic Sclerosis in Massachusetts
Anastasiya Muntyanu¹, Bina Kassamali², Ruth Ann Vleugels³ and Avery LaChance³, ¹McGill University, Montreal, QC, Canada, ²Harvard Medical School, Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune sclerosing disease with a 10-year survival rate of less than 65%. This rate has remained unchanged for…
Abstract Number: 0086 • ACR Convergence 2020
Geographic Distribution of Eosinophilic Fasciitis Cases in Massachusetts and Associated Environmental Triggers
Bina Kassamali¹, Anastasiya Muntyanu², Ruth Ann Vleugels³ and Avery LaChance³, ¹Harvard Medical School, Brigham and Women's Hospital, Boston, MA, ²McGill University, Montreal, QC, Canada, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Eosinophilic fasciitis (EF) is a rare fibrosing disorder of the fascia characterized by induration progressing proximally along the upper and lower extremities. Given the…
Abstract Number: 0091 • ACR Convergence 2020
Helicobacter Pylori Infection, Autoimmune Disease and Paraproteinemia Influence the Presentation of a Cohort of 150 Pernicious Anemia Patients Diagnosed in a Rheumatology Clinic
Michael Lovy¹, Norma Daniela Aguirre Vega¹ and Crystal Escobar¹, ¹Desert Oasis Healthcare, Palm Springs, CA
Background/Purpose: The most familiar presentation of pernicious anemia is an elderly Northern European woman with hematologic and neurologic manifestations. More recently the influence of Helicobacter…
Abstract Number: 0495 • ACR Convergence 2020
Epstein Barr Virus (EBV), an Etiologic Factor for Systemic Lupus Erythematosus (SLE), Interacts with SLE Risk Loci Through EBV-encoded Transcription Co-factors (co-TFs)
Viktoryia Laurynenka¹, Xiaoting Chen¹, Sreeja Parameswaran¹, Shruti Eswar², Kenneth Kaufman³, Bahram Namjou⁴, Matthew Weirauch⁵, Leah Kottyan⁴ and John Harley⁶, ¹Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children’s Hospital Medical Center, Cincinnati, ³Cincinnati Children’s Hospital Medical Center;US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁴Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, Cincinnati, OH, ⁵Cincinnati Children’s Hospital Medical Center/Univ of Cincinnati, 535 Terrace Ave, ⁶Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH
Background/Purpose: SLE affects millions worldwide. The etiology of this complex autoimmune disease is the consequence of both strong genetic and environmental components. Genome-wide association studies…
Abstract Number: 0757 • ACR Convergence 2020
Sunlight Exposure, Sun-protective Behaviour, and Anti-citrullinated Protein Antibody Positivity: A General Population-based Study in Quebec, Canada
Naizhuo Zhao¹, Audrey Smargiassi², Ines Colmegna³, Marie Hudson⁴, Marvin Fritzler⁵ and Sasha Bernatsky⁶, ¹McGill University, Montreal, Canada, ²l’Université de Montréal, Montreal, Canada, ³The Research Institute of the McGill University Health Centre, Montreal, Canada, ⁴Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, ⁵Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁶The Research Institute of the McGill University Health Centre, Montreal, ON, Canada
Background/Purpose: Sunlight exposure has been associated with lower rheumatoid arthritis (RA) risk, but to our knowledge, no one has ever studied sunlight exposure and anti-citrullinated…
Abstract Number: 0779 • ACR Convergence 2020
Antibody Responses to Epstein-Barr Virus Are Altered in the Pre-Clinical Period of Rheumatoid Arthritis
Sabrina Fechtner¹, Heather Berens², Elizabeth Bemis³, M Kristen Demoruelle², Carla J. Guthridge⁴, John Harley⁵, Judith James⁶, Jess Edison⁷, Kevin D. Deane⁸, Jill Norris⁹ and V. Michael Holers², ¹University of Colorado, Aurora, CO, ²University of Colorado, Denver, CO, ³Colorado School of Public Health Anschutz Medical Campus, Aurora, CO, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Cincinnati Children's Hospital Medical Center/Univ of Cincinnati College of Medicine, Cincinnati, OH, ⁶Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation;Department of Pathology, University of Oklahoma Health Sciences Center;Department of Medicine, University of Oklahoma Health Sciences Center, Edmond, OK, ⁷Walter Reed National Military Medical Center, Bethesda, ⁸2 Division of Rheumatology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA, Colorado, ⁹Colorado School of Public Health, Aurora, CO
Background/Purpose: Viral infections, including infection with Epstein-Barr virus (EBV), have been suggested as environmental risk factors for rheumatoid arthritis (RA). EBV infections are known to…
Abstract Number: 187 • 2019 ACR/ARP Annual Meeting
Epidemiology of JIA-Associated Uveitis: Environmental Factors and Disease Characteristics of a JIA-Associated Uveitis Cohort
Theresa Hennard ¹, Najima Mwase ², Amy Cassedy ³, Joseph McDonald ⁴, Virginia Utz ⁵ and Sheila Angeles-Han⁶, ¹Division of Rheumatology, Cincinnati Children's Hospital and Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, ⁴Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, ⁵Division of Ophthalmology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁶Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cinicinnati
Background/Purpose: JIA-associated uveitis (JIA-U) is the most prevalent extra-articular manifestation of JIA and the most common type of uveitis in children. To date, environmental factors…
Abstract Number: 693 • 2019 ACR/ARP Annual Meeting
Hair Chemicals and Systemic Lupus Erythematosus: A Case-Control Study
Jessica English¹, Trevor Faith ², Dulaney Wilson ¹ and Diane Kamen ³, ¹Medical University of South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex chronic autoimmune disease of unknown etiology. Previous studies of beauty products as potential triggers of SLE development…
Abstract Number: 1106 • 2019 ACR/ARP Annual Meeting
Systemic Lupus Erythematosus and Sjögren’s Syndrome in the Agricultural Health Study: Lower Risk Associated with Childhood Farm Residence and Raising Livestock
Christine Parks¹, Stuart Long ², Laura Beane-Freeman ³, Hofmann Jonathan ³ and Sandler Dale ¹, ¹National Institute of Environmental Health Sciences, Research Triangle Park, ²Westat, Research Triangle Park, NC, ³National Cancer Institute, Bethesda
Background/Purpose: Prior research suggests that growing up on a farm and contact with livestock may confer protection against developing systemic autoimmune diseases, such as rheumatoid…
Abstract Number: 2084 • 2019 ACR/ARP Annual Meeting
Why so Fast? A Focus on Reasons for an Increase in Arthritis-Attributable Activity Limitation Trends, 2002-2017
Kristina Theis¹, Michael Boring ² and Ross Wilkie ³, ¹Centers for Disease Control and Prevention, Atlanta, ²Johnson Consulting dba Cutting Edge Technologies and Solutions, Atlanta, ³Keele University, Keele, United Kingdom
Background/Purpose: “Arthritis-attributable activity limitation” (AAAL) is linked to many potentially modifiable characteristics (e.g., work disability, physical inactivity, obesity). By 2015, prevalence of AAAL among adults…
Abstract Number: 69 • 2018 ACR/ARHP Annual Meeting
Possible Association of Early Inflammatory Arthritis with Viral Outbreaks Such As Influenza: Time Series Analysis of the Canadian Early Inflammatory Arthritis Cohort
Fatima Kudaeva¹, Mark Speechley², Neil Klar², Orit Schieir³, Susan J. Bartlett⁴, Louis Bessette⁵, Gilles Boire⁶, Glen Hazlewood⁷, Carol A Hitchon⁸, Edward C. Keystone⁹, Diane Tin¹⁰, Carter Thorne¹¹, Vivian P. Bykerk¹² and Janet E. Pope¹³, ¹Department of Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ²Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, ³Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ⁴Department of Medicine, Division of ClinEpi, Rheumatology, Respirology, McGill University, Montreal, QC, Canada, ⁵Division of Rheumatology, Department of Medicine, CHU de Québec-Université Laval, Québec, QC, Canada, ⁶Rheumatology Division, Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Universitaire de Sherbrooke and Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁷Departments of Medicine and Community Health Sciences, University of Calgary, Calgary, AB, Canada, ⁸University of Manitoba, Winnipeg, MB, Canada, ⁹University of Toronto and Mount Sinai Hospital, Toronto, ON, Canada, ¹⁰The Arthritis Program, Southlake Regional Health Centre, Newmarket, ON, Canada, ¹¹University of Toronto, Newmarket, ON, Canada, ¹²Hospital for Special Surgery, New York, NY, ¹³Department of Medicine, University of Western Ontario, London, ON, Canada
Background/Purpose: Disease clustering suggests a possible environmental cause. Rheumatoid arthritis (RA) is an autoimmune disease that may be triggered by environmental factors such as viruses.…

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