ACR Meeting Abstracts

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Abstracts tagged "Environmental factors"

  • Abstract Number: 132 • 2017 ACR/ARHP Annual Meeting

    Occupational Physical Workload and Development of Anti-Collagen Type II Antibodies in Rheumatoid Arthritis Patients

    Pingling Zeng1, Lars Alfredsson2, Lars Klareskog3, Mohammed Mullazehi4, Saedis Saevarsdottir5, Camilla Bengtsson6 and Johan Rönnelid7, 1Institute of Environmental Medicine, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 2The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 3Dept. of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, 4Department of Immunology, Genetics and Pathology,Uppsala University, Uppsala, Sweden, Uppsala, Sweden, 5Karolinska Institute and Karonlinska University Hospital, Stockholm, Sweden, 6Inst of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 7Department of Immunology Genetics and Pathology, Uppsala University, Uppsala, Sweden

    Background/Purpose: We have previously observed an association between exposure to occupational physical workload (PW) and risk of developing rheumatoid arthritis (RA)[1].We posit that PW could…
  • Abstract Number: 914 • 2017 ACR/ARHP Annual Meeting

    Occupational Exposure to Combustion Products and Risk of Developing Rheumatoid Arthritis

    Anna Ilar1, Pernilla Wiebert1,2, Saedis Saevarsdottir3, Johan Askling4,5, Per Gustavsson1,2 and Lars Alfredsson1,2, 1The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, 2Stockholm County Council, Centre for Occupational and Environmental Medicine, Stockholm, Sweden, 3Rheumatology Unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 4Rheumatology unit, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden, 5Unit of Clinical Epidemiology, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Studies have suggested a potential association between traffic pollutants and rheumatoid arthritis (RA), but findings have been inconclusive. We therefore assessed the risk of…
  • Abstract Number: 915 • 2017 ACR/ARHP Annual Meeting

    Pesticide Exposure and Risk of Systemic Lupus Erythematosus in an Urban Population of Predominantly African-American Women

    Jessica Williams1, Shun-Chiao Chang1, Corine Sinnette1, Susan Malspeis2, Christine G. Parks3, Elizabeth Karlson1, Patricia Fraser1 and Karen H. Costenbader1, 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Durham, NC

    Background/Purpose: Several studies have reported an association between exposure to pesticides and the risk of systemic lupus erythematosus (SLE). However, this association has not yet…
  • Abstract Number: 988 • 2017 ACR/ARHP Annual Meeting

    Association of Ultraviolet-B Radiation and Risk of SLE Among Women in the Nurses’ Health Studies

    Medha Barbhaiya1, Jaime Hart2,3, Susan Malspeis4, Sara K. Tedeschi5, David J. Kreps5, Trang VoPham6, Jeffrey A. Sparks7, Elizabeth Karlson5, Francine Laden2,3,8 and Karen H. Costenbader5, 1Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, 3Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 4Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 6Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, 7Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 8Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA

    Background/Purpose: Ultraviolet-B radiation (UV-B) exposure may lead to worsened photosensitivity, rashes, and systemic flares among SLE patients. Although UV-B radiation damages keratinocytes and may result…
  • Abstract Number: 2140 • 2017 ACR/ARHP Annual Meeting

    Infections and Medications Associated with Onset of Myositis in Myovision, a National Myositis Patient Registry

    Lisa G Rider1, Payam Noroozi Farhadi1, Nastaran Bayat1, Jesse Wilkerson2, Abdullah Faiq1, John McGrath2, Hermine I. Brunner3, Bob Goldberg4 and Frederick W Miller1, 1Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 2Social and Scientific Systems, Inc., Durham, NC, 3Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4The Myositis Association, Alexandria, VA

    Background/Purpose: Myositis is a rare systemic autoimmune disease with suspected environmental and genetic risk factors, but little is known about specific infections and medications that…
  • Abstract Number: 2825 • 2017 ACR/ARHP Annual Meeting

    A Possible Environmental Origin for a Proportion of the Genetic Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

    John B. Harley1, Xiaoting Chen1, Mario Pujato2, Daniel Miller1, Avery Maddox1, Carmy Forney3, Albert Magnusen3, Arthur Lynch1, Kashish Chetal4, Masashi Yukawa5, Artem Barski6, Nathan Salomonis4, Kenneth Kaufman7, Leah C. Kottyan8 and Matthew Weirauch9, 1Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Divisions of Allergy and Immunology and Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 6Divisions of Allergy and Immunology and Bioinformatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center; US Department of Veterans Affairs Medical Center, Cincinnati, OH, 8Center for Autoimmune Genomics and Etiology (CAGE), Division of Allergy and Immunology, Cincinnati Children's Hospital, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 9Center for Autoimmune Genomics and Etiology (CAGE) and Divisions of Biomedical Informatics and Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Nearly 150 genetic loci are convincingly associated with lupus (SLE) or rheumatoid arthritis (RA) and underlie their incompletely understood mechanisms of pathogenesis. Since 90%…
  • Abstract Number: 488 • 2016 ACR/ARHP Annual Meeting

    Exploring the Association Between Air Pollutant Exposure and Seropositivity in Rheumatoid Arthritis

    Asha Mariam Alex1,2, Gary A. Kunkel3, Jorge Flautero Arcos4, Richard Amdur5 and Gail S. Kerr6, 1Rheumatology, Veterans Affairs Medical Center, Washington, DC, 2Rheumatology, Georgetown University Hospital, Washington, DC, 3Division of Rheumatology, George Wahlen VA Medical Center/University of Utah, Salt Lake City, UT, 4Rheumatology, Howard University Hospital, Washington, DC, 5Lead Biostatistician, Medical Faculty Associates Clinical Professor, Dept. of Surgery, George Washington University School of Medicine & Health Sciences, Washington, DC, 6Washington DC VAMC, Georgetown University Hospital, Howard University Hospital, Washington, DC

    Background/Purpose: The etiology of rheumatoid arthritis (RA) is multi-factorial, with expression of HLA-DRB1 shared epitope (SE), smoking and socioeconomic status (SES) exerting influence. Prior studies…
  • Abstract Number: 46 • 2015 ACR/ARHP Annual Meeting

    Feasibility Study of Smartphone Data Collection for Cloudy with a Chance of Pain: Sustained Engagement for Daily Self-Reporting of Disease Severity in Rheumatoid Arthritis over Two Months

    Samuel Reade1, Jamie C Sergeant2,3, Matthew Sperrin4, David M. Schultz5, Karen Spencer6, Caroline Sanders6 and William G Dixon7, 1The University of Manchester, Manchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, 3Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom, 4Institute of Population Health, Health e-Research Centre, The University of Manchester, Manchester, United Kingdom, 5Faculty of Engineering and Physical Sciences, School of Earth, Atmospheric and Environmental Sciences, The University of Manchester, Manchester, United Kingdom, 6Institute of Population Health, Centre for Primary Care, The University of Manchester, Manchester, United Kingdom, 7Manchester Academic Health Sciences Centre, Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Previous research has attempted to study the association between weather and joint pain. Inconclusive results may be due, in part, to infrequent measures of…
  • Abstract Number: 79 • 2015 ACR/ARHP Annual Meeting

    Hypervigilence: Patients with Fibromyalgia Often Appear Very Sensitive to Environmental Stresses

    Robert S. Katz1, Kelli Davis2, Lauren Kwan2 and Jessica L. Polyak2, 1Rush University Medical Center, Chicago, IL, 2Rheumatology Associates S.C., Chicago, IL

    Background/Purpose: We inquired about hypervigilence and hypersensitivity to various environmental stresses in patients with fibromyalgia and in rheumatic disease controls. Methods: 103 fibromyalgia patients with…
  • Abstract Number: 839 • 2015 ACR/ARHP Annual Meeting

    Occupational Exposures in Patients with Systemic Sclerosis Associated with Increased Frequency of Interstitial Lung Disease and Primary Pulmonary Hypertension

    Brandi E. Stevens1,2, Mary Lucas3, Thomas A. Medsger Jr.4 and Robyn T. Domsic5, 1Division of Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Medicine-Rheumatology, University of Pittsburgh, Pittsburgh, PA, 3Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 4Department of Medicine/Rheumatology, University of Pittsburgh, Pittsburgh, PA, 5Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic sclerosis (SSc) has been linked with environmental and occupational exposures. Silica and solvent exposure have the strongest known correlation with SSc. Other agents,…
  • Abstract Number: 1210 • 2015 ACR/ARHP Annual Meeting

    Genetic, Environmental, and Serologic Risk Factors for Inflammatory Joint Signs Among First-Degree Relatives without Rheumatoid Arthritis in a Prospective Cohort

    Jeffrey A. Sparks1, Shun-Chiao Chang2, Kevin D. Deane3, Ryan W. Gan4, Kristen Demoruelle3, Marie L. Feser3, LauraKay Moss3, Jane H. Buckner5, Richard M. Keating6, Karen H. Costenbader7, Peter K. Gregersen8, Michael H. Weisman9, Ted R. Mikuls10, James R. O'Dell10, V. Michael Holers3, Jill M. Norris4 and Elizabeth W. Karlson2, 1Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, 4Epidemiology, Colorado School of Public Health, Aurora, CO, 5Benaroya Research Institute at Virginia Mason, Seattle, WA, 6Division of Rheumatology, Scripps Health, La Jolla, CA, 7Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 8Feinstein Insititute for Medical Research, Manhasset, NY, 9Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 10Veteran Affairs Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Family history of RA in a first-degree relative increases RA risk 4-fold. Determining risk factors for inflammatory joint signs (IJS) in this high risk…
  • Abstract Number: 319 • 2014 ACR/ARHP Annual Meeting

    Systemic Juvenile Idiopathic Arthritis and Exposure to Fine Particulate Air Pollution

    Andrew S. Zeft1, Sampath Prahalad2, Rayfel Schneider3, Alexei Grom4, Fatma Dedeoglu5, Pamela F. Weiss6, Carter Mix7 and C. Arden Pope8, 1Pediatrics, Rheumatology, The Cleveland Clinic, Cleveland, OH, 2Emory University, Atlanta, GA, 3Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 4Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5on behalf of CARRAnet Investigators, Palo Alto, CA, 6Rheumatology, The Children's Hospital of Philadelphia, Philadelphia, PA, 7Brigham Young University, Provo, UT, 8Economics, Brigham Young University, Provo, UT

    Background/Purpose: Environmental factors are understood to play a pathogenic role in the etiology of Systemic Onset Juvenile Idiopathic Arthritis (SJIA). Fine particulate matter (aerodynamic diameter…
  • Abstract Number: 59 • 2014 ACR/ARHP Annual Meeting

    Assessing Dietary Habits in a Large Cohort of Rheumatoid Arthritis and Psoriatic Arthritis Patients: Results of the Spanish Imid Consortium

    Maria López Lasanta1, Jesús Tornero2, Juan D. Cañete3, Antonio Fernandez Nebro4, Francisco Blanco5, Jesus Rodriguez6, Isidoro González-Alvaro7, Jordi Gratacós8, Joan Maymo9, Rubén Queiro10, Mercedes Alperi-López11, Carlos Montilla-Morales12, Benjamin Fernandez Gutierrez13, Juan Carlos Torre-Alonso14, Alejandro Olive15, Jose Javier Perez Venegas16, Hector Corominas17, Alba Erra18, Santiago Muñoz19, Carlos M. Gonzalez20, Daniel Roig21, Gabriela Avila1, Arnald Alonso1, Toni Julia1, Raül Tortosa1, Andrés Garcia Montero22 and Sara Marsal1, 1Rheumatology Research Group, Vall d'Hebron Hospital Research Institute, Barcelona, Spain, 2Hospital Universitario Guadalajara, Guadalajara, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 4Rheumatology, Hospital Regional Carlos Haya, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain, 5Complejo Hospitalario Juan Canalejo, A Coruña, Spain, 6Rheumatology, Hospital Universitari de Bellvitge, Barcelona, Spain, 7Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 8Hospital Parc Taulí, Sabadell, Spain, 9Rheumatology, Hospital del Mar, Barcelona, Spain, 10Rheumatology Department. Hospital Universitario Central de Asturias, Oviedo, Spain, 11Rheumatology Department, Hospital Universitario Central de Asturias, Oviedo, Spain, 12H. de Salamanca, Salamanca, Spain, 13Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 14Rheumatology Department, H. Monte Naranco, Oviedo, Spain, 15Rheumatology Service, Germans Trias Pujol Hospital, Barcelona, Spain, 16Rheumatology Department, Hospital del SAS Jerez de la Frontera, Cadiz, Spain, 17Rheumatology, Hospital de Sant Joan Despí Moisès Broggi, Barcelona, Spain, 18Rheumatology Department, Hospital Sant Rafael, Barcelona, Spain, 19Rheumatology Department, Hospital Infanta Sofia, Madrid, Spain, 20Rheumatology Department, Gregorio Marañon Hospital, Madrid, Spain, 21Rheumatology Service, Hospital Moisès Broggi,, Barcelona, Spain, 22Banco Nacional de ADN, Salamanca, Spain

    Background/Purpose: Rheumatoid arthritis (RA) and Psoriatic arthritis (PsA) are complex diseases of unknown etiology and its pathogenesis results from the combination of genetic susceptibility and…
  • Abstract Number: 2058 • 2014 ACR/ARHP Annual Meeting

    The Impact of Environmental Stress on Pain in Fibromyalgia Patients

    Robert S. Katz1, Ben J Small2 and Susan Shott3, 1Rush Medical College, Chicago, IL, 2MacNeal Hospital, Berwyn, IL, 3Rush University Medical Center, Chicago, IL

    Background/Purpose:  Many fibromyalgia syndrome (FMS) report that their illness is significantly affected by environmental stress. We compared FMS and RA patients with respect to the…
  • Abstract Number: 2008 • 2014 ACR/ARHP Annual Meeting

    Personalized Risk Education for Rheumatoid Arthritis Improves Self-Perceived Risk Accuracy and Risk Factor Knowledge in First-Degree Relatives

    Jeffrey A. Sparks1, Maura D. Iversen1,2,3, Rachel Miller Kroouze1,4, Nellie A. Triedman1, Taysir G. Mahmoud1, Sarah S. Kalia4, Michael L. Atkinson5, Robert C. Green4 and Elizabeth W. Karlson1, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 2Department of Physical Therapy, Movement & Rehabilitation Sciences, Northeastern University, Boston, MA, 3Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden, 4Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 5Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose Having a first-degree relative (FDR) with RA increases personal RA risk by four-fold. Other RA risk factors include demographics, genetics, auto-antibodies, and behaviors. We…
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