Session Type: Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Sunlight exposure has been associated with lower rheumatoid arthritis (RA) risk, but to our knowledge, no one has ever studied sunlight exposure and anti-citrullinated protein antibodies (ACPA). Our objective was to examine associations between sunlight exposure and ACPA using general population data from Quebec, Canada.
Methods: A random sample of 7600 individuals (including 786 positive ACPA subjects and 201 self-reported rheumatoid arthritis, RA cases) from the CARTaGENE cohort was studied cross-sectionally. All subjects were nested in four census metropolitan areas, and mixed effects logistic regression models were used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for ACPA positivity related to sunlight exposure, adjusting for sun-block use, industrial fine particulate matter (PM2.5) exposures, smoking, age, sex, French Canadian ancestry, and family income. We also performed sensitivity analyses excluding subjects with RA, defining ACPA positivity by higher titers, and stratifying by age.
Results: The adjusted ORs and 95% CIs did not suggest conclusive associations between ACPA and sunlight exposure or sun-block use, but robust positive relationships were observed between industrial PM2.5 emissions and ACPA (OR 1.19 per µg/m3, 95% CI 1.03 – 1.36 in primary analyses).
Conclusion: We did not see clear links between ACPA and sunlight exposure or sun-block use, but we did note positive associations with industrial PM2.5. Future studies of sunlight and RA (or ACPA) should consider taking air pollution exposures into account.
To cite this abstract in AMA style:Zhao N, Smargiassi A, Colmegna I, Hudson M, Fritzler M, Bernatsky S. Sunlight Exposure, Sun-protective Behaviour, and Anti-citrullinated Protein Antibody Positivity: A General Population-based Study in Quebec, Canada [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 10). https://acrabstracts.org/abstract/sunlight-exposure-sun-protective-behaviour-and-anti-citrullinated-protein-antibody-positivity-a-general-population-based-study-in-quebec-canada/. Accessed November 26, 2020.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/sunlight-exposure-sun-protective-behaviour-and-anti-citrullinated-protein-antibody-positivity-a-general-population-based-study-in-quebec-canada/