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Abstracts tagged "Environmental factors"

  • Abstract Number: 0739 • ACR Convergence 2021

    Contextual Factors Should Complete the Assessment of Functioning in Patients with Axial Spondyloarthritis (axSpA)

    Uta Kiltz1, Eerik Ahomaa2, Björn Buehring1, Xenofon Baraliakos1, David Kiefer1, Jaclyn-Dalisay Leicht1 and Jürgen Braun1, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2St. Franziskus-Hospital, Department of Orthopedic Surgery, Cologne, Germany

    Background/Purpose: Functioning of axSpA patients (pat.) is influenced by many factors, but how contextual factors influence functioning isn’t well studied. According to the International Classification…
  • Abstract Number: 0988 • ACR Convergence 2021

    Risk Prediction Models for Incident Systemic Lupus Erythematosus Using Lifestyle/Environmental Risk Factors and a Genetic Risk Score

    Jing Cui1, Susan Malspeis1, May Choi2, Bing Lu3, Jeffrey Sparks4, Kazuki Yoshida4 and Karen Costenbader5, 1Brigham Women's Hospital, Boston, MA, 2Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 3Brigham and Women's Hospital and Harvard Medical School, Newton, MA, 4Brigham and Women's Hospital, Boston, MA, 5Brigham and Women's Hospital, Belmont, MA

    Background/Purpose: The identification of lifestyle/environmental and genetic factors, influencing SLE risk introduces the potential to develop risk prediction models. We examined SLE risk prediction incorporating…
  • Abstract Number: 1021 • ACR Convergence 2021

    Organic Dust Exposure Induces Post-translational Protein Modifications and a HLA-DR4-dependent Pro-inflammatory Lung Phenotype in a Murine Model of Interstitial Lung Disease

    Jill Poole1, Ted Mikuls1, Amy Nelson1, Rohit Gaurav1, Michael Duryee1, Geoffrey Thiele1, Bryant England1 and Dana Ascherman2, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Environmental and occupational exposures have been epidemiologically linked to the development of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Previous investigation and modeling have also…
  • Abstract Number: 1023 • ACR Convergence 2021

    Racial and Ethnic Distribution of Rheumatic Diseases in Health Systems of the National Patient-Centered Clinical Research Network

    William Nowell1, Edward L. Barnes2, Nupur Parikh1, Shilpa Venkatachalam1, Michael Kappelman2, Jeffrey Curtis3, Peter Merkel4, Dianne Shaw5, Kalen Young5 and Michael George4, 1Global Healthy Living Foundation, Upper Nyack, NY, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 4University of Pennsylvania, Philadelphia, PA, 5Vasculitis Foundation, Kansas City, MO

    Background/Purpose: Ensuring adequate representation of racial/ethnic minorities in research necessitates understanding the prevalence of rheumatic and musculoskeletal diseases in these populations. We sought to evaluate…
  • Abstract Number: 1047 • ACR Convergence 2021

    Exposure to Industrial Pollutants and Mortality Due to Inmune-mediated Inflammatory Systemic Diseases (IMD) in Spain

    ana Perez1, Arturo Rodriguez Pérez2, Pablo Fernandez-Navarro3, Fernando Albarran4, Cristina Bohorquez4, Atusa Movasat4, Lucia Ruiz4, Paula Pretel4, elena Rabadan4, Valentina Emperiale4, Adrian abbasi5, julio suarez5, Lorena Montano4, emilio rico5, alfredo prieto2, melchor Alvarez de Mon5 and beatriz perez3, 1Hospital Universitario Príncipe de Asturias. Rheumatology. Medicine Faculty. Alcala University Department., Madrid, Spain, 2Faculty of Medicine. Alcala University, Alcala de Henares, Spain, 3Department of Epidemiology of Chronic Diseases.National Center of Epidemiology/CIBERESP. Instituto de Salud Carlos III, Madrid, Spain, 4Hospital Universitario Príncipe de Asturias, Rheumatology Department, Alcala de Henares, 5Hospital Universitario Príncipe de Asturias, Madrid, Spain

    Background/Purpose: The etiology of many IMD is largely unknown; however, available data suggest that environmental contaminants could play a role in their origin. Industrial facilities…
  • Abstract Number: 1772 • ACR Convergence 2021

    Autologous EBV-specific Cytotoxic T Cells in Systemic Lupus Erythematosus: An Innovative Phase I/IIa Clinical Trial

    Antoine Enfrein1, Beatrice Clemenceau2, Soraya Saiagh3, Céline Bressollette4, Zahir Amoura5, Henri Vie2 and Mohamed Hamidou1, 1Médecine interne, CHU de Nantes, Nantes, France, 2Inserm U1232, Université de Nantes, Nantes, France, 3Unité de Thérapie Cellulaire et Génique, CHU de Nantes, Nantes, France, 4Laboratoire de Virologie, CHU de Nantes, Nantes, France, 5Médecine interne, Hôpital Pitié Salpêtrière, AP-HP, Paris, France

    Background/Purpose: Epstein-Barr Virus (EBV) has been suggested as a potential environmental factor in systemic lupus erythematosus (SLE) onset and disease activity. Here, we report the…
  • Abstract Number: 1377 • ACR Convergence 2020

    Raynaud’s Phenomenon and Systemic Sclerosis in Post-9/11 Deployed Veterans Receiving Care Veterans Health Administration Care

    Tracy Frech1, Maureen Murtaugh1, Megan Amuan2 and Mary Jo Pugh1, 1University of Utah and Salt Lake Veterans Affair Medical Center, Salt Lake City, UT, 2Veterans Affair Medical Center, Salt Lake City, UT

    Background/Purpose: The purpose of this project was to describe Raynaud's phenomenon (RP), very early diagnosis of systemic sclerosis (VEDOSS), and systemic sclerosis (SSc) in Veterans…
  • Abstract Number: 1426 • ACR Convergence 2020

    Prevalence of ANCA-associated Vasculitis and Spatial Association with Quarries in a French Northeast Region: A Capture-recapture and Geospatial Analysis

    Stéphane Giorgiutti1, Yannick Dieudonné1, Olivier Hinschberger2, Benoit Nespola3, Julien Campagne4, Hanta Nirina Rakotoarivelo5, Thierry Hannedouche6, Bruno Moulin6, Gilles Blaison5, Jean-Christophe Weber7, Marie-Caroline Dalmas8, Frederic De Blay9, Dan Lipsker10, Francois Chantrel11, Jacques-Eric Gottenberg12, Yves Dimitrov13, Olivier Imhoff14, Pierre-Edouard Gavand15, Emmanuel Andres16, Christian Debry17, Yves Hansmann18, Alexandre Klein19, Caroline Lohmann20, François Mathiaux21, Aurélien Guffroy1, Vincent Poindron1, Thierry Martin1, Anne-Sophie Korganow1 and Laurent Arnaud22, 1Department of Clinical Immunology and Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 2Department of Internal Medicine, Hôpital Emile Muller, Mulhouse, Mulhouse, France, 3Department of Immunobiology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 4Department of Internal Medicine, Hôpitaux Privés de Metz, Metz, France, 5Department of Internal Medicine, Hôpitaux Civils de Colmar, Colmar, France, 6Department of Nephrology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 7Department of Internal Medicine, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 8Department of Internal Medicine Endocrinology and Nutrition, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 9Pneumology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 10Department of Dermatology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 11Department of Nephrology, Hôpital Emile Muller, Mulhouse, Strasbourg, France, 12Strasbourg University Hospital, Strasbourg, France, 13Department of Nephrology, Centre hospitalier de Haguenau, Haguenau, France, 14Department of Nephrology, Clinique Saint-Anne, Strasbourg, Strasbourg, France, 15Department of Internal Medicine, Clinique Rhena, Strasbourg, Strasbourg, France, 16Department of Internal Medicine, Diabete and Metabolic Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 17Department of Otorhinolaryngology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 18Department of Infectious Diseases, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 19Department of Nephrology, Hôpitaux Civils de Colmar, Colmar, France, 20Department of Microbiology, Hôpital Emile Muller, Mulhouse, Mulhouse, France, 21Department of Biology, Hôpitaux Civils de Colmar, Strasbourg, France, 22Department of Rheumatology, Hôpitaux Universitaires de Strasbourg, Strasbourg, France

    Background/Purpose: Studies addressing the epidemiology of ANCA-associated vasculitides (AAV) in different countries reported various prevalence rates and suggested that incidence may have increased over the…
  • Abstract Number: 1447 • ACR Convergence 2020

    Vitamin D Deficiency Enhances Antiphospholipid Antibody-Mediated Thrombosis in a Passive Immunization Mouse Model

    Rohan Willis1, Karen Roye-Green2, Zurina Romay-Penabad1, Elizabeth Papalardo1, Alvaro Schleh3, Vijaya Murthy4, Monica Smikle2 and Emilio Gonzalez1, 1University of Texas Medical Branch, Galveston, TX, 2University of the West Indies, Kingston, Jamaica, 3Antiphospholipid Standardization Laboratory, GALVESTON, TX, 4University of Texas Medical Branch, League City, TX

    Background/Purpose: Abnormal vitamin D levels occur frequently in antiphospholipid (APS) patients and are correlated with thrombosis. It remains unclear however if vitamin D deficiency observed…
  • Abstract Number: 1794 • ACR Convergence 2020

    Systemic Lupus Erythematosus and Geomagnetic Disturbances: A Time Series Analysis

    George Stojan1, Flavia Giammarino2 and Michelle Petri3, 1Johns Hopkins University, BALTIMORE, MD, 2Deutsche Bank, London, United Kingdom, 3Johns Hopkins University School of Medicine, Baltimore

    Background/Purpose: To examine the influence of solar cycle and geomagnetic effects on SLE disease activity.Methods: The data used for the analysis consisted of 327 observations…
  • Abstract Number: 1800 • ACR Convergence 2020

    Association of Air Pollution with Systemic Lupus Erythematosus Disease Activity in the Central Valley of California

    Mosaab Mohameden1, Ali H.Ali2, Zi Ying Li2, Yabsira Abejie3, Ratnali Jain2 and Candice Reyes Yuvienco4, 1University of Cincinnati College of Medicine, Cincinnati, OH, 2University of California San Francisco Fresno, Fresno, CA, 3Floyd B. Buchanan High School, Fresno, CA, 4University of California San Francisco Fresno, Clovis, CA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a complex multisystem autoimmune disease that affects at least 300,000 people in the United States creating a substantial socioeconomic…
  • Abstract Number: 1813 • ACR Convergence 2020

    A Comprehensive Method to Study Environmental Chemicals in Serum in Patients with SLE

    Cristina Lanata1, Kim Taylor2, James Hurst-Hopf1, Laura Trupin1, Patricia Katz3, Jinoos Yazdany1, Maria Dall'Era4, Dimitri Abrahamsson1, Lindsey Criswell5 and Roy Gerona1, 1UCSF, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA, 3University of California, San Francisco, Novato, CA, 4Division of Rheumatology, University of California, San Francisco, CA, 5Rosalind Russell/Ephraim P. Engleman Rheumatology Research Center, University of California San Francisco, San Francisco, CA

    Background/Purpose: Environmental exposures may play a substantial role in the pathogenesis of Systemic Lupus Erythematosus (SLE), however it has been challenging to measure and capture…
  • Abstract Number: 2037 • ACR Convergence 2020

    Geographic Distribution and Environmental Triggers of Systemic Sclerosis in Massachusetts

    Anastasiya Muntyanu1, Bina Kassamali2, Ruth Ann Vleugels3 and Avery LaChance3, 1McGill University, Montreal, QC, Canada, 2Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Systemic sclerosis (SSc) is a chronic autoimmune sclerosing disease with a 10-year survival rate of less than 65%. This rate has remained unchanged for…
  • Abstract Number: 0086 • ACR Convergence 2020

    Geographic Distribution of Eosinophilic Fasciitis Cases in Massachusetts and Associated Environmental Triggers

    Bina Kassamali1, Anastasiya Muntyanu2, Ruth Ann Vleugels3 and Avery LaChance3, 1Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 2McGill University, Montreal, QC, Canada, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Eosinophilic fasciitis (EF) is a rare fibrosing disorder of the fascia characterized by induration progressing proximally along the upper and lower extremities. Given the…
  • Abstract Number: 0091 • ACR Convergence 2020

    Helicobacter Pylori Infection, Autoimmune Disease and Paraproteinemia Influence the Presentation of a Cohort of 150 Pernicious Anemia Patients Diagnosed in a Rheumatology Clinic

    Michael Lovy1, Norma Daniela Aguirre Vega1 and Crystal Escobar1, 1Desert Oasis Healthcare, Palm Springs, CA

    Background/Purpose: The most familiar presentation of pernicious anemia is an elderly Northern European woman with hematologic and neurologic manifestations.  More recently the influence of Helicobacter…
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