ACR Meeting Abstracts

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Abstracts tagged "endothelial cells"

  • Abstract Number: 2425 • 2016 ACR/ARHP Annual Meeting

    The Vasculopathy of Juvenile Dermatomyositis (JDM); Evidence of Persistent Endothelial Injury, Hypercoagulability, Subclinical Inflammation and Increased Arterial Stiffness

    Charalampia Papadopoulou1,2, Ying Hong1, Petra Krol1,2, Yiannis Ioannou3, Clarissa Pilkington2,4,5, Hema Chaplin6, Stephanie Simou1, Marietta Charakida7, Lucy R Wedderburn5,8,9, Paul Brogan10 and Despina Eleftheriou1,8,11, 1Infection, Inflammation and Rheumatology, UCL Institute of Child Health, London, United Kingdom, 2Paediatric Rheumatology, Great Ormond Street Hospital NHS Trust, London, United Kingdom, 3Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology, UCL Division of Medicine, London, United Kingdom, 4Paediatric Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 5Infection, Inflammation and Rheumatology Section, UCL Institute of Child Health, London, United Kingdom, 6Centre for Adolescent Rheumatology, Arthritis Research UK, London, United Kingdom, 7Vascular Physiology Unit, Institute of Cardiovascular Science , University College London, London, United Kingdom, 8Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 9Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 10Department of Paediatric Rheumatology, UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 11Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom

    Background/Purpose:  Vasculopathy is considered central to the pathogenesis of Juvenile Dermatomyositis (JDM). The interplay between persistent JDM-vasculopathy, traditional cardiovascular risk factors, exposure to corticosteroids, and…
  • Abstract Number: 3018 • 2015 ACR/ARHP Annual Meeting

    Paracrine Effect of Proteins Secreted By Normal Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition on the Expression of Genes Associated with Tissue Fibrosis in Normal Human Lung Fibroblasts

    Sonsoles Piera-Velazquez1, Kerri Fasino2 and Sergio A. Jimenez3, 1Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, 3Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA

    Background/Purpose: Progressive tissue fibrosis and microvascular alterations are the hallmarks of Systemic Sclerosis (SSc). The mechanisms involved in SSc pathogenesis are complex and have not…
  • Abstract Number: 3015 • 2015 ACR/ARHP Annual Meeting

    Characterization of the Profibrotic/Antifibrotic Profile of microRNA Contained in Exosomes Isolated from Cultured Normal Human Dermal and Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition in Vitro

    Sergio A. Jimenez1, Sonsoles Piera-Velazquez2, Peter J. Wermuth3 and Kerri Fasino4, 1Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, 3Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 4Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by progressive fibrosis of skin and multiple internal organs, severe alterations in the microvasculature, and numerous immunological abnormalities. Recently…
  • Abstract Number: 3009 • 2015 ACR/ARHP Annual Meeting

    Fli1 Deficiency Contributes to the Downregulation of Endothelial Protein C Receptor in Systemic Sclerosis: A Possible Role in Pro-Thrombotic Condition

    Ryosuke Saigusa1, Yoshihide Asano2, Takashi Taniguchi2, Takashi Yamashita2, Takehiro Takahashi2, Yohei Ichimura2, Tetsuo Toyama2, Ayumi Yoshizaki2, Tomomitsu Miyagaki2, Makoto Sugaya2 and Shinichi Sato2, 17-3-1 Hongo, Bunkyo-ku, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by fibrosis of the skin and certain internal organs due to the constitutive activation…
  • Abstract Number: 2934 • 2015 ACR/ARHP Annual Meeting

    Endothelial Dysfunction in SLE-the Role of Platelets and Type I Interferon

    Helena Tydén1, Christian Lood2, Birgitta Gullstrand3, Andreas Jönsen4 and Anders A. Bengtsson5, 1Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 2Department of Clinical Sciences, Division of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 3Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital, Lund University, Lund, Sweden, 4Department of Rheumatology, Lund University Hospital, Lund, Sweden, 5Rheumatology, Inst of Clinical sciences, Lund, Sweden

    Background/Purpose: Type I interferon (IFN) may affect endothelial progenitor cells leading to endothelial dysfunction in SLE. SLE patients have a type I IFN signature in…
  • Abstract Number: 1919 • 2015 ACR/ARHP Annual Meeting

    Genetic Deletion of Toll-like Receptor 4 (Tlr4) Abrogates TGF-β1-Induced Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells

    Peter J. Wermuth1 and Sergio A. Jimenez2, 1Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology whose pathogenesis involves the regulation of a diverse range of molecular pathways. The…
  • Abstract Number: 1880 • 2015 ACR/ARHP Annual Meeting

    Circulating Microparticle Populations May Differentiate Between Connective Tissue Diseases. 

    Eoghan M. McCarthy1,2, Daniel Moreno-Martinez3, Fiona Wilkinson4, Neil J McHugh5,6, Ian N. Bruce7,8, Yvonne Alexander3, John D. Pauling6,9 and Ben Parker7,8, 1The University of Manchester, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Mmanchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom, 3Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 4School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, 5Rheumatology, Bath Institute of Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 6Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 7Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, 8Stopford Building, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 9Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom

     Background/Purpose: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). Circulating MPs levels are altered…
  • Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting

    Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype

    Robert Good1, Sarah L. Trinder2, Christopher P. Denton3, David Abraham4 and Alan M. Holmes1, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 4Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom

    Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…
  • Abstract Number: 591 • 2015 ACR/ARHP Annual Meeting

    Rosuvastatin Improves Endothelial Function in Patients with Inflammatory Joint Diseases, Longitudinal Associations with Atherosclerosis and Arteriosclerosis

    Eirik Ikdahl1, Jonny Hisdal2, Silvia Rollefstad1, Inge C Olsen3, Tore K. Kvien4, Terje R. Pedersen5 and Anne Grete Semb6, 1Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Section of Vascular Investigations, Oslo University Hospital Aker, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Department of Preventive Cardiology, Ullevaal University Hospital, Oslo, Norway, 6Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Endothelial dysfunction is an early step in the formation of atherosclerotic lesions and can be quantified by the degree of flow mediated vasodilation (FMD)…
  • Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting

    The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Thomas Dr. Umscheid3, Markus Prof. Dr. Schönburg4, Stefan Rehart5, Ulf Müller-Ladner2 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 3William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, 4Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 5Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
  • Abstract Number: 3085 • 2015 ACR/ARHP Annual Meeting

    Platelet Activation and Endothelial Reactivity in the Pathogenesis of Tissue Inflammation/Injury in Systemic Lupus Erythematosus

    Robert Clancy1, Sokha Nhek2, Jonathan Newman3, Janet Nwaukoni1, Sara Rasmussen4, Jill P. Buyon1, Maya Rubin5, Kristen Lee1 and Jeffrey Berger5, 1Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2New York University School of Medicine, New York, NY, 3Medicine, New York University School of Medicine, New York, NY, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 5Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at increased risk for widespread endothelial dysfunction, vascular thromboses, and premature cardiovascular disease.  Enhanced platelet activation and…
  • Abstract Number: 3003 • 2014 ACR/ARHP Annual Meeting

    Am80 Ameliorates Bleomycin-Induced Dermal Fibrosis By Suppressing the Pro-Fibrotic Phenotype of Fibroblasts, Endothelial Cells, and Immune Cells

    Tetsuo Toyama1, Yoshihide Asano1, Takehiro Takahashi1, Ryosuke Saigusa1, Yohei Ichimura1, Takashi Taniguchi1, Shinji Noda1, Kaname Akamata1, Shinichi Sato1, Takafumi Kadono1 and Koichi Shudo2, 1Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Reseach Foundation ITSUU Laboratory, Tokyo, Japan

    Background/Purpose:  Am80 is a synthetic retinoid serving as an agonist for retinoic acid receptor α/β with chemical and pharmacological advantages over all-trans retinoic acid, such…
  • Abstract Number: 2445 • 2014 ACR/ARHP Annual Meeting

    A Distinct Profile of Circulating Microparticles Is Associated with Disease Features in Rheumatoid Arthritis Patients and Impairs Endothelial Functionality in Vitro

    Javier Rodríguez-Carrio1, Mercedes Alperi-López2, Patricia López1, Sara Alonso-Castro2, Santiago Rubén Carro-Esteban1, Javier Ballina-García2 and Ana Suárez1, 1Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, 2Rheumatology Department, Hospital Universitario Central de Asturias, Oviedo, Spain

    Background/Purpose Cell-derived microparticles (MPs) could be considered biomarkers of cell damage and activation and they are thought to have a role in cardiovascular (CV) and inflammatory…
  • Abstract Number: 1980 • 2014 ACR/ARHP Annual Meeting

    Thrombospondin-1 Is Elevetad in the Plasma of Patients with Antiphospholipid Syndrome and Is Correlated with Soluble Fas Ligand and Free Active TGF-B levels

    Markos Patsouras1, Marina Sikara2, Athanasios G. Tzioufas2 and Panayiotis Vlachoyiannopoulos2, 1PATHOPHYSIOLOGY DEPARTMENT, UNIVERSITY OF ATHENS, School of Medicine, National University of Athens, Athens, Greece, 2Pathophysiology, School of Medicine, National University of Athens, Athens, Greece

    Background/Purpose Antiphospholipid syndrome (APS) is an acquired thombophillia characterized by recurrent thromboembolism and pregnancy morbidity. Thrombospondin (TSP-1) is a matricellular glycoprotein with antiangiogenic and proapoptotic…
  • Abstract Number: 1717 • 2014 ACR/ARHP Annual Meeting

    Endothelial to Mesenchymal Transition Contributes to the Development of Pulmonary Vasculopathy in Systemic Sclerosis PAH

    Robert Good1, Adrian Gilbane2, Sarah Trinder2, David Abraham3, Christopher Denton3 and Alan M. Holmes4, 1Rheumatology and Connective Tissue Diseases, UCL, LONDON, United Kingdom, 2Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 4Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom

    Background/Purpose Vascular complications in Scleroderma (SSc) patients are associated with high mortality, particularly in patients who develop pulmonary arterial hypertension (SSc-PAH). Vascular complications, thought to…
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