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Abstract Number: 2836

Microparticles of Endothelial  Origin in  Women with   Systemic LUPUS Erythematosus UNDER Treatment

WALTER CICARINI1, KARINE SILVESTRE FERREIRA1, Renato Vargas Consoli2, Claudia Lopes Santoro Neiva3, PAULO MADUREIRA PADUA4, ANA FLAVIA PADUA DIAS5, fernanda freire Campos Sr.6, LUAN CARLOS ALVES1, Cristina Mello Gomide Loures Sr.6, Marcos Ferreira Silva Sr.6, TANIA MARA PINTO DABES GUIMARAES1, Vicente Peixoto Toledo Sr.6 and MARIA DAS GRAÇAS CARVALHO1, 1Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte/MG, Brazil, 2Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte, Brazil, 3Rheumatology Unit, Santa Casa Hospital-Belo Horizonte- Bras, Belo Horizonte, Brazil, 4Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil., Belo Horizonte/MG, Brazil, 5Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte/MG, Brazil, 6Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte, Brazil

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: endothelial cells

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Session Information

Date: Tuesday, November 15, 2016

Session Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment - Poster III: Biomarkers and Nephritis

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Systemic Lupus Erythematosus (SLE) is an inflammatory and multisystem disease. Microparticles (MPs) are cell membrane-shedded fragments released during apoptosis and cell activation. Several diseases are associated with increased number of circulating MPs, and those from the endothelium (EMPs) can trigger neutrophil activation and stimulate coagulation. On the other hand, they act as potent proinflammatory inducers affecting the function of the endothelium. Objective: To determine the number of MPs of endothelial origin (EMPs) in women with SLE under treatment, compared to controls, as a tool to assess disease activity.

Methods:  This study included 90 women with similar age distributed into 3 groups: Group 1: healthy women (control, n=30); Group 2: SLE patients under treatment with low disease activity (SLEDAI < 4, n=30); Group 3: SLE patients under treatment with /moderate high disease activity (SLEDAI ≥4, n=30). EMPs were purified by ultracentrifugation, labeled with antibody anti-CD51 / 61 and anti – annexin V and then analysed by flow cytometry

Results: The number of EMPs was significantly higher in patients with SLE compared to the control group (p = 0.0178). When SLE patients were stratified according to the activity disease, the number of EMPs was significantly higher in SLE women with moderate / high activity compared to the control group (p = 0.0074). However, no difference was observed between the control group and SLE women with low activity disease. Correlations between the number of EMPs and age (r = -0.3385, P = 0.0123) and between the number of EMPs and SLEDAI (r = 0.2785, p = 0.0377) were observed.

Conclusion: Data from this study suggest that EMPs measurement may be an useful tool in the evaluation of patients with SLE and monitoring of treatment.


Disclosure: W. CICARINI, None; K. S. FERREIRA, None; R. Vargas Consoli, None; C. Lopes Santoro Neiva, None; P. M. PADUA, None; A. F. P. DIAS, None; F. freire Campos Sr., None; L. C. ALVES, None; C. Mello Gomide Loures Sr., None; M. Ferreira Silva Sr., None; T. M. P. D. GUIMARAES, None; V. Peixoto Toledo Sr., None; M. D. G. CARVALHO, None.

To cite this abstract in AMA style:

CICARINI W, FERREIRA KS, Vargas Consoli R, Lopes Santoro Neiva C, PADUA PM, DIAS AFP, freire Campos F Sr., ALVES LC, Mello Gomide Loures C Sr., Ferreira Silva M Sr., GUIMARAES TMPD, Peixoto Toledo V Sr., CARVALHO MDG. Microparticles of Endothelial  Origin in  Women with   Systemic LUPUS Erythematosus UNDER Treatment [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/microparticles-of-endothelial-origin-in-women-with-systemic-lupus-erythematosus-under-treatment/. Accessed January 27, 2021.
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