ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "endothelial cells"

  • Abstract Number: 1044 • 2019 ACR/ARP Annual Meeting

    TGF-β Isoforms Modulate the RNA Cargo of Extracellular Vesicles (Exosomes) Isolated from Cultured Normal Human Lung Microvascular Endothelial Cells: A Mechanistic Link Between Endothelial Cell Dysfunction and the Establishment of a Profibrotic Phenotype in SSc?

    Peter Wermuth1 and Sergio Jimenez 1, 1Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, Philadelphia, PA

    Background/Purpose: Extracellular vesicles (EV) are a diverse assortment of lipid bilayer-bound vesicles of various sizes and origin. Exosomes are a subset of EV arising from…
  • Abstract Number: 1074 • 2019 ACR/ARP Annual Meeting

    Epigenetic Regulation-Mediated Reduction in the Expression of Prostacyclin Receptor and Prostacyclin Synthase in Scleroderma Skin, Vascular Smooth Muscle Cells, and Microvascular Endothelial Cells

    Yongqing Wang 1, nezam Altorok 2 and Bashar Kahaleh2, 1University of Toeldo, TOLEDO, OH, 2University of Toledo, Toledo, OH

    Background/Purpose: Progressive functional and structural vascular disorder is one of the hallmark features of Systemic Sclerosis (Scleroderma, SSc). Vascular dysfunction lead to dysregulated vascular tone…
  • Abstract Number: 1789 • 2019 ACR/ARP Annual Meeting

    Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation

    Ramadan Ali1, Hui Shi 1, Srilakshmi Yalavarthi 1 and Jason Knight 2, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI

    Background/Purpose: Defibrotide is a mixture of phosphodiester oligonucleotides derived from porcine intestinal mucosa, currently approved for treatment of hepatic sinusoidal obstruction syndrome. Defibrotide has been…
  • Abstract Number: 1868 • 2019 ACR/ARP Annual Meeting

    Clinical Correlations of Autoantibodies Against Heat Shock Cognate 71 kDa Protein in Patients with Juvenile Dermatomyositis

    Rie Karasawa1, James N. Jarvis 2, Toshiko Sato 1, Megumi Tanaka 1, Mark Hicar 2, Kazuo Yudoh 1, Terrance O’Hanlon 3, Payam Noroozi-Farhadi 3 and Lisa G. Rider 4, 1Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, 2University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, 3NIEHS, NIH, Bethesda, MD, 4Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Bethesda, MD

    Background/Purpose: Juvenile dermatomyositis (JDM) is an inflammatory myopathy characterized by prominent vascular and perivascular inflammation in affected skeletal muscles. The mechanisms of vessel injury in…
  • Abstract Number: 1962 • 2019 ACR/ARP Annual Meeting

    Whole Transcriptome Analysis Maps Proinflammatory and Procoagulant Pathways in aPL Treated HUVECs

    Markos Patsouras 1, Panagiota Karagianni 1, Marios Agelopoulos 2, Spyros Foutadakis 2, Eirini Alexopoulou 2 and Panagiotis Vlachoyiannopoulos3, 1Department of Pathophysiology, Medical School, National and Kapodistrian University of Athens, Greece, Athens, 2Biomedical Research Foundation, Academy of Athens, ATHENS, 3University General Hospital of Athens “Laiko”, Athens, Greece

    Background/Purpose: Antiphospholipid syndrome is an autoimmune thrombophillia characterized by recurrent thromboembolism and or pregrancy morbidity in the presence of antiphospholipid antibodies (aPL), which recognize either…
  • Abstract Number: 2438 • 2019 ACR/ARP Annual Meeting

    Autoantibody Mediated Salivary Gland Hypofunction in Sjögren’s Syndrome Involves Activation of Innate Immunity and Endothelial Cells

    Harini Bagavant 1, Joanna Papinska 1, Marta Trzeciak 2, Indranil Biswas 1, Nataliya Smith 2, Debra Saunders 2, Rheal Towner 2 and Umesh Deshmukh1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City

    Background/Purpose: The presence of autoantibodies reactive against the Ro52/TRIM21 protein is a hallmark of Sjögren’s syndrome. We have reported that Ro52-immunized mice develop IgG deposits…
  • Abstract Number: 2075 • 2018 ACR/ARHP Annual Meeting

    Vascular Endothelial and Inflammatory Differences in Psoriasis and Psoriatic Arthritis Patients

    Michael Gashick1, Todd Wechter2, Tessa Barrett1, Sarah Azarchi2, Stuart Katz3, Andrea L. Neimann4, James Krueger5, Sanja Jelic6, Edward Fisher1, Jose U. Scher7 and Jeffrey S. Berger8, 1Medicine/Cardiology, New York University School of Medicine, New York City, NY, 2Dermatology, New York University School of Medicine, New York City, NY, 3Medicine/Cardiology, New York University School of Medicine, New York, NY, 4Department of Dermatology, New York University School of Medicine, New York, NY, 5The Rockefeller University, New York, NY, 6Medicine/Pulmonary, Columbia University Medical Center, New York City, NY, 7New York University School of Medicine, New York, NY, 8Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Psoriatic arthritis (PsA) and Psoriasis (PsO) are chronic inflammatory diseases associated with vascular inflammation and increased CVD risk. Few studies have examined vascular inflammatory…
  • Abstract Number: 2076 • 2018 ACR/ARHP Annual Meeting

    Transmembrane TNF (tmTNF) Transgenic Mice Exhibit Enlarged Lymph Nodes and Elevated Numbers of High Endothelial Cells Associated with Increased Lymphocyte Recruitment

    Kim Jeucken1, Jan Piet van Hamburg2, Merlijn Kaaij3, Leonie van Duivenvoorde3, Dominique Baeten3 and Sander W. Tas2, 12Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Amsterdam Rheumatology & immunology Center | Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: The NF-κB family of transcription factors plays a crucial role in chronic inflammatory diseases and can be activated via two distinct pathways. Non-canonical NF-κB…
  • Abstract Number: 92 • 2018 ACR/ARHP Annual Meeting

    Lupus Nephritis Serum Induces Neutrophil Chemotaxis Towards Glomerular Endothelial Cells in Vitro

    Dayvia Russell1, Margaret Markiewicz2, Xian Zhang2 and Jim C. Oates3, 1Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, 2Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC

    Title: Lupus Nephritis Serum Induces Neutrophil Chemotaxis towards Glomerular Endothelial Cells In Vitro Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with…
  • Abstract Number: 2010 • 2018 ACR/ARHP Annual Meeting

    Anti-Endothelial Cell Antibodies in Pediatric Rheumatic Diseases

    Rie Karasawa1, Toshiko Sato1, Megumi Tanaka1, Mayumi Tamaki1, Kazuo Yudoh1 and James Jarvis2, 1Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan, 2Pediatrics, University at Buffalo Jacobs School of Medicine & Biomedical Sciences, Buffalo, NY

    Background/Purpose: Anti-endothelial cell antibodies (AECA) are antibodies detected in multiple autoimmune and inflammatory diseases. Increased levels of such antibodies may be involved in disease activity…
  • Abstract Number: 8 • 2017 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Leukocytes Demonstrate Increased Adhesive Potential:  a Search for Novel Therapeutic Targets

    Gautam Sule1, William J. Kelley1, Srilakshmi Yalavarthi1, Alison Banka1, Omolola Eniola-Adefeso1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: Adhesion of leukocytes to the endothelium is an initiating event in the thrombosis inherent to antiphospholipid syndrome (APS). Over the years, a number of…
  • Abstract Number: 686 • 2017 ACR/ARHP Annual Meeting

    Endothelial Dysfunction in Systemic Lupus Erythematosus Patients without Cardiovascular events and Risk Factors: Correlation with Microvascular Alterations and angiogenic t Cells

    Ilaria Cavazzana1, Mara Taraborelli2, Silvia Piantoni3, Ivano Bonadei4, Edoardo Sciatti5, Micaela Fredi6, Marco Metra4, Angela Tincani7, Franco Franceschini1 and Enrico Vizzardi4, 1Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, 2Internal Medicine; Ospedale Mellini, Chiari (Brescia), Italy, 3Rheumatology and Clinical Immunology Unit, Spedali Civili, University of Brescia, Brescia, Italy, 4Cardiology Unit, Spedali Civili, University of Brescia, Brescia, Italy, 5Cardiology Unit, Spedali Civili, University of Brescia, Brsecia, Italy, 6Department of Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, 7Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy

    Background/Purpose: early identification of subclinical cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients is mandatory to reduce morbidity and mortality. Endothelial dysfunction (ED) is…
  • Abstract Number: 754 • 2017 ACR/ARHP Annual Meeting

    Interferon Siganture in Systemic Sclerosis Lung Microvascular Endothelial Cells

    Fabian A Mendoza1, Sonsoles Piera-Velazquez2, Peter J. Wermuth3, Sankar Addya4, Carol A. Feghali-Bostwick5 and Sergio A. Jimenez6, 1Rheumatology Division, Department of Medicine, Thomas Jefferson University, Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine and Scleroderma Center., Thomas Jefferson University, Philadelphia, PA, 3Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 4Kimmel Cancer Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, 5Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 6Scleroderma Center and Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by severe fibroproliferative vasculopathy, exaggerated deposition of extracellular matrix molecules (ECM) in skin and multiple internal organs, and alterations…
  • Abstract Number: 755 • 2017 ACR/ARHP Annual Meeting

    Genome-Wide DNA Methylation Pattern in Systemic Sclerosis Microvascular Endothelial Cells:  Identification of Epigenetically Affected Key Genes and Pathways

    Shadia Nada1, Ibtissam Gad2, Ali Alqahtani3, Ahmad Assaly2, Sadik Khuder4, Yongqing Wang5, Bashar Kahaleh1 and Nezam Altorok1, 1Medicine/Rheumatology, University of Toledo, Toledo, OH, 2University of Toledo, Toledo, OH, 3Internal Medicine, University of Toledo, Toledo, OH, 4Department of Medicine, University of Toledo, Toledo, OH, 5Medicine, University of Toledo, Toledo, OH

    Background/Purpose: The etiology of systemic sclerosis (SSc) is not clear, but there is evidence suggesting a critical role for epigenetic alterations in disease pathogenesis and…
  • Abstract Number: 939 • 2017 ACR/ARHP Annual Meeting

    Stimulator of Interferon Genes (STING)-Induced Endothelial-Mesenchymal Transition (EndMT) Contributes to Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI) Patients

    Louise Malle1, Dan Yang2, Adriana Almeida de Jesus1, Guibin Chen2, Bernadette Marrero1, Gina A. Montealegre Sanchez1, Yin Liu3, Gregor Dueckers4, Suzanne Ramsey5, Joseph Fontana6, Rachel VanTries1, Yan Huang1, Laisa Santiago7, Benito Gonzalez8, Paul Brogan9, Juergen Brunner10, Ebun Omoyinmi11, Athimalaipet V. Ramanan12, Amy Paller13, Olcay Y. Jones14, Seza Ozen15, Stephen R. Brooks16, Manfred Boehm17 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 2Center for Molecular Medicine, NHLBI/NIH, Bethesda, MD, 3Scientific Review Branch, NIAMS/NIH, Bethesda, MD, 4Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, 5Pediatric Rheumatology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada, 6Cardiovascular and Pulmonary Branch, NHLBI/NIH, Bethesda, MD, 7Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, 8Luis Calvo Mackenna Hospital, Santiago, Chile, 9Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 10Division of Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria, 11University College London Institute of Child Health, London, United Kingdom, 12Bristol Royal Hospital for Children, Bristol, United Kingdom, 13Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IN, 14Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 15Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 16Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, 17Center for Molecular Medicine, NHLBI/ NIH, Bethesda, MD

    Background/Purpose: Pulmonary fibrosis, is a life-threatening complication of the monogenic autoinflammatory interferonopathy, STING-Associated Vasculopathy with onset in Infancy (SAVI) that is caused by gain-of-function mutations…
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ACR Pediatric Rheumatology Symposium 2020

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