ACR Meeting Abstracts

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Abstracts tagged "endothelial cells"

  • Abstract Number: 967 • 2017 ACR/ARHP Annual Meeting

    NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium

    Paulina Kucharzewska1, Chrissta Maracle2, Jan Piet van Hamburg2, Kim Jeucken2, Henric Olsson1 and Sander W. Tas3, 1Bioscience, AstraZeneca, Göteborg, Sweden, 22Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
  • Abstract Number: 1061 • 2017 ACR/ARHP Annual Meeting

    Cardiac Endothelial Cell Transcriptome Analyses Support a Pathological Role of Metabolic and Inflammasome Genes in Anti-SSA/Ro-Associated Congenital Heart Block

    Sara Rasmussen1, Robert M. Clancy2 and Jill P. Buyon2, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2NYU School of Medicine, New York, NY

    Background/Purpose: The role of Type I IFN in anti-SSA/Ro-associated Congenital Heart Block (CHB) may include an adverse consequence to the cardiac vasculature. One scenario consistent…
  • Abstract Number: 1923 • 2017 ACR/ARHP Annual Meeting

    Single Cell RNA Sequencing Reveals a Signature of Endothelial Injury in Scleroderma Skin

    Sokratis Apostolidis1, Giuseppina Stifano2, Tracy Tabib3, Lisa Rice2, Christina Morse3, Bashar Kahaleh4 and Robert A. Lafyatis3, 1Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Boston University School of Medicine, Boston, MA, 3Medicine, Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 4Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: Vascular injury is a hallmark event in the pathogenesis of Systemic Sclerosis (SSc). Endothelial dysfunction happens early in the course of the disease and…
  • Abstract Number: 2143 • 2017 ACR/ARHP Annual Meeting

    Circulating Endothelial Cells and Endothelial Activation Markers As Disease Activity Measures in Idiopathic Inflammatory Myopathies

    Takayuki Kishi1, Jonathan Chipman1, Maryalice Stetler-Stevenson2, Khanh Nghiem3, Melvina Evereklian1, Margaret E. Rick3, Frederick W Miller1 and Lisa G Rider1, 1Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 2Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 3Coagulation Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD

    Background/Purpose: The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases with chronic muscle inflammation and microvasculopathy of muscle and skin capillaries. Circulating endothelial cells (CECs),…
  • Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting

    Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells

    Kaiyu Jiang1, Zihua Hu2, Rie Karasawa3, Yanmin Chen1 and James Jarvis4, 1Pediatrics, University at Buffalo, Buffalo, NY, 2Center for Computational Research, University at Buffalo, Buffalo, NY, 3Institute of Medical Science, St. Marianna University School of Medicine, Japan, Kawasaki, Japan, 4Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY

    Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…
  • Abstract Number: 2813 • 2017 ACR/ARHP Annual Meeting

    Interferon-Induced APOL1 over-Expression Causes Autophagic Dysfunction and Mitochondrial Stress in Risk Variant-Carrying Endothelial Cells

    Ashira Blazer1, Sara Rasmussen2, Androo Markham3, Shilpi Mehta-Lee4, Jill P. Buyon4 and Robert M. Clancy2, 1Division of Rheumatology, NYU School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY, 4NYU School of Medicine, New York, NY

    Background/Purpose: In SLE Apolipoprotein L1 (APOL1) risk variants (RV) associate with cardiovascular and end stage renal disease. APOL1 induction initially promotes cellular maintenance through autophagy;…
  • Abstract Number: 2700 • 2016 ACR/ARHP Annual Meeting

    The Lymphatic System: A Gatekeeper for Migration of Pathogenic T-Cells Towards Synovial Joints and Entheses in Psoriasis

    Radjesh Bisoendial1,2, Errol Prens3, Annemarie Mus2, Patrick Asmawidjaja2, Nadine Davelaar2, Arien Hofman4, Jean-Bart Jaquet4, Mieke Hazes2, Marc Kok1, Wolfgang Weninger5 and Erik Lubberts2, 1Clinical Immunology and Rheumatology, Maasstad hospital, Rotterdam, Netherlands, 2Rheumatology, Erasmus University Medical Center, Rotterdam, Netherlands, 3Dermatology, Erasmus University medical Center, Rotterdam, Netherlands, 4Plastic surgery, Maasstad hospital, Rotterdam, Netherlands, 5Immune imaging, The Centenary Institute, Sydney, Australia

    Background/Purpose: Psoriasis (PsO) is a common inflammatory skin disease that is characterized by acanthosis, impaired immune cell migration, and remodeling of the vascular and lymphatic…
  • Abstract Number: 2836 • 2016 ACR/ARHP Annual Meeting

    Microparticles of Endothelial  Origin in  Women with   Systemic LUPUS Erythematosus UNDER Treatment

    WALTER CICARINI1, KARINE SILVESTRE FERREIRA1, Renato Vargas Consoli2, Claudia Lopes Santoro Neiva3, PAULO MADUREIRA PADUA4, ANA FLAVIA PADUA DIAS5, fernanda freire Campos Sr.6, LUAN CARLOS ALVES1, Cristina Mello Gomide Loures Sr.6, Marcos Ferreira Silva Sr.6, TANIA MARA PINTO DABES GUIMARAES1, Vicente Peixoto Toledo Sr.6 and MARIA DAS GRAÇAS CARVALHO1, 1Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte/MG, Brazil, 2Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte, Brazil, 3Rheumatology Unit, Santa Casa Hospital-Belo Horizonte- Bras, Belo Horizonte, Brazil, 4Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil., Belo Horizonte/MG, Brazil, 5Rheumatology Unit, Santa Casa Hospital, Belo Horizonte, Brazil, Belo Horizonte/MG, Brazil, 6Department of Clinical and Toxicological Analysis, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is an inflammatory and multisystem disease. Microparticles (MPs) are cell membrane-shedded fragments released during apoptosis and cell activation. Several diseases are…
  • Abstract Number: 2876 • 2016 ACR/ARHP Annual Meeting

    SLE Serum Impairs NO Production in Huvecs through Induction of eNOS Uncoupling

    Jim Oates1,2, Diane L. Kamen3 and Joy N Jones Buie4, 1Medical Service, Ralph H. Johnson VAMC, Charleston, SC, 2Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 3Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 4Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Systemic lupus erythematosus (SLE) induces endothelial cell dysfunction (ECD) that can manifest as glomerulonephritis or atherosclerosis. Lupus-prone mice lacking endothelial nitric oxide synthase (eNOS,…
  • Abstract Number: 477 • 2016 ACR/ARHP Annual Meeting

    Conventional Non-Steroidal Anti-Inflammatory Drugs, but Not COX2 Selective Inhibitors, Are Beneficial on Vascular Function in Arthritis: A Study in Adjuvant Induced Arthritis

    Frank Verhoeven1, Clément Prati2, Katy Maguin-Gaté1, Perle Totoson1, Daniel Wendling3 and Céline Demougeot1, 1EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, 2FDE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, 3Service de Rhumatologie, CHU Jean Minjoz, Besancon, France

    Background/Purpose: (RA) is associated with an increase in cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial dysfunction. Non-steroidal…
  • Abstract Number: 1127 • 2016 ACR/ARHP Annual Meeting

    Extracellular Macrophage Migration Inhibitory Factor Is Essential for Hypoxia-Induced Angiogenesis in a Hypoxia Inducible Factor Independent Manner

    Mathias Mursell1,2, Martin Hahne1,2,3, Peggy Kunath1,2, Cindy Strehl1,2, Paula Hoff1,2, Frank Buttgereit2 and Timo Gaber1,2, 1German Rheumatism Research Center (DRFZ), Berlin, Germany, 2Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

    Background/Purpose: Angiogenesis is a hallmark of the pathogenesis of rheumatoid arthritis (RA) but also of other inflammatory processes, tissue regeneration and progressing tumors. In RA,…
  • Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting

    Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation

    Carlos Perez-Sanchez1, Maria Ángeles Aguirre Zamorano1, María Galindo2, Patricia Ruiz-Limon3, Ivan Arias de la Rosa3, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Pedro Segui1, Eduardo Collantes-Estévez1, Maria Jose Cuadrado4 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
  • Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting

    Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Markus Prof. Dr. Schönburg3, Stefan Prof. Dr. Rehart4, Ulf Müller-Ladner5,6 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 3Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 4Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 6Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
  • Abstract Number: 2154 • 2016 ACR/ARHP Annual Meeting

    Novel Pathogenic Functions of IL-11 on RA Joint Fibroblasts and Endothelial Cells

    Hatem A. Elshabrawy1,2, Abdul B. Essani1,2, Zhenlong Chen1, Michael Volin3, Iain B McInnes4, Seung-jae Kim2,5 and Shiva Shahrara2,6, 1Medicine, University of Illinois at Chicago, Chicago, IL, 2Jesse Brown VA Medical Center, Chicago, IL, 3Midwestern University, Downers Grove, IL, 4University of Glasgow, Glasgow, Great Britain, 5University of Illinois at Chicago, Chicago, IL, 6Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 2.5 millions of Americans. Several cytokines are involved in RA pathogenesis and may serve as…
  • Abstract Number: 2287 • 2016 ACR/ARHP Annual Meeting

    Serum Urate and Its Association with Endothelial Dysfunction in Young Adults

    Michael B. Saddekni1, Kenneth G. Saag1, Tanja Dudenbostel2, Suzanne Oparil2, David A. Calhoun2, Daniel I. Feig3, Paul M. Muntner4, David T. Redden5, Phillip J. Foster1, Elizabeth J. Rahn1, Stephanie R. Biggers1, Peng Li5 and Angelo L. Gaffo1, 1Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, 3Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 4Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 5Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Both serum urate (sUA) and endothelial dysfunction have been associated with hypertension and cardiovascular disease. Increasing sUA level has been associated with endothelial dysfunction…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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