ACR Meeting Abstracts

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Abstracts tagged "endothelial cells"

  • Abstract Number: 939 • 2017 ACR/ARHP Annual Meeting

    Stimulator of Interferon Genes (STING)-Induced Endothelial-Mesenchymal Transition (EndMT) Contributes to Interstitial Lung Disease in Sting-Associated Vasculopathy with Onset in Infancy (SAVI) Patients

    Louise Malle1, Dan Yang2, Adriana Almeida de Jesus1, Guibin Chen2, Bernadette Marrero1, Gina A. Montealegre Sanchez1, Yin Liu3, Gregor Dueckers4, Suzanne Ramsey5, Joseph Fontana6, Rachel VanTries1, Yan Huang1, Laisa Santiago7, Benito Gonzalez8, Paul Brogan9, Juergen Brunner10, Ebun Omoyinmi11, Athimalaipet V. Ramanan12, Amy Paller13, Olcay Y. Jones14, Seza Ozen15, Stephen R. Brooks16, Manfred Boehm17 and Raphaela Goldbach-Mansky1, 1Translational Autoinflammatory Disease Studies (TADS), Laboratory of Clinical Investigation and Microbiology (LCIM), NIAID/NIH, Bethesda, MD, 2Center for Molecular Medicine, NHLBI/NIH, Bethesda, MD, 3Scientific Review Branch, NIAMS/NIH, Bethesda, MD, 4Helios Kliniken - Kinderklinik, HELIOS Klinikum Krefeld, Krefeld, Germany, 5Pediatric Rheumatology, IWK Health Centre, Dalhousie University, Halifax, NS, Canada, 6Cardiovascular and Pulmonary Branch, NHLBI/NIH, Bethesda, MD, 7Johns Hopkins All Children's Hospital Rheumatology, Saint Petersburg, FL, 8Luis Calvo Mackenna Hospital, Santiago, Chile, 9Infection Inflammation and Rheumatology, UCL Institute of Child Health, and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 10Division of Pediatric Rheumatology, Medical University Innsbruck, Innsbruck, Austria, 11University College London Institute of Child Health, London, United Kingdom, 12Bristol Royal Hospital for Children, Bristol, United Kingdom, 13Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IN, 14Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, 15Department of Pediatrics, Division of Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 16Biodata Mining and Discovery Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, 17Center for Molecular Medicine, NHLBI/ NIH, Bethesda, MD

    Background/Purpose: Pulmonary fibrosis, is a life-threatening complication of the monogenic autoinflammatory interferonopathy, STING-Associated Vasculopathy with onset in Infancy (SAVI) that is caused by gain-of-function mutations…
  • Abstract Number: 967 • 2017 ACR/ARHP Annual Meeting

    NF-κb-Inducing Kinase Regulates LTβR-Driven NF-κb Signaling and Inflammatory Activation of Endothelium

    Paulina Kucharzewska1, Chrissta Maracle2, Jan Piet van Hamburg2, Kim Jeucken2, Henric Olsson1 and Sander W. Tas3, 1Bioscience, AstraZeneca, Göteborg, Sweden, 22Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, ARC | Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are characterized by neovascularization and often contain tertiary lymphoid structures with characteristic features of…
  • Abstract Number: 1061 • 2017 ACR/ARHP Annual Meeting

    Cardiac Endothelial Cell Transcriptome Analyses Support a Pathological Role of Metabolic and Inflammasome Genes in Anti-SSA/Ro-Associated Congenital Heart Block

    Sara Rasmussen1, Robert M. Clancy2 and Jill P. Buyon2, 1Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 2NYU School of Medicine, New York, NY

    Background/Purpose: The role of Type I IFN in anti-SSA/Ro-associated Congenital Heart Block (CHB) may include an adverse consequence to the cardiac vasculature. One scenario consistent…
  • Abstract Number: 1923 • 2017 ACR/ARHP Annual Meeting

    Single Cell RNA Sequencing Reveals a Signature of Endothelial Injury in Scleroderma Skin

    Sokratis Apostolidis1, Giuseppina Stifano2, Tracy Tabib3, Lisa Rice2, Christina Morse3, Bashar Kahaleh4 and Robert A. Lafyatis3, 1Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Boston University School of Medicine, Boston, MA, 3Medicine, Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 4Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: Vascular injury is a hallmark event in the pathogenesis of Systemic Sclerosis (SSc). Endothelial dysfunction happens early in the course of the disease and…
  • Abstract Number: 2143 • 2017 ACR/ARHP Annual Meeting

    Circulating Endothelial Cells and Endothelial Activation Markers As Disease Activity Measures in Idiopathic Inflammatory Myopathies

    Takayuki Kishi1, Jonathan Chipman1, Maryalice Stetler-Stevenson2, Khanh Nghiem3, Melvina Evereklian1, Margaret E. Rick3, Frederick W Miller1 and Lisa G Rider1, 1Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, 2Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 3Coagulation Laboratory, Clinical Center, National Institutes of Health, Bethesda, MD

    Background/Purpose: The idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases with chronic muscle inflammation and microvasculopathy of muscle and skin capillaries. Circulating endothelial cells (CECs),…
  • Abstract Number: 2338 • 2017 ACR/ARHP Annual Meeting

    Plasma Exosomes from Children with Juvenile Dermatomyositis Are Taken up By Human Aortic Endothelial Cells and Are Associated with Altered Gene Expression in Those Cells

    Kaiyu Jiang1, Zihua Hu2, Rie Karasawa3, Yanmin Chen1 and James Jarvis4, 1Pediatrics, University at Buffalo, Buffalo, NY, 2Center for Computational Research, University at Buffalo, Buffalo, NY, 3Institute of Medical Science, St. Marianna University School of Medicine, Japan, Kawasaki, Japan, 4Department of Genetics, Genomics & Bioinformatics, University at Buffalo, Buffalo, NY

    Background/Purpose: The pathology of juvenile dermatomyositis (JDM) is characterized by prominent vessel wall and perivascular inflammation. This feature of the disease has remained unexplained and…
  • Abstract Number: 2813 • 2017 ACR/ARHP Annual Meeting

    Interferon-Induced APOL1 over-Expression Causes Autophagic Dysfunction and Mitochondrial Stress in Risk Variant-Carrying Endothelial Cells

    Ashira Blazer1, Sara Rasmussen2, Androo Markham3, Shilpi Mehta-Lee4, Jill P. Buyon4 and Robert M. Clancy2, 1Division of Rheumatology, NYU School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY, 4NYU School of Medicine, New York, NY

    Background/Purpose: In SLE Apolipoprotein L1 (APOL1) risk variants (RV) associate with cardiovascular and end stage renal disease. APOL1 induction initially promotes cellular maintenance through autophagy;…
  • Abstract Number: 8 • 2017 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Leukocytes Demonstrate Increased Adhesive Potential:  a Search for Novel Therapeutic Targets

    Gautam Sule1, William J. Kelley1, Srilakshmi Yalavarthi1, Alison Banka1, Omolola Eniola-Adefeso1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: Adhesion of leukocytes to the endothelium is an initiating event in the thrombosis inherent to antiphospholipid syndrome (APS). Over the years, a number of…
  • Abstract Number: 477 • 2016 ACR/ARHP Annual Meeting

    Conventional Non-Steroidal Anti-Inflammatory Drugs, but Not COX2 Selective Inhibitors, Are Beneficial on Vascular Function in Arthritis: A Study in Adjuvant Induced Arthritis

    Frank Verhoeven1, Clément Prati2, Katy Maguin-Gaté1, Perle Totoson1, Daniel Wendling3 and Céline Demougeot1, 1EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, 2FDE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, 3Service de Rhumatologie, CHU Jean Minjoz, Besancon, France

    Background/Purpose: (RA) is associated with an increase in cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial dysfunction. Non-steroidal…
  • Abstract Number: 1127 • 2016 ACR/ARHP Annual Meeting

    Extracellular Macrophage Migration Inhibitory Factor Is Essential for Hypoxia-Induced Angiogenesis in a Hypoxia Inducible Factor Independent Manner

    Mathias Mursell1,2, Martin Hahne1,2,3, Peggy Kunath1,2, Cindy Strehl1,2, Paula Hoff1,2, Frank Buttgereit2 and Timo Gaber1,2, 1German Rheumatism Research Center (DRFZ), Berlin, Germany, 2Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

    Background/Purpose: Angiogenesis is a hallmark of the pathogenesis of rheumatoid arthritis (RA) but also of other inflammatory processes, tissue regeneration and progressing tumors. In RA,…
  • Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting

    Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation

    Carlos Perez-Sanchez1, Maria Ángeles Aguirre Zamorano1, María Galindo2, Patricia Ruiz-Limon3, Ivan Arias de la Rosa3, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Pedro Segui1, Eduardo Collantes-Estévez1, Maria Jose Cuadrado4 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
  • Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting

    Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Markus Prof. Dr. Schönburg3, Stefan Prof. Dr. Rehart4, Ulf Müller-Ladner5,6 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 3Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 4Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 6Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
  • Abstract Number: 2154 • 2016 ACR/ARHP Annual Meeting

    Novel Pathogenic Functions of IL-11 on RA Joint Fibroblasts and Endothelial Cells

    Hatem A. Elshabrawy1,2, Abdul B. Essani1,2, Zhenlong Chen1, Michael Volin3, Iain B McInnes4, Seung-jae Kim2,5 and Shiva Shahrara2,6, 1Medicine, University of Illinois at Chicago, Chicago, IL, 2Jesse Brown VA Medical Center, Chicago, IL, 3Midwestern University, Downers Grove, IL, 4University of Glasgow, Glasgow, Great Britain, 5University of Illinois at Chicago, Chicago, IL, 6Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 2.5 millions of Americans. Several cytokines are involved in RA pathogenesis and may serve as…
  • Abstract Number: 2287 • 2016 ACR/ARHP Annual Meeting

    Serum Urate and Its Association with Endothelial Dysfunction in Young Adults

    Michael B. Saddekni1, Kenneth G. Saag1, Tanja Dudenbostel2, Suzanne Oparil2, David A. Calhoun2, Daniel I. Feig3, Paul M. Muntner4, David T. Redden5, Phillip J. Foster1, Elizabeth J. Rahn1, Stephanie R. Biggers1, Peng Li5 and Angelo L. Gaffo1, 1Department of Medicine, Division of Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL, 3Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, 4Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 5Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Both serum urate (sUA) and endothelial dysfunction have been associated with hypertension and cardiovascular disease. Increasing sUA level has been associated with endothelial dysfunction…
  • Abstract Number: 2425 • 2016 ACR/ARHP Annual Meeting

    The Vasculopathy of Juvenile Dermatomyositis (JDM); Evidence of Persistent Endothelial Injury, Hypercoagulability, Subclinical Inflammation and Increased Arterial Stiffness

    Charalampia Papadopoulou1,2, Ying Hong1, Petra Krol1,2, Yiannis Ioannou3, Clarissa Pilkington2,4,5, Hema Chaplin6, Stephanie Simou1, Marietta Charakida7, Lucy R Wedderburn5,8,9, Paul Brogan10 and Despina Eleftheriou1,8,11, 1Infection, Inflammation and Rheumatology, UCL Institute of Child Health, London, United Kingdom, 2Paediatric Rheumatology, Great Ormond Street Hospital NHS Trust, London, United Kingdom, 3Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology, UCL Division of Medicine, London, United Kingdom, 4Paediatric Rheumatology, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 5Infection, Inflammation and Rheumatology Section, UCL Institute of Child Health, London, United Kingdom, 6Centre for Adolescent Rheumatology, Arthritis Research UK, London, United Kingdom, 7Vascular Physiology Unit, Institute of Cardiovascular Science , University College London, London, United Kingdom, 8Paediatric Rheumatology Department, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom, 9Rheumatology Unit, Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom, 10Department of Paediatric Rheumatology, UCL Institute of Child Health and Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom, 11Arthritis Research UK Centre for Adolescent Rheumatology, University College London, London, United Kingdom

    Background/Purpose:  Vasculopathy is considered central to the pathogenesis of Juvenile Dermatomyositis (JDM). The interplay between persistent JDM-vasculopathy, traditional cardiovascular risk factors, exposure to corticosteroids, and…
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