Abstracts tagged "chondrocytes"

Abstract Number: 157 • 2020 Pediatric Rheumatology Symposium
Chondrocytes Influence Fibroblast-like Synoviocytes from Patients with Juvenile Idiopathic Arthritis, Through the Abrogation of BMP Signaling, to Delay Cell Differentiation and Maturation
Megan Simonds ¹, Amanda Schlefman ², Kathleen Sullivan ³, Carlos Rose ⁴ and AnneMarie Brescia⁵, ¹Nemours Biomedical Research, Wilmington, ²Johns Hopkins Rheumatology, ST PETERSBURG, Florida, ³The Children's Hospital of Philadelphia, Philadelphia, ⁴Thomas Jefferson University/duPont Hospital for Children, Wilmington, ⁵Nemours/ Alfred I duPont Hospital for Children, Wilmington
Background/Purpose: Juvenile Idiopathic Arthritis (JIA) progression leads to growth disturbances in affected joints. Fibroblast-like synoviocytes (FLS) play a key role in JIA pathogenesis; however, the…
Abstract Number: 1967 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor Signals Through AMPK and SIRT1 to Increase Chondrocyte Homeostasis
Benjamin Friedman¹ and Bruce Cronstein ², ¹Department of Medicine, Division of Rheumatology NYUSoM, NYC, ²NYU Langone, New York
Background/Purpose: OA is characterized by loss of cartilage and chondrocyte dysfunction. Our lab has shown CGS21680 (CGS, 1µM) activation of adenosine A2AR leads to chondrocyte…
Abstract Number: 1970 • 2019 ACR/ARP Annual Meeting
Mechanism of Chondroprotective Effects of 4-Methylumbelliferone and 2-Deoxyglucose
Kenya Terabe¹, Nobunori Takahashi ¹, Yoshifumi Ohashi ², Toshihisa Kojima ¹, Naoki Ishiguro ¹, Cheryl Knudson ² and Warren Knudson ², ¹Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²East Carolina University, Greenville
Background/Purpose: We recently reported that the inhibitor of hyaluronan (HA) biosynthesis, 4-methylumbelliferone (4-MU) blocked IL-1β activation of MMP13 mRNA and protein expression in human osteoarthritic…
Abstract Number: 847 • 2018 ACR/ARHP Annual Meeting
Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Chondrocyte Phenotype through Activation of Calcium/Calmodulin Kinase 2
Jing Rong¹, Bregina Pool², Mark Zhu³, Jacob Munro⁴, Geraldine M. McCarthy⁵, Jillian Cornish², Nicola Dalbeth¹ and Raewyn Poulsen³, ¹University of Auckland, Auckland, New Zealand, ²Department of Medicine, University of Auckland, Auckland, New Zealand, ³Medicine, University of Auckland, Auckland, New Zealand, ⁴Orthopaedics, Auckland City Hospital, Auckland, New Zealand, ⁵Mater Misericordiae University Hospital, Dublin, Ireland
Background/Purpose: Basic calcium phosphate crystals (BCP) are frequently found in osteoarthritic joints. Whether BCP crystal deposition is a cause or consequence of osteoarthritis (OA) pathology…
Abstract Number: 848 • 2018 ACR/ARHP Annual Meeting
A2A Adenosine Receptor Stimulation Switches TGF-β Signaling to Promote Chondrocyte Proliferation and Cartilage Regeneration
Carmen Corciulo¹, Cristina Castro², Samson Jacob³, David Fenyo³, Oran Kennedy⁴ and Bruce N. Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Institute for Systems Genetics, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We previously found that intra-articular injections of liposomal preparations of adenosine completely prevent progression and reverse cartilage loss in post-traumatic OA. TGF-β signaling plays…
Abstract Number: 1036 • 2018 ACR/ARHP Annual Meeting
Effects of Three Potential Anabolic Disease-Modifying Osteoarthritis Drugs – Sprifermin, Insulin-like Growth Factor 1 and Bone Morphogenetic Protein 7 – on Matrix Production and the Phenotype of Articular Chondrocytes
Sylvia Muller, Martin Michaelis, Sven Lindemann and Anne Gigout, Merck KGaA, Darmstadt, Germany
Background/Purpose: Disease-modifying osteoarthritis drugs with an anabolic mode of action should stimulate the growth of new hyaline cartilage. For instance, recombinant human fibroblast growth factor…
Abstract Number: 1040 • 2018 ACR/ARHP Annual Meeting
The Potential Role of Choline Kinase Alpha in Osteoarthritis
Roxana Coras^1,2, Liang-Yu Chen³, Elsa Sanchez-Lopez⁴, Martin Lotz⁵, Ru Liu-Bryan^1,3 and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³VA San Diego Healthcare System, San Diego, CA, ⁴University of California San Diego, La Jolla, CA, ⁵Department of Molecular & Experience Medicine, Scripps Research Institute, LaJolla, CA
Background/Purpose: Osteoarthritis (OA) is the most common joint disease and a leading cause of disability. Cartilage degeneration is the central characteristic of OA, and low-grade…
Abstract Number: 1048 • 2018 ACR/ARHP Annual Meeting
Identification of Novel Molecules with Senolytic and Autophagy Activity As Osteoarthritis Therapeutics
Uxia Nogueira-Recalde¹, Francisco J Blanco¹, Maria I. Loza², Diego Grassi³, Paul Robbins³, Eduardo Dominguez⁴ and Beatriz Carames¹, ¹Cartilage Biology Group, Rheumatology Division, INIBIC-CHUAC, A Coruña, A Coruña, Spain, ²BioFarma Research Group. University of Santiago de Compostela, santiago de Compostela, Spain, ³Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, ⁴BioFarma Research Group. University of Santiago de Compostela, Santiago de Compostela, Spain
Background/Purpose: Disease-modifying treatments for Osteoarthritis (OA) are not available. Aging-related features such as failure of homeostasis mechanisms, including autophagy, cause extracellular matrix damage, chondrocyte senescence…
Abstract Number: 1055 • 2018 ACR/ARHP Annual Meeting
The TLR-4 Inhibitor 6-Shogaol As a Treatment in Osteoarthritis Trough the Modulation of Chondrocyte Hypertrophy and Matrix Calcification
Paula Gratal¹, Aranzazu Mediero², Ana Lamuedra¹, Raquel Largo¹ and Gabriel Herrero-Beaumont¹, ¹Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, ²Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a complex joint disease characterized by a progressive loss of articular cartilage (AC) and synovial inflammation. The latest theories of OA…
Abstract Number: 2003 • 2018 ACR/ARHP Annual Meeting
Chondrocyte Size in Articular Cartilage As a Marker of Osteoarthritis Severity
Paula Gratal¹, Aranzazu Mediero², Iván Prieto-Potin¹, Ana Lamuedra¹, Gabriel Herrero-Beaumont¹ and Raquel Largo¹, ¹Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain, ²Joint and Bone Research Unit, IIS-Fundación Jiménez Díaz UAM, Madrid, Spain
Background/Purpose: Terminal differentiating growth plate chondrocytes are mainly characterized by an increase of their cell size and by the expression of hypertrophic markers such as…
Abstract Number: 2025 • 2018 ACR/ARHP Annual Meeting
Fibroblast-like Synoviocytes from Juvenile Idiopathic Arthritis and Controls Influence Expression of Bone Morphogenetic Protein Antagonists in Chondrocytes
Megan Simonds¹, Amanda R. Schlefman², Suzanne M. McCahan³, Kathleen E. Sullivan⁴, Carlos D. Rosé⁵ and AnneMarie C. Brescia⁵, ¹Nemours, Nemours Biomedical Research, Wilmington, DE, ²Pediatric Rheumatology, Nemours/Thomas Jefferson University, Wilmington, DE, ³Nemours Biomedical Research, Wilmington, DE, ⁴Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁵Nemours/Thomas Jefferson University, Wilmington, DE
Background/Purpose: Fibroblast-like synoviocytes (FLS) may play a role in the pathogenesis of Juvenile idiopathic arthritis (JIA) and have chondrogenic potential. Bone morphogenetic proteins (BMP) are…
Abstract Number: 1934 • 2017 ACR/ARHP Annual Meeting
Chondrocytes Derived from Mesenchymal Stem Cells Differentiated in the Presence of Plasma-Derived Extracellular Vesicles from Osteoarthritic Patients Express Disease-Related Genes
Bartijn C.H. Pieters¹, Onno J. Arntz¹, Arjen B. Blom², Peter M. van der Kraan² and Fons A.J. van de Loo², ¹Experimental Rheumatology, Radboudumc, Nijmegen, Netherlands, ²Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Osteoarthritis (OA) is an age-related musculoskeletal disease and the most common form of arthritis characterized by low grade synovial inflammation and articular cartilage degeneration.…
Abstract Number: 2191 • 2017 ACR/ARHP Annual Meeting
Widespread Regulation of Gene Expression By Glucocorticoids in Chondrocytes from OA Patients As Determined By NGS-Based Genome Wide Expression Analysis
Antti Pemmari, Erja-Leena Paukkeri, Mari Hämäläinen, Tiina Leppänen and Eeva Moilanen, The Immunopharmacology Research Group, Faculty of Medicine and Life Sciences, University of Tampere and Tampere University Hospital, Tampere, Finland, Tampere, Finland
Background/Purpose: In osteoarthritis (OA), chondrocytes display marked changes in their gene expression profile. Some of these are thought to be protective [e.g. increased synthesis of…
Abstract Number: 905 • 2017 ACR/ARHP Annual Meeting
Regenerating Cartilage and Reversing Osteoarthritis (OA) Stimulation of Adenosine A2A Receptors (A2AR) Increases Cartilage Volume and Matrix in Vitro and In Vivo
Carmen Corciulo¹, Cristina Castro², Thomas Coughlin³, Tuere Wilder¹, Oran Kennedy⁴ and Bruce Cronstein⁵, ¹Department of Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, NYU School of Medicine, New York, NY, ³Orthopaedic Surgery, NYU School of Medicine, New York, NY, ⁴Department of Anatomy, Royal College of Surgeons, Dublin, Ireland, ⁵Rheumatology, New York University School of Medicine, Division of Rheumatology, New York, NY
Background/Purpose: We have recently reported that endogenously produced adenosine, interacting with A2AR, is a critical autocrine factor for maintenance of chondrocyte and cartilage homeostasis and…
Abstract Number: 132 • 2017 Pediatric Rheumatology Symposium
Influence of Juvenile Idiopathic Arthritis Fibroblast-like Synoviocytes and Mature Chondrocytes on Each Other in Culture: A Pilot Study
Amanda R. Schlefman¹, Megan M. Simonds², Kathleen E. Sullivan³, Carlos D. Rosé¹ and AnneMarie C. Brescia¹, ¹Pediatric Rheumatology, Nemours/Thomas Jefferson University, Wilmington, DE, ²Nemours Biomedical Research, Wilmington, DE, ³Pediatrics, University of Pennsylvania, Philadelphia, PA
Background/Purpose: A chondrocyte-like phenotype has previously been described in pediatric fibroblast-like synoviocytes (FLS), which may contribute to bony overgrowth in juvenile idiopathic arthritis (JIA). The…

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