Abstracts tagged "chondrocytes"

Abstract Number: 2519 • 2012 ACR/ARHP Annual Meeting
IL-1β and TNF-α Regulate the Global and Locus-Specific hydroxymethylation of Genomic DNA by Modulating the Expression and Activity of Tet-1 in Human OA Chondrocytes
Abdul Haseeb¹ and Tariq M. Haqqi², ¹Medicine/Rheumatology, Case Western Reserve University, Cleveland, OH, ²Medicine/Rheumatology/Haman 586, Metro Health Medical Center, Cleveland, OH
Background/Purpose: 5-hydroxymethylcytosine (5-hmC), which is formed by the oxidation of 5-methylcytosine (5-mC), is a recently discovered epigenetic mark and is highest in brain and in…