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Abstracts tagged "chondrocytes"

  • Abstract Number: 1014 • 2014 ACR/ARHP Annual Meeting

    Harpagide, a Low Molecular Weight Natural Product, Suppresses IL-1â-Induced IL-6 Expression By Blocking the Activation of p38 MAPK and Transcription Factors CEBPâ and AP-1 in Primary Human Osteoarthritis Chondrocytes

    Abdul Haseeb1 and Tariq Haqqi2, 1Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, 2Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH

    Background/Purpose: There is growing evidence that shows the involvement of IL-6 in cartilage degradation during OA. Significant correlation between IL-6 levels in serum as well…
  • Abstract Number: 1012 • 2014 ACR/ARHP Annual Meeting

    Role of High Glucose Environment on Chondrocyte Activation and Characterization of Diabetic Osteoarthritic Cartilage: Toward Pathophysiological Delineation of Diabetes Mellitus-Related Osteoarthritis

    Marie-Charlotte Laiguillon1, Alice Courties1,2, Xavier Houard1, Martine Auclair1, Alain Sautet3, Bruno Fève1, Jacqueline Capeau1, Francis Berenbaum2 and Jérémie Sellam2, 1Sorbonne Universités, UPMC Univ Paris 06, UMRS 938 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Paris, France, 2AP-HP, Saint-Antoine Hospital, Rheumatology Department and DHU i2B, Paris, France, 3AP-HP, Saint-Antoine Hospital, Orthopaedic Surgery Department, Paris, France

    Background/Purpose: Recent epidemiological studies have suggested an association between type 2 diabetes/hyperglycemia and osteoarthritis (OA) but experimental evidences are lacking (1). We aimed i) to…
  • Abstract Number: 1011 • 2014 ACR/ARHP Annual Meeting

    Fibroblast Growth Factor-2 and Its Receptor Antagonists in Osteoarthritis

    Elina Nummenmaa1, Mari Hamalainen1, Teemu Moilanen1,2, Katriina Vuolteenaho1 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: The fibroblast growth factor (FGF) family represents an interesting group of molecules which are involved in the regulation of connective tissue development and metabolism.…
  • Abstract Number: 1008 • 2014 ACR/ARHP Annual Meeting

    Autophagy Activation Protects from Mitochondrial Dysfunction in Human Chondrocytes  

    Beatriz Carames1, Paloma López de Figueroa2, Martin Lotz3 and Francisco J. Blanco4, 1Cartilage Biology Group. Rheumatology Division, INIBIC–A Coruña, SPAIN, A Coruña, Spain, 2Cartilage Biology group. Rheumatology Division, INIBIC-A Coruña, Spain, A Coruña, Spain, 3The Scripps Research Institute, La Jolla, USA, La Jolla, CA, 4Rheumatology Division, INIBIC-A Coruña, Spain, A Coruña, Spain

    Background/Purpose Autophagy, is a key pathway of cellular homeostasis for removing damaged macromolecules and organelles, including mitochondria. Recent studies indicate that autophagy activation is defective…
  • Abstract Number: 1006 • 2014 ACR/ARHP Annual Meeting

    Interleukin-4 As Promising, Anti-Inflammatory Transgene for Gene Therapeutic Application in Joint Diseases

    Annemarie Lang1, Johannes Neuhaus2, Moritz Pfeiffenberger3, Erik Schroeder4, Frank Buttgereit5, Michael F. G. Schmidt3 and Timo Gaber6, 1Berlin-Brandenburg School of Regenerative Therapies (BSRT), Berlin, Germany, 2Department of Veterinary Medicine, Research Center of Medical Technology and Biotechnology, Bad Langensalza, Germany, 3Department of Veterinary Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany, 4Department of Rheumatology and Clinical Immunology, Charité University Medicine, Berlin, Germany, 5Charité University Hospital, Berlin, Germany, 6Berlin-Brandenburg Center of Regenerative Therapies (BCRT), Berlin, Germany

    Background/Purpose Interleukin- 4 (IL-4), a Th2-cell released immunomodulatory factor, has potent chondroprotective and anti-inflammatory properties able to inhibit the synthesis of IL-1β and TNFα, and…
  • Abstract Number: 770 • 2013 ACR/ARHP Annual Meeting

    Suppressor Of Cytokine Signaling-3 Is a Critical Regulator Of gp130 Cytokine Signaling In Articular Chondrocytes

    Xiao Liu1,2, Kate E Lawlor1,2, Ben A Croker1 and Ian P Wicks1,2,3, 1Inflammation Division, Walter & Eliza Hall Institute of Medical Research, Parkville, Australia, 2Department of Medical Biology, University of Melbourne, Parkville, Australia, 3Department of Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia

    Background/Purpose: Cartilage damage is a key feature of inflammatory and degenerative arthritis and an important determinant of patient outcomes. Chondrocytes are the only cells in…
  • Abstract Number: 67 • 2013 ACR/ARHP Annual Meeting

    Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) As a Potential Mediator In Osteoarthritis

    Richard F. Loeser1 and David A. Long2, 1Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, 2Section Of Molecular Medicine, Wake Forest University, Winston-Salem, NC

    Background/Purpose:  We recently reported changes in gene expression in knee joint tissue from 12 week-old and 12 month-old mice after OA was induced by surgical…
  • Abstract Number: 63 • 2013 ACR/ARHP Annual Meeting

    Investigations On The Role Of Delta/Notch Like EGF-Related Receptor In The Pathogenesis Of Osteoarthritis

    Lucija Berninger1, Anna Balkenhol1, Clemens Baier2, Stefan Rehart3, Markus Rickert4, Ulf Müller-Ladner1, Elena Neumann5 and Matthias Geyer1, 1Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Orthopaedic surgery, University of Regensburg, Bad Abbach, Germany, 3Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, 4Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany

    Background/Purpose: Delta/Notch like EGF-related receptor (DNER) is a single-pass transmembrane protein with characteristic EGF-like repeats in the extracellular domain, similar to those of the Notch…
  • Abstract Number: 66 • 2013 ACR/ARHP Annual Meeting

    Follistatin-Like Protein 1 Is An Important Regulator Of Chondrogenesis

    Yury Chaly1, Sonja Smith2, Daniel Bushnell3, Brian Campfield4, Harry Blair5 and Raphael Hirsch6, 1Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, 2University of Iowa Carver College of Medicine, Iowa City, IA, 3Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 4Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 5University of Pittsburgh School of Medicine, Pittsburgh, PA, 6Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA

    Background/Purpose: Chondrocytes play a pivotal role in osteoarthritis (OA) because they are the only cells in the articular cartilage that are responsible for maintenance of…
  • Abstract Number: 68 • 2013 ACR/ARHP Annual Meeting

    Autophagy Activation Protects From Mitochondrial Dysfunction In Human Chondrocytes

    Beatriz Caramés1, Paloma López de Figueroa2, Martin Lotz3 and Francisco J. Blanco4, 1Osteoarticular and Aging Research Lab, INIBIC–Complejo Hospitalario Universitario A Coruña, SPAIN, A Coruña, Spain, 2Cartilage Biology group. Rheumatology Division, INIBIC-A Coruña, Spain, A Coruña, Spain, 3The Scripps Research Institute, La Jolla, USA, La Jolla, CA, 4Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC- University of A Coruña, A Coruña, Spain

    Background/Purpose: A common feature of aging-related diseases, such as osteoarthritis (OA), is the progressive accumulation of damaged macromolecules leading to cell dysfunction and death. Autophagy,…
  • Abstract Number: 76 • 2013 ACR/ARHP Annual Meeting

    Protective Effect Of Intra-Articular Injection Of Alginate-Chitosan Beads In An Hydrogel Against The Development Of Experimental Osteoarthritis Lesions In Rabbit

    Frédéric Oprenyeszk1, Mickael Chausson2, Véronique Maquet2, Jean-Emile Dubuc3 and Yves Henrotin1, 1University of Liège, Bone and Cartilage Research Unit, Liège, Belgium, 2Parc industriel des Haut-Sarts, KitoZyme SA, Herstal, Belgium, 3Clinical University Saint Luc, Orthopaedic Department, Bruxelles, Belgium

    Background/Purpose: Today, there is no treatment to cure osteoarthritis (OA) or to delay effectively its progression. Current treatments are mainly based on the alleviation of…
  • Abstract Number: 58 • 2013 ACR/ARHP Annual Meeting

    Saturated Fatty Acids Act Synergistically With Interleukin 1 Beta To Increase Inflammation, Endoplasmic Reticulum Stress and Cell Death In Human Articular Chondrocytes 

    Oscar Alvarez-Garcia1, Nicole H Rogers2, Roy G Smith3 and Martin K. Lotz1, 1Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, 2California Institute for Biomedical Research (Calibr), La Jolla, CA, 3Department of Metabolism and Aging, Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL

    Background/Purpose: Obesity is a major risk factor for the development of osteoarthritis (OA). Altered biomechanics have been postulated as the main causative mechanism, but recent…
  • Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting

    Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis

    Anna Koskinen1, Katriina Vuolteenaho1, Riku Korhonen1, Teemu Moilanen1,2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…
  • Abstract Number: 47 • 2013 ACR/ARHP Annual Meeting

    Exogenous Hydrogen Sulfide Donors Show Anti-Catabolic and Anti-Inflammatory Properties But Limited Anti-Oxidant Capability On Human Articular Osteoarthritic Chondrocytes

    Elena F. Burguera1,2, Angela Vela-Anero2,3, Rosa Meijide-Failde2 and Francisco J. Blanco1,4, 1Rheumatology Service, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Universidade da Coruña (UDC)., Grupo de Bioingeniería Tisular y Terapia Celular (CBTTC-CHUAC). CIBER-BBN/ISCIII., A Coruña, Spain, 3Department of Medicine, University of A Coruña, A Coruña, Spain, 4Tissue Engineering and Cellular Therapy Group (CBTTC-CHUAC), CIBER BBN/ISCIII, A Coruña, Spain

    Background/Purpose: Osteoarthritis (OA) is characterized by an imbalance between catabolism and anabolism, higher than normal levels of matrix metalloproteinases (MMPs), an increase in inflammatory markers…
  • Abstract Number: 54 • 2013 ACR/ARHP Annual Meeting

    ANTI-Fibrotic and ANTI-Hypertrophic Effect Of Adipose Mesenchymal Stromal CELLS On Osteoarthritic Chondrocytes

    Marie Maumus1, C. Manferdini2, Karine Toupet1, A. Piacentini2, A. Gabusi2, A. Facchini2, G. Lisignoli2, Christian Jorgensen3 and Daniele Noel4, 1Université Montpellier1, INSERM U844, Montpellier, France, 2Laboratorio di Immunoreumatologia e Rigenerazione tissutale, IOR BOLOGNA, BOLOGNA, Italy, 3Department of therapy & Immuno-Rhumatology, Inserm U844, CHU saint-Eloi, Université Montpellier 1, CHU Lapeyronie, Montpellier, France, 4Inserm U844, UM1, Montpellier, France

    Background/Purpose: Mesenchymal stem cells (MSC) isolated from bone marrow (MSC) or adipose (ASC) tissues secrete a large amount of trophic factors. The possibility that these…
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