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Abstracts tagged "Apoptosis"

  • Abstract Number: 2705 • 2015 ACR/ARHP Annual Meeting

    AAA-Atpase p97-HDAC6 Controlled Poly-Ubiquitin Turnover Regulates Apoptotic and Autophagy-Associated Cell Death in Arthritis

    Masaru Kato1, Kerstin Klein2, Caroline Ospelt2, Christoph Kolling3, Michihito Kono1, Shinsuke Yasuda1, Renate E. Gay4, Steffen Gay5 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Schulthess Clinic, Zurich, Switzerland, 4Center of Experimental Rheumatology, University Hospital Zurich, Switzerland, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich, University Zurich, Zurich, Switzerland

    Background/Purpose: The AAA-ATPase valosin containing protein (p97) and histone deacetylase 6 (HDAC6) interact with each other and are implicated in the degradation of ubiquitin-labelled proteins.…
  • Abstract Number: 2559 • 2015 ACR/ARHP Annual Meeting

    PRO-Resolving Mediators Issued from Apoptotic CELL Efferocytosis (SUPERMAPO) Modulate Antigen Presenting CELL Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen- Induced Arthritis

    Francis Bonnefoy1, Romain Vallion2, Mélanie Couturier3, Anna Daoui3, Eric Toussirot4 and Sylvain Perruche1, 1UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, 2INSERM UMR 1098, EFS Bourgogne Franche Comté, Besançon, France, 3INSERM UMR1098, EFS Bourgogne Franche Comté, Besançon, France, 4Service de Rhumatologie, CHU J Minjoz, Besancon, France

    Background/Purpose: Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and…
  • Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting

    Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)

    Rachel Audo1,2, Bernard Combe3,4, Michael Hahne5 and Jacques Morel6, 1Rheumatology, Teaching Hospital of Lapeyronie, Montpellier, France, 2IGMM, CNRS UMR5535, Montpellier, Montpellier, France, 3Department of Rheumatology, Lapeyronie Hospital, Montpellier, France, 4Montpellier University, Montpellier, France, 5IGMM-CNRS UMR5535, Montpellier, France, 6Department of rheumatology, Lapeyronie Hospital and Montpellier University, Montpellier, France

    Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…
  • Abstract Number: 1037 • 2015 ACR/ARHP Annual Meeting

    Impaired Regulatory T Cell Survival in the Pathogenesis of Autoreactive Arthritis Mediated By CD11c-Deletion of Flip

    Qi Quan Huang1, Renee E. Doyle1, Robert Birkett2, Deyu Fang3, Syamal K. Datta1 and Richard M. Pope1, 1Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose:  We have generated a mouse line with Flip conditionally deleted in CD11c-cre expressing cells (CD11c-Flip-KO, named HUPO), which spontaneously develops erosive arthritis resembling rheumatoid…
  • Abstract Number: 810 • 2015 ACR/ARHP Annual Meeting

    Human Parvovirus B19 Nonstructural Protein 1 (NS1) Helicase Breaks Tolerance to Self dsDNA: A Model for Viral Induction of Autoimmunity

    Heidi Pirttinen1, Kanoktip Puttaraksa1, Robert J. Lagier2, Stanley J. Naides3 and Leona Gilbert1, 1Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland, 2Research Support, Alameda, Quest Diagnostics Alameda, Alameda, CA, 3Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA

    Background/Purpose:  B19 virus (B19V) is common, infects all ages, and is associated with various clinical syndromes including SLE-like autoimmunity. We previously demonstrated that B19 NS1,…
  • Abstract Number: 8 • 2015 ACR/ARHP Annual Meeting

    Bay 11-7085 Induces Glucocorticoid Receptor Activation and Autophagy to Initiate Human Synovial Fibroblast Cell Death

    Biserka Relic1, Edith Charlier2, Céline Deroyer1, Olivier Malaise1, Sophie Neuville1, Aline Desoroux1, Philippe Gillet3, Michel G. Malaise1 and Dominique de Seny1, 1Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, 2Department of Rheumatology, Department of Rheumatology- GIGA Research - Arthropôle - University of Liège - CHU Liège, Liège, Belgium, 3Orthopaedic Surgery Department-University of Liège-CHU de Liège, Liège, Belgium

    Background/Purpose: BAY 11-7085 is an inhibitor of IκBα phosphorylation that leads to NF-κB inactivation and downregulation of inflammation in mouse model of asthma, in articular…
  • Abstract Number: 2734 • 2014 ACR/ARHP Annual Meeting

    B55β Regulates T Cell Survival through the Modulation of AKT during Cytokine Deprivation

    José C. Crispin1, Sokratis A. Apostolidis2, Noe Rodriguez Rodriguez1, Tran Nguyen2 and George C. Tsokos3, 1Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 3Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose . The abundance of cytokines controls the length of immune responses through poorly defined mechanisms. B55β is a molecule that triggers apoptosis in activated…
  • Abstract Number: 2166 • 2014 ACR/ARHP Annual Meeting

    Bim Suppresses the Development of Glomerulonephritis By Inhibiting M2 Polarization

    Fu-Nien Tsai, Northwestern University, Chicago, IL

    Background/Purpose Only recently have monocytes and macrophages been accepted as critical players in the pathogenesis of SLE.  However, very little is known regarding the molecular…
  • Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting

    Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a

    Salahuddin Ahmed1, Laura Walsh2, Anil Singh1, Maria Beamer3, Kuladeep Sudini4 and Douglas Leaman4, 1Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, 2Department of Pharmacology, University of Toledo, Toledo, OH, 3Department of Pharmacology, Department of Pharmacology, University of Toledo, Toledo, OH, 4Department of Biological Sciences, University of Toledo, Toledo, OH

    Background/Purpose:  In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…
  • Abstract Number: 757 • 2014 ACR/ARHP Annual Meeting

    Distinctive Patterns of Telomere Shortening and Apoptosis in Limited and Diffuse cutaneous  Systemic Sclerosis

    Jasper Broen1, Liane McGlynn2, Dagmara McGuinness2, Rina Wichers3, Jacqueline Thomson2, Rajan Madhok4, Robert Lafyatis5, Carol A. Feghali-Bostwick6, Paul Shiels2 and T.R.D.J. Radstake1, 1Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 2University of Glasgow, Glasgow, United Kingdom, 3UMC Utrecht, Utrecht, Netherlands, 4Glasgow Royal Infirmary, Glasgow, United Kingdom, 5Arthritis Center, Boston University, Boston, MA, 6Medicine, Medical University of South Carolina, Charleston, SC

    Background/Purpose: Aberrant telomere shortening and DNA damage-responses have been previously described in SSc, here we aim to validate these observations and incorporate them in a…
  • Abstract Number: 343 • 2014 ACR/ARHP Annual Meeting

    The Caspase 8/RIPK3 Signaling Axis Has Opposing Roles in Myeloid and Dendritic Cells during Progression of a Murine Model of Acute Inflammatory Arthritis

    Carla M. Cuda1, Alexander Misharin2, George Kenneth Haines III3 and Harris R. Perlman4, 1Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Northwestern University, Chicago, IL, 3Pathology, The Mount Sinai Hospital, New York, NY, 4Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose Rheumatoid arthritis (RA) manifests in persistent synovial inflammation, cellular infiltration and pro-inflammatory cytokine production, and results in progressive joint destruction.  Both myeloid cells and…
  • Abstract Number: 2872 • 2014 ACR/ARHP Annual Meeting

    B-Cell Autoepitope and Tetramer Analysis Reveals Expansion of Apoptotic Autoantigen La and snRNP Reactive B Cells in BXD2 Mice

    Jennie Hamilton1, Jun Li2, Qi Wu3, PingAr Yang3, Bao Luo3, Hao Li4, Troy Randall5, John Edwin Bradley5, Justin J. Taylor6, John D. Mountz7,8 and Hui-Chen Hsu3,4, 1University of Alabama at Birmingham, Birmingham, AL, 2Med - Immunology/Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 4Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 5Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 6Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, 7Dept of Med/Rheumatology Div, University of Alabama at Birmingham, Birmingham, AL, 8Birmingham VA Medical Center, Birmingham, AL

    Background/Purpose Systemic lupus erythematous (SLE) is characterized by production of highly pathogenic IgG autoantibodies (autoAbs).  While serum autoAb profiling is standard, it remains challenging to…
  • Abstract Number: 2839 • 2014 ACR/ARHP Annual Meeting

    BCL-2 As a Potential Therapeutic Target in Human Lupus Tubulointerstitial Inflammation

    Kichul Ko1, Denisse Yanez1, Natalya Kaverina1, Vladimir M. Liarski1, Yahui Peng2, Li Lan3, Stuart Perper4, Annette Schwartz5, Liz O'connor6, Andrew Souers7, Steven Elmore7, Lisa Olson5, Maryellen L. Giger3, Li Chun Wang4 and Marcus R. Clark1, 1Rheumatology and Knapp Center for Lupus Research, University of Chicago, Chicago, IL, 2School of Electronic and Information Engineering, Beijing Jiaotong University, Beijing, China, 3Radiology, University of Chicago, Chicago, IL, 4Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, 5AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, 6Toxicology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, 7AbbVie Inc, North Chicago, IL

    Background/Purpose Lupus nephritis (LuN) is the most common, severe manifestation of systemic lupus erythematosus (SLE). We have previously shown that glomerulonephritis appears to be a…
  • Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting

    Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant  Induced Arthritis In Rats Via Induction Of Immune Tolerance

    Howard Amital1, Smadar Gertel2 and Yehuda Shoenfeld3, 1The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B',, Sheba Medical Center,Tel-Hashomer, Tel-Aviv University, Tel-hashomer, Israel, 2The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel, 3Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel

    Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…
  • Abstract Number: 2822 • 2013 ACR/ARHP Annual Meeting

    IKKε Deficiency Prolongs Neutrophil Survival Paradoxically Prolonging Inflammation In The Absence Of a Type I Interferon Response

    Maripat Corr1, Christopher Chung2, Seong-Kyu Kim3, D. L Boyle4 and G. S. Firestein5, 1Medicine, Univ of California-San Diego, La Jolla, CA, 2Medicine, UCSD School of Medicine, La Jolla, CA, 3Catholic University of Daegu School of Medicine, Daegu, South Korea, 4Div of Rheum, UCSD School of Medicine, La Jolla, CA, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Deficiency of the IKK-related kinases IKKε synergizes with the anti-inflammatory effects of IFNß in a murine model of arthritis., and this effect is mediated…
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