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Abstracts tagged "Apoptosis"

  • Abstract Number: 0837 • ACR Convergence 2020

    Deletion of miR-223 Exacerbates Lupus Nephritis by Targeting S1pr1 in Faslpr/lpr Mice

    Sumie Hiramatsu Asano1, Tomoyuki Mukai2, Yoshitaka Morita3 and Jun Wada4, 1Kawasaki Medical School/Department of Rheumatology, Kurashiki city, Japan, 2Kawasaki Medical School, Kurashiki-shi, Okayama, Japan, 3Kawasaki Medical School/Department of Rheumatology, Kurashiki, Okayama, Japan, 4Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences., Okayama city, Japan

    Background/Purpose: To identify new candidate genes regulated by micro RNAs (miRNAs) and involved in the pathogenesis of systemic lupus erythematosus (SLE), we integrated miRNA and…
  • Abstract Number: 0894 • ACR Convergence 2020

    Efficacy and Safety of Neihulizumab (AbGn-168H) in Patients with Active Psoriatic Arthritis: 24-week Results from a Phase II Open Label Study

    Stanley Cohen1, Justus Fiechtner2, Philip Mease3, Jeffrey Kaine4, Arthur Kavanaugh5, Yi-Lin (Irene) Cheng6, Claire Chou6, Ting-Ying Cheng7, Shih-Yao Lin6 and Mark Genovese8, 1University of Texas Southwestern Medical School at Dallas, and Metroplex Clinical Research Center, Dallas, TX, 2Michigan State University, Grand Rapids,, MI, 3Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, 4Sarasota Arthritis Research Center, Sapphire, NC, 5UC San Diego Health System, San Diego, CA, 6AltruBio, Taipei, Taiwan (Republic of China), 7AltruBio, Redwood City, CA, 8Stanford University Medical Center, Palo Alto, CA

    Background/Purpose: Neihulizumab is a novel immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), thereby preferentially inducing apoptosis in late stage activated T cells.…
  • Abstract Number: 0968 • ACR Convergence 2020

    Combined Inhibition of Autophagy and Glutamine Metabolism Suppresses Cell Growth of RA Synoviocytes and Ameliorates Arthritis in SKG Mice

    Ikuko Naka1, Jun Saegusa2, Kenichi Uto2, Yuzuru Yamamoto3, Yoshihide Ichise4, Hirotaka Yamada4, Yo Ueda5, Takaichi Okano4, Soshi Takahashi6, Sho Sendo7 and Akio Morinobu8, 1Kobe University, Kobe, 2Department of Clinical Laboratory, Kobe University Hospital, Kobe, Japan, 3Kobe University, Kobe-city, Japan, 4Kobe University, Kobe, Japan, 5Kobe UniversityRheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan, 6Kobe univerity, Kobe, Japan, 7Kobe university, Kobe city, Japan, 8Rheumatology and Clinical Immunology, Kobe University Hospital, Kobe, Japan

    Background/Purpose: Immunometabolism is now recognaized to be crucial in the pathogenesis of rheumatoid arthritis (RA). We have recently shown that the expression of glutaminase 1…
  • Abstract Number: 1927 • 2019 ACR/ARP Annual Meeting

    Role of Mitochondrial DNA from OA Patients in Cellular Apoptosis, Senescence and Autophagy

    Mercedes Fernandez-Moreno1, Andrea Dalmao-Fernández 2, Uxia Nogueira-Recalde 3, Tamara Hermida-Gómez 4, Maria E Vazquez-Mosquera 5, Sara Relaño 6, Ignacio Rego-Pérez 6 and Francisco J. Blanco 6, 1Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain, 2Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain, 3Grupo de Biología del Cartílago, Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, A Coruña, Spain, A Coruña, Spain, 4Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, 5Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, 6Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain

    Background/Purpose: Background. With the redefinition of Osteoarthritis (OA) and the understanding that the joint behaves as an organ, OA is now considered a systemic illness…
  • Abstract Number: 2422 • 2019 ACR/ARP Annual Meeting

    Increased Apoptosis and Compromised Suppressive Capacity of Regulatory T Cells in Primary Sjögren’s Syndrome

    Min Feng1, Xiangcong Zhao 1 and Jing Luo 1, 1the second hospital of shanxi medical university, Taiyuan, China (People's Republic)

    Background/Purpose: To investigate the apoptosis and suppressive function of regulatory T cells (Tregs) in primary Sjögren’s syndrome (pSS), and the effect of low-dose IL-2 on apoptosis of Tregs.Methods:…
  • Abstract Number: 36 • 2018 ACR/ARHP Annual Meeting

    The Pleiotropic Effects of TAM Signaling on Inflammatory Arthritis in Mice Using Kbxn Serum Transfer Induced Arthritis

    Anna B Montgomery1, Salina Dominguez2, Maximilian Mayr3 and Harris Perlman3, 1Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: TAM receptors are a small family of receptor tyrosine kinases comprising Tyro-3, Axl and Mer, which are activated by GAS6 and Protein-S. TAM signaling…
  • Abstract Number: 1017 • 2018 ACR/ARHP Annual Meeting

    Autoantigen Pentraxin-3 Is an Inflammatory Cytokine Storms Suppressor By Switching Monocytes Pyroptosis to Apoptosis in a Complement-Dependent Manner in Rheumatoid Arthritis

    Xuan Zhang1 and Xunyao Wu2, 1Rheumatology, Peking Union Medical College Hospital, Beijing, China, 2Peking Union Medical College Hospital, beijing, China

    Background/Purpose: A delayed diagnoses and therapy of ACPA (Anti cyclic citrullinated peptide antibody)-negative RA patients might be associated with effective serum biomarkers in clinic. Methods:…
  • Abstract Number: 2114 • 2018 ACR/ARHP Annual Meeting

    Interferon Kappa Regulates Apoptotic Response to UVB in Control and Lupus Keratinocytes

    Grace Hile1, Mrinal Sarkar2, Jianhua Liu3, Tamra J. Reed4, Johann Gudjonsson2 and Michelle Kahlenberg4, 1University of Michigan, Ann Arbor, MI, 2Dermatology, University of Michigan, Ann Arbor, MI, 3Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, 4Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI

    Background/Purpose: Photosensitivity, defined as increased cutaneous erythema and inflammation after ultraviolet light (UV) exposure, is a hallmark of patients with systemic lupus erythematosus (SLE), cutaneous…
  • Abstract Number: 2121 • 2018 ACR/ARHP Annual Meeting

    Serum High Type I Interferon Is Associated with Active Proliferative Lupus Nephritis in Lupus Patients Accompanied with High Interferon Signature Gene Expression and Plasmacytoid Dendritic Cell Infiltration in Lupus Nephritis Kidney

    Taro Iwamoto1, Jessica M. Dorschner2, Mark A. Jensen1, Shanmugapriya Selvaraj3, Danielle Vsetecka2, Shreyasee Amin2, Ashima Makol2, Floranne C. Ernste2, Thomas Osborn2, Kevin Moder2, Vaidehi R. Chowdhary2, Valeria Mezzano4, Peter M. Izmirly5, H. Michael Belmont5, Robert M. Clancy1, Jill P. Buyon1, Ming Wu3, Cynthia A. Loomis3 and Timothy B. Niewold1, 1Colton Center for Autoimmunity, New York University, New York, NY, 2Mayo Clinic College of Medicine, Rochester, MN, 3Department of Pathology, New York University, New York, NY, 4Division of Cardiology, New York University, New York, NY, 5Division of Rheumatology, New York University, New York, NY

    Background/Purpose: Despite recent advancements in immunosuppressive therapies, lupus nephritis (LN) remains one of the most severe organ manifestations in systemic lupus erythematosus (SLE). High type…
  • Abstract Number: 1011 • 2017 ACR/ARHP Annual Meeting

    Mitochondrial Haplogroups-Mediated Methylation Regulates Apoptosis in Osteoathritis Cartilage

    Ignacio Rego-Pérez1, Estefanía Cortés-Pereira1, Juan Fernández-Tajes Sr.2, Mercedes Fernandez Moreno1, Maria Eugenia Vazquez Mosquera1, Sara Relaño-Fernandez3, Natividad Oreiro4, Carlos Fernandez-Lopez1 and Francisco J Blanco1, 1Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 2The Wellcome Trust Center for Human Genetics. McCarthy´s Group. University of Oxford, Oxford, United Kingdom, 3Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, 41) Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruna, Spain

    Background/Purpose: Recent studies revealed that haplogroup J associates with a decreased rate of incident knee Osteoarthritis. Among the functional characteristics of this haplogroup, lower rates…
  • Abstract Number: 1409 • 2017 ACR/ARHP Annual Meeting

    Ursolic Acid Promotes Apoptosis of Rheumatoid Athritis Synovial Fibroblasts By Upregulating Noxa Expression and Recruiting E3 Ligase Mule to Degrade Mcl-1

    Eugene Kim1, Solomon Agere1, Sadik Khuder2 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Department of Medicine, University of Toledo, Toledo, OH

    Background/Purpose: In our previous study, we discovered that ursolic acid (UA), a pentacyclic triterpenoid with anti-inflammatory properties, induces apoptosis in synovial fibroblasts from rheumatoid arthritis…
  • Abstract Number: 1835 • 2017 ACR/ARHP Annual Meeting

    Microglial Defects Contribute to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Hadijat Makinde1, Philip J. Homan2, Harris Perlman2 and Carla Cuda2, 1Northwestern University, Chicago, IL, 2Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Neuropsychiatric symptoms of systemic lupus erythematosus (NP-SLE), including headaches, cognitive dysfunction and psychiatric disorders, appear in up to 75% of SLE patients and may…
  • Abstract Number: 2576 • 2017 ACR/ARHP Annual Meeting

    Caspase 8 in Dendritic Cells Suppresses IRF5 Activation through Endosomal TLR Signaling to Prevent SLE-like Disease

    FuNien Tsai1, Harris Perlman2 and Carla Cuda2, 1Medicine-Rheumatology, Northwestern University-Feinberg School of Medicine, Chicago, IL, 2Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Previous studies implicate dendritic cells (DCs) in the pathogenesis of systemic lupus erythematosus (SLE), yet the mechanisms underlying this involvement are not yet clear.…
  • Abstract Number: 2838 • 2017 ACR/ARHP Annual Meeting

    Apoptotic Bodies Containing dsDNA Covalently Modified By Parvovirus B19 Non-Structural Protein NS1 Induce dsDNA Autoantibodies and End Organ Damage in Non-Autoimmune Mice

    Stanley J. Naides1, Kanoktip Puttaraksa2, Heidi Pirttinen2 and Leona Gilbert2, 1Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, 2Department of Biological and Environmental Science and Nanoscience Center, University of Jyvaskyla, Jyvaskyla, Finland

    Background/Purpose: Persistent viral infections can induce aberrant immune responses and are implicated in the development of autoimmunity. Parvovirus B19 (B19V) non-structural protein, NS1, a helicase,…
  • Abstract Number: 37 • 2017 ACR/ARHP Annual Meeting

    β2-Glycoprotein I Binds to Necroptotic Cells and Serves As a Target for SLE Autoantibodies

    David Salem1, Rebecca Subang1, Maziar Divangahi1, Christian Pineau2, Sasha Bernatsky3, Jerrold S. Levine4 and Joyce Rauch5, 1Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 2Division of Rheumatology, McGill University Health Centre, Montreal, QC, Canada, 3Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, 4Section of Nephrology, Department of Medicine, University of Illinois at Chicago and Jesse Brown Veterans Affairs Medical Center, Chicago, IL, 5Division of Rheumatology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada

    Background/Purpose: β2-glycoprotein I (β2GPI), a phospholipid-binding protein, binds to apoptotic cells and serves as an antigenic target for autoantibodies from patients with systemic lupus erythematosus…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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