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Abstracts tagged "Apoptosis"

  • Abstract Number: 555 • 2013 ACR/ARHP Annual Meeting

    Therapeutic Inhibition Of Anti-Apoptotic BCL-2 Family Proteins In a Murine Model Of Lupus Nephritis

    Li Chun Wang1, Stuart Perper2, Danise Perron3, Edit Tarcsa4, Philip Bardwell3, Neelufar Mozaffarian5, Andrew Souers5, Steven Elmore6, Tariq Ghayur7 and Lisa Olson3, 1Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, 2Pharmacology, AbbVie Bioresearch Center, Inc, Worcester, MA, 3Immunology, AbbVie Bioresearch Center, Inc, Worcester, MA, 4Immunology, AbbVie Bioresearch Center, Worcester, MA, 5AbbVie, North Chicago, IL, 6AbbVie Inc, North Chicago, IL, 7AbbVie Bioresearch Center, Inc, Worcester, MA

    Background/Purpose: Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed…
  • Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting

    Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury

    Lauren Bourke1, James McCormick2, Vera Ripoll3, Charis Pericleous4, Anna Radziszewska5, Anastasis Stephanou6 and Yiannis Ioannou7, 1Centre for Rheumatology Research, University College London, London, United Kingdom, 2Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, 3Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, 4Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 5The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, 6Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, 7Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom

    Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
  • Abstract Number: 2819 • 2013 ACR/ARHP Annual Meeting

    Administration Of a Multi-Epitope Citrullinated Peptide Attuneuates adjuvant  Induced Arthritis In Rats Via Induction Of Immune Tolerance

    Howard Amital1, Smadar Gertel2 and Yehuda Shoenfeld3, 1The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B',, Sheba Medical Center,Tel-Hashomer, Tel-Aviv University, Tel-hashomer, Israel, 2The Zabludowicz Center For Autoimmune Diseases, and Department of Medicine 'B', Sheba Medical Center, Tel-Hashomer, Israel, 3Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Affiliated to Sackler Faculty of Medicine, Tel-Aviv University,Tel-Aviv, Tel-Aviv, Israel

    Background/Purpose: Antigen-induced peripheral tolerance is a potentially efficient and specific therapeutic approach to attenuate autoimmunity. Citrullinated peptides are major targets of disease-specific autoantibodies in Rheumatoid…
  • Abstract Number: 2822 • 2013 ACR/ARHP Annual Meeting

    IKKε Deficiency Prolongs Neutrophil Survival Paradoxically Prolonging Inflammation In The Absence Of a Type I Interferon Response

    Maripat Corr1, Christopher Chung2, Seong-Kyu Kim3, D. L Boyle4 and G. S. Firestein5, 1Medicine, Univ of California-San Diego, La Jolla, CA, 2Medicine, UCSD School of Medicine, La Jolla, CA, 3Catholic University of Daegu School of Medicine, Daegu, South Korea, 4Div of Rheum, UCSD School of Medicine, La Jolla, CA, 5Div of Rheumatology, UCSD School of Medicine, La Jolla, CA

    Background/Purpose: Deficiency of the IKK-related kinases IKKε synergizes with the anti-inflammatory effects of IFNß in a murine model of arthritis., and this effect is mediated…
  • Abstract Number: 2260 • 2013 ACR/ARHP Annual Meeting

    Smoking and Antibodies To Cyclic Citrullinated Peptides Predict Persistently High Levels Of Survivin In Early Rheumatoid Arthritis

    Bjorn Svensson1, Ingiäld Hafström2, Malin Erlandsson3, Kristina Forslind4 and Maria Bokarewa3, 1Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden, 2Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden, 3Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, 4Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden

    Background/Purpose: High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor…
  • Abstract Number: 2215 • 2013 ACR/ARHP Annual Meeting

    Apoptotic Cell-Based Therapy To Treat Collagen-Induced Experimental Arthritis. Rationale For The Use Of Apoptotic Cells In The Treatment Of Rheumatoid Arthritis

    Sylvain Perruche1, Amandine Clauzon1, Francis Bonnefoy1, Eric Toussirot2 and Philippe Saas3, 1UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, 2Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, 3Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France

    Background/Purpose: Most of the currently available biological agents used in the treatment of rheumatoid arthritis (RA) target a cellular or soluble factor involved in the…
  • Abstract Number: 1860 • 2013 ACR/ARHP Annual Meeting

    Novel Proinflammatory Microvesicles That Carry LL-37 In Patients With Cutaneous Lupus

    Ming-Lin Liu1,2,3, Muhammad Bashir1,4, Meena Sharma1,4, Honghui Xu1,4, Kevin Williams3, Cynthia O. Anyanwu4,5, Joyce Okawa1,6 and Victoria P. Werth1,4, 1Department of Dermatology, University of Pennsylvania, Philadelphia, PA, 2Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, 3Department of Medicine, Temple University School of Medicine, Philadelphia, PA, 4Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, 5Department of Dermatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, 6Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA

    Background/Purpose: Cutaneous lupus erythematosus (CLE) refers to variants of lupus erythematosus (LE) with exclusively or predominantly skin manifestations. CLE is associated with accumulation of autoantibodies…
  • Abstract Number: 1728 • 2013 ACR/ARHP Annual Meeting

    Amelioration Of Collagen-Induced Arthritis By Modulation Of Inhibitory Apoptosis Stimulating Protein Of p53 To Activate Transcription Factor p73

    Chrong-Reen Wang1, Shih-Yao Chen2, Ai-Li Shiau3, Yuan-Tsung Li4, Chia-Tse Weng5, I-Ming Jou6, Ming-Fei Liu7 and Chao-Liang Wu2, 1Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 4Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 5Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, 6Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, 7Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Background/Purpose: Our previous studies have demonstrated p53 mutations competent for the inactivation of wild type p53 in synovial fibroblasts (SF) from either rheumatoid arthritis patients…
  • Abstract Number: 1406 • 2013 ACR/ARHP Annual Meeting

    The Scaffold Protein p62 Is Involved In NF-κB Signaling, Caspase-3 Dependent and -Independent Cell Death and Autophagy In Rheumatoid Arthritis Synovial Fibroblasts

    Masaru Kato1, Caroline Ospelt1, Christoph Kolling2, Beat A. Michel3, Renate E. Gay4, Steffen Gay5 and Kerstin Klein1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Schulthess Clinic, Zurich, Switzerland, 3Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 4Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland

    Background/Purpose: Sequestosome 1 (p62/ SQSTM1) is a multifunctional ubiquitin-binding protein implicated in selective autophagy, cell signaling pathways and regulation of cell death. Recently, we described…
  • Abstract Number: 1522 • 2012 ACR/ARHP Annual Meeting

    Differential Response to Endoplasmic Reticulum Stress Between Alveolar Epithelial Cells and Lung Fibroblasts in Systemic Sclerosis

    Jun Liang1, Tanjina Akter2, Ilia Atanelishvili3, Richard M. Silver4 and Galina S. Bogatkevich2, 1Department of Rheumatology, Medical University of SC, Charleston, SC, 2Department of Rheumatology, Medical University of South Carolina,Charleston,USA, Charleston, SC, 3Division of Rheumatology & Immunology, Medical University of South Carolina,Charleston,USA, Charleston, SC, 4Rheumatology, Medical University of SC, Charleston, SC

    Background/Purpose: Interstitial lung disease is a prevalent and worrisome complication of systemic sclerosis (SSc), which is now the leading cause of death in SSc. There…
  • Abstract Number: 1494 • 2012 ACR/ARHP Annual Meeting

    CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy

    Bashar Kahaleh1 and Yongqing Wang2, 1Medicine/Rheumatology, University of Toledo, Toledo, OH, 2Medicine, University of Toledo, Toledo, OH

    Background/Purpose: Increased expression of CD40 in SSc- Microvascular Endothelial Cells (MVEC) was noted on a gene expression array and increased concentrations of soluble CD40 ligand (sCD40L)…
  • Abstract Number: 1069 • 2012 ACR/ARHP Annual Meeting

    The Effects of TNF Stimulation On Control of Apoptosis in Neutrophils

    Direkrit Chiewchengchol1, Connie Lam1, Kate Roberts1, Helen Wright1, Huw Thomas1, Robert Moots2 and Steven Edwards1, 1Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom, 2University Hospital Aintree, Liverpool, United Kingdom

    Background/Purpose: TNF is a key regulator of immune function and plays a pivotal role in inflammatory conditions such as rheumatoid arthritis. Human neutrophils express and…
  • Abstract Number: 902 • 2012 ACR/ARHP Annual Meeting

    Activation of NF-Kb Via Poly(I:C)-Induced Monocyte-Derived Microparticles Decreases TRAIL-Induced Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts

    Mojca Frank Bertoncelj1, Blaz Rozman2, Beat A. Michel3, Renate E. Gay1, David S. Pisetsky4, Oliver Distler5, Steffen Gay6 and Astrid Juengel7, 1Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 2Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 3Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 4Department of Medicine, Duke University Medical Center, Durham, NC, 5Department of Rheumatology and Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 6Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, CH-8091, Switzerland, 7Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland

    Background/Purpose: Decreased sensitivity of rheumatoid arthritis (RA) synovial fibroblasts (SF) to apoptosis leads to synovial hyperplasia and destruction of joints in RA. Activation of NF-kB…
  • Abstract Number: 435 • 2012 ACR/ARHP Annual Meeting

    CIP2A Facilitates Apoptotic Resistance of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis Independent of c-Myc Expression

    Jaejoon Lee1, Jiwon Hwang1, Jinseok Kim2, Joong Kyong Ahn3, Hoon-Suk Cha1 and Eun-Mi Koh4, 1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, 2Internal Medicine, Jeju National University Hospital, Jeju, South Korea, 3Department of Medicine, Kangbuk Samsung hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea, 4Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Seoul, South Korea

    Background/Purpose: Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein that leads to cellular proliferation in cancer cells by stabilizing c-Myc protein.…
  • Abstract Number: 410 • 2012 ACR/ARHP Annual Meeting

    Early Growth Response-1 (EGR-1) Controls Synoviocyte Apoptosis, and Its Expression Is Regulated by the Direct Binding of Fibroblast Growth Factor-1 (FGF1) or Insulin-Like Growth Factor-1 (IGF1) to Integrin αvβ3

    Shino Tanaka1, Jun Saegusa1, Seiji Kawano1, Yoshikazu Takada2, Shunichi Kumagai3 and Akio Morinobu1, 1Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, 2Dermatology, University of California, Davis, School of Medicine, Sacramento, CA, 3The Center of Rheumatic Diseases, Shinko Hospital, Kobe, Japan

    Background/Purpose: Growth factors such as fibroblast growth factor (FGF) and insulin-like growth factor (IGF) are of interest in the initiation and development of rheumatoid arthritis…
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