Abstracts tagged "Apoptosis"

Abstract Number: 2260 • 2013 ACR/ARHP Annual Meeting
Smoking and Antibodies To Cyclic Citrullinated Peptides Predict Persistently High Levels Of Survivin In Early Rheumatoid Arthritis
Bjorn Svensson¹, Ingiäld Hafström², Malin Erlandsson³, Kristina Forslind⁴ and Maria Bokarewa³, ¹Section of Rheumatology, Institution of Clinical Science, Lund University, Lund, Sweden, ²Unit of Rheumatology, Department of Medicine, Karolinska University Hospital, Stockholm, Sweden, ³Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ⁴Department of Medicine, Karolinska Institute, Stockholm, Department of Medicine, Karolinska Institute,, Stockholm, Sweden
Background/Purpose: High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor…
Abstract Number: 2215 • 2013 ACR/ARHP Annual Meeting
Apoptotic Cell-Based Therapy To Treat Collagen-Induced Experimental Arthritis. Rationale For The Use Of Apoptotic Cells In The Treatment Of Rheumatoid Arthritis
Sylvain Perruche¹, Amandine Clauzon¹, Francis Bonnefoy¹, Eric Toussirot² and Philippe Saas³, ¹UMR1098 INSERM, EFS Bourgogne Franche Comté, Besançon, France, ²Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, ³Etablisement Français du Sang ; Université de Franche Comté, INSERM UMR1098, Besançon, France
Background/Purpose: Most of the currently available biological agents used in the treatment of rheumatoid arthritis (RA) target a cellular or soluble factor involved in the…
Abstract Number: 1860 • 2013 ACR/ARHP Annual Meeting
Novel Proinflammatory Microvesicles That Carry LL-37 In Patients With Cutaneous Lupus
Ming-Lin Liu^1,2,3, Muhammad Bashir^1,4, Meena Sharma^1,4, Honghui Xu^1,4, Kevin Williams³, Cynthia O. Anyanwu^4,5, Joyce Okawa^1,6 and Victoria P. Werth^1,4, ¹Department of Dermatology, University of Pennsylvania, Philadelphia, PA, ²Department of Dermatology,, Philadelphia V.A. Hospital, Philadelphia, PA, ³Department of Medicine, Temple University School of Medicine, Philadelphia, PA, ⁴Department of Dermatology, Philadelphia V.A. Hospital, Philadelphia, PA, ⁵Department of Dermatology, Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, ⁶Department of Dermatology, Veteran Affairs Medical Center, Philadelphia, PA
Background/Purpose: Cutaneous lupus erythematosus (CLE) refers to variants of lupus erythematosus (LE) with exclusively or predominantly skin manifestations. CLE is associated with accumulation of autoantibodies…
Abstract Number: 1728 • 2013 ACR/ARHP Annual Meeting
Amelioration Of Collagen-Induced Arthritis By Modulation Of Inhibitory Apoptosis Stimulating Protein Of p53 To Activate Transcription Factor p73
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Chia-Tse Weng⁵, I-Ming Jou⁶, Ming-Fei Liu⁷ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ⁶Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, ⁷Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
Background/Purpose: Our previous studies have demonstrated p53 mutations competent for the inactivation of wild type p53 in synovial fibroblasts (SF) from either rheumatoid arthritis patients…
Abstract Number: 1406 • 2013 ACR/ARHP Annual Meeting
The Scaffold Protein p62 Is Involved In NF-κB Signaling, Caspase-3 Dependent and -Independent Cell Death and Autophagy In Rheumatoid Arthritis Synovial Fibroblasts
Masaru Kato¹, Caroline Ospelt¹, Christoph Kolling², Beat A. Michel³, Renate E. Gay⁴, Steffen Gay⁵ and Kerstin Klein¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Schulthess Clinic, Zurich, Switzerland, ³Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, ⁵Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland
Background/Purpose: Sequestosome 1 (p62/ SQSTM1) is a multifunctional ubiquitin-binding protein implicated in selective autophagy, cell signaling pathways and regulation of cell death. Recently, we described…
Abstract Number: 1392 • 2013 ACR/ARHP Annual Meeting
The Expression Of Proto-Oncogene Survivin Splicing Variant 2B In Synovial Tissues and Blood From Patients With Rheumatoid Arthritis
Sho Mokuda^1,2, Tatsuhiko Miyazaki³, Junya Masumoto³, Masamoto Kanno⁴ and Kiyoshi Takasugi⁵, ¹Department of Immunology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan, ²Department of Internal Medicine, Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan, ³Department of Pathology, Division of Analyticalpathology, Ehime University Graduate School of Medicine, Toon, Japan, ⁴Department of Immunology, Graduate School of Biomedical Sciences, Hiroshima University, Hirosima, Japan, ⁵Center for Rheumatic Diseases, Dohgo Spa Hospital, Matsuyama, Japan
Background/Purpose: It has been reported that serum survivin level was an independent risk factor for predicting joint destruction in early rheumatoid arthritis (RA). The proto-oncogene…
Abstract Number: 939 • 2013 ACR/ARHP Annual Meeting
Reduction Of Circulating Blood Neutrophils In Mice By Anti-IL-6R Alpha Monoclonal Antibody is Not Due To Apoptosis Or Blockade Of Neutrophil Differentiation
Ludmila Kelly, Vilma Decman and Dimitris Skokos, Research, Regeneron Pharmaceuticals, Inc., Tarrytown, NY
Background/Purpose: Blockade of IL-6/IL-6Rα signaling is associated with a reduction of circulating neutrophils in the blood of patients treated with anti-IL-6Rα mAb but the mechanism…
Abstract Number: 569 • 2013 ACR/ARHP Annual Meeting
Hydroxycholorquine Is Cardioprotective In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury.-An Effect Mediated Through ERK Phosphorylation
Lauren Bourke¹, James McCormick², Anastasis Stephanou³ and Yiannis Ioannou⁴, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ³MMBU, University College London, London, United Kingdom, ⁴Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 546 • 2013 ACR/ARHP Annual Meeting
The Survival Of Gr1⁺CD11b⁺cells Is Differentially Regulated In Male and Female Lupus-Prone Mice
Elena Gonzalez^1,2, Trine Jorgensen² and Abhishek Trigunaite², ¹Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, ²Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Systemic Lupus Erythematosis (SLE) is a multisystem autoimmune disease that develops far more frequently in females than in males (9:1 ratio). The (NZBxNZW)F1 lupus-prone…
Abstract Number: 551 • 2013 ACR/ARHP Annual Meeting
Different Cell Death Programs Contribute To Severity Of Lupus Glomerulonephritis In Males and Females
Neelakshi Jog¹ and Roberto Caricchio², ¹Rheumatology, Temple University, Philadelphia, PA, ²Medicine/Rheumatology, Temple University, Philadelphia, PA
Background/Purpose: Lupus glomerulonephritis (GN) is a leading cause of long-term disability in SLE. Although lupus is more common in females, GN occurs earlier and in…
Abstract Number: 555 • 2013 ACR/ARHP Annual Meeting
Therapeutic Inhibition Of Anti-Apoptotic BCL-2 Family Proteins In a Murine Model Of Lupus Nephritis
Li Chun Wang¹, Stuart Perper², Danise Perron³, Edit Tarcsa⁴, Philip Bardwell³, Neelufar Mozaffarian⁵, Andrew Souers⁵, Steven Elmore⁶, Tariq Ghayur⁷ and Lisa Olson³, ¹Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²Pharmacology, AbbVie Bioresearch Center, Inc, Worcester, MA, ³Immunology, AbbVie Bioresearch Center, Inc, Worcester, MA, ⁴Immunology, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie, North Chicago, IL, ⁶AbbVie Inc, North Chicago, IL, ⁷AbbVie Bioresearch Center, Inc, Worcester, MA
Background/Purpose: Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed…
Abstract Number: 560 • 2013 ACR/ARHP Annual Meeting
Purified IgG From Patients With Systemic Lupus Erythematosus Enhances Apoptosis In Neonatal Rat Cardiomyocytes Exposed To Simulated Myocardial Ischaemic/Reperfusion Injury
Lauren Bourke¹, James McCormick², Vera Ripoll³, Charis Pericleous⁴, Anna Radziszewska⁵, Anastasis Stephanou⁶ and Yiannis Ioannou⁷, ¹Centre for Rheumatology Research, University College London, London, United Kingdom, ²Clinical & Molecular Genetics Unit, University College London, London, United Kingdom, ³Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ⁵The Rayne Institute, Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom, ⁶Medical and Molecular Biology Unit (MMBU), University College London, London, United Kingdom, ⁷Arthritis Research UK Centre for Adolescent Rheumatology at University College London, Great Ormond Street Hospital and UCLH, University College London, London, United Kingdom
Background/Purpose: A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage which is known as ischaemic reperfusion (I/R) injury…
Abstract Number: 429 • 2012 ACR/ARHP Annual Meeting
The Significance of the Apoptosis Level and the Apoptosis Related Signal Proteins of CD4⁺t�ACD4⁺Foxp3⁺t Cell in Patients with Rheumatoid Arthritis
Ning Li¹, Tianrui Ma², Jie Han¹, Jieru Zhou¹ and Songguo Zheng³, ¹Rheumatology, Shanghai East Hospital, Shanghai, China, ²Rheumatology, Ningbo Pediatric Hospital, Ningbo, China, ³Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA
Background/Purpose: To investigate the apoptosis of CD4+T cell and Tregs in the pathogenesis and disease activity of rheumatoid arthritis patients. Methods: Isolated lymphocytes from human…
Abstract Number: 418 • 2012 ACR/ARHP Annual Meeting
Immediate Early Response Gene X-1 Is Over-Expressed and Regulates Apoptosis and Cytokine Production in Rheumatoid Arthritis Synovial Fibroblasts
Akio Morinobu¹, Masaaki Fujita², Shino Tanaka³, Jun Saegusa⁴ and Shunichi Kumagai⁵, ¹Department of clinical pathology and immunology, Kobe university graduate school of medicine, Kobe 650-0017, Japan, ²Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Clinical Pathology and Immunology, Rheumatology and Clinical Immunology, Kobe, Japan, ⁴Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Center of rheumatic diseases, Shinko hospital, Kobe, Japan
Background/Purpose: Histone deacetylase inhibitors (HDACi) are potential therapeutic drugs for the treatment of rheumatoid arthritis (RA). We found that an HDACi up-regulates the gene expression…
Abstract Number: 410 • 2012 ACR/ARHP Annual Meeting
Early Growth Response-1 (EGR-1) Controls Synoviocyte Apoptosis, and Its Expression Is Regulated by the Direct Binding of Fibroblast Growth Factor-1 (FGF1) or Insulin-Like Growth Factor-1 (IGF1) to Integrin αvβ3
Shino Tanaka¹, Jun Saegusa¹, Seiji Kawano¹, Yoshikazu Takada², Shunichi Kumagai³ and Akio Morinobu¹, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Dermatology, University of California, Davis, School of Medicine, Sacramento, CA, ³The Center of Rheumatic Diseases, Shinko Hospital, Kobe, Japan
Background/Purpose: Growth factors such as fibroblast growth factor (FGF) and insulin-like growth factor (IGF) are of interest in the initiation and development of rheumatoid arthritis…