Abstracts tagged "Systemic sclerosis"

Abstract Number: 1836 • ACR Convergence 2021
Outcomes Linked to Eligibility for Stem Cell Transplantation Trials in Diffuse Cutaneous Systemic Sclerosis
Julia Spierings¹, Svetlana Nihtyanova², Emma Derrett-Smith³, Kristina Clark², Jacob van Laar⁴, Voon Ong⁵ and Christopher Denton⁶, ¹University Medical Center Utrecht, Utrecht, Netherlands, ²University College London, Royal Free Campus, London, United Kingdom, ³University College London Division of Medicine, London, United Kingdom, ⁴University Medical Centre Utrecht, Utrecht, Netherlands, ⁵University College London Medical School Royal Free Campus, London, United Kingdom, ⁶University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom
Background/Purpose: Autologous haematopoietic stem cell transplantation (SCT) has emerged as an effective treatment for patients with severe diffuse systemic sclerosis (dcSSc) based upon the results…
Abstract Number: 1856 • ACR Convergence 2021
Serum IFN Score Predicts Long Term Outcome in Limited Cutaneous SSc
Ranjitha Karanth¹, Giuseppina Abignano², Vishal Kakkar², Rebecca Ross², Christopher Denton³ and Francesco Del Galdo², ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, LTHT, Leeds, United Kingdom, ²University of Leeds, Leeds, United Kingdom, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom
Background/Purpose: Limited cutaneous systemic sclerosis (lcSSc) carries a highly variable prognosis and to date there are no stratification tools to predict clinical outcomes. Evidence suggests…
Abstract Number: 0401 • ACR Convergence 2021
Item Reduction for the Assessment of Systemic Sclerosis-associated RAynaud’s Phenomenon (ASRAP) Questionnaire Using Data from the International Multicentre ASRAP Validation Study
John Pauling¹, Lan Yu², Christopher Denton³, Tracy Frech⁴, Ariane Herrick⁵, Laura Hummers⁶, Lesley Ann Saketkoo⁷, Ami Shah⁸, Dinesh Khanna⁹ and Robyn Domsic², ¹Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ²University of Pittsburgh, Pittsburgh, PA, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, ⁴University of Utah, Salt Lake City, UT, ⁵University of Manchester, Salford, United Kingdom, ⁶Johns Hopkins Univerisity, Baltimore, MD, ⁷University Medical Center - Comprehensive Pulmonary Hypertension Center, New Orleans, LA, ⁸Johns Hopkins Rheumatology, Baltimore, MD, ⁹University of Michigan, Ann Arbor, MI
Background/Purpose: The Assessment of Systemic sclerosis-associated RAynaud’s Phenomenon (ASRAP) questionnaire is a novel patient-reported outcome (PRO) instrument devised to assess the severity and impact of…
Abstract Number: 0547 • ACR Convergence 2021
Autologous Haematopoietic Stem Cell Transplantation for Systemic Sclerosis Results in Sustained Changes in Immunoregulatory T and NK Cells
Ross Penglase, Malini Visweswaran, John Zaunders, Laila Girgis, David Ma and John Moore, St Vincent's Hospital, Sydney, Australia
Background/Purpose: Autologous Haematopoietic Stem Cell Transplantation (AHSCT) is an effective treatment for severe systemic sclerosis (SSc). To date, mechanistic studies have indicated possible pro-regulatory and…
Abstract Number: 1001 • ACR Convergence 2021
Exosomes Mediate a Cooperative Mechanism of Macrophage/Fibroblast Activation in Systemic Sclerosis
Rajan Bhandari¹, Heetaek Yang², Noelle Kosarek³, Michael Whitfield⁴ and Patricia Pioli¹, ¹Geisel School of Medicine at Dartmouth, Lebanon, NH, ²Geisel School of Medicine, Hanover, NH, ³Dartmouth Geisel School of Medicine, Hartford, VT, ⁴Geisel School of Medicine, Lebanon, NH
Background/Purpose: Prior work demonstrates that macrophages (MØs) from patients with Systemic Sclerosis (SSc) produce fibrotic and pro-inflammatory mediators and that cocultured MØs and SSc fibroblasts…
Abstract Number: 1375 • ACR Convergence 2021
Improvement in Overall Survival, Skin Fibrosis and Lung Function with Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis
Nancy Maltez¹, Mianbo Wang², Georges Wells³, Peter Tugwell¹, Murray Baron⁴, Zora Marjanovic⁵, Pauline Lansiaux⁶, Dominique Farge⁶ and Marie Hudson⁷, ¹The Ottawa Hospital, Ottawa, ON, Canada, ²Lady Davis institute for Medical Research, Montréal, QC, Canada, ³University of Ottawa, Ottawa, ON, Canada, ⁴Jewish General Hospital, Montréal, QC, Canada, ⁵Hopital Saint-Antoine, Paris, France, ⁶8. Centre de Référence des Maladies auto-immunes systémiques Rares d’Ile-de-France, Paris, France, ⁷McGill University, Montréal, QC, Canada
Background/Purpose: Systemic sclerosis (SSc) is a chronic disease characterized by vasculopathy, inflammation and fibrosis. Rheumatologists have limited options to effectively treat rapidly progressive disease. There…
Abstract Number: 1838 • ACR Convergence 2021
Further Construct Validation of the
Julia Spierings¹, Voon Ong² and Christopher Denton³, ¹University Medical Center Utrecht, Utrecht, Netherlands, ²University College London Medical School Royal Free Campus, London, United Kingdom, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom
Background/Purpose: Evaluation of skin is central in clinical management of systemic sclerosis (SSc). Due to the COVID-19 pandemic remote consultations were widely implemented, which inevitably…
Abstract Number: 1857 • ACR Convergence 2021
Ultra-High Frequency Ultrasound Compared to Durometry and Skin Score for Cutaneous Assessment in Systemic Sclerosis
Marco Di Battista¹, Saverio Vitali², Simone Barsotti³, Alessandra Della Rossa⁴, Valentina Dini⁵, Marco Romanelli⁵ and Marta Mosca³, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²Radiology Unit - University of Pisa, Pisa, Italy, ³Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁴Rheumatology Unit - University of Pisa, Pisa, Italy, ⁵Dermatology Unit - University of Pisa, Pisa, Italy
Background/Purpose: To assess skin involvement in a cohort of patients with systemic sclerosis (SSc) comparing results obtained from modified Rodnan skin score (mRSS), durometry and…
Abstract Number: 0402 • ACR Convergence 2021
What Is the Patient’s Perspective on Symptoms Experience in Limited Cutaneous Systemic Sclerosis?
Alain Lescoat¹, Susan Murphy², Yen Chen³, Nadia Vann¹, David Cella⁴ and Dinesh Khanna³, ¹Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, ²University of Michigan, Grosse Ile, MI, ³University of Michigan, Ann Arbor, MI, ⁴Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Limited cutaneous SSc (lcSSc) affects approximately 60-70% of SSc patients but drug development and therapeutic research has largely focused on the more severe diffuse…
Abstract Number: 0549 • ACR Convergence 2021
Upregulation of Prostanoid EP2 Receptors and Meditation of Treprostinil Anti-Proliferative Effects in Scleroderma Smooth Muscle Cells
Yongqing Wang¹, Nezam Altorok² and Bashar Kahaleh², ¹University of Toledo Medical Center, Toledo, OH, ²University of Toledo, Toledo, OH
Background/Purpose: Progressive functional and structural vascular disorder is one of the hallmark features of Systemic Sclerosis (Scleroderma, SSc). Vascular dysfunction leads to dysregulated vascular tone…
Abstract Number: 1044 • ACR Convergence 2021
Older Patients with Rheumatic Disease Are Commonly Prescribed Potentially Inappropriate Medications
Christine Anastasiou, Michael Evans, Gabriela Schmajuk and Jinoos Yazdany, University of California San Francisco, San Francisco, CA
Background/Purpose: Reducing exposure to potentially inappropriate medications (PIMs) in older adults may minimize adverse drug events. The American Geriatrics Society (AGS) Beers Criteria® of Potentially…
Abstract Number: 1378 • ACR Convergence 2021
Presence of Anti-RNA Polymerase 3 Antibody in Systemic Sclerosis, Renal Disease, Malignancy and ILD from a Single Academic Center Cohort
Matthew Kirkpatrick¹, Janet Lee¹, Anne Tebo², Haojia Li¹, yue zhang¹ and Tracy Frech¹, ¹University of Utah, Salt Lake City, UT, ²Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN
Background/Purpose: Autoantibodies are included in the disease classification criteria for systemic sclerosis (SSc). Our group previously reported the level of topoisomerase autoantibody as an important…
Abstract Number: 1839 • ACR Convergence 2021
Hispanic Patients with Systemic Sclerosis Have More Severe Disease and Higher Mortality: A Longitudinal Cohort Study
Bochra Jandali¹, Marka Lyons², Julio Charles², Maureen Mayes³ and Shervin Assassi¹, ¹University of Texas McGovern Medical School at Houston, Houston, TX, ²Division of Rheumatology, University of Texas McGovern Medical School at Houston, Houston, TX, ³Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, TX
Background/Purpose: Systemic sclerosis (SSc) shows disparities in incidence, disease manifestations, and prognosis in different ethnic groups. The data regarding disease characteristics and outcomes in Hispanic…
Abstract Number: 1860 • ACR Convergence 2021
Three Distinct Transcriptional Profiles of Monocytes Correlate with Disease Activity in SSc Patients
Hadijat Makinde¹, Gaurav Gadhvi¹, Salina Dominguez¹, Miranda Gurra¹, Kathleen Aren², Mary Carns², Tracy Frech³, Dinesh Khanna⁴, Shervin Assassi⁵, Lutfiyya Muhammad⁶, Carla Cuda¹, Monique Hinchcliff⁷, Deborah Winter² and Harris Perlman¹, ¹Northwestern University, Chicago, IL, ²Northwestern University Division of Rheumatology, Chicago, IL, ³University of Utah, Salt Lake City, UT, ⁴University of Michigan, Ann Arbor, MI, ⁵University of Texas McGovern Medical School at Houston, Houston, TX, ⁶Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Yale School of Medicine, Westport, CT
Background/Purpose: Patients with SSc display a complex clinical phenotype.Our group has made important contributions to an emerging understanding of monocytes and macrophages as central to…
Abstract Number: L09 • ACR Convergence 2020
A Phase 2a Randomized, Double-blind, Placebo-controlled Study of Ziritaxestat in Early Diffuse Cutaneous Systemic Sclerosis (NOVESA)
Dinesh Khanna¹, Christopher Denton², Daniel Furst³, Maureen Mayes⁴, Marco Matucci-Cerinic⁵, Vanessa Smith⁶, Dick de Vries⁷, Liesbeth Deberdt⁸, Pieter‑Jan Stiers⁸, Niyati Prasad⁸ and Sohail Ahmed⁹, ¹University of Michigan, Ann Arbor, MI, ²Royal Free Hospital, University College London, London, United Kingdom, ³David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴University of Texas Health Science Center at Houston, Houston, TX, ⁵Università degli Studi di Firenze, Firenze, Italy, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Galapagos BV, Leiden, Netherlands, ⁸Galapagos NV, Mechelen, Belgium, ⁹Ahmed Science Medicine, Basel, Switzerland
Background/Purpose: There is a high unmet need for systemic sclerosis (SSc) treatments. Ziritaxestat (ziri; GLPG1690) is an autotaxin inhibitor with a novel mechanism of action.…

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