ACR Meeting Abstracts

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Abstracts tagged "Systemic sclerosis"

  • Abstract Number: L18 • ACR Convergence 2024

    CCL19+ Fibroblasts Orchestrate Fibrotic Microenvironment via CCL19-CCR7 Axis in Systemic Sclerosis

    Wei Guo1, Zhaohua Li2, Dan Xu2 and Rong Mu2, 1Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing, China, 2Peking University Third Hospital, Beijing, China

    Background/Purpose: Understanding the roles of diverse fibroblast subsets is of great importance in elucidating the pathogenesis of fibrosis in systemic sclerosis (SSc). However, how the…
  • Abstract Number: 0706 • ACR Convergence 2024

    Single Center Prospective Cohort of Systemic Sclerosis Patients Who Are At-Risk for Pulmonary Hypertension

    Carleigh Zahn1, Scott Visovatti2, Rosemary Gedert1, Suiyuan Huang1, Victor Moles1, Amber Young1, Vallerie McLaughlin1 and Dinesh Khanna1, 1University of Michigan, Ann Arbor, MI, 2The Ohio State University, Columbus

    Background/Purpose: Pulmonary hypertension (PH) is a leading cause of mortality in systemic sclerosis (SSc). We launched an IRB approved prospective study (NOVEL) in 2013 at…
  • Abstract Number: 0958 • ACR Convergence 2024

    TCR Motifs Identify Unique Clones in African Americans with Systemic Sclerosis

    Urvashi Kaundal1, Chloe Borden2, Devin Teehan2, Brittany Dulek3, Justin Lack4, Ami Shah5, Maureen Mayes6, Daniel Shriner7, Ayo P. Doumatey7, Amy Bentley7, Robyn Domsic8, Thomas Medsger, Jr9, Paula Ramos10, Richard Silver11, Virginia Steen12, John Varga13, Vivien Hsu14, Lesley Ann Saketkoo15, Dinesh Khanna13, Elena Schiopu16, Jessica Gordon17, Lindsey Criswell18, Heather Gladue19, Chris Derk20, Elana Bernstein21, S. Louis Bridges17, Victoria Shanmugam22, Lorinda Chung23, Suzanne Kafaja24, Reem Jan25, Marcin Trojanowski26, Avram Goldberg27, Benjamin Korman28, Faiza Naz29, Stefania Dell'Orso30, Adebowale Adeyemo7, Elaine Remmers31, Charles Rotimi7, Fredrick Wigley32, Francesco Boin33, Daniel Kastner34 and Pravitt Gourh29, 1Scleroderma Genomics and Health Disparities Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Chevy Chase, MD, 2Scleroderma Genomics and Health Disparities Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 3Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 4Integrated Data Science Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, Bethesda, MD, 5Division of Rheumatology, Johns Hopkins University, Ellicott City, MD, 6UTHealth Houston Division of Rheumatology, Houston, TX, 7Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 8Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 9Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Verona, PA, 10Medical University of South Carolina, Charleston, SC, 11Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, 12Georgetown University School of Medicine, Washington, DC, 13University of Michigan, Ann Arbor, MI, 14Department of Medicine, Rheumatology Division, Rutgers-RWJ Medical School, South Plainfield, NJ, 15New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, Louisiana State University and Tulane University Medical Schools, New Orleans, LA, 16Division of Rheumatology, Medical College of Georgia at Augusta University, Martinez, GA, 17Division of Rheumatology, Weill Cornell Medical College, New York, NY, 18Genomics of Autoimmune Rheumatic Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, Bethesda, MD, 19Arthritis & Osteoporosis Consultants of the Carolinas, Charlotte, NC, 20Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 21Division of Rheumatology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, 22NIH Office of Autoimmune Disease Research in the Office of Research on Women's Health, National Institutes of Health, Bethesda, MD, Bethesda, MD, 23Stanford University, Woodside, CA, 24Division of Rheumatology, University of California, Los Angeles, Los Angeles, CA, 25Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL, 26Department of Rheumatology, Boston University School of Medicine, Boston, MA, 27NYU Langone Health - NYU Hospital for Joint Diseases, Lake Success, NY, 28University of Rochester, Rochester, NY, 29National Institutes of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Bethesda, MD, Bethesda, MD, 30Genomic Technology Section, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 31Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 32Johns Hopkins University, Division of Rheumatology, Baltimore, MD, Baltimore, MD, 33Cedars-Sinai Medical Center, Los Angeles, CA, 34National Human Genome Research Institute, Bethesda, MD

    Background/Purpose: Systemic sclerosis (SSc) is a rare multisystem autoimmune disease that disproportionately affects African Americans (AA). Previous work from our lab has suggested a pivotal…
  • Abstract Number: 1561 • ACR Convergence 2024

    Association of Large Vessel Vasculitis and Development of SSc and SSc-Associated Antibodies: Impact of Pulmonary Arterial Hypertension

    Brett Dinner1, Ahmed Abdelmaksoud2, Ann Igoe3, Taylor Viggiano4 and Vivek Nagaraja5, 1Creighton University, Paradise Valley, AZ, 2University of California, Riverside, Riverside, CA, 3Flow, Tempe, AZ, 4Mayo Clinic, Phoenix, 5Mayo Clinic Arizona, Scottsdale, AZ

    Background/Purpose: Large vessel vasculitis (LVV) comprises a spectrum of rare, potentially life-threatening disorders, including giant cell arteritis (GCA) and Takayasu's arteritis (TAK), defined by granulomatous…
  • Abstract Number: 1587 • ACR Convergence 2024

    Predictors of Body Mass Index in an Early Systemic Sclerosis Cohort

    Ali Ayla1, Meng Zhang1, Claudia Pedroza2, Bingrui Chen2, Brian Skaug1, Maureen Mayes1, Shervin Assassi1 and Zsuzsanna McMahan1, 1UTHealth Houston Division of Rheumatology, Houston, TX, 2UTHealth Houston, Houston, TX

    Background/Purpose: Malnutrition is a significant problem among patients with systemic sclerosis (SSc). Body mass index (BMI) is often low in patients with malnutrition. Low BMI…
  • Abstract Number: 1824 • ACR Convergence 2024

    Skin Macrophage Subtypes and Impact of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis: Results from Single-cell Analyses of an Observational Data Set and a Phase I/II Randomized Controlled Trial

    Juliette Ferrant1, Alain Lescoat2, Valérie Lecureur3, Marie Lelong3, John Varga4, Robert Lafyatis5, Johann Gudjonsson4 and Dinesh Khanna4, 1CHU Rennes, Rennes, France, 2CHU Rennes - University Rennes 1, Rennes, France, 3Rennes University, Rennes, France, 4University of Michigan, Ann Arbor, MI, 5University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Macrophages play a major role in dcSSc-related skin fibrosis, with a mixed M1-M2 activation profile relying on the activation of JAK/STAT. Tofacitinib, a pan-JAK…
  • Abstract Number: 2207 • ACR Convergence 2024

    Improvement Across Physician and Patient Reported Outcome Measures over a 24 Months-time Period in the Juvenile Systemic Scleroderma Inception Cohort

    Ivan Foeldvari1, Jens Klotsche2, Ozgur Kasapcopur3, Amra Adrovic4, Kathryn Torok5, Maria Teresa Terreri6, Ana Sakamoto7, Jordi Anton8, Brian Feldman9, Raju Khubchandani10, Tadey Avcin11, Sindhu R. Johnson12, Mikhail Kostik13, Edoardo Marrani14, Flavio Sztajnbok15, Maria Katsicas16, Dana Nemcova17, Maria Jose Santos18, Simone Appenzeller19, Cristina Battagliotti20, Lillemor Berntson21, Jürgen Brunner22, Liora Harel23, Gerd Horneff24, Tilmann Kallinich25, Kirsten Minden2, Farzana Nuruzzaman26, Anjali Patwardhan27, Dieneke Schonenberg-Meinema28 and Nicola Helmus29, 1Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Istanbul University-Cerrahpasa, Cerrahpasa Medical School, istanbul, Turkey, 4Cerrahpasa Medical School, Istanbul, Turkey, 5Division of Rheumatology, Scleroderma Center, Department of Pediatrics, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, USA, Pittsburgh, PA, 6UNIFESP, São Paulo, SP, Brazil, 7Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil, 8Hospital Sant Joan de Déu. Universitat de Barcelona, Esplugues de Llobregat (Barcelona), Spain, 9Division of Rheumatology, The Hospital for Sick Children; Departments of Pediatrics and Medicine, Faculty of Medicine; The Institute for Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, 10SRCC Childrens Hospital, Mumbai, India, 11University Children's Hospital University Medical Center Ljubljana, Ljubljana, Slovenia, 12University of Toronto, Toronto, Canada, 13Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 14University of Florence, Firenze, Florence, Italy, 15UFRJ/UERJ, SAO PAULO, Brazil, 16Hospital Garrahan, Buenos Aires, Argentina, 17MD, Prague, Czech Republic, 18Hospital Garcia de Orta and Centro Académico de Medicina de Lisboa, Lisboa, Portugal, 19Unicamp, Campinas, SP, Brazil, 20Hospital de Niños Dr Orlando Alassia, Santa Fe, Argentina, 21Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 22Medical University Innsbruck; Department of Pediatrics, Pediatric Rheumatology, Innsbruck, Austria, 23Faculty of Medicine, Tel Aviv University, Tel Aviv; Pediatric Rheumatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, Israel, Petach Tikva, HaMerkaz, Israel, 24Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 25Charite, Berlin, Germany, 26Stony Brook Children's Hospital, Stony Brook, NY, 27University of Missouri-Columbia, Department of Child Health, 404 N Keene Street, Columbia MO 65210, Columbia, 28Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 29Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1 000 000 children. The Juvenile Systemic Scleroderma Inception cohort…
  • Abstract Number: 2470 • ACR Convergence 2024

    Progression Patterns in Systemic Sclerosis – Associated Interstitial Lung Diseases

    anais Roeser1, Pierre-Yves Brillet1, Marouane Boubaya1, Frédéric Caux1, Robin Dhote1, Hilario Nunes1 and Yurdagül Uzunhan2, 1APHP, Bobigny, France, 2Service de Pneumologie, Hôpital Avicenne, AP-HP, Bobigny, France

    Background/Purpose: The occurrence of interstitial lung disease (ILD) in the course of systemic sclerosis (SSc) is associated with increased morbidity and mortality. SSc-ILD evolution is…
  • Abstract Number: 0247 • ACR Convergence 2024

    Enhanced Immunogenicity of the Recombinant Herpes Zoster Vaccine After One-Week of Mycophenolate Mofetil Discontinuation in Patients with Autoimmune Rheumatic Diseases: Interim Results from a Prospective Randomized Phase 4 Study

    Sandra Pasoto1, Isabele Antonelli1, Ana Cristina Medeiros-Ribeiro2, Nadia Aikawa3, Leonard Kupa1, Eduardo Borba1, Luciana Seguro4, Emily Figueiredo Neves Yuki1, ANA PAULA ASSAD1, Carla Saad4, Andrea Shimabuco4, Andrea Negrini1, Julia Medeiros1, Talita Ribeiro1, Samuel Shinjo4, Percival Sampaio-Barros4, Danieli Andrade5, Fernando Souza4, Renata Miossi4, Clovis Silva6 and Eloisa Bonfa1, 1Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 2Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Jose Dos Campos, Brazil, 3Rheumatology Division and Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil, 4Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil, 5University of São Paulo, São Paulo, SP, Brazil, 6Rheumatology Division and Pediatric Rheumatology Unit, Instituto da Criança e do Adolescente, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil

    Background/Purpose: Recently, it was demonstrated that temporarily halting mycophenolate mofetil (MMF) for 1-week post-COVID-19 vaccination in systemic lupus erythematosus (SLE) patients improved humoral response, without…
  • Abstract Number: 0707 • ACR Convergence 2024

    Comprehensive Skin Assessment in Systemic Sclerosis Using Spatial Frequency Domain Imaging (SFDI)

    Hung Vo1, Aarohi Mehendale2, Mahendra Chaudhari3, Fatima El adili3, Jeffrey Browning4, Michael York5, Marcin Trojanowski6, Eugene Kissin7, Darren Roblyer2 and Andreea Bujor5, 1Boston Medical Center, Peabody, MA, 2Department of Biomedical Engineering, Boston University, Boston, MA, 3Boston Medical Center, Boston, MA, 4Boston University, Cambridge, MA, 5Boston University, Boston, MA, 6Department of Rheumatology, Boston University School of Medicine, Boston, MA, 7Boston University, Newton, MA

    Background/Purpose: The modified Rodnan skin score (mRSS) is the gold standard for scleroderma (SSc) skin assessment, yet it suffers from subjectivity and interrater variability. Spatial…
  • Abstract Number: 0959 • ACR Convergence 2024

    Radiomics Non-Invasively Conveys Time-Resolved Molecular Pathway Activity in Experimental Fibrosing Interstitial Lung Disease

    David Lauer1, Matthias Brunner2, Hubert Gabrys3, Kerstin Klein2, Oliver Distler4, Britta Maurer5 and Janine Gote-Schniering2, 1University Hospital Bern, Bern, Switzerland, 2University of Bern, Bern, Switzerland, 3University Hospital Zurich, Zurich, Zurich, Switzerland, 4Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Zurich, Switzerland, 5University Hospital Bern, University Bern, Bern, Switzerland

    Background/Purpose: Interstitial lung disease (ILD) is a major cause of mortality in patients with autoimmune-related CTD such as SSc and RA. Molecular characterization of the…
  • Abstract Number: 1565 • ACR Convergence 2024

    Prevalence and Risk Factors of Lower Extremities Arterial Disease in Systemic Sclerosis: Preliminary Data from a Single Centre Multidisciplinary Study

    Maria-Grazia Lazzaroni1, Paolo Baggi2, Liala Moschetti1, Eleonora Pedretti3, Elda Piovani1, Claudia Barison1, Emma Manzoni4, Franco Franceschini1, Stefano Bonardelli2 and Paolo Airò1, 1Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, 2Vascular Surgery Unit, ASST Spedali Civili of Brescia, University of Brescia, Italy, Brescia, Italy, 3Scleroderma Unit, Rheumatology Unit, ERN ReCONNET, ASST Spedali Civili and University of Brescia; Italy, Brescia, Italy, 4University of Brescia, Brescia, Italy

    Background/Purpose: Microvascular changes represent a key step of pathogenic process in Systemic Sclerosis (SSc). However, SSc has been demonstrated to carry an increased risk of…
  • Abstract Number: 1589 • ACR Convergence 2024

    Whole Skin Gene Expression Analysis Identifies Discrete Modules That Differentiate Antinuclear Antibody Subsets in Systemic Sclerosis

    Kristina Clark1, Corrado Campochiaro2, Philip Yee3, Emma Derrett-Smith4, Voon Ong5 and Christopher Denton6, 1University of Oxford, Oxford, United Kingdom, 2IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 3UCL, London, United Kingdom, 4University College London Division of Medicine, Birmingham, United Kingdom, 5University College London, London, England, United Kingdom, 6University College London, Northwood, United Kingdom

    Background/Purpose: Hallmark autoantibody reactivities predict different patterns of skin involvement and risk of internal organ involvement.  We have asked whether whole skin gene expression may…
  • Abstract Number: 1826 • ACR Convergence 2024

    Unveiling the Primary Cilia Signature Driving Systemic Sclerosis Pathogenesis

    Le My Tu Nguyen1, Carlos Córdova-Fletes2, Poulami Dey3, Johann Gudjonsson3, Rebecca Wells4, Rebecca Ross5, Natalia Riobo-Del Galdo4, Francesco Del Galdo4, Dibyendu Bhattacharyya3, John Varga3 and Maria Teves1, 1Virginia Commonwealth University, Richmond, VA, 2Universidad Autónoma de Nuevo León, Monterrey, Mexico, 3University of Michigan, Ann Arbor, MI, 4University of Leeds, Leeds, United Kingdom, 5Medicine and Health, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Fibrosis in multiple organs is the defining hallmark that accounts for the high mortality associated with systemic sclerosis (SSc). Understanding how SSc patients develop…
  • Abstract Number: 2443 • ACR Convergence 2024

    The Clinical Phenotype of Anti-Th/To+ Patients in Systemic Sclerosis: A Case-control Study Within the European Scleroderma Trials and Research (EUSTAR) Cohort

    Liala Moschetti1, Eleonora Pedretti2, Francesco Bonomi3, María Martín López4, Fabio Cacciapaglia5, cristiana sieiro santos6, Gianluca Moroncini7, Yannick Allanore8, Joana Caetano9, Brigitte Granel10, Laura Groseanu11, Maria De Santis12, Masataka Kuwana13, Veronica Codullo14, Mariana Pereira Silva15, Pietro Bearzi16, Laura Belloli17, Alida Taberner-Cortés18, Cristina Maglio19, Francesco Del Galdo20, Corrado Campochiaro21, Marie-Elise Truchetet22, Giovanna Cuomo23, Magda Parvu24, Florenzo Iannone25, Patricia Carreira26, Serena Guiducci27, Franco Franceschini1, Paolo Airò1 and Maria-Grazia Lazzaroni1, 1Scleroderma Unit, Rheumatology and Clinical Immunology Unit, ERN ReCONNET, ASST Spedali Civili, Brescia, Italy, Brescia, Italy, 2Scleroderma Unit, Rheumatology Unit, ERN ReCONNET, ASST Spedali Civili and University of Brescia; Italy, Brescia, Italy, 3Division of Rheumatology, Scleroderma Unit, University of Florence, AOU Careggi Firenze; Italy, Firenze, Italy, 4General University Hospital of Ciudad Real, Ciudad de México, Spain, 5Rheumatology Unit � DiMePRe-J, University and AOU Policlinico of Bari, Italy, Bari, Italy, 6Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 7Marche Polytechnic University, Ancona, Italy, 8Rheumatology department, Université Paris Cité, Cochin Hospital of Paris; France, Paris, France, 9Systemic Autoimmune Diseases Unit, Fernando Fonseca Hospital, Amadora; Portugal, Amadora, Portugal, 10Service de Médecine Interne Hôpital Nord de Marseille; France, Marseille, France, 11Spitalul Sfanta Maria, Bucharest, Romania, 12Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital and Biomedical Sciences, Hu-manitas University, Milan; Italy, Milan, Italy, 13Department of Allergy and Rheumatology, Nippon Medical School, Tokyo, Japan, Tokyo, Japan, 14Unit of Rheumatology, San Matteo Hospital, Pavia, Italy, 15Rheumatology Department, Unidade Local de Saúde Santa Maria, Centro Académico de Medicina de Lisboa; Portugal, Lisboa, Portugal, 16Immunorheumatology Unit, Università Campus Bio-Medico University of Roma; Italy, Roma, Italy, 17Niguarda Hospital, Milan, Milan, Italy, 18Hospital Universitario Doctor Peset, Valencia, Spain, 19University of Gothenburg, Gothenburg, Sweden, 20University of Leeds, Leeds, United Kingdom, 21IRCCS San Raffaele Hospital. Vita-Salute San Raffaele University, Milan, Milan, Italy, 22Bordeaux University Hospital, Bordeaux, France, 23Università degli studi della Campania Luigi Vanvitelli, Napoli, Italy, 24Colentina Clinical Hospital, Rheumatology Department, Bucharest; Romania, Bucharest, Romania, 25Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 26Hospital Universitario 12 de Octubre, Madrid, Madrid, Spain, 27Division of Rheumatology, Scleroderma Unit, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

    Background/Purpose: To evaluate clinical associations of anti-Th/To antibodies in SSc patients in a multicentre international cohort, focusing on interstitial lung disease (ILD), pulmonary arterial hypertension…
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