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Abstract Number: 1843

Perceptions and Concerns Regarding COVID-19 Vaccination in Patients with Systemic Sclerosis in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort

Jessica Gordon1, Kimberly Showalter1, Yin Wu2, Linda Kwakkenbos3, Marie-Eve Carrier4, Richard Henry2, Nora Østbø2, Julia Nordlund2, Angelica Bourgeault2, Mara Canedo Ayala2, Marie-Nicole Discepola2, Andrea Carboni Jiménez2, Christopher Denton5, Luc Mouthon6, Brett Thombs7 and Robert Spiera1, 1Hospital for Special Surgery, New York, NY, 2Lady Davis Institute of the Jewish General Hospital, Montréal, QC, Canada, 3Department of Clinical Psychology, Radboud University Behavioural Science Institute, Nijmegen, Netherlands, 4Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, 5University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 6Hopital Cochin - Paris University, Paris, France, 7Lady Davis Institute for Medical Research, Jewish General Hospital; Department of Psychiatry, McGill University, Montréal, QC, Canada

Meeting: ACR Convergence 2021

Keywords: COVID-19, Scleroderma, Systemic, Surveys, Systemic sclerosis, Vaccination

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Session Information

Date: Tuesday, November 9, 2021

Session Title: Systemic Sclerosis & Related Disorders – Clinical Poster III (1836–1861)

Session Type: Poster Session D

Session Time: 8:30AM-10:30AM

Background/Purpose: Hesitancy about COVID-19 vaccination exists among patients with rheumatic and musculoskeletal diseases, but previous studies have not assessed this specifically in patients with systemic sclerosis (SSc, or scleroderma). We surveyed patients enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort regarding their willingness to be vaccinated as well as their perceptions and concerns about the vaccines.

Methods: Participants were adults with physician-verified SSc enrolled in the SPIN Cohort. SPIN includes 47 international centers and has approximately 1600 active participants. From April 9 to May 15, 2021, participants from the SPIN Cohort were invited by email and popups during regular SPIN Cohort assessments to participate in a COVID-19 vaccine survey, which was conducted in English and French. Participants were asked if they had received the vaccine and if not, whether they planned to and their degree of certainty. All were asked to rate factors of importance in the decision to get vaccinated using a 5-point Likert scale (1 – not important, 2 – slightly important, 3 – somewhat important, 4 – important, 5 – very important). These questions were developed based on previous surveys by SPIN investigators in conjunction with patient partners. Responses of those who had or who planned to receive the vaccine were compared to those who were unsure, unlikely or certainly would not get the vaccine. Descriptive statistics and t-tests for mean item differences are presented.

Results: The demographic and clinical characteristics of the 932 responders are shown in Table 1. Of these, 699 (75%) had received at least one dose of COVID-19 vaccine, and 842 (90.3%) had either been vaccinated or planned to do so. 90 participants (9.7%) reported feeling unsure [35 (3.8%)], unlikely [31 (3.4%)], or that they would certainly not [24 (2.6%)] get vaccinated.

Responses were compared based on hesitancy (table 2). Patients who received the vaccine or who planned to do so rated multiple considerations of higher importance than those who were hesitant. (2A) The highest mean differences were noted for the following factors: civic duty/setting an example, reducing risk of illness, protecting others. When asked about decision making about getting the vaccine, hesitant patients were more likely to rank as important or very important that enough time had passed to assess risk of long-term side effects and the experiences of other SSc patients. Compared to those who were hesitant, patients who had received the vaccine or who planned to were more likely to rank as important or highly important: their rheumatologist’s recommendation, the ability to discuss concerns with their doctor, and convenience. (2B)

Conclusion: Approximately 1 in 10 participants reported vaccine hesitancy. These results identify factors associated with hesitancy in this group of SSc patients and highlight topics that may be emphasized in providing education which may be helpful for hesitant SSc patients.

Table 1. Demographic and clinical description of survey responders

Table 2. Perceptions of patients based on degree of hesitancy


Disclosures: J. Gordon, Cumberland Pharmaceuticals, 5, EICOS Sciences, 5; K. Showalter, None; Y. Wu, None; L. Kwakkenbos, None; M. Carrier, None; R. Henry, None; N. Østbø, None; J. Nordlund, None; A. Bourgeault, None; M. Canedo Ayala, None; M. Discepola, None; A. Carboni Jiménez, None; C. Denton, Acceleron, 2, 6, Actelion, 2, 6, Arxx Therapeutics, 2, 6, Boehringer Ingelheim, 2, 6, Bristol-Myers Squibb, 2, 6, Corbus, 2, 6, CSL Behring, 2, 6, Galapagos NV, 2, 6, GlaxoSmithKline, 2, 6, Horizon, 2, 6, Inventiva, 2, 6, Roche, 2, 6, Sanofi, 2, 6, Servier, 2; L. Mouthon, None; B. Thombs, None; R. Spiera, GSK, 2, 5, Boehringer Ingelheim Pharmaceuticals, 5, Chemocentryx, 2, 5, Corbus Pharmaceutical, 5, Formation Biologics, 2, 5, InflaRx, 5, Kadmon, 5, Astra Zeneca, 5, Abbvie, 2, CSL Behring, 2, Sanofi, 2, Janssen Pharmaceuticals, 2, Genentech/Roche, 2, 5.

To cite this abstract in AMA style:

Gordon J, Showalter K, Wu Y, Kwakkenbos L, Carrier M, Henry R, Østbø N, Nordlund J, Bourgeault A, Canedo Ayala M, Discepola M, Carboni Jiménez A, Denton C, Mouthon L, Thombs B, Spiera R. Perceptions and Concerns Regarding COVID-19 Vaccination in Patients with Systemic Sclerosis in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort [abstract]. Arthritis Rheumatol. 2021; 73 (suppl 9). https://acrabstracts.org/abstract/perceptions-and-concerns-regarding-covid-19-vaccination-in-patients-with-systemic-sclerosis-in-the-scleroderma-patient-centered-intervention-network-spin-cohort/. Accessed February 2, 2023.
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