Abstracts tagged "SLE"

Abstract Number: 671 • 2019 ACR/ARP Annual Meeting
Peripheral Nervous System Disease in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study
John G Hanly¹, Qiuju Li ², Li Su ³, Murray Urowitz ⁴, Caroline Gordon ⁵, Sang-Cheol Bae ⁶, Juanita Romero-Diaz ⁷, Jorge Sanchez-Guerrero ⁸, Sasha Bernatsky ⁹, Ann E Clarke ¹⁰, Daniel J Wallace ¹¹, David A Isenberg ¹², Anisur Rahman ¹³, Joan Merrill ¹⁴, Paul Fortin ¹⁵, Dafna Gladman ¹⁶, Ian Bruce ¹⁷, Michelle Petri ¹⁸, Ellen M Ginzler ¹⁹, MA Dooley ²⁰, Kristjan Steinsson ²¹, Rosalind Ramsey-Goldman ²², Asad A Zoma ²³, Susan Manzi ²⁴, Ola Nived ²⁵, Andreas Jönsen ²⁵, Munther A Khamashta ²⁶, Graciela Alarcón ²⁷, Elisabet Svenungsson ²⁸, Ronald F Van Vollenhoven ²⁹, Cynthia Aranow ³⁰, Meggan Mackay ³¹, Guillermo Ruiz-Irastorza ³², Manuel Ramos-Casals ³³, S Sam Lim ³⁴, Murat Inanc ³⁵, Kenneth C Kalunian ³⁶, Soren Jacobsen ³⁷, Christine Peschken ³⁸, Diane Kamen ³⁹, Anca Askanase ⁴⁰, Chris Theriault ¹ and Vernon Farewell ², ¹Dalhousie University, Halifax, NS, Canada, ²University of Cambridge, Cambridge, United Kingdom, ³Universidy of Cambridge, Cambridge, United Kingdom, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, ⁷Instituto Nacional de Ciencias Medicas y Nutricion Salvador, Zubiran Vasco de Quiroga, Mexico City, Mexico, ⁸Toronto Western Hospital, Toronto, ON, Canada, ⁹Research Institute of the McGill University Health Centre, Montreal, QC, Canada, ¹⁰University of Calgary, Calgary, AB, Canada, ¹¹Cedars-Sinai Medical Centre, Beverly Hills, CA, ¹²Centre for Rheumatology, London, United Kingdom, ¹³University College London, London, United Kingdom, ¹⁴Oklahoma Medical Research Foundation, Oklahoma City, ¹⁵Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Canada, Quebec, QC, Canada, ¹⁶Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ¹⁷University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom, ¹⁸Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁹State University of New York Downstate Medical Center, Brooklyn, NY, ²⁰UnC Kidney Centre, Chapel Hill, NC, ²¹Landspitali, University Hospital, Reykjavik, Iceland, ²²Northwestern University, Chicago, IL, ²³University of Glasgow, East Kilbride, United Kingdom, ²⁴Allegheny Health Network, Pittsburg, PA, ²⁵Lund University, Lund, Sweden, ²⁶King's College London School of Medicine, London, United Kingdom, ²⁷University of Alabama at Birmingham, Birmingham, ²⁸Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden, ²⁹Amsterdam Rheumatology & Immunology Center, Amsterdam, Netherlands, ³⁰Feinstein Institute for Medical Research, Manhasset, NY, ³¹Feinstein Institute for Medical Research, New York, ³²Unidad de Enfermedades Autoinmunes, BioCruces Health Research Institute, Barakaldo, Spain, ³³Department of Autoimmune Diseases, ICMiD. Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX. Department of Medicine, University of Barcelona, Hospital Clínic, Barcelona, Spain., Barcelona, Spain, ³⁴Emory University, Atlanta, GA, ³⁵Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey, ³⁶UC San Diego School of Medicine, LaJolla, CA, ³⁷Copenhagen Lupus and Vasculitis Clinic, Copenhagen, Denmark, ³⁸University of Manitoba, Winnipeg, Canada, ³⁹Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC, ⁴⁰Columbia University Medical Center, New York, NY
Background/Purpose: Although there is a large body of work on central nervous system (CNS) disease in SLE patients, involvement of the peripheral nervous system (PNS)…
Abstract Number: 1017 • 2019 ACR/ARP Annual Meeting
The Integration of Genetic Data, Molecular Pathway Analysis and Differential Expression to Delineate the Impact of Ancestral Differences on Lupus
Katherine Owen¹, Bryce Aidukaitis ¹, Adam Labonte ¹, Michelle Catalina ¹, Prathyusha Bachali ¹, Nicholas Geraci ², Miranda Marion ³, Hannah Ainsworth ⁴, kip Zimmerman ³, Timothy Howard ⁴, Carl Langefeld ⁴, Peter Lipsky ² and Amrie Grammer ⁵, ¹AMPEL Biosolutions and the RILITE research institute, Charlottesville, VA, ²AMPEL BioSolutions, LLC, Charlottesville, VA, ³Wake Forest School of Medicine, Winston-Salem, NC, ⁴Wake Forest School of Medicine, Winston-Salem, ⁵AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA
Background/Purpose: Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disorder with a prominent genetic component. Evidence has shown that individuals of African-Ancestry (AA) experience the…
Abstract Number: 1578 • 2019 ACR/ARP Annual Meeting
Factors Implicated in the Development of Early Osteonecrosis in Systemic Lupus Erythematosus
Konstantinos Tselios¹, Dafna Gladman ², Jiandong Su ³ and Murray Urowitz ³, ¹University Health Network, University of Toronto, Toronto, ²Toronto Western Hospital, Toronto, Canada, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteonecrosis (ON) complicates approximately 15-20% of patients with systemic lupus erythematosus (SLE) on an average of six years after diagnosis. However, a small subgroup…
Abstract Number: 2023 • 2019 ACR/ARP Annual Meeting
Gene-Expression Analysis of Male and Female SLE Patients Reveals Candidate Pathogenic Pathways
MIKHAIL OLFERIEV¹, David Fernandez ², Dina Greenman ¹, Mary Peng ¹, Kyriakos Kirou ¹ and Mary Crow ¹, ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY
Background/Purpose: The female predisposition for development of multiple autoimmune diseases is well recognized. The female to male ratio reaches a maximum during the reproductive years…
Abstract Number: 2820 • 2019 ACR/ARP Annual Meeting
Calcium/ Calmodulin – Dependent Protein Kinase IV Associates with Phosphofructokinase to Promote Glycolysis and Limit IL-2 Production
Milena Vukelic¹, Nobuya Yoshida ², Masataka Umeda ³, Seo Yeon Orite ³, Rhea Bhargava ³, Michihito Kono ⁴, Irina Gavanescu-Stockton ³, Ryo Hisada ³ and George Tsokos ², ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA, ⁴Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is disease characterized by an imbalance between pro-inflammatory (such as Th1 and Th17) and regulatory cells (Tregs). Th1 and Th17…
Abstract Number: 672 • 2019 ACR/ARP Annual Meeting
Mouse SLE Studies Do Not Describe Human SLE
Ecem Sevim¹, Linjia Jia ², David Fernandez ³ and Michael Lockshin ⁴, ¹Hospital for Special Surgery, New York, NY, ²Weill Cornell Medicine, New York, NY, ³Hospital for Special Surgery, Mary Kirkland Center for Lupus Research, New York, NY, ⁴Hospital for Special Surgery, Barbara Volcker Center for Women and Rheumatic Diseases, New York, NY
Background/Purpose: Although mouse models of systemic lupus erythematosus (SLE) are useful proxies for human illness, they are heterogeneous, and publications about mouse SLE may not…
Abstract Number: 1024 • 2019 ACR/ARP Annual Meeting
Lysosome Defects in SLE Promote the Accumulation of Nuclear Antigens on the Surface of Hematopoietic Cells
Sun Ah Kang¹, Jennifer Rogers ², Saira Sheikh ³, Megan Clowse ², Lisa Criscione-Schreiber ² and Barb Vilen ⁴, ¹University of NOrth Carolina at Chapel Hlil, Chapel Hill, NC, ²Duke University, Durham, ³University of North Carolina, Chapel Hill, NC, ⁴University of North Carolina CHapel Hill, Chapel Hill, NC
Background/Purpose: Impaired clearance of cell debris allows nuclear self-antigens such as DNA to accumulate, bind autoreactive IgG and form immune complexes (IgG-ICs) in SLE. We…
Abstract Number: 1579 • 2019 ACR/ARP Annual Meeting
Presence of Antiphospholipid Antibodies in Patients with SLE and Venous Thromboembolic Events of African American and Caucasian Race
Elena Gkrouzman¹, Julia Davis-Porada ¹, Mary Peng ² and Kyriakos Kirou ², ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery, New York, NY
Background/Purpose: Risk of thrombosis is elevated in patients with systemic lupus erythematosus (SLE) compared to healthy individuals, especially during the first year after diagnosis. The…
Abstract Number: 2034 • 2019 ACR/ARP Annual Meeting
Identification of IL-17+ and IL-10+ TCRαβ+ CD4- CD8- Double Negative (DN) T Cell Subsets in Lupus-prone Mice and Patients with SLE and Their Significance in Predicting Renal Involvement
Yi Li¹, Hao Li ², Shui Lian Yu ³, Vasileios Kyttaris ⁴ and George Tsokos ⁴, ¹BIDMC, Boston, MA, ²Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, ³The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China (People's Republic), ⁴Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: We have previously shown that DN T cells are expanded in both lupus-prone mice and patients with SLE and we have demonstrated that this…
Abstract Number: 64 • 2019 ACR/ARP Annual Meeting
Rab4A Controls mTOR Pathway Activation, Pro-inflammatory Lineage Development, and Disease Pathogenesis in Lupus-prone Mice
Nick Huang¹, Zhiwei Lai ², Brandon Wyman ², Thomas Winans ², Manuel Duarte ², Joshua Lewis ², Mark Haas ³, Laurence Morel ⁴ and Andras Perl ⁵, ¹Upstate Medical University, Syracuse, NY, ²Upstate Medical University, Syracuse, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Florida, Gainesville, FL, ⁵SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Mouse models of SLE have been indispensable tools for studying disease pathogenesis; however, each model only recapitulates limited aspects of lupus. SLE1.2.3. (TC) mice…
Abstract Number: 673 • 2019 ACR/ARP Annual Meeting
Clinical Characteristics of Lymphadenopathy in Systemic Lupus Erythematous: A Case Control Study from a Tertiary Care Center
Elizabeth Graef¹, Daniel Magliulo ¹, Norris Hollie ¹, Chelsea Marcus ² and Vasileios Kyttaris ³, ¹Beth Israel Deaconess Medical Center, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, ³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Background/Purpose: While lymphadenopathy and/or lymphadenitis (LAD) is considered a relatively common clinical finding in SLE patients, its clinical significance is poorly understood. Previous studies described…
Abstract Number: 1025 • 2019 ACR/ARP Annual Meeting
Dynamic Changes During SLE Flare Implicate Age-Associated B Cells and Altered T Follicular and Peripheral Helper Cell Responses in Disease Activity
Kieran Manion¹, Zahi Touma ², Dennisse Bonilla ², Dafna Gladman ³, Murray Urowitz ² and Joan Wither ⁴, ¹Krembil Research Institute, Toronto, ON, Canada, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Krembil Research Institute, U of Toronto, Toronto, ON, Canada, ⁴University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: SLE is a chronic autoimmune disorder in which periods of relative disease inactivity are punctuated by flares that present with increased inflammation and tissue…
Abstract Number: 1586 • 2019 ACR/ARP Annual Meeting
All-cause Hospitalizations and Mortality in Systemic Lupus Erythematosus in the US- results from a National Inpatient Database
Rashmi Dhital¹, Dilli Ram Poudel ², Ramesh Kumar Pandey ³ and Paras Karmacharya ⁴, ¹Reading Hospital ,PA, Shillington, PA, ²University of Pennsylvania, Philadelphia, ³Fox Chase Hospital, Philadelphia, ⁴Reading Hospital, Mayo Clinic, Rochester
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a chronic multisystem autoimmune disorder with variable presentation. While several studies have outlined the risk factors for hospitalization and…
Abstract Number: 2036 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA: A Potential Trigger of Cyclic GMP-AMP Synthase Activation in Systemic Lupus Erythematosus
Jie An¹, Bhargavi Duvvuri ¹, Xizhang Sun ¹, Lena Tanaka ¹, Christian Lood ¹ and Keith Elkon ¹, ¹University of Washington, Seattle
Background/Purpose: Approximately 70% of patients with Systemic Lupus Erythematosus (SLE) show a striking Type I Interferon (IFN-I) signature in peripheral blood. Although we have some…
Abstract Number: 65 • 2019 ACR/ARP Annual Meeting
CD6 Modulation Ameliorates Skin and Kidney Disease in a Spontaneous Murine Model of SLE
Samantha Chalmers¹, Sayra Garcia ¹, Rajalakshmy Ayilam Ramachandran ², Chandra Mohan ², Jeanette Ampudia ³, Cherie Ng ³, Stephen Connelly ³ and Chaim Putterman ⁴, ¹Albert Einstein College of Medicine, Bronx, NY, ²University of Houston, Houston, ³Equillium, Inc, San Diego, CA, ⁴Albert Einstein College of Medicine, New York, NY
Background/Purpose: T cells are an important contributor the pathogenesis of SLE and its various end organ manifestations. Thus, they present themselves as potential therapeutic targets;…

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