Abstracts tagged "pregnancy"

Abstract Number: 2288 • 2019 ACR/ARP Annual Meeting
Pregnancy Outcomes in Women Exposed to Golimumab
Suzan Esslinger¹, Susan Gabriel ², Marijo Otero-Lobato ³, Michael Clark ⁴, Pamela Sheridan ⁴ and Anja Geldhof ⁵, ¹Janssen Biologics BV, Leiden, Netherlands, ²Janssen Rearch & Development, LLC, Horsham, PA, ³Janssen Biologics BV, Leiden, Zuid-Holland, Netherlands, ⁴Janssen Research & Development, LLC, Horsham, PA, ⁵Janssen Research & Development, LLC, Leiden, Netherlands
Background/Purpose: Rheumatologic disorders and inflammatory bowel disease can affect women of childbearing potential. Golimumab (GLM) is approved for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, non-radiographic…
Abstract Number: 142 • 2019 ACR/ARP Annual Meeting
Antiphospholipid Antibodies Prevalence in Women with Late Pregnancy Complication and Low-Risk for Chromosomal Abnormalities
Silvia Grazietta Foddai¹, Massimo Radin ¹, Elena Rubini ¹, Irene Cecchi ¹, Savino Sciascia ², Dario Roccatello ¹, Elisa Menegatti ¹, Silvia Gaito ¹, Luca Marozio ¹, Tilde Manetta ¹ and Giulio Mengozzi ¹, ¹University of Turin, Turin, Italy, ²Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
Background/Purpose: While current guidelines help defining correct pregnancy standard of care for patients with systemic lupus erythematosus andantiphospholipid syndrome (APS),little is known about the significance…
Abstract Number: 2290 • 2019 ACR/ARP Annual Meeting
A Multicentre Study of 244 Pregnancies in Women with Undifferentiated Connective Tissue Disease: Foetal/Perinatal and Maternal Outcomes and Disease Evolution Towards a Definite Connective Tissue Disease
Massimo Radin¹, Karen Schreiber ², Irene Cecchi ¹, Alessandra Bortoluzzi ³, Francesca Crisafulli ⁴, Cristiano M. De Freitas ⁵, Beatrice Bacco ¹, Elena Rubini ¹, Silvia Grazietta Foddai ¹, Melissa Padovan ³, Silvia Gallo Cassarino ¹, Franco Franceschini ⁶, Danieli Andrade ⁷, Chiara Benedetto ⁸, Marcello Govoni ⁹, Tiziana Bertero ¹, Luca Marozio ¹, Dario Roccatello ¹, Laura Andreoli ⁴ and Savino Sciascia ¹⁰, ¹University of Turin, Turin, Italy, ²Department of Rheumatology, Copenhagen University Hospital, Copenhagen, Denmark, ³University of Ferrara, Ferrara, Italy, ⁴University of Brescia, Brescia, Italy, ⁵Universidade de Sao Paolo, San Paolo, Brazil, ⁶Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy, ⁷Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil, ⁸University of Turin, Turin, Piemonte, Italy, ⁹University of Ferrara, Rheumatology Unit, Ferrara, Italy, ¹⁰Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
Background/Purpose: Undifferentiated connective tissue disease(UCTD) represents a common autoimmune condition in clinical practice, however, therapeutic strategies and follow-up are mostly based on clinician expertise. Little…
Abstract Number: 144 • 2019 ACR/ARP Annual Meeting
Antiphospholipid Syndrome-Associated Preeclampsia Is Defined by a Distinct Clinical Phenotype
Shashank Cheemalavagu¹, Beth Wallace ², Wendy Marder ³, Jason Knight ⁴ and Andrew Vreede ⁵, ¹Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ²Center for Clinical Management Research, VA Ann Arbor Healthcare System; Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ³Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, ⁴Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, ⁵Division of Rheumatology, Department of Internal Medicine, Michigan Medicine; Rheumatology Section, VA Ann Arbor Health System, Ann Arbor, MI
Background/Purpose: Antiphospholipid syndrome (APS) significantly increases risk of preeclampsia. It is assumed that APS is associated with a subset of severe preeclampsia, HELLP (Hemolysis; Elevated…
Abstract Number: 2292 • 2019 ACR/ARP Annual Meeting
Disease Flares of Rheumatoid Arthritis During Pregnancy: What Is the Impact of Stopping bDMARDs at the Beginning of Pregnancy?
Maria Chiara Gerardi¹, Laura Andreoli ¹, Antía García-Fernández ², Chiara Bazzani ³, MATTEO FILIPPINI ³, MICAELA FREDI ¹, ROBERTO GORLA ³, Maria Grazia Lazzaroni ⁴, Cecilia Nalli ³, MARCO TAGLIETTI ⁵, SONIA ZATTI ⁶, ANDREA LOJACONO ⁶, Franco Franceschini ¹ and Angela Tincani ¹, ¹Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy, ²Ramon y Cajal University Hospital, Madrid, Spain, Madrid, Madrid, Spain, ³Rheumatology and Clinical Immunology, Spedali Civili, Brescia, Italy, Brescia, Italy, ⁴Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy., Brescia, Italy, ⁵[email protected], Brescia, Italy, ⁶Obstetrics and Gynaecology, Spedali Civili and University of Brescia, Brescia, Italy, Brescia, Italy
Background/Purpose: During pregnancy, patients with rheumatoid arthritis (RA) can experience flares that might influence pregnancy outcomes. We aimed at assessing disease course during pregnancy and…
Abstract Number: 1075 • 2019 ACR/ARP Annual Meeting
The Impact of Race on Birth Outcomes Among Women with Autoimmune Rheumatic Diseases
Lena Sabih¹, Jennifer Strouse ¹, Nichole Nidey ², Gretchen Bandoli ³, Rebecca Baer ⁴, Sky Feuer ⁵, Laura Jelliffe-Pawlowski ⁵, Christina Chambers ⁶, Kelli Ryckman ² and Namrata Singh ⁷, ¹University of Iowa Hospitals and Clinics, Iowa City, ²UIOWA, Iowa City, ³University of California, San Diego, La Jolla, ⁴UCSD, La Jolla, ⁵UCSF, San Francisco, ⁶UCSD, San Diego, ⁷University of Iowa, Iowa City
Background/Purpose: Autoimmune rheumatic diseases (ARDs) are associated with adverse pregnancy outcomes (APOs). There are only a small number of studies that have looked at the…
Abstract Number: 2297 • 2019 ACR/ARP Annual Meeting
Anti-TNF-α Exposure During Pregnancy: Impact on the Neonate’s Immune System
Yiyi Luo ¹, Andrea Pluma ², Raul Castellanos-Moreira³, Estefania Moreno ⁴, Nuria Baños ⁵, Sebastian DC Rodriguez-Garcia ⁶, Angela Deyà-Martínez ¹, Ana Pilar Garcia-Garcia ¹, Mireia Torres ⁷, Dolors Grados ⁸, Manel Casellas ⁹, Manel Juan ¹, Ana Esteve-Sole ¹ and Laia Alsina ¹⁰, ¹Immunology Department. Center for Biomedical Diagnosis. Hospital Clínic of Barcelona IDIBAPS. Barcelona University. Barcelona. Functional unit of Clinical Immunology HSJD-HCP.Universidad de Barcelona. Pediatric Investigation Institute SJD, Barcelona, Spain, ²Hospital Universitari Vall d'Hebron, Barcelona, Spain, ³Rheumatology Department. Hospital Clínic Barcelona, Barcelona, Catalonia, Spain, ⁴Rheumatology Department. Vall d'Hebron University Hospital, Barcelona, Spain, Barcelona, Spain, ⁵Matern-Infantile Department, Hospital Clínic of Barcelona. Barcelona. Spain, Barcelona, Spain, ⁶Arthritis Unit. Rheumatology Department. Hospital Clinic of Barcelona. Barcelona. Spain, Barcelona, Spain, ⁷Neonatology Department. Vall d'Hebron University Hospital, Barcelona, Spain, Barcelona, Spain, ⁸Hospital d'Igualada, Barcelona, ⁹Hospital Universitari Vall d'Hebron, Barcelona, ¹⁰Hospital Sant Joan de Déu, Barcelona, Spain
Background/Purpose: Up to half of pregnant patients with rheumatic diseases experience disease activity which can increase the risk of pregnancy complications and poor disease outcomes. Treatment…
Abstract Number: 1273 • 2019 ACR/ARP Annual Meeting
Certolizumab Therapy in Patients with Uveitis During Pregnancy: Multicenter Study
DIANA PRIETO- PENA¹, Vanesa Calvo Río ², Mónica Calderón-Goercke ³, Olga Maíz Alonso ⁴, JR Jimenez-Aberasturi ⁵, Raul Veroz ⁶, Maria Soledad Blanco ⁷, José Manuel Santos ⁸, Francisco Navarro ⁹, Adela Gallego ¹⁰, Rosalia Demetrio ¹¹, Victor Manuel Martínez Taboada ¹¹, Miguel Angel González-Gay ¹² and Ricardo Blanco ², ¹Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ²Rheumatology, Hospital Universitario Marques de Valdecilla, Santander, Spain, ³Hospital Marqués de Valdecilla, Santander, Cantabria, Spain, ⁴H. Donostia, San Sebastián, Spain, ⁵HU Araba, Vitoria, Spain, ⁶H. Mérida, Merida, Spain, ⁷H. Galdakano, Bilbao, Spain, ⁸H. Río Hortega, Valladolid, Spain, ⁹H.Elche, Alicante, Spain, ¹⁰H. Badajoz, Badajoz, Spain, ¹¹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ¹²Universidad de Cantabria and IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain
Background/Purpose: Uveitis often occur in women who are in their reproductive years. The management of uveitis during pregnancy is a challenge, making the physician to…
Abstract Number: 1761 • 2019 ACR/ARP Annual Meeting
The Prospective Open Label Preventive Approach to Congenital Heart Block with Hydroxychloroquine (PATCH) Study Demonstrates a Reduction in the Recurrence Rate of Advanced Block
Peter Izmirly¹, Mimi Kim ², Nathalie Costedoat-Chalumeau ³, Deborah Friedman ⁴, Amit Saxena ⁵, Joshua Copel ⁶, Rebecca Cohen ¹, Mala Masson ¹, Tishaun Middleton ¹, Kimberly Robins ¹, Robert Clancy ¹ and Jill Buyon ¹, ¹NYU School of Medicine, New York, ²Albert Einstein College of Medicine, Bronx, NY, ³Cochin University Hospital, Paris, France, ⁴New York Medical College, Valhalla, ⁵New York University School of Medicine, New York, NY, ⁶Yale School of Medicine, New Haven
Background/Purpose: Based on encouraging bench to bedside results including experimental evidence supporting Toll-like receptor signaling in the pathogenesis of CHB, a case control study demonstrating…
Abstract Number: 1896 • 2019 ACR/ARP Annual Meeting
Breastfeeding in Women with Rheumatic Diseases
Naira Ikram¹, Amanda Eudy ¹ and Megan Clowse ¹, ¹Duke University, Durham
Background/Purpose: For many women, breastfeeding is a central aspect of motherhood, but many worry that their rheumatic disease or treatment will interfere. Fortunately, most anti-rheumatic…
Abstract Number: 1899 • 2019 ACR/ARP Annual Meeting
sFlt-1, PlGF and VEGF in the Differential Diagnosis Between Active SLE Nephritis During Pregnancy and Preeclampsia
Guilherme De Jesus¹, Marcela Lacerda ¹, Bruna Rodrigues ¹, Flavia dos Santos ¹, Adriana Nascimento ¹, Luis Cristóvão Porto ¹, Nilson Ramires de Jesús ¹, Roger Levy ² and Evandro Klumb ¹, ¹Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil, ²GlaxoSmithKline, Upper Providence, PA
Background/Purpose: Pregnancy in patients with SLE is associated with significant morbidity and mortality. SLE activity during pregnancy, specifically nephritis, makes the differential diagnosis with preeclampsia…
Abstract Number: 1900 • 2019 ACR/ARP Annual Meeting
Assessing Commercial Titers of anti-Ro60 and Ro52 Antibodies to Risk Stratify Surveillance of Anti-Ro/SSA Antibody Positive Pregnancies
Kimberly Robins ¹, Rohit Bhan¹, Catherine Trad ¹, Rebecca Cohen ¹, Miao Chang ¹, Benjamin Wainwright ¹, Mala Masson ¹, Shilpi Mehta-Lee ¹, Peter Izmirly ¹, Robert Clancy ¹, Bettina Cuneo ² and Jill Buyon ¹, ¹NYU School of Medicine, New York, ²Children's Hospital Colorado, Aurora
Background/Purpose: Pregnancy counseling of all anti-Ro positive women includes advice regarding the development of congenital heart block (CHB), albeit the risk is only 2% for…
Abstract Number: 1901 • 2019 ACR/ARP Annual Meeting
Serious Infections in Offspring Exposed in Utero to Non-TNFi Biologics and Tofacitinib
Evelyne Vinet¹, Yvan St-Pierre ¹, Cristiano S. Moura ¹, Jeffrey Curtis ² and Sasha Bernatsky ³, ¹McGill University Health Centre, Montreal, QC, Canada, ²University of Alabama at Birmingham, Birmingham, AL, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: During pregnancy, maternal circulating immunoglobulins G (IgG) are actively transported across the placenta through their Fc portion. Thus, TNFi and other biologics harbouring an Fc…
Abstract Number: 1938 • 2019 ACR/ARP Annual Meeting
The Pre-pregnancy Rheumatoid Arthritis Gene Expression Signature Correlates with Improvement or Worsening of Disease Activity During Pregnancy: A Pilot Study
Amogh Pathi ¹, Mette Smed ², Lior Pachter ³, Elizabeth Purdom ⁴, Matthew Wright ⁵, Nicholas Jewell ⁴, J. Lee Nelson ⁶, Jørn Olsen ⁷, Merete Lund Hetland ⁸, Vibeke Zoffmann ⁹ and Damini Jawaheer¹⁰, ¹UCSF Benioff Children's Hospital Oakland, Oakland, ²Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, ³Caltech, Pasadena, ⁴University of California Berkeley, Berkeley, ⁵UCSF Benioff Children's Hopsital Oakland, Oakland, ⁶Fred Hutchinson Cancer Research Center, Seattle, ⁷Aarhus University Hospital, Aarhus, Denmark, ⁸DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark, ⁹Juliane Marie Center, Copenhagen University Hospital, Rigshospitalet, Copenhagen, ¹⁰UCSF Benioff Children's Hospital Oakland, Oakland, CA
Background/Purpose: Pregnancy is known to induce a natural improvement of Rheumatoid Arthritis (RA) symptoms in 50-75% of patients as gestation progresses. However, the underlying mechanisms…
Abstract Number: 2273 • 2019 ACR/ARP Annual Meeting
Risk of Serious Infections in Offspring According to TNFi Subtypes
Evelyne Vinet¹, Yvan St-Pierre ¹, Cristiano S. Moura ¹, Jeffrey Curtis ² and Sasha Bernatsky ³, ¹McGill University Health Centre, Montreal, QC, Canada, ²University of Alabama at Birmingham, Birmingham, AL, ³Research Institute of the McGill University Health Centre, Montreal, QC, Canada
Background/Purpose: TNFi subtypes have differential placental transfer, with some reaching higher fetal than maternal blood levels. Thus, certain TNFi subtypes could cause immunosuppression in the offspring.…

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