Abstracts tagged "Osteoarthritis"

Abstract Number: 1549 • ACR Convergence 2020
Joint Damage and Malalignment Determine Articular Tenderness More Than Inflammation in Rheumatoid Arthritis, Psoriatic Arthritis or Osteoarthritis in Established Disease
Mihaela Popescu¹, Victoria Schimpl², Gabriela Supp³, Martina Durechova³, Paul Studenic³, Michael Zauner³, Josef Smolen³, Daniel Aletaha⁴, Peter Mandl³ and Irina Gessl³, ¹Hôpital Maisonneuve-Rosemont, Montreal, Canada, ²Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria, ⁴Division of Rheumatology, Department of Medicine III, Medical University of Vienna,, Vienna, Austria
Background/Purpose: To determine whether clinical tenderness can be considered a sign of inflammatory joint activity in patients with rheumatoid arthritis (RA), osteoarthritis (OA) or psoriatic…
Abstract Number: 1653 • ACR Convergence 2020
Bilateral vs Unilateral Total Knee Arthroplasty: Racial Variation in Utilization and In-Hospital Major Complication Rates
Bella Mehta¹, Kaylee Ho², Jennifer Bido³, Stavros Memtsoudis³, Michael Parks⁴, Susan Goodman¹, Linda Russell⁵ and Said Ibrahim⁶, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Weill Cornell Medicine, New York, ³Hospital for Special Surgery, New York, ⁴Hospital for Special Surgery, Weill Cornell Medicine, New York, ⁵Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Weill Cornell Medicine, Cleveland, OH
Background/Purpose: Compared to White Patients, African Americans (AAs) are reported to have lower utilization and higher complication rates outcomes in Unilateral Total knee arthroplasty (UTKA).…
Abstract Number: 0099 • ACR Convergence 2020
Interleukin 6 Concentration in Synovial Fluid of Patients with Different Types of Arthritis
Aleksandra Bukina¹ and Anna Mihailova¹, ¹Rigas Stradins university, Riga, Latvia
Background/Purpose: Persistent synovitis without known markers such as rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA) as well as without genetic markers as HLAB27 is not…
Abstract Number: 0628 • ACR Convergence 2020
Factors Associated with Knee Osteoarthritis in an Outpatient HIV-1 Clinic over a 26 Year Interval
Benjamin Naovarat¹, Francis Williams¹, Jonathan Dau², Marka Lyons³, Binh Nguyen⁴, Gloria Salazar³ and John Reveille⁵, ¹The University of Texas McGovern Medical School, Houston, TX, ²Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³University of Texas Houston, McGovern Medical School, Division of Rheumatology and Clinical Immunogenetics, Houston, TX, ⁴The University of Texas-McGovern Medical School, Houston, TX, ⁵Department of Internal Medicine, University of Texas, Houston, TX
Background/Purpose: With the advent of combined antiretroviral therapy (cART), patients with HIV-1 began living longer and started to develop diseases associated with aging such as…
Abstract Number: 0960 • ACR Convergence 2020
The Risk of Venous Thromboembolism After Septic Total Knee Replacement (TKR) Revision Is Double the Risk After Aseptic TKR Revision: An Analysis of Administrative Discharge Data
Anne Bass¹, Bella Mehta¹, Peter Sculco¹, Yi Zhang², Huong Do², Linda Russell¹ and Susan Goodman³, ¹Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, Weill Cornell Medicine, New York, NY
Background/Purpose: Infection can trigger coagulation pathways and increase the risk of thrombosis. However, the impact of infection on postoperative venous thromboembolism (VTE) risk is poorly…
Abstract Number: 1112 • ACR Convergence 2020
Relationship of Depth-Specific Subchondral Bone Mineral Density and Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Jean Liew¹, JD Johnston², Na Wang³, John Lynch⁴, Cora Lewis⁵, James Torner⁶ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Saskatchewan, Saskatoon, SK, Canada, ³Boston University School of Medicine, Boston, MA, ⁴UCSF, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA
Background/Purpose: OA has traditionally been considered a disease of cartilage but early OA changes in subchondral bone may precede cartilage abnormalities. Altered subchondral bone mineral…
Abstract Number: 1459 • ACR Convergence 2020
The Association of Frequent Knee Bending with Trajectories of Pain and Physical Function over 8 Years in Knee Osteoarthritis
Jason Jakiela¹, Dana Voinier¹, Thomas Bye¹, Maria Tukis¹, Kiely Konyak¹, Dylan Orloff¹ and Daniel White¹, ¹University of Delaware, Newark, DE
Background/Purpose: Frequent bending increases loading at the knee and is a risk factor for worsening knee pain associated with knee osteoarthritis (OA). Knee bending is…
Abstract Number: 1564 • ACR Convergence 2020
Feasibility of Ultra-low-dose, Short-duration, Total-body Evaluation of Inflammatory Arthritis Using uEXPLORER 18F-FDG PET/CT
Soumajyoti Sarkar¹, Siba Raychaudhuri², Lorenzo Nardo³, Heather Hunt³, Denise Caudle⁴, Mike Nguyen⁴, Simon Cherry⁴, Ramsey Badawi⁴, Abhijit Chaudhari⁵ and Yasser Abdelhafez³, ¹University of California, Davis, Davis, ²Division of Rheumatology, Allergy & Clinical Immunology, University of California School of Medicine, Davis, and VA Medical Center Sacramento, Sacramento, CA, ³University of California Davis, Sacramento, CA, ⁴University of California Davis, Sacramento, ⁵University of California, Davis, Sacramento, CA
Background/Purpose: The uEXPLORER system enables the unique, simultaneous acquisition of PET data over the entire adult human body with a high-sensitivity, alongside concurrent CT data.…
Abstract Number: 1654 • ACR Convergence 2020
The Relationship Between Patient-Reported Readiness for Total Knee Arthroplasty and the Likelihood of a Good Outcome at One Year
Gillian Hawker¹, Barbara Conner-Spady², Eric Bohm³, Michael Dunbar⁴, Allyson Jones⁵, Bheeshma Ravi¹, Tom Noseworthy², Linda Woodhouse⁶, Peter Faris⁷, Donald Dick⁸, James Powell², Paulose Paul⁵ and Deborah Marshall², ¹University of Toronto, Toronto, ON, Canada, ²University of Calgary, Calgary, AB, Canada, ³Concordia Hip & Knee Institute, University of Manitoba, Winnipeg, MB, Canada, ⁴Dalhousie University, Halifax, NS, Canada, ⁵University of Alberta, Edmonton, AB, Canada, ⁶Curtin University, Perth, Western Australia, Australia, ⁷Alberta Health Services, Calgary, ON, Canada, ⁸Alberta Bone and Joint Health Institute, Edmonton, AB, Canada
Background/Purpose: In prior qualitative research, we found that patients with knee osteoarthritis (OA) equated appropriateness for total knee arthroplasty (TKA) with candidacy for the procedure.…
Abstract Number: L05 • 2019 ACR/ARP Annual Meeting
Safety, Tolerability, Pharmacokinetics, and Clinical Outcomes Following Single-Dose IA Administration of UBX0101, a Senolytic MDM2/p53 Interaction Inhibitor, in Patients with Knee OA
Benjamin Hsu¹, Jennifer Visich ², Mark Genovese ³, Kimberly Walter ², Mahru An ⁴, Remi-Martin Laberge ⁴ and Jamie Dananberg ⁴, ¹Unity Biotechnology, Brisbane, ²Unity Biotechnology, Brisbane, California, ³Stanford University, Stanford, CA, ⁴Unity Biotechnology, Brisbane, CA
Background/Purpose: A non-drug biomarker study showed senescent cell (SnC) burden in OA synovial tissue to correlate with disease severity, inflammation, and knee pain (C. Yohn,…
Abstract Number: 888 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models
Morena Scotece¹, Ignacio Rego-Pérez ², Ana Victoria Lechuga-Vieco ³, María Concepción Jiménez Gómez ³, Purificación Filgueira-Fernández ⁴, José Antonio Enriquez ³ and Francisco J. Blanco ², ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Madrid, Spain, ⁴Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Galicia, Spain
Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…
Abstract Number: 1311 • 2019 ACR/ARP Annual Meeting
Prevalence of Symptomatic Axial Osteoarthritis and Poliarticular Phenotypes in Spain: EPISER 2016 Study
Maite Silva-Díaz¹, Francisco J. Blanco ², Victor Quevedo Vila ³, Daniel Seoane-Mato ⁴, Sagrario Bustabad-Reyes ⁵ and on behalf of the Working Group Proyecto EPISER2016 ⁶, ¹Servicio de Reumatología. Complexo Hospitalario Universitario A Coruña (CHUAC)-INIBIC, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Unidad de Reumatología. Hospital Comarcal Monforte de Lemos., Lugo, Spain, ⁴Unidad de Investigación. Sociedad Española de Reumatología., Madrid, Spain, ⁵eumatología. Hospital Universitario de Canarias., La Laguna, Santa Cruz de Tenerife, Spain, ⁶Grupo de trabajo del proyecto EPISER2016, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a heterogeneous group of diseases with common clinical and radiographic manifestations involving the peripheral and axial skeletal. OA is the most…
Abstract Number: 1846 • 2019 ACR/ARP Annual Meeting
Does Cartilage Loss Cause Pain in Osteoarthritis?
KATHRYN BACON¹, Lavalley Michael ² and David Felson ³, ¹Boston University School of Medicine, Boston, MA, ²Boston University, Boston, ³Boston University School of Medicine, Department of Rheumatology, Boston
Background/Purpose: Treatment development in osteoarthritis continues to focus on chondroprotection, but it is unclear if delaying cartilage loss would reduce joint pain. In published studies,…
Abstract Number: 1988 • 2019 ACR/ARP Annual Meeting
Establishing an in Vitro Model of Hand Osteoarthritis by Generating Induced Pluripotent Stem Cells (iPSc) That Carry Single Nucleotide Polymorphisms Associated with Hand Osteoarthritis Risk
Rocío Castro-Viñuelas¹, Clara Sanjurjo-Rodríguez ², María Piñeiro-Ramil ¹, Silvia Rodríguez-Fernández ¹, Tamara Hermida-Gómez ³, Francisco J. De Toro ⁴, Isaac Fuentes-Boquete ¹, Francisco J. Blanco ⁵ and Silvia Díaz-Prado ¹, ¹Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España., A Coruña, Spain, ²Grupo de investigación en Terapia Celular y Medicina Regenerativa. Departamento de Fisioterapia, Medicina y Ciencias Biomédicas. Universidade da Coruña. Agrupación estratégica CICA-INIBIC. A Coruña, España; University of Leeds; Newcastle University, A Coruña, Spain, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴University Hospital A Coruña, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Knowledge and research results in the field of hand osteoarthritis (hOA) are currently limited, mainly due to the unavailability of tissue samples to develop…
Abstract Number: 2185 • 2019 ACR/ARP Annual Meeting
MRI-detected Abnormalities in Prediction Models of Incident Radiographic Knee Osteoarthritis over 10 Years of Follow-up
C. Kent Kwoh¹, Frank Roemer ², Erin Ashbeck ³, ChengCheng Hu ¹, Edward Bedrick ¹, Leena Sharma ⁴ and Ali Guermazi ⁵, ¹University of Arizona, Tucson, AZ, ²University of Erlangen-Nuremberg, Erlangen, Germany, ³The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁴Northwestern University, Chicago, IL, ⁵Boston Medical Center, Boston
Background/Purpose: MRI Osteoarthritis Knee Score (MOAKS) is a semi-quantitative scoring system used to assess MRI-detected structural abnormalities including over 100 raw scores representing multiple joint…

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