Abstracts tagged "Osteoarthritis"

Abstract Number: 438 • 2018 ACR/ARHP Annual Meeting
What Characterizes Osteoarthritis: Ultrasound-Detected Inflammation but Not Osteophytes Is More Common in Hand Osteoarthritis Than in Painless Bony Enlargements
Nina Gasperi¹, Antonella Adinolfi², Arnd Kleyer³, Melanie Hagen³, Christiane Gasperi⁴, Martin Weger⁵, Stefan Kiechl⁶, Johann Willeit⁶, Georg Schett³, Annamaria Iagnocco⁷, Arno Gasperi⁸, Agnes Mayr⁹ and Christian Dejaco^10,11, ¹Medical University of Graz, Graz, Austria, Graz, Austria, ²Department of Medicine, surgery and Neurosciences, University of Siena, Siena, Italy, Siena, Italy, ³Department of Internal Medicine 3—Rheumatology and Immunology, Friedrich-Alexander-University Erlangen–Nürnberg (FAU), Universitätsklinikum Erlangen, Erlangen, Germany, Erlangen, Germany, ⁴Department of Neurology, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany, Munich, Germany, ⁵Department of Internal Medicine, Bruneck Hospital, Bruneck, Italy, Bruneck, Italy, ⁶Department of Neurology, Medical University of Innsbruck, Austria, Innsbruck, Austria, ⁷Academic Rhematology Center, University of Torino, Turin, Italy, Turin, Italy, ⁸Department of Neurology, Bruneck Hospital, Bruneck, Italy, Bruneck, Italy, ⁹Department of Laboratory Medicine, Bruneck Hospital, Italy, Bruneck, Italy, ¹⁰Rheumatology Service, South tyrolean Health trust, Hospital of Bruneck, Bruneck, Italy, Bruneck, Italy, ¹¹Department of Rheumatology and Immunology, Medical University Graz, Graz, Austria, Graz, Austria
Background/Purpose: To study structural and inflammatory ultrasound lesions in elderly subjects with hand osteoarthritis (HOA) as well as in pain-free subjects with bony enlargements of…
Abstract Number: 1359 • 2018 ACR/ARHP Annual Meeting
A Machine Learning Approach to Knee OA Phenotyping: The Johnston County Osteoarthritis Project
Amanda Nelson¹, Matthew Fuller², Becki Cleveland³, Todd Schwartz⁴, Joanne M. Jordan¹, Leigh F. Callahan¹, J.S. Marron² and Richard Loeser¹, ¹Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, ²Statistics and Operations Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁴Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Knee osteoarthritis (KOA) is a heterogeneous condition characterized by changes in a variety of joint tissues and driven by a number of different potential…
Abstract Number: 2009 • 2018 ACR/ARHP Annual Meeting
A Novel Role of ZCCHC6 in the Regulation of MMP13 in Experimental Osteoarthritis in Mice
Mohammad Y Ansari¹, Nashrah Ahmad² and Tariq M Haqqi³, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH, ²School of Biomedical Science, Kent State University, kent, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Zinc Finger CCHC Domain Containing Protein 6 (ZCCHC6) or Terminal Uridylyltransferase 7 (TUT7) is a member of terminal uridylyltransferase family that mediate terminal uridylation…
Abstract Number: 452 • 2018 ACR/ARHP Annual Meeting
Features of Peripheral and Central Sensitization and Neuropathic Pain Are Seen in Both Osteoarthritis and Rheumatoid Arthritis
Jacquelin R. Chua¹, Shingo Ishihara², Mariam Riad¹, Isabel Castrejón¹, Rachel E. Miller³, Anne-Marie Malfait⁴, Joel A. Block¹, Theodore Pincus¹ and Najia Shakoor¹, ¹Division of Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Biochemistry, Rush University Medical Center, Chicago, IL, ⁴Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: OA and RA are among the most common chronic painful rheumatic diseases. Appreciation of the role of pain sensitization in OA has revolutionized the…
Abstract Number: 1363 • 2018 ACR/ARHP Annual Meeting
Progression of Pain, Stiffness, Function Changes, and Ultrasound Detected Synovitis and Osteophyte Formation in Patients with Hand Osteoarthritis over Three Years
Olga Sleglova¹, Olga Ruzickova², Karel Pavelka¹ and Ladislav Šenolt¹, ¹Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, ²Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive…
Abstract Number: 2345 • 2018 ACR/ARHP Annual Meeting
Systematic Review of Patient Decision Aids for Chronic Musculoskeletal Pain
Rabih Nayfe¹, Emily Bowen², Nathaniel Milburn², Helen Mayo², Ethan Halm², MC. Reid³, Liana Fraenkel⁴ and Una E. Makris⁵, ¹Department of Medicine, UT Southwestern Medical Center, Dallas, TX, ²UT Southwestern Medical Center, Dallas, TX, ³Weill Cornell Medicine, New York, NY, ⁴Yale University School of Medicine, New Haven, CT, ⁵UT Southwestern Medical Center and Dallas VA, Dallas, TX
Background/Purpose: Chronic musculoskeletal (MSK) pain is common and disabling; it is among the top reasons for doctor’s visits in the US. Most treatment decisions for…
Abstract Number: 484 • 2018 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patients Have Lower Preoperative Expectations but Greater Clinical Improvement after Total Knee Arthroplasty Compared to Osteoarthritis Patients
Jason Blevins¹, Yu-fen Chiu², Stephen Lyman³, Susan M. Goodman¹, Lisa A. Mandl⁴, Peter K. Sculco⁵, Mark P. Figgie⁶ and Alexander McLawhorn², ¹Hospital for Special Surgery, New York, NY, ²Hospital for Special Surgery, new york, NY, ³Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁴Rheumatology, Hospital for Special Surgery, New York, NY, ⁵Orthopaedic Surgery, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁶Surgery, Hospital for Special Surgery, New York, NY
Background/Purpose: Preoperative patient expectations of Total Knee Arthroplasty (TKA) influence postoperative outcomes and satisfaction. Rheumatoid Arthritis (RA) may lower preoperative expectations after TKA compared to…
Abstract Number: 1367 • 2018 ACR/ARHP Annual Meeting
Efficacy of Intra-Articular Cntx-4975 for Knee OA Pain Varies with Radiographic Presence of OA in the Opposite Knee
Randall Stevens¹, James Campbell¹, Kimberly Guedes¹, Robin Burges¹, Valerie Smith² and Peter Hanson¹, ¹Centrexion Therapeutics, Boston, MA, ²Premier Research, Durham, NC
Background/Purpose: Nearly 60% of patients with knee OA have unilateral OA; most of those patients develop bilateral OA. CNTX-4975 is a highly purified, synthetic trans-capsaicin…
Abstract Number: 2909 • 2018 ACR/ARHP Annual Meeting
Diagnostic and Prognostic Value of Ultrasound Compared with Plain Radiography in Knee Osteoarthritis
Annie Yang¹, Fernando Bomfim², Kristen Lee², Mukundan Attur³, Steven B. Abramson⁴ and Jonathan Samuels⁵, ¹Department of Medicine, NYU Langone Health, New York, NY, ²NYU Langone Health, New York, NY, ³Rheumatology, NYU Langone Health, New York, NY, ⁴Dept of Medicine, NYU Langone Health, New York, NY, ⁵Department of Medicine, Divison of Rheumatology, NYU Langone Health, New York, NY
Background/Purpose: Plain radiography of knee osteoarthritis (OA) has inherent diagnostic and prognostic limitations, especially in early disease. Ultrasound (US) examination sheds light on disease activity…
Abstract Number: 846 • 2018 ACR/ARHP Annual Meeting
CD14 Deficiency Dampens Osteoclastogenesis and Alters Bone Remodeling in a Murine Model of Osteoarthritis
Cheng Zhou^1,2, Vu Nguyen^2,3, Ryan Smalley², Nisha Sambamurthy^1,2, George R. Dodge^2,4 and Carla Scanzello^1,2, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Department of Orthopaedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
Background/Purpose: Pathogenesis of osteoarthritis (OA) is accompanied by chronic inflammation evidenced by macrophage infiltration into the joint. CD14, is expressed by monocyte/macrophage lineage cells, and…
Abstract Number: 1368 • 2018 ACR/ARHP Annual Meeting
Diabetes Mellitus Is Not a Risk Factor for Knee Osteoarthritis, a Systematic Review and Meta-Analysis
Cassandra Hong^1,2, Andrew Yu Keat Khor³, Cheryl Ann Pei Wen Ma^2,3, Laura Li Yao Hui³ and Ying Ying Leung^2,3, ¹Rheumatology and Immunology, Singapore General Hospital, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Singapore General Hospital, Singapore, Singapore
Diabetes Mellitus is Not a Risk Factor for Knee Osteoarthritis, a Systematic Review and Meta-analysisBackground/Purpose: Obesity is a strong risk factor for both osteoarthritis (OA)…
Abstract Number: 2952 • 2018 ACR/ARHP Annual Meeting
Major NSAID Toxicity: Derivation and Internal Validation of a Simple Clinical Risk Score
Daniel Solomon¹, Ming Shao², Katherine E Wolski³, Steven E Nissen⁴, M. Elaine Husni⁵ and Nina Paynter⁶, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, ⁴Cardiovascular Medicine, Chair, Cleveland Clinic, Cleveland, OH, ⁵Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ⁶Medicine, Harvard University, Boston, MA
Background/Purpose: NSAIDs and Coxibs represent one of the most commonly prescribed drugs by rheumatologists and are used regularly by >10 million Americans. While most patients…
Abstract Number: 913 • 2018 ACR/ARHP Annual Meeting
Risk Factors for Knee Pain Exacerbation on Walking: A within-Person Knee-Matched Study
Qiang Liu^1,2, David J. Hunter³, Manuela Ferreira⁴, Barton L Wise⁵, Ke Tao¹, Yuqing Zhang⁶ and Jianhao Lin¹, ¹Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China, ²Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ⁴Institute of Bone and Joint Research | The Kolling Institute, Sydney Medical School, Sydney, Australia, ⁵Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ⁶Department of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA
Background/Purpose: Pain exacerbation on walking is common among patients with knee osteoarthritis and often lead to activity avoidance. To date, few risk factors for pain…
Abstract Number: 1371 • 2018 ACR/ARHP Annual Meeting
Systemic Exposure of Triamcinolone Acetonide Following Bilateral Injection of Extended-Release Triamcinolone Acetonide and Standard Triamcinolone in Patients with Bilateral Knee Osteoarthritis
Alan J. Kivitz¹, Louis Kwong², Tammi Shlotzhauer³, Joelle Lufkin⁴, Teresa Curto⁵ and Scott Kelley⁴, ¹Altoona Center for Clinical Research, Duncansville, PA, ²Department of Orthopaedic Surgery, Harbor-UCLA Medical Center, Torrance, CA, ³Rochester Clinical Research, Inc., Rochester, NY, ⁴Flexion Therapeutics, Inc., Burlington, MA, ⁵Cytel Inc., Waltham, MA
Background/Purpose: Current ACR guidelines recommend the use of IACS for short-term acute pain relief in patients (pts) with knee OA.1 Bilateral knee OA can occur…
Abstract Number: 915 • 2018 ACR/ARHP Annual Meeting
The Association between Structural and Symptomatic Progression in Knee Osteoarthritis
Jamie E. Collins¹, Swastina Shrestha² and Elena Losina³, ¹Department of Orthopedic Surgery, Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ³Harvard Medical School, Boston, MA
Background/Purpose: The link between progression of structure and symptoms in knee osteoarthritis (OA) is not well understood. This uncertainty hinders the effort to develop therapies…

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