Abstracts tagged "Osteoarthritis"

Abstract Number: 1982 • 2019 ACR/ARP Annual Meeting
Senescent Synoviocytes in Knee Osteoarthritis Correlate with Disease Biomarkers, Synovitis, and Knee Pain
Christopher Yohn ¹, Robert O'Brien ¹, Stephanie Lussier ¹, Casey Berridge ¹, Rathi Ryan ¹, Ali Guermazi ², Mahru An ¹, Remi-Martin Laberge ¹, Benjamin Hsu¹, Carl Millward ¹, Kate Doherty ¹ and Jamie Dananberg ¹, ¹Unity Biotechnology, Brisbane, CA, ²Boston Medical Center, Boston
Background/Purpose: Background/Purpose: Cellular senescence is a natural state in which a cell permanently halts division through upregulation of a set of intracellular proteins including p16INK4A…
Abstract Number: 2181 • 2019 ACR/ARP Annual Meeting
Natural Disease Progression in Hand Osteoarthritis: Results from a Belgian Ten-years Prospective Cohort Study
Lisa Pardaens ¹, Tine Vanhaverbeke ¹, Jordy Vandercruyssen ¹ and Ruth Wittoek², ¹Ghent University, Gent, Belgium, ²Ghent University Hospital, Gent University, Gent, Belgium
Background/Purpose: Limited evidence is available about natural disease progression in hand osteoarthritis (HOA). A previous study of the Ghent HOA cohort showed a positive association…
Abstract Number: 2244 • 2019 ACR/ARP Annual Meeting
What Are the Prescribing Trends and Satisfaction Levels with Analgesics for Osteoarthritis as Reported by US Rheumatogists, Orthopaedic Surgeons, and Primary Care Physicians?
Thomas Schnitzer¹, Rebecca Robinson ², Lars Viktrup ², Joseph Cappelleri ³, Andrew Bushmakin ³, Leslie Tive ⁴, Jennifer Mellor ⁵, Nathan Williams ⁵, Pavlina Hubanova ⁵ and James Jackson ⁵, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Eli Lilly and Company, Indianapolis, IN, ³Pfizer Inc, Groton, CT, ⁴Pfizer, Inc, New york, NY, ⁵Adelphi Real World, Bollington, England, United Kingdom
Background/Purpose: To describe patterns of care and physician satisfaction with prescribed treatments for osteoarthritis (OA).Methods: Data were collected from February-May 2017 using US Adelphi Disease…
Abstract Number: 886 • 2019 ACR/ARP Annual Meeting
Mesenchymal Stem Cell Senescence Alleviates Their Chondrogenic and Seno-Suppressive Properties, Contributing to Osteoarthritis Development
Olivier Malaise¹, Yassin Tachikart ², Michael Constantinides ², Marcus Mumme ³, Daniele Noel ², Jing Wang ⁴, Christian Jorgensen ² and Jean-Marc brondello ², ¹GIGA Research, CHU and University of Liège, Liège, Belgium, ²IRMB, INSERM U1183, University of Montpellier, Montpellier, France, ³University Hospital of Basel, Basel, Switzerland, ⁴INM, INSERM U1050, University of Montpellier, Montpeller, France
Background/Purpose: Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders such as osteoarthritis (OA). These senescent cells induce a tissue loss of function through…
Abstract Number: 1309 • 2019 ACR/ARP Annual Meeting
Concordance of Baseline Pain Measures (Across Two Reporting Instruments) Influences Treatment Effect: Post Hoc Analysis of a Phase 3 Randomized Controlled Trial of Triamcinolone Acetonide Extended-Release in Patients with Knee Osteoarthritis
Philip G Conaghan¹, Edgar Ross ², Alan Kivitz ³, Dennis Turk ⁴, Andrew Spitzer ⁵, Deryk Jones ⁶, Ryan Lanier ⁷, Amy Cinar ⁸, Joelle Lufkin ⁸ and Scott Kelley ⁸, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ²Brigham and Women's Hospital, Boston, MA, ³Altoona Center for Clinical Research, Duncansville, PA, ⁴University of Washington, Seattle, ⁵Cedars-Sinai Medical Center, Los Angeles, ⁶Ochsner Sports Medicine Institute, Harahan, GA, ⁷Analgesic Solutions, Natick, ⁸Flexion Therapeutics, Burlington
Background/Purpose: In a Phase 3 randomized controlled study, differing efficacy results were observed when triamcinolone acetonide extended-release (TA-ER) was compared to conventional TA crystalline suspension…
Abstract Number: 1759 • 2019 ACR/ARP Annual Meeting
Methotrexate in Patients with Hand Erosive Osteoarthritis Refractory to Usual Treatments: A Randomized, Double-blind, Placebo-controlled Trial
stéphanie Ferrero ¹, Ruth Wittoek ², Edem Allado ³, Coralie Cruzel ⁴, Véronique Breuil ¹, Liana Euller Ziegler ⁵, Damien louille ⁶, Christian Roux⁷ and Joel Kremer ⁸, ¹University of Nice, nice, France, ²Ghent University Hospital, Gent University, Gent, Belgium, ³Centre Hospitalier Universitaire de Nancy, Nancy, France, ⁴Université Cote d'Azur, nice, France, ⁵PUPH CHU NICE, nice, France, ⁶Université Cote d'Azur, Nancy, France, ⁷Université Cote d'Azur, Nice, ⁸Albany Medical College, Albany, NY
Background/Purpose: No studies have assessed the effect of methotrexate (MTX) in osteoarthritis of the hand (HOA). The purpose of our study was to examine the…
Abstract Number: 1983 • 2019 ACR/ARP Annual Meeting
Preclinical Evaluation of Targeting TGF-beta Signaling and Senescence in ex Vivo Models of Human Knee and Spine Osteoarthritis
Jeroen Geurts¹, Cordula Netzer ², Stefan Schären ² and Thomas Hugle ³, ¹University Hospital Lausanne (CHUV), Lausanne, Switzerland, ²University Hospital Basel, Basel, Switzerland, ³University Hospital Lausanne, Lausanne, Switzerland
Background/Purpose: The absence of effective disease-modifying drugs remains an important unmet need in the treatment of osteoarthritis. In recent years, novel pharmacological treatments including targeting…
Abstract Number: 2183 • 2019 ACR/ARP Annual Meeting
Relation of Intra-Articular Knee Mineralization on CT to Knee Pain in People with or at Risk of Knee Osteoarthritis
Tuhina Neogi¹, John Lynch ², Mohamed Jarraya ³, David Felson ⁴, Na Wang ¹, Michael Nevitt ², James Torner ⁵, Beth Lewis ⁶ and Ali Guermazi ¹, ¹Boston University School of Medicine, Boston, MA, ²University of California at San Francisco, San Francisco, CA, ³Mercy Catholic Medical Center, Darby, ⁴Boston University School of Medicine, Department of Rheumatology, Boston, ⁵University of Iowa at Iowa City, Iowa City, ⁶University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Intra-articular (i.a.) calcium crystal deposition is common in knee osteoarthritis (OA), particularly in end-stage disease. It is possible that low-grade inflammation related to crystals…
Abstract Number: 2409 • 2019 ACR/ARP Annual Meeting
24-hour Activity Profiling in People Living with Arthritis: Habits Matter
Lynne Feehan¹, Linda Li ¹, Na Lu ² and Hui Xie ³, ¹Arthritis Research Canada and University of British Columbia, Vancouver, Canada, Vancouver, BC, Canada, ²Arthritis Research Canada, Vancouver, Canada, Vancouver, BC, Canada, ³Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada
Background/Purpose: Current practices promoting change in physical activity classify individuals as being more or less active. However, across 24-hours people spend time in different types…
Abstract Number: 887 • 2019 ACR/ARP Annual Meeting
Critical Role of the Cholinergic System Involvement in Osteoarthritis
Alice Courties¹, Ariane Do ¹, Sarah Leite ², Audrey Pigenet ², Morgane Belle ³, Geoffroy Nourissat ⁴, Alain Sautet ⁵, Alain Chedotal ³, Uwe Maskos ⁶, Francis Berenbaum ⁷ and Jérémie Sellam ¹, ¹Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ²Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ³Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France, Paris, France, ⁴Chirurgie orthopédique, Clinique Maussins, Groupe Ramsay générale de santé, 67 rue de Romainville, 75019, Paris, Paris, France, ⁵Chirurgie orthopédique, AP-HP Hôpital Saint-Antoine, Paris, Paris, France, ⁶Unité de neurobiologie intégrative des systèmes cholinergiques, CNRS UMR 3571, Institut Pasteur, Paris, Paris, France, ⁷Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France
Background/Purpose: The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred as the 'cholinergic anti-inflammatory pathway'. ACh interacts with members of…
Abstract Number: 1310 • 2019 ACR/ARP Annual Meeting
Osteoarthritis: What’s in a Name?
Warren A Katz¹, ¹Penn Medicine; University of Pennsylvania School of Medicine, Upper Gwynedd, PA
Background/Purpose: The nomenclature of "osteoarthritis" (OA) has been a source of confusion and likely misdiagnosis for centuries. Prior to 1759, most patients with joint diseases…
Abstract Number: 1760 • 2019 ACR/ARP Annual Meeting
Six-week Treatment with Low-dose Prednisolone in Patients with Painful Hand Osteoarthritis (HOPE): Results from a Randomised Double-blind Placebo-controlled Trial
Féline Kroon¹, Marion Kortekaas ¹, Annelies Boonen ², Stephan Böhringer ³, Monique Reijnierse ¹, Frits R Rosendaal ³, Naghmeh Riyazi ⁴, Mirian Starmans ⁵, Franktien Turkstra ⁶, Jende van Zeben ⁷, CF Allaart ⁸ and Margreet Kloppenburg ³, ¹Leiden University Medical Center, Leiden, Netherlands, ²Maastricht University Medical Center, Maastricht, Netherlands, ³Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, ⁴Haga Hospital, The Hague, Netherlands, ⁵Zuyderland Medical Center, Heerlen, Netherlands, ⁶Amsterdam Rheumatology and immunology Center | Reade, Amsterdam, Netherlands, ⁷Sint Franciscus Vlietland Groep, Rotterdam, Netherlands, ⁸Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands
Background/Purpose: Hand osteoarthritis (OA) is a prevalent joint disease with high disease-burden in need for effective therapeutic options. Studies have shown that synovial inflammation is…
Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting
Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis
Ricardo Grieshaber-Bouyer¹, Till Kämmerer ², Nils Rosshirt ², Philipp Koniezke ², Sebastien Hagmann ², Elena Tripel ², Johannes Kirsch ², Tobias Gotterbarm ² and Babak Moradi ², ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, ²Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany
Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…
Abstract Number: 2184 • 2019 ACR/ARP Annual Meeting
A Flexion Contracture Is a Risk Factor for Radiographic Progression and Earlier Need for Arthroplasty in Knee Osteoarthritis: Data from the Osteoarthritis Initiative
T Mark Campbell¹ and Dennis McGonagle ², ¹Elisabeth Bruyere Hospital, Ottawa, ON, Canada, ²University of Leeds, Leeds, United Kingdom
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritis. Knee OA is often accompanied by a knee flexion contracture (FC), but the impact of…
Abstract Number: 2410 • 2019 ACR/ARP Annual Meeting
Using External Data to Estimate Omitted Variables in Observational Data: A Plasmode Simulation Study Investigating the Relationship Between Osteoarthritis and Cardiovascular Diseases to Compare Alternative Approaches in Imputing the Body Mass Index Variable
Mohammad Atiquzzaman¹, Mohammad Karim ², Jacek Kopec ³, Hubert Wong ⁴, Mary De Vera ⁵ and Aslam Anis ², ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Surrey, BC, Canada, ²School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ⁴University of British Columbia, Vancouver, BC, Canada, ⁵Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: BMI is a well-known confounding factor in the association between osteoarthritis (OA) and cardiovascular diseases (CVD). However, BMI is not usually recorded in administrative…

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