Abstracts tagged "microbiome"

Abstract Number: 0704 • ACR Convergence 2020
The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation
Christopher Dunn¹, Cassandra Garman², Cassandra Velasco², Vladislav Izda², Jake Martin² and Matlock Jeffries², ¹University of Oklahoma Health Sciences Center, Oklahoma City, ²University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 0788 • ACR Convergence 2020
Rigorous Plasma Microbiome Analysis Method Enables Disease Association Discovery
Wei Jiang¹, Alexander Alekseyenko², Gary Gilkeson³, Jim Oates⁴, Elizabeth Ogunrind⁵, Quan Li⁶, Diane Kamen², Betty Tsao⁵ and Zhenwu Luo⁵, ¹MUSC, Charleston, SC, ²Medical University of South Carolina, Charleston, SC, ³Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ⁴Medical University of South Carolina, Charleston, SC, Charleston, SC, ⁵Medical University of South Carolina, Charleston, ⁶UT South Western Medical Center, Texas
Background/Purpose: The mucosal microbiome contributes to disease pathogenesis via local and systemic interaction with the host. The hallmark of this interaction in the physiological condition…
Abstract Number: 0795 • ACR Convergence 2020
Minimum Clinically Important Improvement in Patients with Rheumatoid Arthritis Associates with Gut Microbiome
Vinod Gupta¹, Kevin Cunningham², Benjamin Hur¹, John Davis¹ and Jaeyun Sung¹, ¹Mayo Clinic, Rochester, MN, ²University of Minnesota, Minneapolis, MN
Background/Purpose: Within the past decade, there have been several major discoveries in cross-sectional gut microbiome studies suggesting that dysbiosis of the gut microbiota is a…
Abstract Number: 0959 • ACR Convergence 2020
Altered Gut Microbiome in Dermatomyositis
Sangmee Bae¹, Tien Dong², Venu Lagishetty³, William Katzka⁴, Jonathan Jacobs³ and Christina Charles-Schoeman⁵, ¹University of California Los Angeles, Los Angeles, CA, ²University of California Los Angeles, Los Angeles, ³University of California, Los Angeles, Los Angeles, ⁴UCLA, Los Angeles, ⁵University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Dermatomyositis (DM) is an autoimmune myopathy associated with marked microvascular dysfunction and high morbidity and mortality. The gut microbiome has been implicated in the…
Abstract Number: 1310 • ACR Convergence 2020
Gut Microbiome Changes Are Different Between Ankylosing Spondylitis and Inflammatory Bowel Disease, and Correlate with Disease Activity in Both Diseases
Peter Sternes¹, Laurel Brett², Julie Phipps³, Francesco Ciccia⁴, Erika de Guzman³, Mark Morrison⁵, Gerald Holtmann⁶, Eva Klingberg⁷, Carolyn McIvor², Helena Forsblad-d'Elia⁸ and Matthew Brown⁹, ¹Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, Brisbane, Queensland, Australia, ²Department of Gastroenterology, Logan Hospital, Brisbane, Queensland, Australia, ³Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia, ⁴Dipartimento di Medicina di Precisione, Università della Campania L. Vanvitelli, Naples, Naples, Campania, Italy, ⁵University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, ⁶Department of Gastrenterology, Princess Alexandra Hospital, Brisbane, Queensland, Australia, ⁷Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Vastra Gotaland, Sweden, ⁸Department of Public Health and Clinical Medicine/Rheumatology, Umeå University, Umeå, Vasterbottens Lan, Sweden, ⁹Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom
Background/Purpose: Multiple studies have confirmed that the gut and stool microbiome in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) are distinct from healthy controls,…
Abstract Number: 1908 • 2019 ACR/ARP Annual Meeting
Preliminary Identification of Arthritis-Associated Microbiota in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran ², Stephen Brooks ³ and Robert Colbert ⁴, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: Gut microbiota are strongly implicated in the pathogenesis of spondyloarthritis (SpA). Previous studies from our lab have documented extensive gut microbial dysbiosis in rats…
Abstract Number: 2042 • 2019 ACR/ARP Annual Meeting
Intestinal Microbiota Alters Th1/Th17 Balance but Is Dispensable for the Development of Systemic Autoimmune Disease in BXD2 Mice
Huixian Hong¹, Qi Wu ¹, PingAr Yang ¹, Bao Luo ², Alex Essman ², Oluwagbemiga Ojo ², Michael R. Crowley ³, David K. Crossman ³, Casey D. Morrow ⁴, Jeremy B. Foote ⁵, Trenton R. Schoeb ⁶, Charles O. Elson ⁷, Hui-Chen Hsu ⁸ and John D. Mountz ⁹, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ³Department of Genetics, University of Alabama at Birmingham, Birmingham, ⁴Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, ⁵Department of Microbiology, University of Alabama at Birmingham, Birmingham, ⁶Department of Genetics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁸1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham & University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham
Background/Purpose: Intestinal microbiota dysbiosis has been implicated in the pathogenesis of autoimmune disease. How the microbiota affects the peripheral immune system leading to the development…
Abstract Number: 2317 • 2019 ACR/ARP Annual Meeting
Gut Dysbiosis Is Associated with Measures of Early Vascular Dysfunction in Patients with Rheumatoid Arthritis
Michelle Ormseth¹, Joseph Solus ¹, Annette Oeser ¹ and C. Michael Stein ¹, ¹Vanderbilt University Medical Center, Nashville
Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated cardiovascular disease independent of traditional risk factors. Previous studies demonstrate that the gut microbiome is altered in…
Abstract Number: 2490 • 2019 ACR/ARP Annual Meeting
The Cutaneous Microbiome of Psoriatic Disease Is Influenced by Disease Susceptibility HLA Alleles but Not Clinical Phenotype
Meital Yerushalmi¹, Osvaldo Espin-Garcia ², Justine (Yang) Ye ³, Remy Pollock ⁴, Sara Rahmati ³, Lihi Eder ⁵, Mark Silverberg ⁶ and Vinod Chandran ⁷, ¹University of Toronto, University Health Network, Toronto, ON, Canada, ²Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, ON, Canada, ⁴Krembil Research Institute, University Health Network, Toronto, Canada, ⁵Women’s College Hospital and the Department of Medicine, University of Toronto, Toronto, Canada, ⁶Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷University Health Network, University of Toronto, Toronto, Canada
Background/Purpose: Psoriasis is an inflammatory skin disease. Psoriatic arthritis (PsA) is an inflammatory arthritis that affects 30% of psoriasis patients. The heterogeneity of psoriatic disease…
Abstract Number: 2550 • 2019 ACR/ARP Annual Meeting
Impact of Pathogenic and Protective Environmental Exposures on Autoimmune Disease—The Microbiome Effects on Lupus (MEL) Study
Hayley Walter¹, Trevor Faith ², Alexander Alekseyenko ³, Ali Bakhtiari ³, Paula Ramos ² and Diane Kamen ⁴, ¹Division of Rheumatology/Medical University South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Medical University South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic and often severe multi-organ autoimmune disease characterized by the production of autoantibodies and heterogeneous clinical manifestations. African…
Abstract Number: 2769 • 2019 ACR/ARP Annual Meeting
The Pre-Treatment Gut Microbiome Predicts Early Response to Methotrexate in Rheumatoid Arthritis
Sandrine Isaac ¹, Alejandro Artacho ¹, Renuka Nayak ², Steven B. Abramson ³, Margaret Alexander ², Imhoi Koo ⁴, Pamela Rosenthal ⁵, Peter Izmirly ⁶, Andrew Patterson ⁷, Antonio Pineda ⁸, Leonor Puchades-Carrasco ⁸, Peter Turnbaugh ², Carles Ubeda ⁹ and Jose Scher¹⁰, ¹FISABIO, Valencia, Spain, ²UCSF, San Francisco, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Pennsylvania State University; Penn State · Huck Institutes of Life Sciences, University Park, PA, ⁵NYU Langone Orhopedic Hospital, New York, ⁶NYU School of Medicine, New York, ⁷Penn State, University Park, PA, ⁸Centro de Investigación Príncipe Felipe/Instituto de Investigación Sanitaria La Fe, Valencia, Spain, ⁹Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain, ¹⁰New York University School of Medicine, New York, NY
Background/Purpose: Early treatment initiation in rheumatoid arthritis (RA) is fundamental to avoid chronic joint destruction and disability. Despite remarkable advances in RA therapeutics, oral methotrexate…
Abstract Number: 2788 • 2019 ACR/ARP Annual Meeting
Longitudinal Changes in the Nasal Microbiome and Disease Activity in Patients with Granulomatosis with Polyangiitis
Rennie Rhee¹, Antoine Sreih ², Jung-Jin Lee ³, Kyle Bittinger ³, Lisa Mattei ³, Ronald Collman ⁴ and Peter Merkel ², ¹University of Pennsylvania, Division of Rheumatology, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Children's Hospital of Philadelphia, Philadelphia, ⁴University of Pennsylvania, Philadelphia
Background/Purpose: Microbial organisms have been theorized to contribute to disease activity in granulomatosis with polyangiitis (GPA) but little is known about what changes occur in…
Abstract Number: 2860 • 2019 ACR/ARP Annual Meeting
Perturbation of the Human Gut Microbiome by Methotrexate Contributes to the Resolution of Inflammation and Autoimmune Disease
Renuka Nayak¹, Margaret Alexander ¹, Kye Stapleton-Grey ², Carles Ubeda ³, Jose Scher ⁴ and Peter Turnbaugh ¹, ¹UCSF, San Francisco, ²Carnegie Mellon, Pittsburg, ³Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain, ⁴Division of Rheumatology, New York University School of Medicine and NYU Langone Orthopedic Hospital, New York, NY
Background/Purpose: The trillions of microorganisms (microbiota) found within the human gut play a critical role in shaping the immune system, yet these complex microbial communities…
Abstract Number: 621 • 2019 ACR/ARP Annual Meeting
The Use of Microbial Flow Cytometry to Analyze the Intestinal and Oral Microbiota
Patrick Stauffer¹, Mark Klick ¹, Tammy Martin ¹, James T. Rosenbaum ² and Mark Asquith ¹, ¹Oregon Health and Science University, Portland, OR, ²Devers Eye Institute and Oregon Health & Science University, Portland, OR
Background/Purpose: The role of the microbiome in the pathogenesis of autoimmune disorders such as axial spondyloarthritis (SpA) has been well-established through means of describing gross…
Abstract Number: 983 • 2019 ACR/ARP Annual Meeting
Fecal Transfer from Mice on High or Low Magnesium Diets Confers Arthritis Protection
Teresina Laragione¹, Carolyn Harris ¹ and Percio Gulko ¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Magnesium (Mg) plays a key role in the immune response. We have previously demonstrated that alterations in the Mg balance by increasing or decreasing…

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