Abstracts tagged "microbiome"

Abstract Number: 1849 • ACR Convergence 2020
Identification of New Associations Between Psoriatic Arthritis and the Gut Microbiota. the Mi-PART, a Phenomic Study
Jesus Miguens Blanco¹, Uma Selvarajah¹, Zhigang Lui¹, Benjamin Mullish¹, James Alexander¹, Julie McDonald², Sonya Abraham¹ and Julian Marchesi¹, ¹Imperial College London, London, United Kingdom, ²Imperial College London, London
Background/Purpose: Perturbations of the gut microbiota have been associated with Psoriatic Arthritis (PsA), a chronic inflammatory disease. We aim to test the microbiome-metabolic interface of…
Abstract Number: 1853 • ACR Convergence 2020
Association of Gut Dysbiosis with Radiographic and Enthesis Involvement, Disease Activity and Duration in Axial Spondyloarthritis. Data from CASTRO Registry
Ignacio Gómez-García¹, Isabel Moreno-Indias², María-Carmen Abalos-Aguilera¹, Clementina Lopez-Medina³, Lourdes Ladehesa-Pineda⁴, Concepción Aranda-Valera⁴, Carolina Gutierrez-Repiso², Yolanda Jimenez-Gomez⁵, Nuria Barbarroja¹, Chary Lopez-Pedrera¹, Francisco-Jose Tinahones², Eduardo Collantes-Estévez⁴, Alejandro Escudero-Contreras⁴ and Patricia Ruiz-Limon⁶, ¹Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ²Biomedical Research Institute of Malaga (IBIMA)/ Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Malaga, Spain/ CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain, Malaga, Spain, ³Rheumatology Department, Cochin Hospital, Paris, Paris, France, ⁴Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, ⁵Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ⁶Biomedical Research Institute of Málaga (IBIMA)/ Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Malaga, Spain, Malaga, Spain
Background/Purpose: The etiopathogenesis of axial spondyloarthritis (AxSpA) is multifactorial. The possible role of alteration in gut microbiome (dysbiosis) has been recently suggested. However, the association…
Abstract Number: 1859 • ACR Convergence 2020
Curdlan-induced Villous Permeability, Luminal Pathobiont Translocation to the Ileal Crypts, Ileitis and Arthritis Are Mitigated by Clostridia in Colonised Germ-free SKG Mice
Anne-Sophie Bergot¹, Rabina Giri², Amy Cameron¹, Emily Duggan³, Jeimy Jimenez Loayza¹, Mark Morrison⁴, Linda Rehaume³, Jakob Begun² and Ranjeny Thomas⁵, ¹University of Queensland, Brisbane, Australia, ²Mater Research Institute UQ, Brisbane, Australia, ³University of Queensland, Brisbane, Queensland, Australia, ⁴University of Queensland Diamantina Institute, University of Queensland, Brisbane, Queensland, Australia, ⁵University of Queensland Diamantina Institute and Rheumatology Department, Princess Alexandra Hospital, Brisbane – Australia., Brisbane, Australia
Background/Purpose: IL-23 dependent spondylitis, arthritis and inflammatory bowel disease (IBD) recapitulate human spondyloarthropathy (SpA) in 1,3 beta glucan (curdlan)-treated SKG mice. Human SpA and SKG…
Abstract Number: 1971 • ACR Convergence 2020
Gut Microbiome Transplantation from MRL/MpJ Mice Prevents Post-Traumatic Osteoarthritis in C57BL6/J Mice
Matlock Jeffries¹, Jake Martin¹, Vladislav Izda¹, Cassandra Garman¹, Cassandra Velasco¹ and Christopher Dunn², ¹University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²University of Oklahoma HSC, Edmond, OK
Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
Abstract Number: 1994 • ACR Convergence 2020
Rheumatoid Arthritis Improvement After Exposure to an Anti-Inflammatory “ITIS” Diet Is Associated with Changes of Gut Microbiome and Systemic Metabolome
Roxana Coras¹, Cameron Martino², Julia Gauglitz³, Anupriya Tripathi³, Alan Jarmusch⁴, Francesca Cedola⁵, Marta Fernandez Bustamante⁶, Meritxall Agustín-Perez⁷, Maram Alharthi⁸, Susan Lee⁸, Abha Singh⁸, Soo In Choi⁸, Tania Rivera⁸, Katherine Nguyen⁸, Tatyana Shekhtman⁹, Tiffany Holt¹⁰, Shahrokh Golshan¹¹, Rob Knight³, Pieter Dorrestein¹² and Monica Guma¹³, ¹University of California San Diego, La Jolla, CA, ²Bioinformatics and Systems Biology, University of California San Diego, San Diego, ³University of California San Diego, San Diego, ⁴Univesity of California San Diego, San Diego, ⁵Hospital Policlinico Tor Vergata, Rome, Italy, ⁶Departement of Medicine, Division of Rheumatology, University of California San Diego, San Diego, ⁷Department of Medicine, University of California San Diego, San Diego, San Diego, ⁸Department of Medicine, Division of Rheumatology, University of California San Diego, San Diego, ⁹Department of Psychiatry, University of California, San Diego, San Diego, ¹⁰Center for Integrative Nutrition, University of California San Diego, San Diego, ¹¹Department of Psychiatry, University of California San Diego, San Diego, CA, USA, San Diego, ¹²Department of Pharmacology and Pediatrics, University of California San Deigo, San Diego, ¹³Division of Rheumatology, University of California San Diego, Department of Medicine, Autonomous University of Barcelona, La Jolla, CA
Background/Purpose: A new dimension has been added to the link between diet and health, the gut microbiome. Of particular interest is the influence of diet…
Abstract Number: 621 • 2019 ACR/ARP Annual Meeting
The Use of Microbial Flow Cytometry to Analyze the Intestinal and Oral Microbiota
Patrick Stauffer¹, Mark Klick ¹, Tammy Martin ¹, James T. Rosenbaum ² and Mark Asquith ¹, ¹Oregon Health and Science University, Portland, OR, ²Devers Eye Institute and Oregon Health & Science University, Portland, OR
Background/Purpose: The role of the microbiome in the pathogenesis of autoimmune disorders such as axial spondyloarthritis (SpA) has been well-established through means of describing gross…
Abstract Number: 983 • 2019 ACR/ARP Annual Meeting
Fecal Transfer from Mice on High or Low Magnesium Diets Confers Arthritis Protection
Teresina Laragione¹, Carolyn Harris ¹ and Percio Gulko ¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Magnesium (Mg) plays a key role in the immune response. We have previously demonstrated that alterations in the Mg balance by increasing or decreasing…
Abstract Number: 1464 • 2019 ACR/ARP Annual Meeting
The Oral Microbiome as a Risk Factor for Benign or Pathologic Autoimmunity Associated with Anti-SSA/Ro Positivity and Mimicry for Von Willebrand Factor Type a Domain Protein (vWFA) of L. Mirabilis
Robert Clancy¹, Miranda Marion ², Peter Izmirly ¹, Hannah Ainsworth ³, Timothy Howard ³, Mala Masson ¹, Jill Buyon ¹ and Carl Langefeld ³, ¹NYU School of Medicine, New York, ²Wake Forest School of Medicine, Winston-Salem, NC, ³Wake Forest School of Medicine, Winston-Salem
Background/Purpose: Autoantibody production precedes SLE or SS by years, including anti-Ro. Anti-Ro+ mothers of children with congenital heart block (CHB) are a unique population at…
Abstract Number: 1780 • 2019 ACR/ARP Annual Meeting
Microbiome in Offspring of Ankylosing Spondylitis Patients
Matthew Stoll¹, Kimberly DeQuattro ², Zhixiu Li ³, Henna Sawhney ⁴, Maria Castillo ⁴, Pamela F. Weiss ⁵, Peter Nigrovic ⁶, Lynn Punaro ⁷, Kenneth Schikler ⁸, Barbara Edelheit ⁹, John Reveille ¹⁰, Matthew Brown ³ and Lianne Gensler ¹¹, ¹University of Alabama at Birmingham, Birmingham, AL, ²University of California, San Francisco, San Francisco, CA, ³Queensland University of Technology, Queensland, Australia, ⁴University of California in San Francisco, San Francisco, CA, ⁵Children's Hospital of Philadelphia, Philadelphia, PA, ⁶Boston Children's Hospital, Boston, MA, ⁷Texas Scottish Rite Hospital, Dallas, TX, ⁸University of Kentucky, Louisville, KY, ⁹Connecticut Children's Medical Center, Hartford, CT, ¹⁰University of Texas McGovern Medical School, Houston, ¹¹University San Francisco California, San Francisco, CA
Background/Purpose: Spondyloarthritis (SpA) results from the interplay between genetic and environmental factors. An emerging factor is the human intestinal microbiota, which multiple studies in children…
Abstract Number: 1908 • 2019 ACR/ARP Annual Meeting
Preliminary Identification of Arthritis-Associated Microbiota in Experimental Spondyloarthritis
Tejpal Gill¹, Tri Tran ², Stephen Brooks ³ and Robert Colbert ⁴, ¹NIAMS/NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Pediatric Clinical Trials Unit, Pediatric Translational Research Branch, NIAMS, NIH, Bethesda, MD
Background/Purpose: Gut microbiota are strongly implicated in the pathogenesis of spondyloarthritis (SpA). Previous studies from our lab have documented extensive gut microbial dysbiosis in rats…
Abstract Number: 2042 • 2019 ACR/ARP Annual Meeting
Intestinal Microbiota Alters Th1/Th17 Balance but Is Dispensable for the Development of Systemic Autoimmune Disease in BXD2 Mice
Huixian Hong¹, Qi Wu ¹, PingAr Yang ¹, Bao Luo ², Alex Essman ², Oluwagbemiga Ojo ², Michael R. Crowley ³, David K. Crossman ³, Casey D. Morrow ⁴, Jeremy B. Foote ⁵, Trenton R. Schoeb ⁶, Charles O. Elson ⁷, Hui-Chen Hsu ⁸ and John D. Mountz ⁹, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ³Department of Genetics, University of Alabama at Birmingham, Birmingham, ⁴Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, ⁵Department of Microbiology, University of Alabama at Birmingham, Birmingham, ⁶Department of Genetics, Animal Resources Program, University of Alabama at Birmingham, Birmingham, ⁷Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁸1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, ⁹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham & University of Alabama at Birmingham and Birmingham VA Medical center, Birmingham
Background/Purpose: Intestinal microbiota dysbiosis has been implicated in the pathogenesis of autoimmune disease. How the microbiota affects the peripheral immune system leading to the development…
Abstract Number: 2317 • 2019 ACR/ARP Annual Meeting
Gut Dysbiosis Is Associated with Measures of Early Vascular Dysfunction in Patients with Rheumatoid Arthritis
Michelle Ormseth¹, Joseph Solus ¹, Annette Oeser ¹ and C. Michael Stein ¹, ¹Vanderbilt University Medical Center, Nashville
Background/Purpose: Patients with rheumatoid arthritis (RA) have accelerated cardiovascular disease independent of traditional risk factors. Previous studies demonstrate that the gut microbiome is altered in…
Abstract Number: 2490 • 2019 ACR/ARP Annual Meeting
The Cutaneous Microbiome of Psoriatic Disease Is Influenced by Disease Susceptibility HLA Alleles but Not Clinical Phenotype
Meital Yerushalmi¹, Osvaldo Espin-Garcia ², Justine (Yang) Ye ³, Remy Pollock ⁴, Sara Rahmati ³, Lihi Eder ⁵, Mark Silverberg ⁶ and Vinod Chandran ⁷, ¹University of Toronto, University Health Network, Toronto, ON, Canada, ²Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada, ³University Health Network, University of Toronto, Toronto, ON, Canada, ⁴Krembil Research Institute, University Health Network, Toronto, Canada, ⁵Women’s College Hospital and the Department of Medicine, University of Toronto, Toronto, Canada, ⁶Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ⁷University Health Network, University of Toronto, Toronto, Canada
Background/Purpose: Psoriasis is an inflammatory skin disease. Psoriatic arthritis (PsA) is an inflammatory arthritis that affects 30% of psoriasis patients. The heterogeneity of psoriatic disease…
Abstract Number: 2550 • 2019 ACR/ARP Annual Meeting
Impact of Pathogenic and Protective Environmental Exposures on Autoimmune Disease—The Microbiome Effects on Lupus (MEL) Study
Hayley Walter¹, Trevor Faith ², Alexander Alekseyenko ³, Ali Bakhtiari ³, Paula Ramos ² and Diane Kamen ⁴, ¹Division of Rheumatology/Medical University South Carolina, Charleston, SC, ²Medical University of South Carolina, Charleston, ³Medical University South Carolina, Charleston, SC, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic and often severe multi-organ autoimmune disease characterized by the production of autoantibodies and heterogeneous clinical manifestations. African…
Abstract Number: 2769 • 2019 ACR/ARP Annual Meeting
The Pre-Treatment Gut Microbiome Predicts Early Response to Methotrexate in Rheumatoid Arthritis
Sandrine Isaac ¹, Alejandro Artacho ¹, Renuka Nayak ², Steven B. Abramson ³, Margaret Alexander ², Imhoi Koo ⁴, Pamela Rosenthal ⁵, Peter Izmirly ⁶, Andrew Patterson ⁷, Antonio Pineda ⁸, Leonor Puchades-Carrasco ⁸, Peter Turnbaugh ², Carles Ubeda ⁹ and Jose Scher¹⁰, ¹FISABIO, Valencia, Spain, ²UCSF, San Francisco, ³NYU School of Medicine and NYU Langone Orthopedic Hospital, New York City, NY, ⁴Pennsylvania State University; Penn State · Huck Institutes of Life Sciences, University Park, PA, ⁵NYU Langone Orhopedic Hospital, New York, ⁶NYU School of Medicine, New York, ⁷Penn State, University Park, PA, ⁸Centro de Investigación Príncipe Felipe/Instituto de Investigación Sanitaria La Fe, Valencia, Spain, ⁹Centro Superior de Investigación en Salud Pública - FISABIO, Valencia, Spain, ¹⁰New York University School of Medicine, New York, NY
Background/Purpose: Early treatment initiation in rheumatoid arthritis (RA) is fundamental to avoid chronic joint destruction and disability. Despite remarkable advances in RA therapeutics, oral methotrexate…

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