Abstracts tagged "Magnetic resonance imaging (MRI)"

Abstract Number: 1L • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: Results of the 2-Year Primary Analysis from a 5-Year Randomised, Placebo-Controlled, Phase II Study
Marc C. Hochberg¹, Ali Guermazi², Hans Guehring³, Aida Aydemir⁴, Stephen Wax⁵, Patricia Fleuranceau-Morel⁴, Asger Reinstrup Bihlet⁶, Inger Byrjalsen⁶, Jeppe Ragnar Andersen⁶ and Felix Eckstein⁷, ¹University of Maryland School of Medicine, Baltimore, MD, ²Boston Imaging Core Lab, LLC, and Boston University School of Medicine, Boston, MA, ³Merck KGaA, Darmstadt, Germany, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ⁵EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁶Nordic Bioscience, Herlev, Denmark, ⁷Institute of Anatomy, Paracelsus Medical University, Salzburg, Austria

Background/Purpose: Sprifermin, a novel recombinant human fibroblast growth factor-18 is currently investigated as a potential disease-modifying osteoarthritis (OA) drug. Two-year primary data from a 5-year…
Abstract Number: 236 • 2017 ACR/ARHP Annual Meeting
Are Magnetic Resonance Imaging Features of the Hand Associated with Patient Reported Physical Function, Global Assessment of Disease Activity, Pain and Health Related Quality of Life in Rheumatoid Arthritis in Clinical Remission? – Longitudinal Results from an Observational Cohort
Daniel Glinatsi¹, Cecilie Heegaard Brahe², Merete Lund Hetland^1,3,4, Lykke Ørnbjerg¹, Simon Krabbe⁵, Joshua Baker⁶, Mikael Boesen⁷, Zoreh Rastiemadabadi⁸, Lone Morsel-Carlsen^8,9, Henrik Rogind^1,3, Hanne Slott Jensen¹⁰, Annette Hansen¹¹, Jesper Nørregaard¹², Søren Jacobsen^3,13, Lene Terslev¹, Tuan Huynh¹², Natalia Manilo¹⁴, Dorte Vendelbo Jensen^1,15, Jakob M. Møller¹⁶, Niels Steen Krogh¹⁵ and Mikkel Østergaard^1,3,17, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Copenhagen, Denmark, ²Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Denmark, Glostrup, Denmark, ³University of Copenhagen, Copenhagen, Denmark, ⁴The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁵Center for Rheumatology and Spine Diseases, Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, ⁶Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, ⁷Department of Radiology and the Parker institute, Copenhagen University Hospital Frederiksberg, Copenhagen, Denmark, ⁸Department of Radiology, Copenhagen University Hospital Frederiksberg, Copenhagen, Denmark, ⁹Department of Radiology, Rigshospitalet, Copenhagen, Denmark, ¹⁰Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Frederiksberg, Denmark, Copenhagen, Denmark, ¹¹Department of Rheumatology, Copenhagen University Hospital Gentofte, Copenhagen, Denmark, ¹²Center for Rheumatology and Spine Diseases, Nordsjællands Hospital, Hillerød, Denmark, ¹³Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ¹⁴Center for Rheumatology and Spine Diseases, Copenhagen University Hospital Frederiksberg, Copenhagen, Denmark, ¹⁵The DANBIO Registry, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ¹⁶Department of Radiology, Copenhagen University Hospital Herlev and Gentofte, Copenhagen, Denmark, ¹⁷Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Background/Purpose: To assess whether magnetic resonance imaging (MRI) inflammation and damage in the wrist and hand of rheumatoid arthritis (RA) patients are associated with patient-reported…
Abstract Number: 783 • 2017 ACR/ARHP Annual Meeting
European League Against Rheumatisms Recommendations for the Use of Imaging in Large Vessel Vasculitis in Clinical Practice
Christian Dejaco¹, Sofia Ramiro², Christina Duftner³, Florent L. Besson⁴, Thorsten Bley⁵, Daniel Blockmans⁶, Elisabeth Brouwer⁷, Marco A. Cimmino⁸, Eric Clark⁹, Bhaskar Dasgupta¹⁰, Andreas P Diamantopoulos¹¹, Haner Direskeneli¹², Annamaria Iagnocco¹³, Thorsten Klink⁵, Lorna Neill¹⁴, Cristina Ponte¹⁵, Carlo Salvarani¹⁶, Riemer Slart¹⁷, Madeline Whitlock¹⁸ and Wolfgang A. Schmidt¹⁹, ¹Rheumatology, Hospital of Bruneck, Bruneck, Italy, ²Rheumatology, Department of Rheumatology, LUMC, Leiden, Netherlands, Leiden, Netherlands, ³Department of Internal Medicine, Clinical Division of Internal Medicine II, Medical University Innsbruck, Innsbruck, Austria, ⁴Department of Nuclear Medicine, CHU Bicêtre, AP-HP, Université Paris-Sud, Paris, France, ⁵University of Würzburg, Würzburg, Germany, ⁶General Internal Medicine, University Hospital Gasthuisberg, Leuven, Belgium, ⁷Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁸Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁹PMRGCAuk, London, United Kingdom, ¹⁰Rheumatology, Southend University Hospital NHS Foundation Trust, Southend, UK, Westcliff-on-Sea, United Kingdom, ¹¹Rheumatology, Martina Hansens Hospital, Bærum, Oslo, Norway, ¹²Departement of İnternal Medicine, Division of Rheumatology, Marmara University, Istanbul, Turkey, ¹³Academic Rheumatology Unit, Università degli Studi di Torino, Torino, Italy, ¹⁴PMRGCAuk, Dundee, United Kingdom, ¹⁵Instituto de Medicina Molecular (IMM), Rheumatology Research Unit, Lisbon, Portugal, ¹⁶Rheumatology Unit, Arcispedale Santa Maria Nuova - IRCCS; Università di Modena e Reggio Emilia, Reggio-Emilia, Italy, ¹⁷University of Groningen, Enschede, Netherlands, ¹⁸Southend University Hospital, Southend, United Kingdom, ¹⁹Medical Center for Rheumatology and Clinical Immunology Berlin-Buch, Immanuel Krankenhaus Berlin, Berlin, Germany
Background/Purpose: Modern imaging modalities including ultrasound, magnetic resonance imaging (MRI), computed tomography (CT) and 18F-FDG positron emission tomography (PET/CT) have been increasingly used in primary…
Abstract Number: 1207 • 2017 ACR/ARHP Annual Meeting
Clinical Relevance of Structural Measures in Knee Osteoarthritis: Baseline Values and Change from Baseline Discriminate Patients Subsequently Receiving Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Michael J Hannon³ and Aida Aydemir⁴, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Structural measures of knee OA (KOA) progression include assessment of radiographic joint space width (JSW) and quantitative MRI (qMRI) measurement of cartilage thickness, both…
Abstract Number: 1875 • 2017 ACR/ARHP Annual Meeting
Assessment of Structural Damage of the Thumb Base in Patients with Hand Osteoarthritis: Comparing the Newly Developed Omeract Magnetic Resonance Imaging Scoring System with Standard Radiography
S. van Beest¹, F.P.B. Kroon¹, W. Damman¹, R. Liu¹, H.M. Kroon² and M. Kloppenburg³, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Radiology, Leiden University Medical Center, Leiden, Netherlands, ³Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Thumb base osteoarthritis (OA) is characterized by structural damage, most commonly evaluated by radiography. However radiography is insensitive. Magnetic resonance (MR) imaging could be…
Abstract Number: 2300 • 2017 ACR/ARHP Annual Meeting
Predictive Value of Magnetic Resonance Imaging in Patients with Juvenile Idiopathic Arthritis in Clinical Remission
Clara Malattia¹, Marta Mazzoni Sr.², Stefania Viola Sr.², Angela Pistorio³, Francesca Magnaguagno⁴, Alessia Urro Jr.², Angelo Ravelli⁵ and Alberto Martini⁶, ¹Pediatria2 Reumatologia, Istituto Giannina Gaslini, Genoa, Italy, ²Pediatria 2 Reumatologia, Istituto Giannina Gaslini, Genova, Italy, ³Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, ⁴UO Radiologia, Istituto Giannina Gaslini, Genoa, Italy, ⁵University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, ⁶Istituto Giannina Gaslini, Genoa, Italy
Background/Purpose: MRI studies on RA revealed that subclinical synovitis is common in patients in clinical remission and it is responsible for structural damage progression. MRI-detected…
Abstract Number: 2962 • 2017 ACR/ARHP Annual Meeting
MRI Results Following Discontinuation of Methotrexate in Patients with Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab: Results from a Randomized Controlled Trial
Charles Peterfy¹, Joel Kremer², William F C Rigby³, Nora Singer⁴, Christine Birchwood⁵, Darcy Gill⁵, William Reiss⁵, Jinglan Pei⁵ and Margaret Michalska⁵, ¹Spire Sciences, Inc., Boca Raton, FL, ²Albany Medical College, Albany, NY, ³Geisel School of Medicine at Dartmouth, Lebanon, NH, ⁴Case Western Reserve University School of Medicine, Cleveland, OH, ⁵Genentech, Inc., South San Francisco, CA
Background/Purpose: Although previous studies have established the efficacy of tocilizumab (TCZ) initiated as monotherapy (MONO) for the treatment of rheumatoid arthritis (RA),1,2 changes in active…
Abstract Number: 18L • 2016 ACR/ARHP Annual Meeting
Primary CNS Vaculitis Vs Neurosarcoidosis: Can We Predict the Diagnosis with MRI?
Didem Saygin¹, Priya Sundaram-Simonelli², Leonard H. Calabrese³, Elisabeth Ray⁴, William Messner⁵, Stephen Jones², Jinny Tavee⁶ and Rula A Hajj-Ali⁷, ¹Cleveland Clinic, Cleveland, OH, ²Neuroradiology, Cleveland Clinic, Cleveland, OH, ³Rheumatic & Immunologic Disease, Cleveland Clinic, Cleveland, OH, ⁴Rheumatology, Cleveland Clinic, Cleveland, OH, ⁵Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ⁶Neuromuscular diseases, Cleveland Clinic, Cleveland, OH, ⁷Rheumatic and Immunologic Dis, Cleveland Clinic, Cleveland, OH

Background/Purpose: Neurosarcoidosis and primary angiitis of central nervous system (PACNS) are inflammatory diseases affecting central nervous system, with overlapping clinical and pathological characteristics. Differentiating between…
Abstract Number: 2367 • 2016 ACR/ARHP Annual Meeting
Association Between MRI-Detected Osteophytes and Changes in Knee Pain and Structures in Older Adults: A Population Based Cohort Study
Zhaohua Zhu¹, Laura Laslett², Xingzhong Jin³, Weiyu Han¹, Benny Samuel Eathakkattu Antony⁴, Xia Wang⁵, Flavia M Cicuttini⁶, Graeme Jones^7,8 and Changhai Ding⁷, ¹Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ²Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ³Menzies institute for Medical Research, University of Tasmania, Hobart, Australia, ⁴Musculoskeletal, Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia, ⁵Menzies institute for medical research, University of Tasmania, Hobart, Australia, ⁶Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia, ⁷Musculoskeletal Unit, Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia, ⁸Musculoskeletal Unit, Menzies Research Institute Tasmania, University of Tasmania, Hobart,7000, Australia
Background/Purpose: Osteophyte (OP) formation is one of the clinical features of osteoarthritis (OA), so early detection of OP formation can be of diagnostic value. OP…
Abstract Number: 3090 • 2016 ACR/ARHP Annual Meeting
Inflammation Detected with Modern Sensitive MRI Analysis Demonstrates That Therapeutic Response As Early As One Month Predicts 12-Month Radiographic Progression: Data from a Study Using Tofacitinib and Methotrexate in Early RA
Philip G. Conaghan¹, Michael A Bowes², Mikkel Østergaard³, Gwenael Guillard², Douglass Chapman⁴, Amy Stein⁵, John Andrews⁴, Zhiyong Xie⁶, Andrew Koenig⁷, Koshika Soma⁴ and Bethanie Wilkinson⁶, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Imorphics Ltd, Manchester, United Kingdom, ³Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ⁴Pfizer Inc, New York, NY, ⁵Biostatistics, Quintiles, Morrisville, NC, ⁶Pfizer Inc, Groton, CT, ⁷Pfizer Inc, Collegeville, PA
Background/Purpose: Tofacitinib is an oral Janus kinase inhibitor for the treatment of RA. A novel automated quantification method for RA MRI-detected pathology using statistical shape…
Abstract Number: 3158 • 2016 ACR/ARHP Annual Meeting
What Predicts Absence of Spinal Damage in Patients with Spondyloarthritis after Prolonged Follow up?
Walter Maksymowych¹, Stephanie Wichuk¹, Praveena Chiowchanwisawakit², Robert G Lambert³ and Susanne J Pedersen⁴, ¹Medicine, University of Alberta, Edmonton, AB, Canada, ²Medicine, Mahidol University, Bangkok, Thailand, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Rheumatology, Copenhagen University Hospitals, Copenhagen, Denmark
Background/Purpose: After 20 years of follow up the majority of patients with aspondyloarthritis (SpA) have developed new bone in the spine although disease may remain…
Abstract Number: 150 • 2016 ACR/ARHP Annual Meeting
Ultrasonography and Magnetic Resonance Imaging Changes in Polymyalgia Rheumatica Patients Treated By Tocilizumab
Anais Huwart¹, Florent Garrigues², Sandrine Jousse-Joulin³, Thierry Marhadour⁴, Jean-Marie Berthelot⁵, Maelenn Gouillou⁶, Alain Saraux⁷ and Valerie Devauchelle-Pensec⁸, ¹Radiology, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ²Radiology department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France, ³Rheumatology, CHu La cavle Blanche, Brest, France, ⁴Rheumatology, CHU La Cavale Blanche, Brest, France, ⁵Service Rheumatology, CHU de Nantes, Nantes, France, ⁶Clinical Investigation Centre (CIC) 1412, CHU Cavale Blanche- Institut National de la Santé et de la Recherche Médicale (INSERM), Brest, France, ⁷Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ⁸Rheumatology, Brest university medical school, EA 2216, Lab Ex, INSERM, IGO,UBO and CHU de la Cavale Blanche,, Brest, France
Background/Purpose: Clinical and biological exams are the basis for polymyalgia rheumatic (PMR) monitoring. New imaging techniques such as ultrasound (US) and magnetic resonance imaging (MRI)…
Abstract Number: 159 • 2016 ACR/ARHP Annual Meeting
Assessing Agreement Among Measures of Inflammation Detected on Magnetic Resonance Imaging, Ultrasound and Clinical Findings in the Feet of Patients with Early Rheumatoid Arthritis
Karen A. Beattie¹, George Ioannidis², Sydney Scheffler³, Saara Totterman⁴, Edward Schreyer⁵ and Maggie Larche¹, ¹Medicine, McMaster University, Hamilton, ON, Canada, ²St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, ³McMaster University, Hamilton, ON, Canada, ⁴Radiology, VirtualScopics Inc., Rochester, NY, ⁵QMetrics Technologies, Rochester, NY
Background/Purpose: In metatarsalphalangeal (MTP) joints 2-5 of patients with early rheumatoid arthritis (RA), we aimed to assess the agreement between i) Magnetic Resonance Imaging (MRI)…
Abstract Number: 736 • 2016 ACR/ARHP Annual Meeting
A Multi-Center, Open Label, Randomized Clinical Tries of Etanercept and Celecoxib Alone/Combined Treatment in Effectiveness and Safety of Ankylosing Spondylitis
Jieruo Gu¹, Liudan Tu², Minjing Zhao³, Zhiming Lin⁴, Zetao Liao⁵, Shuangyan Cao⁶, Qinghong Yu⁷ and Zhizhong Ye⁸, ¹Rheumatology, Third affiliated hospital of Sun Yat-sen Universtiy, Guangzhou, China, ²The Third Hospital of Sun Yat-sen University, Guangzhou, China, ³The Third Affiliated Hospital of Sun Yat-sen University, guangzhou, China, ⁴Rheumatology, 3rd Affiliated Hospital of Sun Yat-Sen Uni, Guangzhou, China, ⁵Rheumatology, 3rd Affiliated Hoapital of Sun Yat-Sen Uni, Guangzhou, China, ⁶Rheumatology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁷Department of Rheumatology, Fourth People’s Hospital of Shenzhen City, Xiangmi Lake branch, Guangzhou, China, ⁸Department of Rheumatology，ZhuJiang Hospital of Southern Medical University, Guangzhou, China
Background/Purpose: To compare the clinical、radiographic and magnatic resonance imaging change in active ankylosing spondylitis patients with etanercept and celecoxib alone/combined treatment，and to evaluate the effectiveness…
Abstract Number: 938 • 2016 ACR/ARHP Annual Meeting
Prevalence of Non-Radiographic Axial Spondyloarthritis in Psoriatic Arthritis – a Single Center Observational Study
Victoria Furer¹, Moshe Stark², Hagit Matz³, David Levartovsky⁴, Jonathan Wallman⁵, Irena Wigler⁶, Hagit Sarvagyl-Maman⁷, Ofir Elalouf⁸, Sara Borok Lev-Ran⁹, Daphna Paran⁶, Gideon Flusser¹⁰, Iddo Drukman¹⁰, Iris Eshed¹¹ and Ori Elkayam¹², ¹Rheumatology, Tel Aviv Sourasky Medical Center, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ²Tel Aviv Medical Center, Tel Aviv, Tel Aviv, Israel, ³Dermatology, Tel Aviv Medical Center, Tel Aviv, Israel, ⁴Rheumatology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel, ⁵Rheumatology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel, ⁶Rheumatology, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel, ⁷Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel-aviv, Israel, ⁸Rheumatology, Tel Aviv Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel, ⁹Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine,Tel Aviv University, Tel AViv, Israel, ¹⁰Radiology, Tel Aviv Medical Center, Tel Aviv, Israel, ¹¹Department of Radiology, Sheba Medical Center, Israel, Tel Hashomer, Israel, ¹²Rheumatology, Tel Aviv Medical Center, Tel Aviv, Israel
Background/Purpose: Sacroiliitis, as detected by plain radiographs of the sacroiliac joints (SIJ), has been reported in a third of the psoriatic arthritis (PsA) population. (1)…

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