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Abstracts tagged "Lung Disease"

  • Abstract Number: 040 • 2023 Pediatric Rheumatology Symposium

    HLA DRB1*15 and Eosinophilia Are Common Among Patients with Systemic Juvenile Idiopathic Arthritis

    Alison Lerman1, Shawn Mahmud1, Zineb Alfath2, Benjamin Langworthy3, Patricia Hobday1, Mona Riskalla1 and Bryce Binstadt1, 1Division of Pediatric Rheumatology, Allergy & Immunology, Department of Pediatrics, University of Minnesota and M Health Fairview Masonic Children’s Hospital, Minneapolis, MN, 2University of Minnesota, Minneapolis, 3Division of Biostatistics, School of Public Health and Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN

    Background/Purpose: Over the last two decades, some children with systemic juvenile idiopathic arthritis (SJIA) have developed a severe form of interstitial lung disease (ILD) termed…
  • Abstract Number: 376 • 2019 ACR/ARP Annual Meeting

    Long-term Outcome and Prognostic Factors of Patients with Interstitial Pneumonia with Autoimmune Features: A Single Center Large-scale Observational Cohort Study

    Okinori Murata1, Katsuya Suzuki 2, Nobuhito Sasaki 3, Tsutomu Takeuchi 2 and Makoto Maemondo 3, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, 3Division of Pulmonary medicine, Allergy, and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan

    Background/Purpose: Patients with idiopathic interstitial pneumonia (IIP) may have features of connective tissue diseases (CTDs). The term interstitial pneumonia with autoimmune features (IPAF) has been…
  • Abstract Number: 2343 • 2019 ACR/ARP Annual Meeting

    Treatment with Biologic DMARDs Does Not Increase Risk of Severe Pulmonary Events in Patients with Rheumatoid Arthritis and Pre-existing Lung Disease

    Shinji Watanabe1, Takahisa Gono 1, Ryosuke Fukue 1, Seiji Kobayashi 1, Yuichiro Shirai 2, Mitsuhiro Takeno 3 and Masataka Kuwana 2, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Tokyo, Japan, 2Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, Bunkyo-ku, Tokyo, Japan, 3Nippon Medical School, Tokyo, Japan

    Background/Purpose: Pulmonary complication is one of the leading causes of mortality in patients with rheumatoid arthritis (RA). Pre-existing lung disease is known as a risk…
  • Abstract Number: 1118 • 2018 ACR/ARHP Annual Meeting

    Identification of Transcriptional Regulatory Networks in Systemic Sclerosis

    Yue Wang1, Jennifer Franks2 and Michael L. Whitfield3, 1Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 2Geisel School of Medicine at Dartmouth, Hanover, NH, 3Biomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, NH

    Background/Purpose: Systemic sclerosis (SSc) is a heterogeneous autoimmune disorder with poor outcomes and no FDA-approved therapies. Prior work has shown gene expression patterns associated with…
  • Abstract Number: 1123 • 2018 ACR/ARHP Annual Meeting

    Plasmacytoid Dendritic Cells in Bronchoalveolar Lavage Correlate with Pulmonary Artery Diameter and Infiltrate Perivascular Areas in the Lungs from Patients with Systemic Sclerosis Associated Pulmonary Hypertension

    Isela Valera1, Anagha Divekar2, Dinesh Khanna3, Fereidoun Abtin4, Rajan Saggar4 and Ram R. Singh4, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, UCLA, Los Angeles, CA, 2Biolegend, Sa Diego, CA, 3Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 4UCLA, Los Angeles, CA

    Background/Purpose: In patients with systemic sclerosis (SSc), plasmacytoid dendritic cells (pDCs) increase in the bronchoalveolar lavage (BAL) and lung tissues (Kafaja S, et al, JCI…
  • Abstract Number: 1339 • 2018 ACR/ARHP Annual Meeting

    Myositis Specific Anti-Histidyl tRNA Synthetase (HisRS) Autoantibodies Display High Reactivity Against Hisrs Conformational Epitopes and Associate with Lung and Joint Involvement

    Catia Fernandes-Cerqueira1,2, Nuria Renard1,2, Antonella Notarnicola1,2, Edvard Wigren1,2,3, Per-Johan Jakobsson2,4, Susanne Graslund1,2,3 and Ingrid E. Lundberg1,2, 1Department of Medicine, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden, 2Center for Molecular Medicine, Stockholm, Sweden, 3Structural Genomics Consortium, Stockholm, Sweden, 4Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Autoimmune myositis (rheumatic muscle inflammation) associated with interstitial lung disease (ILD) and arthritis is strongly correlated with the presence of anti-histidyl tRNA synthetase (HisRS)…
  • Abstract Number: 1717 • 2018 ACR/ARHP Annual Meeting

    Expert Consensus on the Screening, Treatment, and Management of Patients with Systemic Sclerosis-Interstitial Lung Disease, and the Potential Role of Anti-Fibrotics in a Treatment Paradigm for Systemic Sclerosis-Interstitial Lung Disease: A Delphi Consensus Study

    Dinesh Khanna1,2, Mary Strek3, Brian Southern4, Rajan Saggar5, Vivien Hsu6, Maureen D. Mayes7, Rick Silver8, Virginia D. Steen9, Donald Zoz10 and Franck Rahaghi11, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3Pulmonology, University of Chicago, Chicago, IL, 4Pulmonology, Cleveland Clinic Ohio, Cleavland, OH, 5Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 6Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, 7Rheumatology, University of Texas Medical School at Houston, Houston, TX, 8Rheumatology, Medical University of SC, Charleston, SC, 9Dept of Rheumatology, Georgetown Univ Medical Center, Washington, DC, 10Pulmonology, Boehringer Ingelheim, Ridgefield, CT, 11Cleveland Clinic Florida Weston, Weston, FL

    Background/Purpose: Systemic sclerosis (SSc), or scleroderma, is a rare, autoimmune, multisystem connective tissue disorder characterized by vascular damage, autoimmunity, and fibrosis of the skin and…
  • Abstract Number: 1740 • 2018 ACR/ARHP Annual Meeting

    Effectiveness and Safety of Tocilizumab for the Treatment of Refractory Systemic Sclerosis Associated Interstitial Lung Disease: A Case Series

    Judit Lluch1, Ivan Castellvi2, J Alegre3, Pablo Juárez1, Joan Miquel Nolla1 and Francisco Javier Narváez4, 1Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 2Rheumatology, Hospital Santa Creu i San Pau, Barcelona, Spain, 3Rheumatology, Hospital Universitario Doctor Peset. Valencia. Spain, Valencia, Spain, 4Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain

    Background/Purpose: To evaluate the efficacy and safety of TCZ as as a rescue therapy in patients with refractory scleroderma-associated interstitial lung disease (SSc-ILD). Methods: We…
  • Abstract Number: 2462 • 2018 ACR/ARHP Annual Meeting

    Efficacy and Safety in the Middle-LONG Period of Rituximab in the Treatment of Diffuse Interstitial Pulmonary Disease Associated with Rheumatoid Arthritis

    Francisco Javier Narváez1, Alejandro Robles Perez2, Patricio Luburich3, J Alegre4, Milagros Ricse5, Carmen Gomez Vaquero6, Joan Miquel Nolla5 and Maria Molina5, 1Rheumatology Department, Hospital de Bellvitge. Barcelona. Spain, L’Hospitalet de Llobregat, Spain, 2Pneumology, Hospital Universitario de Bellvitge, Barcelona, Spain, 3Radiology, Hospital Universitario de Bellvitge, Barcelona, Spain, 4Rheumatology, Hospital Universitario Doctor Peset. Valencia. Spain, Valencia, Spain, 5Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain, 6Rheumatology Department, Hospital Universitario de Bellvitge, Idibell, Barcelona, Spain

    Background/Purpose: To evaluate the efficacy and safety of rituximab (RTX) in the medium- to long-term for the management of progressive rheumatoid arthritis–related interstitial lung disease…
  • Abstract Number: 2919 • 2018 ACR/ARHP Annual Meeting

    An Epidemic: Severe Lung Disease in Patients with Systemic Juvenile Idiopathic Arthritis, Risk Factors and Predictors

    Shima Yasin1, Christopher Towe2,3, Ndate Fall4, Alexei Grom3,4 and Grant Schulert1,5, 1Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Pulmonology, Division of Pulmonology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 4Division of Rheumatology, Divisions of Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 5Pediatrics, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH

    Background/Purpose: There is growing awareness of severe and often fatal chronic lung disease in patients with systemic juvenile idiopathic arthritis (sJIA). However, clinical features and…
  • Abstract Number: 2974 • 2018 ACR/ARHP Annual Meeting

    Long-Term Survival in Lung Transplantation for Interstitial Lung Disease Due to Rheumatic Systemic Diseases. Study of 26 Cases of a Single Center

    Diana Prieto Peña1, Amaya Martinez Meñaca2, Monica Calderón Goercke1, José Luis Martín-Varillas3, Belén Atienza-Mateo3, Victor Manuel Mora Cuesta2, Sonia Fernandez Rozas4, David Iturbe Fernandez4, Carmen González-Vela5, Jose Manuel Cifrian Martinez4, Miguel Angel González-Gay6 and Ricardo Blanco3, 1Rheumatology, Rheumatology. Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 2Neumology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, SANTANDER, Spain, 3Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 4Neumology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 5Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Universidad de Cantabria. Spain, Santander, Spain, 6School of Medicine, University of Cantabria, Santander, Spain, Santander, Spain

    Background/Purpose: Interstitial lung disease (ILD) is one of the most serious complications associated with rheumatic systemic diseases. Patients with ILD have increased mortality and limited…
  • Abstract Number: 2979 • 2018 ACR/ARHP Annual Meeting

    Innovative Approaches for the Assessment of Interstitial Lung Disease in Idiopathic Inflammatory Myopathies: Ultrasound Evaluation of Pleural Irregularities and Semiquantitative and Quantitative Analysis of Lung CT

    Simone Barsotti1,2, Chiara Romei3, Elisa Cioffi4, Claudia Roncella5, Elisabetta Perrone3, Alessandra Tripoli1, Marta Mosca1, Fabio Falaschi3 and Rossella Neri6, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Department of Medical Biotechnologies, University of Siena, Siena, Italy, 3Pisa University Hospital, II Radiology Unit, Pisa, Italy, 4Rheumatology Unit, Rheumatology Unit, University of Pisa, Pisa, Italy, 5Pisa University Hospital, I Radiology Unit, Pisa, Italy, 6Rheumatology Unit, University of Pisa, PISA, Italy

    Background/Purpose: Interstitial Lung Disease (ILD) in patients with Idiopathic Inflammatory Myopathies (IIM) is associated to high mortality and morbidity. The study of pleural irregularities (PI)…
  • Abstract Number: 2980 • 2018 ACR/ARHP Annual Meeting

    Calcineurin Inhibitor for the Treatment of Myositis-Associated Interstitial Lung Disease: Comparison between Cyclosporine and Tacrolimus

    Takahisa Gono1, Kenichi Masui2, Naoshi Nishina3, Shinji Sato4 and Masataka Kuwana1, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 2Department of Anesthesiology, Show University Hospital, Tokyo, Japan, 3Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 4Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan

    Background/Purpose: Treatment options for myositis-associated interstitial lung disease (ILD) include corticosteroids (CS) in combination with or without cyclophosphamide (CY), calcineurin inhibitors (CNIs) such as cyclosporine…
  • Abstract Number: 4 • 2018 ACR/ARHP Annual Meeting

    Anti-Jo1 Positive Myositis Patients Display a Characteristic IgG Fc-Glycan Profile Which Is Further Enhanced in Anti-Jo1 Autoantibodies

    Catia Fernandes-Cerqueira1,2, Nuria Renard1,2, Antonella Notarnicola1,2, Edvard Wigren1,2,3, Susanne Graslund1,2,3, Roman Zubarev4, Ingrid E. Lundberg1,2 and Susanna L. Lundström4, 1Department of Medicine, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden, 2Center for Molecular Medicine, Stockholm, Sweden, 3Structural Genomics Consortium, Stockholm, Sweden, 4Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry I, Stockholm, Sweden

    Background/Purpose: IgG Fc-glycans affect IgG function and are altered in autoimmune diseases and autoantibodies. Anti-histidyl tRNA synthetase autoantibodies (anti-Jo1) are frequent in myositis associated with…
  • Abstract Number: 70 • 2018 ACR/ARHP Annual Meeting

    Colocalization of Malondialdehyde-Acetaldehyde Adducts (MAA) and Extracellular Matrix Proteins in Joint and Lung Tissues from Rheumatoid Arthritis Patients

    Geoffrey M. Thiele1, Michael J. Duryee2, Jacob D. McGowan1, Logan M. Duryee1, Lynell W. Klassen3, James R. O'Dell3, Bryant R. England4 and Ted R. Mikuls5, 1University of Nebraska Medical Center, Omaha, NE, 2Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 4Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 5Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Malondialdehyde-acetaldehyde adducts (MAA) are products of oxidative stress that modify self-proteins and stimulate potent cellular and humoral immune responses. We have previously demonstrated…
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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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