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Abstracts tagged "Lung Disease"

  • Abstract Number: 1339 • 2018 ACR/ARHP Annual Meeting

    Myositis Specific Anti-Histidyl tRNA Synthetase (HisRS) Autoantibodies Display High Reactivity Against Hisrs Conformational Epitopes and Associate with Lung and Joint Involvement

    Catia Fernandes-Cerqueira1,2, Nuria Renard1,2, Antonella Notarnicola1,2, Edvard Wigren1,2,3, Per-Johan Jakobsson2,4, Susanne Graslund1,2,3 and Ingrid E. Lundberg1,2, 1Department of Medicine, Division of Rheumatology, Karolinska Institutet, Stockholm, Sweden, 2Center for Molecular Medicine, Stockholm, Sweden, 3Structural Genomics Consortium, Stockholm, Sweden, 4Rheumatology Unit, Dept. of Medicine, Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Autoimmune myositis (rheumatic muscle inflammation) associated with interstitial lung disease (ILD) and arthritis is strongly correlated with the presence of anti-histidyl tRNA synthetase (HisRS)…
  • Abstract Number: 1717 • 2018 ACR/ARHP Annual Meeting

    Expert Consensus on the Screening, Treatment, and Management of Patients with Systemic Sclerosis-Interstitial Lung Disease, and the Potential Role of Anti-Fibrotics in a Treatment Paradigm for Systemic Sclerosis-Interstitial Lung Disease: A Delphi Consensus Study

    Dinesh Khanna1,2, Mary Strek3, Brian Southern4, Rajan Saggar5, Vivien Hsu6, Maureen D. Mayes7, Rick Silver8, Virginia D. Steen9, Donald Zoz10 and Franck Rahaghi11, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan, Ann Arbor, MI, 3Pulmonology, University of Chicago, Chicago, IL, 4Pulmonology, Cleveland Clinic Ohio, Cleavland, OH, 5Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 6Rheumatology, Robert Wood Johnson University Scleroderma Program, New Brunswick, NJ, 7Rheumatology, University of Texas Medical School at Houston, Houston, TX, 8Rheumatology, Medical University of SC, Charleston, SC, 9Dept of Rheumatology, Georgetown Univ Medical Center, Washington, DC, 10Pulmonology, Boehringer Ingelheim, Ridgefield, CT, 11Cleveland Clinic Florida Weston, Weston, FL

    Background/Purpose: Systemic sclerosis (SSc), or scleroderma, is a rare, autoimmune, multisystem connective tissue disorder characterized by vascular damage, autoimmunity, and fibrosis of the skin and…
  • Abstract Number: 1722 • 2017 ACR/ARHP Annual Meeting

    Identification of a Sub-Population of Autoantibodies Targeting BICD2 Cross-Reacting with CENP-a Derived Peptides in Patients with Systemic Sclerosis

    Michael Mahler1, Chelsea Bentow1, Jay Milo1, May Choi2, Mianbo Wang3, Petra Budde4, Murray Baron5, Marie Hudson6 and Marvin J. Fritzler7, 1Research and Development, Inova Diagnostics, San Diego, CA, 2University of Calgary, Calgary, AB, Canada, 3Lady Davis Institute for Medical Research, Montreal, QC, Canada, 4Protagen AG, Dortmund, Germany, 5Rheumatology, Jewish General Hospital, Montreal, QC, Canada, 6Division of Rheumatology, Jewish General Hospital, Lady David Institute for Medical Research, Montreal, QC, Canada, 7Medicine, University of Calgary, Calgary, AB, Canada

    Background/Purpose: Anti-nuclear antibodies (ANA) are present in approximately 90% of sera from systemic sclerosis (SSc) patients and play an important role in the diagnosis and…
  • Abstract Number: 1756 • 2017 ACR/ARHP Annual Meeting

    Interstitial Lung Disease in ANCA Associated Vasculitis: A Distinct or an Incomplete Subset in ANCA Vasculitis Patients?

    Simone Barsotti1,2, Francesco Ferro1, Elena Elefante1, Rossella Neri3, Marta Mosca1 and Chiara Baldini4, 1Rheumatology Unit, University of Pisa, Pisa, Italy, 2Department of Medical Biotechnologies, University of Siena, Siena, Italy, 3Rheumatology Unit, University of Pisa, PISA, Italy, 4Internal Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy

    Background/Purpose: ANCA-associated vasculitis (AAV) are heterogeneous disorders with a clinical presentation that may range from a full-blown disease to incomplete forms with isolated organ involvement.…
  • Abstract Number: 2386 • 2017 ACR/ARHP Annual Meeting

    The Risk Factors of Newly Developing/Worsening Pulmonary Abnormalities in Rheumatoid Arthritis

    Ayae Tanaka1, Kazuhiro Kurasawa1, Yuta Takamura1, Tomoyuki Miyao1, Ryutaro Yamazaki2, Satoko Arai1, Takayoshi Owada1, Reika Maezawa1 and Masafumi Arima1, 1Rheumatology, Dokkyo Medical University, Mibu, Tochigi, Japan, 2Rheumatology, Dokkyo Medical University, Mibu, tochigi, Japan

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that affects various organs including the lung. The pulmonary involvement is critical for prognosis of the…
  • Abstract Number: 2566 • 2017 ACR/ARHP Annual Meeting

    Myxomavirus-Derived Serpin (Serp-1) Reduces Diffuse Alveolar Hemorrhage in a Murine Model of Lupus

    Haoyang Zhuang1, Shuhong Han1, Lijun Yang2, Sriram Ambadapadi3, Alexandra Lucas4 and Westley Reeves5, 1Medicine, University of Florida, Gainesville, FL, 2Pathology, Immunology and laboratory medicine, University of Florida, Gainesville, FL, 3Arizona state University, Tempe, AZ, 4Arizona State University, Tempe, AZ, 5Rheumatology & Clinical Immology, University of Florida, Gainesville, FL

    Background/Purpose: Diffuse alveolar hemorrhage (DAH) is an unusual complication of lupus with over 50% mortality. In both humans and mice, DAH is associated with ANCA-negative…
  • Abstract Number: 2688 • 2017 ACR/ARHP Annual Meeting

    Collagen Metabolite Biomarker Levels Are Associated with the Amount of Fibrosis in Internal Organs in Systemic Sclerosis Patients

    Anne Sofie Siebuhr1, Satoshi Kubo2, Pernille Juhl3, K Nakano4, S Nakayamada5, Morten Karsdal6, Anne-C. Bay-Jensen7 and Yoshiya Tanaka8, 1the first department of internal medicine, University of occupational and environmental health, Fukuoka, Japan, 2The first department of internal medicine, University of Occupational en environmental Health, Fukuoka, Japan, 3Nordic Bioscience, Herlev, Denmark, 4the first department of internal medicin, University of occupational and environmental health, fukuoka, Japan, 5The first department of internal medicine, University of Occupational and environmental Health, fukuoka, Japan, 6Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, 7Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark, 8The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Background/Purpose: Biomarkers that can monitor the fibrotic burden will aid in trial enrichment and personalized health care in SSc. SSc is associated with internal organ…
  • Abstract Number: 2737 • 2017 ACR/ARHP Annual Meeting

    Pulmonary Manifestations of Primary Systemic Vasculitides

    Jean-Paul Makhzoum1, Raashid Luqmani2, Richard A. Watts3, Anthea Craven4, Peter A. Merkel5 and Christian Pagnoux6, 1Rheumatology, Vasculitis Clinic, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, 2Botnar Research Centre, University of Oxford, Oxford, United Kingdom, 3Rheumatology Department, The Ipswich Hospital, Ipswich, Great Britain, 4Nuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, Oxford University Hospitals, Oxford, United Kingdom, 5Division of Rheumatology, University of Pennsylvania; Perelman School of Medicine, Philadelphia, PA, 6Rheumatology-Vasculitis clinic, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Pulmonary involvement in systemic primary vasculitides is diverse and occurs with variable incidence depending on the type of vasculitis. This study aimed to describe…
  • Abstract Number: 2776 • 2017 ACR/ARHP Annual Meeting

    Plasmacytoid Dendritic Cells in Systemic Fibrosis: Pathogenic Role in Bleomycin-Induced Fibrosis Model and Correlation with Disease in Patients with Systemic Sclerosis

    Suzanne Kafaja1, Isela Valera2, Anagha Divekar3, Rajan Saggar4, Dinesh Khanna5, Daniel E. Furst6 and Ram R. Singh7, 1Department of Internal Medicine, University of California Los Angeles, David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, 2Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 3Biolegend, Sa Diego, CA, 4Medicine, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA, 5University of Michigan, Ann Arbor, MI, 6David Geffen School of Medicine at UCLA, Los Angeles, CA, 7Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Fibrosis is the end-result of most inflammatory conditions, but its pathogenesis remains unclear. Studies in patients and animal models suggest a role for T-cells…
  • Abstract Number: 24 • 2017 ACR/ARHP Annual Meeting

    Trafficking of Innate B Cells to the Lungs As a Novel Mechanism in a Model of Pulmonary Lupus and Vasculitis

    Priti Prasad1, Michael Fishbein2, Rohan Sharma3, Ramesh Halder4, Isela Valera1 and Ram R. Singh5, 1Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, 2Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los ángeles, CA, 3Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los angeles, CA, 4Autoimmunity and Tolerance Laboratory, Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los ángeles, CA, 5Autoimmunity and Tolerance Laboratory, Department of Medicine/Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA

    Background/Purpose: Lung is involved in up to 50% patients with SLE. Among manifestations of pulmonary lupus, pneumonitis, vasculitis and diffuse pulmonary hemorrhage (DPH) carry a…
  • Abstract Number: 257 • 2017 ACR/ARHP Annual Meeting

    The Use of Positron Emission Tomography (PET)-Scan for the Quantitative Assessment of Interstitial Lung Disease in Systemic Sclerosis

    Daphne Peelen1, Ben Zwezerijnen2, Esther Nossent1, Lilian Meijboom1, Otto Hoekstra3, Conny van der Laken4 and Alexandre Voskuyl4, 1VUmc, Amsterdam, Netherlands, 2Nuclear Medicine, VUmc, Amsterdam, Netherlands, 3Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 4Department of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands

    Background/Purpose: Interstitial lung disease (ILD) in systemic sclerosis is treated by immunosuppressive drugs (e.g. cyclophosphamide), aimed at reduction of inflammatory response . Differentiation between inflamed…
  • Abstract Number: 400 • 2017 ACR/ARHP Annual Meeting

    Combination of the Collagen-Induced Arthritis and Organic Dust-Induced Airway Inflammation Models As a Model of Interstitial Lung Disease in Rheumatoid Arthritis

    Katherine Janike1, Jill Poole1, Geoffrey M. Thiele2, Michael J. Duryee3, Lynell W. Klassen4, Amy Nelson5, Kristi Warren6, Benjamin Swanson7 and Ted R. Mikuls8, 1Medicine, University of Nebraska Medical Center, Omaha, NE, 2Int Med/Sec of Rheum/Immun, Univ of NE Medical Ctr, Omaha, NE, 3Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 5Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, 6Department of Medicine, University of Nebraska Medical Center, Omaha, NE, 7Department of Pathology, University of Nebraska Medical Center, Omaha, NE, 8Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Rheumatoid Arthritis (RA) is characterized by extra-articular involvement including interstitial/inflammatory lung disease (ILD).  Whereas the coexistence of RA and ILD is known, mechanisms…
  • Abstract Number: 568 • 2017 ACR/ARHP Annual Meeting

    Complement Consumption As a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational Study

    Alisson Pugliesi1, RACHEL ZERBINI MARIANO2, Raquel Baldini Campos3, Simone Appenzeller4, Manoel Bertolo5 and ZORAIDA SACHETTO1, 1INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 2Radiology and Diagnostic Imaging, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 3Internal Medicine, Faculty of Medical Sciences, State University of Campinas (UNICAMP), CAMPINAS, Brazil, 4Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, 5INTERNAL MEDICINE, DISCIPLINE OF RHEUMATOLOGY, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil

    Complement Consumption as a Predictor of Pulmonary Manifestation in Patients with Primary Sjögren’s Syndrome: Results from a Unicentric Observational StudyBackground/Purpose: Primary Sjögren’s syndrome (pSS) may…
  • Abstract Number: 838 • 2017 ACR/ARHP Annual Meeting

    Rates of New-Onset Pulmonary Disease Among Patients with Systemic Lupus Erythematosus in Sweden

    Lindsy J. Forbess1, Michael Weisman2 and Julia F Simard3, 1Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Cedars-Sinai Medical Center Division of Rheumatology, Los Angeles, CA, 3Division of Epidemiology, Health Research and Policy Department, Stanford School of Medicine, Stanford, CA

    Background/Purpose: Our goal was to examine lung disease and types of pulmonary manifestations observed in patients with SLE. We studied population-based register data from Sweden…
  • Abstract Number: 854 • 2017 ACR/ARHP Annual Meeting

    Predictive Modeling of Mortality in Polymyositis/Dermatomyositis Patients with Interstitial Lung Disease Based on Combination of Serum Myositis-Specific Autoantibodies and Conventional Biomarkers

    Takahisa Gono1, Kenichi Masui2, Yasushi Kawaguchi3, Kei Ikeda4, Atsushi Kawakami5, Maasa Tamura6, Yoshinori Tanino7, Takahiro Nunokawa8, Yuko Kaneko9, Shinji Sato10, Katsuaki Asakawa11, Naoshi Nishina9 and Masataka Kuwana1, 1Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 2Department of Anesthesiology, National Defense Medical College School of Medicine, Tokorozawa, Japan, 3Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Department of Allergy and Clinical Immunology, Chiba University Hospital, Chiba, Japan, 5Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, 6Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan, 7Department of Pulmonary Medicine, Fukushima Medical University School of Medicine, Fukushima, Japan, 8Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan, 9Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 10Division of Rheumatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan, 11Division of Respiratory Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan

    Background/Purpose: Interstitial lung disease (ILD) is one of the leading causes of mortality in patients with polymyositis or dermatomyositis (PM/DM). Since clinical courses and outcomes…
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