Abstracts tagged "Knee"

Abstract Number: 1201 • 2017 ACR/ARHP Annual Meeting
Reducing Heterogeneity in OA Clinical Trials: Data from a Phase 2 Study of SM04690, a Novel, Intra-Articular, Wnt Pathway Inhibitor in Knee Osteoarthritis
Philip G. Conaghan¹, Anita DiFrancesco², Christopher J. Swearingen², Sarah Kennedy², Ismail Simsek², Jeymi Tambiah² and Yusuf Yazici², ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Samumed, LLC, San Diego, CA
Background/Purpose: Kellgren-Lawrence [KL] radiographic grading is used to classify knee osteoarthritis (OA), but may not accurately reflect disease progression. Classifying subjects by baseline medial joint…
Abstract Number: 2204 • 2017 ACR/ARHP Annual Meeting
Neuropathic Pain in Patients with Knee Osteoarthritis and Related Factors: A Multicenter Longitudinal Study-Preliminary Report
Ece Kaptanoglu¹, Ozlem Şahin², Tiraje Tuncer³, Sami Hizmetli¹, Lale Altan⁴, Figen Ayhan⁵, Ajda Bal⁶, Meral Bilgilisoy⁷, Gulnur Bozbas⁸, Lale Cerrahoglu⁹, Remzi Cevik¹⁰, Tuncay Duruoz¹¹, Deniz Dulgeroglu⁶, Gulcan Gurer¹², Savas Gursoy¹³, Simin Hepguler¹⁴, Cahit Kacar¹⁵, Taciser Kaya¹⁶, Meltem Melikoglu¹⁷, Kemal Nas¹⁸, Suheda Ozcakir¹⁹, Senay Ozdolap²⁰, merih Saridogan²¹, Selda Sarikaya²⁰, Dilsad Sindel²², Omer F Şendur⁸, Canan Tikiz²³ and Hatice Ugurlu²⁴, ¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Cumhuriyet University School of Medicine, Sivas, Turkey, ²Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey, ³Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey, ⁴Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Uludag University School of Medicine, Bursa, Turkey, ⁵Department of Physical Medicine and Rehabilitation, University of Health Ankara Training and Research Hospital, Ankara, Turkey, ⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, ⁷Department of Physical Medicine and Rehabilitation, University of Health Sciences Antalya Training and Research Hospital, Antalya, Turkey, ⁸Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydin, Turkey, ⁹Department of Physical Medicine and Rehabilitation, Celal Bayar University School of Medicine, Manisa, Turkey, ¹⁰Department of Physical Medicine and Rehabilitation, Dicle University School of Medicine, Diyarbakir, Turkey, ¹¹Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Marmara University School of Medicine, Istanbul, Turkey, ¹²Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Adnan Menderes University School of Medicine, Aydin, Turkey, ¹³Department of Physical Medicine and Rehabilitation, Gaziantep University School of Medicine, Gaziantep, Turkey, ¹⁴Department of Physical Medicine and Rehabilitation, Ege University School of Medicine, Izmir, Turkey, ¹⁵Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Akdeniz University School of Medicine, Antalya, Turkey, ¹⁶Department of Physical Medicine and Rehabilitation, University of Health Sciences İzmir Bozyaka Training and Research Hospital, Izmir, Turkey, ¹⁷Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ataturk University School of Medicine, Erzurum, Turkey, ¹⁸Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey, ¹⁹Department of Physical Medicine and Rehabilitation, Uludag University School of Medicine, Bursa, Turkey, ²⁰Department of Physical Medicine and Rehabilitation, Bulent Ecevit University School of Medicine, Zonguldak, Turkey, ²¹Department of Physical Medicine and Rehabilitation, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey, ²²Department of Physical Medicine and Rehabilitation, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey, ²³Celal Bayar University School of Medicine, Manisa, Turkey, ²⁴Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
Background/Purpose: Neuropathic pain (NP) was accused for increased pain and reduced functional capacity in knee osteoarthritis (KO). Here we aimed to find out the prevalence…
Abstract Number: 933 • 2017 ACR/ARHP Annual Meeting
Longitudinal Association between Sleep Quality and Knee Pain in the Multicenter Osteoarthritis Study
Zhaoli (Joy) Dai¹, Carrie Brown², Tuhina Neogi³ and David T. Felson³, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Sleep and pain have been shown to be reciprocally related. Studies have suggested a stronger effect of sleep impairment on chronic pain such as…
Abstract Number: 1205 • 2017 ACR/ARHP Annual Meeting
Effectiveness of Low-Dose Radiation Therapy on Symptoms in Knee Osteoarthritis: First Results of a Triple Blinded, Randomized Controlled Trial
E.A.M. Mahler¹, M.J.M Minten¹, M.M. Leseman-Hoogenboom², P.M.P. Poortmans², S.S. Boks³, J.W.J. Bijlsma⁴, F.H.J. van den Hoogen^1,5, A.A. Den Broeder^1,5 and C.H.M. van den Ende^1,5, ¹Rheumatology, Sint Maartenskliniek, Nijmegen, Netherlands, ²Radiation Therapy, Radboud university medical centre, Nijmegen, Netherlands, ³Radiology, Sint Maartenskliniek, Nijmegen, Netherlands, ⁴Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands, ⁵Rheumatology, Radboud university medical centre, Nijmegen, Netherlands
Background/Purpose: Previous research in animal osteoarthritis (OA) has shown that low-dose radiation therapy (LD-RT) exerts anti-inflammatory effects, but a systematic review concluded that the evidence…
Abstract Number: 2205 • 2017 ACR/ARHP Annual Meeting
Trajectories of Knee Bone Shape Change Are Associated with Sex and Osteoarthritis
Barton L Wise¹, Jingbo Niu², Yuqing Zhang³, Felix Liu⁴, Joyce Pang⁵, John A. Lynch⁶ and Nancy E. Lane⁷, ¹Orthopaedics, Internal Medicine, University of California, Davis School of Medicine, Sacramento, CA, ²Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁵University of Nevada, Reno, Reno, NV, ⁶Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ⁷Center for Musculoskeletal Health, University of California, Davis School of Medicine, Sacramento, CA
Background/Purpose: Knee osteoarthritis (OA) is more common in women than men; however, the biological mechanisms for sex difference in knee OA are not well understood.…
Abstract Number: 934 • 2017 ACR/ARHP Annual Meeting
Effectiveness of FX006 Intra-Articular Injection in Patients with Knee Osteoarthritis Who Present with and without Clinical Inflammation at Baseline: A Pooled Analysis of Data from 3 Double-Blind, Randomized, Parallel-Group Clinical Trials
Herbert S. B. Baraf¹, Christian Lattermann², Deryk G. Jones³, Philip G. Conaghan⁴, Joelle Lufkin⁵, James Johnson⁶, Scott Kelley⁵ and Neil Bodick⁵, ¹Center for Rheumatology and Bone Research, Wheaton, MD, ²University of Kentucky, Orthopaedic Surgery and Sports Medicine, Lexington, KY, ³Ochsner Sports Medicine Institute, New Orleans, LA, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁵Flexion Therapeutics, Inc., Burlington, MA, ⁶Summit Analytical, Denver, CO
Background/Purpose: Inflammation is a key contributor to osteoarthritis (OA).1 OA pain is mediated by interactions between inflammatory cytokines and other features including local tissue damage,…
Abstract Number: 1206 • 2017 ACR/ARHP Annual Meeting
Chondroitin Sulfate Reduces Pain and Improves Function in Knee Osteoarthritis Significantly Better Than Placebo, Independently of the Definition of Responders
J-Y Reginster, Bone Cartilage Unit, University of Liege, Liege, Belgium
Background/Purpose: In addition to the assessment of the two co-primary endpoints – pain and function – regulatory agencies recommend the use of responder rates in…
Abstract Number: 2217 • 2017 ACR/ARHP Annual Meeting
Combined Impacts of Lifestyle Factors on Knee Osteoarthritis in the Osteoarthritis Initiative
Zhaoli (Joy) Dai¹, Carrie Brown², Yuqing Zhang³ and David T. Felson⁴, ¹Boston University School of Medicine, Boston, MA, ²Boston University School of Public Health, Boston, MA, ³School Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ⁴Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA
Background/Purpose: Body mass index (BMI), healthy diet or components, physical activity, and tobacco smoking have been examined independently with risk of knee osteoarthritis (OA). Sleep…
Abstract Number: 936 • 2017 ACR/ARHP Annual Meeting
Knee Confidence Trajectories over 8 Years and Factors Associated with Poor Trajectories: Data from the Osteoarthritis Initiative
Alison H. Chang, Julia (Jungwha) Lee, Orit Almagor, Joan S. Chmiel, Kirsten C. Moisio, Karen W. Hayes, Julie Szymaszek and Leena Sharma, Northwestern University, Chicago, IL
Background/Purpose: Lack of knee confidence, a frequent complaint, has been associated with function decline in knee OA. Given its key role in weight-bearing activities, a…
Abstract Number: 1207 • 2017 ACR/ARHP Annual Meeting
Clinical Relevance of Structural Measures in Knee Osteoarthritis: Baseline Values and Change from Baseline Discriminate Patients Subsequently Receiving Knee Replacement
C. Kent Kwoh¹, Hans Guehring², Michael J Hannon³ and Aida Aydemir⁴, ¹University of Arizona Arthritis Center, Tuscan, AZ, ²Merck KGaA, Darmstadt, Germany, ³Medicine, University of Pittsburgh, Pittsburgh, PA, ⁴EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA
Background/Purpose: Structural measures of knee OA (KOA) progression include assessment of radiographic joint space width (JSW) and quantitative MRI (qMRI) measurement of cartilage thickness, both…
Abstract Number: 2251 • 2017 ACR/ARHP Annual Meeting
Preferences for Physical Activity: A Discrete Choice Experiment in People with Chronic Knee Pain
Daniel Pinto¹, Ulf Bockenholt², Rowland W. Chang^3,4, Julia (Jungwha) Lee⁵, Jane Holl⁶, Daniel Finn⁶, Leena Sharma⁷, Allen Heinemann⁸ and Paul Hansen⁹, ¹Department of Physical Therapy & Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Department of Marketing, Kellogg School of Management, Northwestern University, Evanston, IL, ³Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Preventive Medicine, Medicine, and Physical Medicine & Rehabilitation, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁵Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁶Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁷Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁸Center for Rehabilitation Outcomes Research, Shirley Ryan Ability Lab, Chicago, IL, ⁹Economics, University of Otago, Dundin, New Zealand
Preferences For Physical Activity: A Discrete Choice Experiment In People With Chronic Knee Pain Background/Purpose: Understanding preferences for physical activity (PA) can help guide patient…
Abstract Number: 977 • 2017 ACR/ARHP Annual Meeting
Association of Leisure-Time Physical Activity with Late-Life Mobility Limitation Among Women with Total Joint Replacement for Hip or Knee Osteoarthritis
Aladdin Shadyab¹, Wenjun Li², Charles Eaton³ and Andrea LaCroix⁴, ¹Family Medicine and Public Health, University of California, San Diego, La Jolla, CA, ²Medicine, University of Massachusetts Medical School, Worcester, MA, ³Family Medicine and Epidemiology, Warren Alpert Medical School, School of Public Health, Brown University, Providence, RI, ⁴Family Medicine and Public Health, University of California, San Diego School of Medicine, La Jolla, CA
Background/Purpose: Maintaining mobility in old age is an important public health goal for patients with hip or knee osteoarthritis (OA), who are vulnerable to functional…
Abstract Number: 1208 • 2017 ACR/ARHP Annual Meeting
Levels of Serum Biomarkers from a Two-Year Multicentre Trial Are Associated with Treatment Response on Knee Osteoarthritis Cartilage Loss As Assessed By MRI: An Exploratory Study
Johanne Martel-Pelletier¹, Jean-Pierre Raynauld¹, François Mineau¹, François Abram², Patrice Paiement³, Philippe Delorme³ and Jean-Pierre Pelletier¹, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ³ArthroLab Inc., Montreal, QC, Canada
Background/Purpose: There is an obvious need to identify biomarkers that could predict patient response to an osteoarthritis (OA) treatment. This post hoc study explored in…
Abstract Number: 2767 • 2017 ACR/ARHP Annual Meeting
Active Yet Sedentary: The Association of Moderate to Vigorous Physical Activity and Sedentary Behavior with Incident Functional Limitation in Knee OA
Hiral Master¹, Louise Thoma¹, Meredith Christiansen¹, Dana Mathews² and Daniel White³, ¹Physical Therapy and Biomechanics and Movement Science, University of Delaware, Newark, DE, ²Physical Therapy, Biomechanics and Movement Science, University of Delaware, Newark, DE, ³Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Engaging in adequate levels of moderate to vigorous physical activity (MVPA) reduces the risk of functional limitation in people with knee osteoarthritis (OA). Sedentary…
Abstract Number: 980 • 2017 ACR/ARHP Annual Meeting
Is Intra-Articular Injection of Synvisc Associated with a Delay to Knee Arthroplasty in Knee OA Patients?
Kevin Ong¹, Maria Runa¹, Edmund Lau² and Roy Altman³, ¹Exponent, Inc., Philadelphia, PA, ²Exponent, Inc., Menlo Park, CA, ³UCLA Medical Center, Los Angeles, CA
Background/Purpose: Knee OA patients may undergo intra-articular (IA) hyaluronic acid (HA) injection treatment, but there is debate about its effectiveness. We asked: (1) What is…

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