ACR Meeting Abstracts

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Abstracts tagged "juvenile SLE"

  • Abstract Number: 054 • 2020 Pediatric Rheumatology Symposium

    Clinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus Erythematosus Across Age Groups

    Joseph Massias 1, Eve Smith 1, Michael Beresford 1 and Christian Hedrich1, 1University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with…
  • Abstract Number: 055 • 2020 Pediatric Rheumatology Symposium

    Differential Analysis of Serum and Urine S100 Proteins in Juvenile-onset Systemic Lupus Erythematosus (jSLE)

    Sean Donohue 1, Angela Midgley 1, Jennifer Davies 1, Rachael Wright 1, Ian Bruce 2, Michael Beresford 1 and Christian Hedrich1, 1University of Liverpool, Liverpool, United Kingdom, 2The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is a systemic autoimmune/inflammatory disease. Up to 80% of patients develop lupus nephritis (LN) that affects treatment and prognosis(1-3).…
  • Abstract Number: 075 • 2020 Pediatric Rheumatology Symposium

    Pseudotumor Cerebri Syndrome in Children with Systemic Lupus Erythematosus

    Taha Moussa1, Moussa Abdelhak 2 and Cuoghi Edens 3, 1University of Chicago Medicine, Chicago, 2Cambridge GPVTS, Cambridge, United Kingdom, 3University of Chicago, Chicago

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that typically affects multiple organs and can lead to potentially fatal complications. Management of…
  • Abstract Number: 094 • 2020 Pediatric Rheumatology Symposium

    A Good Inter- and Intra-observer Reliability of Subtypes in Nailfold Capillary Micro-haemorrhages in Childhood-onset Systemic Lupus Erythematosus

    Sandy Bergkamp1, Dieneke Schonenberg-Meinema 2, Merlijn van den Berg 2, Vanessa Smith 3, Amber Vanhaecke 4, Karin Melsens 4, Amara Nassar Sheikh Rashid 5, Taco Kuijpers 6 and Maartje Boumans 7, 1Amsterdam Medical Center, Uithoorn, Netherlands, 2Amsterdam, Netherlands, 3Ghent University Hospital, Ghent, Belgium, 4Ghent University, Ghent, Belgium, 5Amsterdam Medical Center, Amsterdam, Netherlands, 6AMC, Amsterdam, Netherlands, 7Maxima Medical Center, Eindhoven, Netherlands

    Background/Purpose: In previous studies, micro-haemorrhages have often been observed in nailfold capillaroscopy in SLE.1 The interpretation of this finding is still a topic of research.…
  • Abstract Number: 096 • 2020 Pediatric Rheumatology Symposium

    Medication Adherence in Adolescents and Young Adults with Childhood Onset SLE

    Rotem Semo Oz1, Linda Wagner-Weiner 2, Cuoghi Edens 1, Grace Cameron 1 and Melissa Tesher 1, 1university of chicago, Chicago, 2University of Chicago, Chicago, Illinois

    Background/Purpose: Compared to adults with SLE, young patients with SLE face particular challenges, including more severe disease, more renal involvement and medications side effects like…
  • Abstract Number: 119 • 2020 Pediatric Rheumatology Symposium

    Actual Medication Usage of Patients with Juvenile Onset Systemic Lupus Erythematosus Using Japanese Health Insurance Database

    Takayuki Kishi1, Takako Miyamae 2, Ryoko Sakai 3, Yumi Tani 2, Satoru Nagata 1 and Masayoshi Harigai 3, 1Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan, 2Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 3Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan

    Background/Purpose: Background: Immunosuppressive therapy is the mainstay of treatment of child systemic lupus erythematosus (cSLE). However until very recently, the treatment of cSLE lacked uniformity.…
  • Abstract Number: 122 • 2020 Pediatric Rheumatology Symposium

    Systemic Inflammation and Cognitive Dysfunction in jSLE Patients

    Sara Ganhão 1, Mariana Rodrigues2, Beatriz Silva 1, Francisca Aguiar 1, Margarida Figueiredo-Braga 1 and Iva Brito 1, 1Centro Hospitalar de São João, Oporto, Portugal, 2Porto, Portugal

    Background/Purpose: Neurocognitive dysfunction (NCD) is one of the most commonly reported neuropsychiatric symptoms in patients with juvenile systemic lupus erythematosus (SLE), even without overt CNS…
  • Abstract Number: 130 • 2020 Pediatric Rheumatology Symposium

    Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in Anti-dsDNA Positive Lupus Nephritis

    Matthew Sherman1, Amali Gunawardana 2, Janine Amirault 2, Asha Moudgil 3, James Bost 3 and Hemalatha Srinivasalu 1, 1Children's National Medical Center, Washington, 2George Washington University, Washington, 3Children's Health Center, Children's National Medical Center, Washington

    Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody profiles…
  • Abstract Number: 134 • 2020 Pediatric Rheumatology Symposium

    Evaluation of Self-report Screening Measures in the Detection of Depressive and Anxiety Disorders Among Children and Adolescents with Systemic Lupus Erythematosus

    Michelle Quilter1, Katherine Cost 2, Reva Schachter 3, Julie Couture 4, Ashley Danguecan 5, Lawrence Ng 6, Daniela Dominguez 6, Linda Hiraki 7, Deborah Levy 8, Earl D. Silverman 9, Kate Neufeld 10, Andrea Knight 11 and Daphne Korczak 2, 1Dept. of Psychiatry, Hospital for Sick Children, Dept. of Psychiatry, University of Toronto, Toronto, Ontario, Canada, 2Dept. of Psychiatry, Hospital for Sick Children, Dept. of Psychiatry, University of Toronto, Toronto, Canada, 3Dept. of Psychiatry, Hospital for Sick Children,, Toronto, Canada, 4Division of Pediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada, 5Hospital for Sick Children, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, 7Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada, 8Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, 9Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, 10University of Toronto, The Hospital for Sick Children, Toronto, Canada, 11SickKids Research Institute, Toronto, Canada

    Background/Purpose: Screening for co-morbid psychiatric disorder is of high clinical importance in childhood-onset systemic lupus erythematosus (cSLE). However, there are no validated screening measures for…
  • Abstract Number: 158 • 2020 Pediatric Rheumatology Symposium

    Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus

    Raffaella Carlomagno1, Fangming Liao 1, JingJing Cao 2, Dafna Gladman 3, Marisa Klein-Gitelman 4, Andrea Knight 5, Deborah Levy 1, Andrew Paterson 2, Zahi Touma 3, Murray Urowitz 3, Declan Webber 1, Joan Wither 3, Earl D. Silverman 6 and Linda Hiraki 7, 1Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, 2Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3Krembil Research Institute, Toronto Western Hospital, Toronto, Canada, 4Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, 5SickKids Research Institute, Toronto, Canada, 6Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, 7Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada

    Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS)…
  • Abstract Number: 177 • 2020 Pediatric Rheumatology Symposium

    Educational Outcomes in a Young-Adult Cohort of Patients with Childhood Onset Systemic Lupus Erythematosus (SLE)

    Anita Dhanrajani1, Earl D. Silverman 2, Andrea Knight 3, Deborah Levy 4 and Amanda Steiman 5, 1Hospital for Sick Kids, Edmonton, Alberta, Canada, 2Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, 3SickKids Research Institute, Toronto, Canada, 4Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, 5Sinai Health System, Toronto, Ontario, Canada

    Background/Purpose: The literature regarding educational and socioeconomic outcomes in young adults with childhood-onset Systemic Lupus Erythematosus (cSLE) are sparse. cSLE patients recently transitioned to adult…
  • Abstract Number: 188 • 2020 Pediatric Rheumatology Symposium

    A New Multidisciplinary Pediatric SLE Clinic in a Large Urban Care Center: Feasibility, Patient Satisfaction, and Quality After One Year

    Laura Santangelo 1, Grace Cameron 2, Christopher Clardy 2, Cuoghi Edens 2, Shireen Hashmat 2, Taha Moussa 3, Rotem Semo Oz 2, Linda Wagner-Weiner 4, Suzanne Wychocki 2, Carolyn Zic 5 and Melissa Tesher2, 1Prtizker School of Medicine, Chicago, 2university of Chicago, Chicago, 3University of Chicago Medicine, Chicago, 4University of Chicago, Chicago, Illinois, 5Chicago

    Background/Purpose: Clinical care for pediatric systemic lupus erythematosus (pSLE) is complex, requiring close attention to medical, developmental and psychosocial issues. Moreover, pSLE patients tend to…
  • Abstract Number: 1725 • 2019 ACR/ARP Annual Meeting

    Disease Activity in Childhood-Onset Systemic Lupus Erythematosus: Initial Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry

    Emily Smitherman1, Mary Beth Son 2, Andrea Knight 3, Timothy Beukelman 4, Jeffrey Curtis 1 and Aimee Hersh 5, 1University of Alabama at Birmingham, Birmingham, AL, 2Boston Children's Hospital, Boston, MA, 3Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4University of Alabama Birmingham, Birmingham, AL, 5University of Utah, Salt Lake City, UT

    Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE) despite widespread use of immunosuppressive therapy. There are…
  • Abstract Number: 1734 • 2019 ACR/ARP Annual Meeting

    Low Bone Mineral Density Was Associated with Lupus Nephritis Irrespective of Duration on Steroid Treatment in a Large Observational Study of Juvenile Systemic Lupus Erythematosus Patients

    Anastasia-vasiliki Madenidou1, Yasmin Mahfouz 2, Oliver Cheng 2, Farah El-Sharnouby 2, Charlene Foley 2 and Coziana Ciurtin 3, 1Centre for Adolescent Rheumatology, University College London London, UK, LOndon, 2Centre for Adolescent Rheumatology, University College London London, UK, London, United Kingdom, 3Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom

    Background/Purpose: An estimated 10-20% of all patients with systemic lupus erythematosus (SLE) develop clinical disease before the age of 18 years and are therefore classified…
  • Abstract Number: 1736 • 2019 ACR/ARP Annual Meeting

    Cognitive Impairment in Childhood-Onset Systemic Lupus Erythematosus: Early Detection with MRI Spectroscopy and Its Association with MOG Antibodies

    Huseyin Kilic 1, Sezgin Sahin 2, Mekiya Filiz Toprak 3, Gokce Hale Atay 4, Kubra Yilmaz 1, Amra Adrovic 5, Kenan Barut 6, Esin Ozturk Isik 4, Erdem Tuzun 7, Osman Kizilkilic 8, Sema Saltik 1 and Ozgur Kasapcopur9, 1Department of Pediatric Neurology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, 2Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Istanbul, Turkey, 3Department of Pediatric Neurology, Bezmialem Vakif University, School of Medicine, Istanbul, Turkey, Istanbul, Turkey, 4Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey, Istanbul, Turkey, 5Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, 6Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, İstanbul, Istanbul, Turkey, 7Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, Istanbul, Turkey, 8Department of Neuroradiology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, 9Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the presence of various autoantibodies. Unnoticed and progressive cognitive impairment may develop in…
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ACR Pediatric Rheumatology Symposium 2020

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