Abstracts tagged "juvenile SLE"

Abstract Number: 054 • 2020 Pediatric Rheumatology Symposium
Clinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus Erythematosus Across Age Groups
Joseph Massias ¹, Eve Smith ¹, Michael Beresford ¹ and Christian Hedrich¹, ¹University of Liverpool, Liverpool, United Kingdom
Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with…
Abstract Number: 055 • 2020 Pediatric Rheumatology Symposium
Differential Analysis of Serum and Urine S100 Proteins in Juvenile-onset Systemic Lupus Erythematosus (jSLE)
Sean Donohue ¹, Angela Midgley ¹, Jennifer Davies ¹, Rachael Wright ¹, Ian Bruce ², Michael Beresford ¹ and Christian Hedrich¹, ¹University of Liverpool, Liverpool, United Kingdom, ²The University of Manchester, Manchester, United Kingdom
Background/Purpose: Juvenile-onset systemic lupus erythematosus (jSLE) is a systemic autoimmune/inflammatory disease. Up to 80% of patients develop lupus nephritis (LN) that affects treatment and prognosis(1-3).…
Abstract Number: 075 • 2020 Pediatric Rheumatology Symposium
Pseudotumor Cerebri Syndrome in Children with Systemic Lupus Erythematosus
Taha Moussa¹, Moussa Abdelhak ² and Cuoghi Edens ³, ¹University of Chicago Medicine, Chicago, ²Cambridge GPVTS, Cambridge, United Kingdom, ³University of Chicago, Chicago
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that typically affects multiple organs and can lead to potentially fatal complications. Management of…
Abstract Number: 094 • 2020 Pediatric Rheumatology Symposium
A Good Inter- and Intra-observer Reliability of Subtypes in Nailfold Capillary Micro-haemorrhages in Childhood-onset Systemic Lupus Erythematosus
Sandy Bergkamp¹, Dieneke Schonenberg-Meinema ², Merlijn van den Berg ², Vanessa Smith ³, Amber Vanhaecke ⁴, Karin Melsens ⁴, Amara Nassar Sheikh Rashid ⁵, Taco Kuijpers ⁶ and Maartje Boumans ⁷, ¹Amsterdam Medical Center, Uithoorn, Netherlands, ²Amsterdam, Netherlands, ³Ghent University Hospital, Ghent, Belgium, ⁴Ghent University, Ghent, Belgium, ⁵Amsterdam Medical Center, Amsterdam, Netherlands, ⁶AMC, Amsterdam, Netherlands, ⁷Maxima Medical Center, Eindhoven, Netherlands
Background/Purpose: In previous studies, micro-haemorrhages have often been observed in nailfold capillaroscopy in SLE.1 The interpretation of this finding is still a topic of research.…
Abstract Number: 096 • 2020 Pediatric Rheumatology Symposium
Medication Adherence in Adolescents and Young Adults with Childhood Onset SLE
Rotem Semo Oz¹, Linda Wagner-Weiner ², Cuoghi Edens ¹, Grace Cameron ¹ and Melissa Tesher ¹, ¹university of chicago, Chicago, ²University of Chicago, Chicago, Illinois
Background/Purpose: Compared to adults with SLE, young patients with SLE face particular challenges, including more severe disease, more renal involvement and medications side effects like…
Abstract Number: 119 • 2020 Pediatric Rheumatology Symposium
Actual Medication Usage of Patients with Juvenile Onset Systemic Lupus Erythematosus Using Japanese Health Insurance Database
Takayuki Kishi¹, Takako Miyamae ², Ryoko Sakai ³, Yumi Tani ², Satoru Nagata ¹ and Masayoshi Harigai ³, ¹Department of Pediatrics, Tokyo Women's Medical University, Tokyo, Japan, ²Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ³Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan
Background/Purpose: Background: Immunosuppressive therapy is the mainstay of treatment of child systemic lupus erythematosus (cSLE). However until very recently, the treatment of cSLE lacked uniformity.…
Abstract Number: 122 • 2020 Pediatric Rheumatology Symposium
Systemic Inflammation and Cognitive Dysfunction in jSLE Patients
Sara Ganhão ¹, Mariana Rodrigues², Beatriz Silva ¹, Francisca Aguiar ¹, Margarida Figueiredo-Braga ¹ and Iva Brito ¹, ¹Centro Hospitalar de São João, Oporto, Portugal, ²Porto, Portugal
Background/Purpose: Neurocognitive dysfunction (NCD) is one of the most commonly reported neuropsychiatric symptoms in patients with juvenile systemic lupus erythematosus (SLE), even without overt CNS…
Abstract Number: 130 • 2020 Pediatric Rheumatology Symposium
Anti-Ro/SSA Is Associated with Progression to End-Stage Renal Disease in Anti-dsDNA Positive Lupus Nephritis
Matthew Sherman¹, Amali Gunawardana ², Janine Amirault ², Asha Moudgil ³, James Bost ³ and Hemalatha Srinivasalu ¹, ¹Children's National Medical Center, Washington, ²George Washington University, Washington, ³Children's Health Center, Children's National Medical Center, Washington
Background/Purpose: Lupus nephritis (LN) is related to disease severity, morbidity, and mortality in juvenile systemic lupus erythematosus (jSLE). Cluster analysis emerged to identify autoantibody profiles…
Abstract Number: 134 • 2020 Pediatric Rheumatology Symposium
Evaluation of Self-report Screening Measures in the Detection of Depressive and Anxiety Disorders Among Children and Adolescents with Systemic Lupus Erythematosus
Michelle Quilter¹, Katherine Cost ², Reva Schachter ³, Julie Couture ⁴, Ashley Danguecan ⁵, Lawrence Ng ⁶, Daniela Dominguez ⁶, Linda Hiraki ⁷, Deborah Levy ⁸, Earl D. Silverman ⁹, Kate Neufeld ¹⁰, Andrea Knight ¹¹ and Daphne Korczak ², ¹Dept. of Psychiatry, Hospital for Sick Children, Dept. of Psychiatry, University of Toronto, Toronto, Ontario, Canada, ²Dept. of Psychiatry, Hospital for Sick Children, Dept. of Psychiatry, University of Toronto, Toronto, Canada, ³Dept. of Psychiatry, Hospital for Sick Children,, Toronto, Canada, ⁴Division of Pediatric Rheumatology-Immunology, CHU Sainte-Justine, Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada, ⁵Hospital for Sick Children, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, ⁹Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ¹⁰University of Toronto, The Hospital for Sick Children, Toronto, Canada, ¹¹SickKids Research Institute, Toronto, Canada
Background/Purpose: Screening for co-morbid psychiatric disorder is of high clinical importance in childhood-onset systemic lupus erythematosus (cSLE). However, there are no validated screening measures for…
Abstract Number: 158 • 2020 Pediatric Rheumatology Symposium
Genetics of Age at Diagnosis in Childhood-Onset Systemic Lupus Erythematosus
Raffaella Carlomagno¹, Fangming Liao ¹, JingJing Cao ², Dafna Gladman ³, Marisa Klein-Gitelman ⁴, Andrea Knight ⁵, Deborah Levy ¹, Andrew Paterson ², Zahi Touma ³, Murray Urowitz ³, Declan Webber ¹, Joan Wither ³, Earl D. Silverman ⁶ and Linda Hiraki ⁷, ¹Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, ²Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, Canada, ⁴Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, ⁵SickKids Research Institute, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: The genetic contribution to the development of systemic lupus erythematosus (SLE) is estimated to be 66% in twin studies. Genome wide association studies (GWAS)…
Abstract Number: 177 • 2020 Pediatric Rheumatology Symposium
Educational Outcomes in a Young-Adult Cohort of Patients with Childhood Onset Systemic Lupus Erythematosus (SLE)
Anita Dhanrajani¹, Earl D. Silverman ², Andrea Knight ³, Deborah Levy ⁴ and Amanda Steiman ⁵, ¹Hospital for Sick Kids, Edmonton, Alberta, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ³SickKids Research Institute, Toronto, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Canada, ⁵Sinai Health System, Toronto, Ontario, Canada
Background/Purpose: The literature regarding educational and socioeconomic outcomes in young adults with childhood-onset Systemic Lupus Erythematosus (cSLE) are sparse. cSLE patients recently transitioned to adult…
Abstract Number: 188 • 2020 Pediatric Rheumatology Symposium
A New Multidisciplinary Pediatric SLE Clinic in a Large Urban Care Center: Feasibility, Patient Satisfaction, and Quality After One Year
Laura Santangelo ¹, Grace Cameron ², Christopher Clardy ², Cuoghi Edens ², Shireen Hashmat ², Taha Moussa ³, Rotem Semo Oz ², Linda Wagner-Weiner ⁴, Suzanne Wychocki ², Carolyn Zic ⁵ and Melissa Tesher², ¹Prtizker School of Medicine, Chicago, ²university of Chicago, Chicago, ³University of Chicago Medicine, Chicago, ⁴University of Chicago, Chicago, Illinois, ⁵Chicago
Background/Purpose: Clinical care for pediatric systemic lupus erythematosus (pSLE) is complex, requiring close attention to medical, developmental and psychosocial issues. Moreover, pSLE patients tend to…
Abstract Number: 1725 • 2019 ACR/ARP Annual Meeting
Disease Activity in Childhood-Onset Systemic Lupus Erythematosus: Initial Analysis of the Childhood Arthritis and Rheumatology Research Alliance Registry
Emily Smitherman¹, Mary Beth Son ², Andrea Knight ³, Timothy Beukelman ⁴, Jeffrey Curtis ¹ and Aimee Hersh ⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Boston Children's Hospital, Boston, MA, ³Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴University of Alabama Birmingham, Birmingham, AL, ⁵University of Utah, Salt Lake City, UT
Background/Purpose: Substantial risk of early morbidity and mortality exists for patients with childhood-onset systemic lupus erythematosus (cSLE) despite widespread use of immunosuppressive therapy. There are…
Abstract Number: 1734 • 2019 ACR/ARP Annual Meeting
Low Bone Mineral Density Was Associated with Lupus Nephritis Irrespective of Duration on Steroid Treatment in a Large Observational Study of Juvenile Systemic Lupus Erythematosus Patients
Anastasia-vasiliki Madenidou¹, Yasmin Mahfouz ², Oliver Cheng ², Farah El-Sharnouby ², Charlene Foley ² and Coziana Ciurtin ³, ¹Centre for Adolescent Rheumatology, University College London London, UK, LOndon, ²Centre for Adolescent Rheumatology, University College London London, UK, London, United Kingdom, ³Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom
Background/Purpose: An estimated 10-20% of all patients with systemic lupus erythematosus (SLE) develop clinical disease before the age of 18 years and are therefore classified…
Abstract Number: 1736 • 2019 ACR/ARP Annual Meeting
Cognitive Impairment in Childhood-Onset Systemic Lupus Erythematosus: Early Detection with MRI Spectroscopy and Its Association with MOG Antibodies
Huseyin Kilic ¹, Sezgin Sahin ², Mekiya Filiz Toprak ³, Gokce Hale Atay ⁴, Kubra Yilmaz ¹, Amra Adrovic ⁵, Kenan Barut ⁶, Esin Ozturk Isik ⁴, Erdem Tuzun ⁷, Osman Kizilkilic ⁸, Sema Saltik ¹ and Ozgur Kasapcopur⁹, ¹Department of Pediatric Neurology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, ²Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Istanbul, Turkey, ³Department of Pediatric Neurology, Bezmialem Vakif University, School of Medicine, Istanbul, Turkey, Istanbul, Turkey, ⁴Institute of Biomedical Engineering, Boğaziçi University, Istanbul, Turkey, Istanbul, Turkey, ⁵Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, ⁶Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, İstanbul, Istanbul, Turkey, ⁷Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey, Istanbul, Turkey, ⁸Department of Neuroradiology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey, ⁹Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey, Istanbul, Turkey
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease characterized by the presence of various autoantibodies. Unnoticed and progressive cognitive impairment may develop in…