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Abstracts tagged "Enthesitis"

  • Abstract Number: 2065 • 2018 ACR/ARHP Annual Meeting

    Blockade of the JAK/STAT Pathway Inhibits Inflammation and Bone Formation in Two Murine Models of Spondyloarthritis

    Yukiko Maeda1, Zheni Stavre1, Tingting Huang2, Catherine Manning2, Bryant Shaughn3, Michael Macoritto3, Deborah Hyland3, Wendy Waegell3 and Ellen M. Gravallese4, 1Medicine, University of Massachusetts Medical School, Worcester, MA, 2Medicine, University of Massachusetts Medical School, worcester, MA, 3Abbvie Bioresearch Center, worcester, MA, 4Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA

    Background/Purpose: Spondyloarthritis (SpA) results in significant pain and loss of function due to inflammation and resulting enthesial/periosteal bone formation. Inhibition of the Janus kinase (JAK)/STAT…
  • Abstract Number: 2398 • 2018 ACR/ARHP Annual Meeting

    Children with Enthesitis Have Worse Quality of Life, Function, and Pain, Irrespective of Their Juvenile Arthritis Category

    Dax G. Rumsey1, Jaime Guzman2, Alan Rosenberg3, Adam Huber4, Rosie Scuccimarri5, Natalie J. Shiff6, Alessandra Bruns7, Brian M. Feldman8 and Dean Eurich9, 1Paediatrics, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, 4Dalhousie University, Halifax, NS, Canada, 5Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada, 6University of Florida, Gainesville, FL, 7Hospitalier de l’Universite de Sherbrooke, Sherbrooke, QC, Canada, 8Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 9University of Alberta, Edmonton, AB, Canada

    Background/Purpose: To estimate the impact of enthesitis on patient reported outcomes (PROs) in children with juvenile idiopathic arthritis (JIA), irrespective of their JIA category. Methods:…
  • Abstract Number: 2826 • 2018 ACR/ARHP Annual Meeting

    Emergence of Severe Spondyloarthropathy Related Entheseal Pathology Following Successful Vedolizumab Therapy for Inflammatory Bowel Disease

    Sayam Dubash1,2, Marianayagam Thiraupathy3, Ilaria Tinazzi4, Tariq Al Araimi5, Christian Pagnoux6, Adam Weizman7, Pascal Richette8,9, My-Linh Tran Minh10, Mattieu Allez10, Animesh Singh11, Francesco Ciccia12, John Hamlin13, Ai Lyn Tan1,2, Helena Marzo-Ortega1,2 and Dennis McGonagle1,2, 1Rheumatology, Chapel Allerton Hospital, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 2Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 3East and North Hertfordshire NHS Trust, Stevenage, United Kingdom, 4Rheumatology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy, 5Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 6Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, 7Gastroenterology, Mount Sinai Hospital, Toronto, ON, Canada, 8Rheumatology, Université Paris Diderot, Paris, France, 9Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France, 10Department of Gastroenterology, APHP, Hôpital Saint Louis, Sorbonne Paris-Cité University, Paris, France, 11Rheumatology, The Royal Free Hospital, London, United Kingdom, 12Rheumatology, University of Palermo, Palermo, Italy, 13Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Vedolizumab therapy for inflammatory bowel disease (IBD) has been associated with mild spondyloarthritis (SpA) related features including sacroiliitis and synovitis.  Herein, we report a…
  • Abstract Number: 2886 • 2018 ACR/ARHP Annual Meeting

    Secukinumab Provides Rapid and Sustained Resolution of Enthesitis in Psoriatic Arthritis Patients: Pooled Analysis of Two Phase 3 Studies

    Laura C. Coates1, Dennis McGonagle2, Georg Schett3, Philip J. Mease4, Erhard Quebe-Fehling5, D. L. Asquith6, L. Rasouliyan7, Shephard Mpofu5 and Corine Gaillez5, 1University of Oxford, Oxford, United Kingdom, 2University of Leeds, Leeds, United Kingdom, 3University of Erlangen-Nuremberg, Erlangen, Germany, 4Swedish Medical Centre and University of Washington, Seattle, WA, 5Novartis Pharma AG, Basel, Switzerland, 6Novartis Pharmaceuticals UK Ltd, Camberley, United Kingdom, 7RTI Health Solutions, Barcelona, Spain

    Background/Purpose: Secukinumab (SEC), a fully human monoclonal antibody that selectively neutralizes IL-17A, provided significant and sustained improvement in the signs and symptoms of active PsA,…
  • Abstract Number: 314 • 2018 ACR/ARHP Annual Meeting

    Development and Preliminary Validation of an Omeract Magnetic Resonance Imaging (MRI) Scoring System for Ankle Enthesitis in Spondyloarthritis

    Ashish J Mathew1, Simon Krabbe2, Iris Eshed3, Frédérique Gandjbakhch4, Robert G. Lambert5, Paul Bird6, Kay-Geert Hermann7, Susanne J Pedersen8, Maria Stoenoiu9, Violaine Foltz10, Walter P. Maksymowych11, Daniel Glinatsi2, Ida K Haugen12, Jacob L. Jaremko13, Rene P Poggenborg14, Joel Paschke15, Jean Denis Laredo16, Philip G. Conaghan17 and Mikkel Østergaard18, 1Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, 2Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 3Department of Radiology, Sheba Medical Center, Israel, Tel Hashomer, Israel, 4Service de Rhumatologie, Groupe Hospitalier Pitie Salpetriere, Paris, France, Paris, France, 5University of Alberta, Edmonton, Canada, Edmonton, AB, Canada, 6University of New South Wales, Sydney, Australia, Sydney, Australia, 7Radiology, Charité Universitätmeidzin, Berlin, Germany, Berlin, Germany, 8Depart of Rheumatology VRR, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, 9Université catholique de Louvain, Brussels, Belgium, Brussels, Belgium, 10UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, Paris, France, 11Department of Medicine, CaRE Arthritis and University of Alberta, Edmonton, Canada, Edmonton, AB, Canada, 12P.O. Box 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, 13Radiology, University of Alberta, Edmonton, Canada, Edmonton, AB, Canada, 14Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Glostrup, Denmark, 15CaRE Arthritis, Edmonton, Canada, Edmonton, AB, Canada, 16Hôpital Lariboisière, APHP and Université Paris-Diderot, Paris, France, Paris, France, 17University of Leeds, Leeds, UK, Leeds, United Kingdom, 18Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark

    Background/Purpose: Enthesitis is a key feature in spondyloarthritis (SpA). MRI allows sensitive visualization of entheseal inflammation and damage, but no validated, internationally accepted MRI scoring…
  • Abstract Number: 678 • 2018 ACR/ARHP Annual Meeting

    Ultrasonographic Evaluation of Achilles Tendon in Early Axial Spondyloarthropathy: Is There Any Difference between Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthropathy?

    Shahla Vahidfar1, Ismihan Sunar2, Sebnem Ataman3, Gürkan Yılmaz4, Javid M. AZARABADI5 and Ayşe Bölükbaşı1, 1Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, 2Department of Physical Medicine and Rehabilitation, Division of Rheumatology,, Ankara University, Faculty of Medicine, Ankara, Turkey, 3Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey, 4Physical Medicine and Rehabilitation, Rheumatology Division, Ankara University Faculty of Medicine, Ankara, Turkey, 5ORTHOPEDICS AND TRAUMATOLOGY, Başkent University Faculty of Medicine, Ankara, Turkey

    Background/Purpose: Along with emergence of the term of ‘non-radiographic axial SpA’ (nr-AxSpA), studies comparing AS and nr-AxSpA in terms of genetic, epidemiologic, and clinical issues…
  • Abstract Number: 252 • 2017 ACR/ARHP Annual Meeting

    Correlations between Clinical and Ultrasound Scores of Peripheral Enthesitis and Disease Activity Scores in a Cohort of Spondyloarthritis

    Assia Haddouche1, Sabrina Haid2, Siham Bencheikh3, Samy Slimani4, Amina Abdessemed5, Nadjia Brahimi6, Aïcha Ladjouz Rezig6 and Fella Hanni6, 1of Medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, 2medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, 3EPH HADJOUT, Algiers, Algeria, 4Department of Medicine, University of Batna, Batna, Algeria, 5Medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, 6Department of Medicine, University of Algiers 1, Algiers, Algeria

    Background/Purpose: To look correlations between clinical and ultrasound (US) scores of peripheral enthesitis (PE) and disease activity scores of SpAMethods: A prospective study of 208…
  • Abstract Number: 254 • 2017 ACR/ARHP Annual Meeting

    Psoriatic Arthritis Sonographic Enthesitis Scores – Systematic Review of the Literature

    Ofir Elalouf1, Sibel Bakirci2, Zahi Touma3, Melanie A Anderson4, Gurjit S. Kaeley5, Sibel Z. Aydin6 and Lihi Eder7,8, 1Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 2Fellow in Rheumatology, Antalya, Turkey, 3Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, 4Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 5University of Florida, Ponte Vedra Beach, FL, 6University of Ottawa, Ottawa, ON, Canada, 7Medicine, University of Toronto, Toronto, ON, Canada, 8Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada

    Background/Purpose: Enthesitis is a prominent feature of spondyloarthropathy (SpA), including psoriatic arthritis (PsA). The evaluation of enthesitis has conventionally been conducted by clinical exam, a…
  • Abstract Number: 1515 • 2017 ACR/ARHP Annual Meeting

    Improvements in Enthesitis Scores with Certolizumab Pegol Treatment in Males and Females with Active Axial Spondyloarthritis Are Maintained to Week 204

    Maxime Dougados1, Philip J Mease2, Joachim Sieper3, Peter C. Taylor4, Natasha de Peyrecave5, Tommi Nurminen6 and Jürgen Braun7, 1Rheumatology Department, Paris-Descartes University and Cochin Hospital, Paris, France, 2Swedish Medical Center and University of Washington, Seattle, WA, 3Charité University Hospital, Berlin, Germany, 4Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal, Sciences, Kennedy Institute of Rheumatology, University of Oxford,, Oxford, United Kingdom, 5UCB Pharma, Slough, United Kingdom, 6UCB Pharma, Monheim, Germany, 7Rheumazentrum Ruhrgebiet, Herne, Germany

    Background/Purpose: Axial spondyloarthritis (axSpA), characterized by spinal inflammation, is also associated with extra-spinal manifestations including inflammation of the entheses (enthesitis). Enthesitis is equally prevalent throughout…
  • Abstract Number: 1551 • 2017 ACR/ARHP Annual Meeting

    Avoidance of Physical Activity Leads to Reduced Inflammatory Enthesitis on Ultrasound

    Kim Wervers1, Irene Herrings1, Jolanda J. Luime2, Marlies Moed1, Ilja Tchetverikov3, Andreas H. Gerards4, J.M.W. Hazes5 and Marijn Vis2, 1Erasmus Medical Centre, Rotterdam, Netherlands, 2Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, 3Albert Schweitzer Hospital, Dordrecht, Netherlands, 4Sint Franciscus Vlietland Group, Schiedam, Netherlands, 5Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands

    Background/Purpose: Enthesitis is one of the manifestations of psoriatic arthritis (PsA), but no clear definition for the diagnosis exists. To further evaluate the added value…
  • Abstract Number: 1608 • 2017 ACR/ARHP Annual Meeting

    Entheseal Involvement in Systemic Lupus Erythematosus: An Ultrasound Study

    Andrea Di Matteo1, Emilio Filippucci2, Edoardo Cipolletta2, Valentina Lato2, Jana Hurnakova3,4, Iulia Satulu5, Rossella De Angelis2 and Walter Grassi2, 1Polytechnic University of Marche, Rheumatology Clinic, Jesi, Italy, 2Polytechnic University of Marche, Rheumatology Clinic, jesi, Italy, 31st Faculty of Medicine, Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, 4University Hospital Motol, Department of Pediatric and Adult Rheumatology, Prague, Czech Republic, 5Rheumatology Department, Internal Medicine Clinic, Kalmar County Hospital, kalmar, Sweden

    Background/Purpose: A recent study revealed ultrasound (US) findings indicative of entheseal involvement in a small group of patients with systemic lupus erytemathosus (SLE), raising the…
  • Abstract Number: 1874 • 2017 ACR/ARHP Annual Meeting

    Development of an Ultrasonographic Enthesitis Score for Psoriatic Arthritis Patients

    Stephanie Tom1,2, Yujie Zhong3, Richard J. Cook4, Sibel Z. Aydin5,6, Gurjit S. Kaeley7 and Lihi Eder8,9, 1Women's College Hospital, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom, 4Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, 5The Ottawa Hospital, Ottawa, ON, Canada, 6University of Ottawa, Ottawa, ON, Canada, 7University of Florida, Ponte Vedra Beach, FL, 8Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, 9Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Enthesitis affects approximately a third of patients with psoriatic arthritis (PsA) and is often considered the earliest site of inflammation. The accuracy of clinical…
  • Abstract Number: 2311 • 2017 ACR/ARHP Annual Meeting

    Prospective Validation of the Juvenile Spondyloarthritis Disease Activity Index and Its Comparison with Adult Spondyloarthritis Disease Activity Scores

    Abhishek Zanwar, Sanat Phatak and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Among JIA children with Enthesitis related arthritis (ERA) category have more pain, poorer health status and are less likely to achieve or maintain sustained…
  • Abstract Number: 2503 • 2017 ACR/ARHP Annual Meeting

    Does Maastricht Ankylosing Spondylitis Enthesitis Scores Differ between Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis Patients?

    Steffan Robstad Nilssen1, Jintana B: Andersen1, Hanne K. Vestaby1, Glenn Haugeberg2 and Brigitte Michelsen3, 1Dept. of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, 2Martina Hansens Hospital, Bærum, Norway, 3Dept. of Rheumatology, Hospital of Southern Norway Trust, kristiansand, Norway

    Background/Purpose: The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) is an enthesitis index developed and validated as an outcome measure in ankylosing spondylitis (AS), but is…
  • Abstract Number: 2878 • 2017 ACR/ARHP Annual Meeting

    Efficacy and Safety Results of Guselkumab in Patients with Active Psoriatic Arthritis over 56 Weeks from a Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study

    Atul A. Deodhar1, Alice B Gottlieb2, Wolf-Henning Boehncke3, Bin Dong4, Yuhua Wang4, Yanli Zhuang4, William Barchuk5, Xie L. Xu5 and Elizabeth Hsia4, 1Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, 2Department of Dermatology, New York Medical College, Valhalla, NY, 3Geneva University Hospital and University of Geneva, Geneva, Switzerland, 4Janssen Research & Development, LLC, Spring House, PA, 5Janssen Research & Development, LLC, San Diego, CA

    Background/Purpose: Evaluate efficacy and safety of guselkumab (GUS) in patients (pts) with active psoriatic arthritis (PsA) over 56 weeks (wks). Methods: Pts w/active PsA (defined…
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