Abstracts tagged "Enthesitis"

Abstract Number: 2065 • 2018 ACR/ARHP Annual Meeting
Blockade of the JAK/STAT Pathway Inhibits Inflammation and Bone Formation in Two Murine Models of Spondyloarthritis
Yukiko Maeda¹, Zheni Stavre¹, Tingting Huang², Catherine Manning², Bryant Shaughn³, Michael Macoritto³, Deborah Hyland³, Wendy Waegell³ and Ellen M. Gravallese⁴, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Medicine, University of Massachusetts Medical School, worcester, MA, ³Abbvie Bioresearch Center, worcester, MA, ⁴Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Spondyloarthritis (SpA) results in significant pain and loss of function due to inflammation and resulting enthesial/periosteal bone formation. Inhibition of the Janus kinase (JAK)/STAT…
Abstract Number: 2398 • 2018 ACR/ARHP Annual Meeting
Children with Enthesitis Have Worse Quality of Life, Function, and Pain, Irrespective of Their Juvenile Arthritis Category
Dax G. Rumsey¹, Jaime Guzman², Alan Rosenberg³, Adam Huber⁴, Rosie Scuccimarri⁵, Natalie J. Shiff⁶, Alessandra Bruns⁷, Brian M. Feldman⁸ and Dean Eurich⁹, ¹Paediatrics, University of Alberta, Edmonton, AB, Canada, ²Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, ³Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, ⁴Dalhousie University, Halifax, NS, Canada, ⁵Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada, ⁶University of Florida, Gainesville, FL, ⁷Hospitalier de l’Universite de Sherbrooke, Sherbrooke, QC, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁹University of Alberta, Edmonton, AB, Canada
Background/Purpose: To estimate the impact of enthesitis on patient reported outcomes (PROs) in children with juvenile idiopathic arthritis (JIA), irrespective of their JIA category. Methods:…
Abstract Number: 2826 • 2018 ACR/ARHP Annual Meeting
Emergence of Severe Spondyloarthropathy Related Entheseal Pathology Following Successful Vedolizumab Therapy for Inflammatory Bowel Disease
Sayam Dubash^1,2, Marianayagam Thiraupathy³, Ilaria Tinazzi⁴, Tariq Al Araimi⁵, Christian Pagnoux⁶, Adam Weizman⁷, Pascal Richette^8,9, My-Linh Tran Minh¹⁰, Mattieu Allez¹⁰, Animesh Singh¹¹, Francesco Ciccia¹², John Hamlin¹³, Ai Lyn Tan^1,2, Helena Marzo-Ortega^1,2 and Dennis McGonagle^1,2, ¹Rheumatology, Chapel Allerton Hospital, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³East and North Hertfordshire NHS Trust, Stevenage, United Kingdom, ⁴Rheumatology, Sacro Cuore-Don Calabria Hospital, Negrar, Italy, ⁵Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁶Division of Rheumatology, Division of Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada, ⁷Gastroenterology, Mount Sinai Hospital, Toronto, ON, Canada, ⁸Rheumatology, Université Paris Diderot, Paris, France, ⁹Lariboisière Hospital, Lariboisière, University of Paris 7, Paris, France, ¹⁰Department of Gastroenterology, APHP, Hôpital Saint Louis, Sorbonne Paris-Cité University, Paris, France, ¹¹Rheumatology, The Royal Free Hospital, London, United Kingdom, ¹²Rheumatology, University of Palermo, Palermo, Italy, ¹³Department of Gastroenterology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Background/Purpose: Vedolizumab therapy for inflammatory bowel disease (IBD) has been associated with mild spondyloarthritis (SpA) related features including sacroiliitis and synovitis. Herein, we report a…
Abstract Number: 2886 • 2018 ACR/ARHP Annual Meeting
Secukinumab Provides Rapid and Sustained Resolution of Enthesitis in Psoriatic Arthritis Patients: Pooled Analysis of Two Phase 3 Studies
Laura C. Coates¹, Dennis McGonagle², Georg Schett³, Philip J. Mease⁴, Erhard Quebe-Fehling⁵, D. L. Asquith⁶, L. Rasouliyan⁷, Shephard Mpofu⁵ and Corine Gaillez⁵, ¹University of Oxford, Oxford, United Kingdom, ²University of Leeds, Leeds, United Kingdom, ³University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Swedish Medical Centre and University of Washington, Seattle, WA, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Novartis Pharmaceuticals UK Ltd, Camberley, United Kingdom, ⁷RTI Health Solutions, Barcelona, Spain
Background/Purpose: Secukinumab (SEC), a fully human monoclonal antibody that selectively neutralizes IL-17A, provided significant and sustained improvement in the signs and symptoms of active PsA,…
Abstract Number: 314 • 2018 ACR/ARHP Annual Meeting
Development and Preliminary Validation of an Omeract Magnetic Resonance Imaging (MRI) Scoring System for Ankle Enthesitis in Spondyloarthritis
Ashish J Mathew¹, Simon Krabbe², Iris Eshed³, Frédérique Gandjbakhch⁴, Robert G. Lambert⁵, Paul Bird⁶, Kay-Geert Hermann⁷, Susanne J Pedersen⁸, Maria Stoenoiu⁹, Violaine Foltz¹⁰, Walter P. Maksymowych¹¹, Daniel Glinatsi², Ida K Haugen¹², Jacob L. Jaremko¹³, Rene P Poggenborg¹⁴, Joel Paschke¹⁵, Jean Denis Laredo¹⁶, Philip G. Conaghan¹⁷ and Mikkel Østergaard¹⁸, ¹Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, ²Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, ³Department of Radiology, Sheba Medical Center, Israel, Tel Hashomer, Israel, ⁴Service de Rhumatologie, Groupe Hospitalier Pitie Salpetriere, Paris, France, Paris, France, ⁵University of Alberta, Edmonton, Canada, Edmonton, AB, Canada, ⁶University of New South Wales, Sydney, Australia, Sydney, Australia, ⁷Radiology, Charité Universitätmeidzin, Berlin, Germany, Berlin, Germany, ⁸Depart of Rheumatology VRR, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Copenhagen, Denmark, ⁹Université catholique de Louvain, Brussels, Belgium, Brussels, Belgium, ¹⁰UPMC University Paris 06, Pitié-Salpétrière Hospital, Paris, France, Paris, France, ¹¹Department of Medicine, CaRE Arthritis and University of Alberta, Edmonton, Canada, Edmonton, AB, Canada, ¹²P.O. Box 23 Vinderen, Diakonhjemmet Hospital, Oslo, Norway, Oslo, Norway, ¹³Radiology, University of Alberta, Edmonton, Canada, Edmonton, AB, Canada, ¹⁴Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, Glostrup, Denmark, ¹⁵CaRE Arthritis, Edmonton, Canada, Edmonton, AB, Canada, ¹⁶Hôpital Lariboisière, APHP and Université Paris-Diderot, Paris, France, Paris, France, ¹⁷University of Leeds, Leeds, UK, Leeds, United Kingdom, ¹⁸Center for Rheumatology and Spine Diseases, Rigshospitalet Glostrup Copenhagen Center for Arthritis Research, Copenhagen, Denmark
Background/Purpose: Enthesitis is a key feature in spondyloarthritis (SpA). MRI allows sensitive visualization of entheseal inflammation and damage, but no validated, internationally accepted MRI scoring…
Abstract Number: 678 • 2018 ACR/ARHP Annual Meeting
Ultrasonographic Evaluation of Achilles Tendon in Early Axial Spondyloarthropathy: Is There Any Difference between Ankylosing Spondylitis and Non-Radiographic Axial Spondyloarthropathy?
Shahla Vahidfar¹, Ismihan Sunar², Sebnem Ataman³, Gürkan Yılmaz⁴, Javid M. AZARABADI⁵ and Ayşe Bölükbaşı¹, ¹Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey, ²Department of Physical Medicine and Rehabilitation, Division of Rheumatology,, Ankara University, Faculty of Medicine, Ankara, Turkey, ³Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Ankara University Faculty of Medicine, Ankara, Turkey, ⁴Physical Medicine and Rehabilitation, Rheumatology Division, Ankara University Faculty of Medicine, Ankara, Turkey, ⁵ORTHOPEDICS AND TRAUMATOLOGY, Başkent University Faculty of Medicine, Ankara, Turkey
Background/Purpose: Along with emergence of the term of ‘non-radiographic axial SpA’ (nr-AxSpA), studies comparing AS and nr-AxSpA in terms of genetic, epidemiologic, and clinical issues…
Abstract Number: 252 • 2017 ACR/ARHP Annual Meeting
Correlations between Clinical and Ultrasound Scores of Peripheral Enthesitis and Disease Activity Scores in a Cohort of Spondyloarthritis
Assia Haddouche¹, Sabrina Haid², Siham Bencheikh³, Samy Slimani⁴, Amina Abdessemed⁵, Nadjia Brahimi⁶, Aïcha Ladjouz Rezig⁶ and Fella Hanni⁶, ¹of Medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, ²medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, ³EPH HADJOUT, Algiers, Algeria, ⁴Department of Medicine, University of Batna, Batna, Algeria, ⁵Medicine, Department of Medicine, University of Algiers 1, Algiers, Algeria, ⁶Department of Medicine, University of Algiers 1, Algiers, Algeria
Background/Purpose: To look correlations between clinical and ultrasound (US) scores of peripheral enthesitis (PE) and disease activity scores of SpAMethods: A prospective study of 208…
Abstract Number: 254 • 2017 ACR/ARHP Annual Meeting
Psoriatic Arthritis Sonographic Enthesitis Scores – Systematic Review of the Literature
Ofir Elalouf¹, Sibel Bakirci², Zahi Touma³, Melanie A Anderson⁴, Gurjit S. Kaeley⁵, Sibel Z. Aydin⁶ and Lihi Eder^7,8, ¹Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Fellow in Rheumatology, Antalya, Turkey, ³Rheumatology, University of Toronto, Division of Rheumatology, Institute of Health Policy, Management and Evaluation, Toronto, ON, Canada, ⁴Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵University of Florida, Ponte Vedra Beach, FL, ⁶University of Ottawa, Ottawa, ON, Canada, ⁷Medicine, University of Toronto, Toronto, ON, Canada, ⁸Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Enthesitis is a prominent feature of spondyloarthropathy (SpA), including psoriatic arthritis (PsA). The evaluation of enthesitis has conventionally been conducted by clinical exam, a…
Abstract Number: 1515 • 2017 ACR/ARHP Annual Meeting
Improvements in Enthesitis Scores with Certolizumab Pegol Treatment in Males and Females with Active Axial Spondyloarthritis Are Maintained to Week 204
Maxime Dougados¹, Philip J Mease², Joachim Sieper³, Peter C. Taylor⁴, Natasha de Peyrecave⁵, Tommi Nurminen⁶ and Jürgen Braun⁷, ¹Rheumatology Department, Paris-Descartes University and Cochin Hospital, Paris, France, ²Swedish Medical Center and University of Washington, Seattle, WA, ³Charité University Hospital, Berlin, Germany, ⁴Nuffield Dept. of Orthopaedics, Rheumatology and Musculoskeletal, Sciences, Kennedy Institute of Rheumatology, University of Oxford,, Oxford, United Kingdom, ⁵UCB Pharma, Slough, United Kingdom, ⁶UCB Pharma, Monheim, Germany, ⁷Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: Axial spondyloarthritis (axSpA), characterized by spinal inflammation, is also associated with extra-spinal manifestations including inflammation of the entheses (enthesitis). Enthesitis is equally prevalent throughout…
Abstract Number: 1551 • 2017 ACR/ARHP Annual Meeting
Avoidance of Physical Activity Leads to Reduced Inflammatory Enthesitis on Ultrasound
Kim Wervers¹, Irene Herrings¹, Jolanda J. Luime², Marlies Moed¹, Ilja Tchetverikov³, Andreas H. Gerards⁴, J.M.W. Hazes⁵ and Marijn Vis², ¹Erasmus Medical Centre, Rotterdam, Netherlands, ²Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands, ³Albert Schweitzer Hospital, Dordrecht, Netherlands, ⁴Sint Franciscus Vlietland Group, Schiedam, Netherlands, ⁵Department of Rheumatology, Erasmus Medical Centre, Rotterdam, Netherlands
Background/Purpose: Enthesitis is one of the manifestations of psoriatic arthritis (PsA), but no clear definition for the diagnosis exists. To further evaluate the added value…
Abstract Number: 1608 • 2017 ACR/ARHP Annual Meeting
Entheseal Involvement in Systemic Lupus Erythematosus: An Ultrasound Study
Andrea Di Matteo¹, Emilio Filippucci², Edoardo Cipolletta², Valentina Lato², Jana Hurnakova^3,4, Iulia Satulu⁵, Rossella De Angelis² and Walter Grassi², ¹Polytechnic University of Marche, Rheumatology Clinic, Jesi, Italy, ²Polytechnic University of Marche, Rheumatology Clinic, jesi, Italy, ³1st Faculty of Medicine, Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ⁴University Hospital Motol, Department of Pediatric and Adult Rheumatology, Prague, Czech Republic, ⁵Rheumatology Department, Internal Medicine Clinic, Kalmar County Hospital, kalmar, Sweden
Background/Purpose: A recent study revealed ultrasound (US) findings indicative of entheseal involvement in a small group of patients with systemic lupus erytemathosus (SLE), raising the…
Abstract Number: 1874 • 2017 ACR/ARHP Annual Meeting
Development of an Ultrasonographic Enthesitis Score for Psoriatic Arthritis Patients
Stephanie Tom^1,2, Yujie Zhong³, Richard J. Cook⁴, Sibel Z. Aydin^5,6, Gurjit S. Kaeley⁷ and Lihi Eder^8,9, ¹Women's College Hospital, Toronto, ON, Canada, ²University of Toronto, Toronto, ON, Canada, ³MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom, ⁴Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁵The Ottawa Hospital, Ottawa, ON, Canada, ⁶University of Ottawa, Ottawa, ON, Canada, ⁷University of Florida, Ponte Vedra Beach, FL, ⁸Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, ⁹Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: Enthesitis affects approximately a third of patients with psoriatic arthritis (PsA) and is often considered the earliest site of inflammation. The accuracy of clinical…
Abstract Number: 2311 • 2017 ACR/ARHP Annual Meeting
Prospective Validation of the Juvenile Spondyloarthritis Disease Activity Index and Its Comparison with Adult Spondyloarthritis Disease Activity Scores
Abhishek Zanwar, Sanat Phatak and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Among JIA children with Enthesitis related arthritis (ERA) category have more pain, poorer health status and are less likely to achieve or maintain sustained…
Abstract Number: 2503 • 2017 ACR/ARHP Annual Meeting
Does Maastricht Ankylosing Spondylitis Enthesitis Scores Differ between Ankylosing Spondylitis, Psoriatic Arthritis and Rheumatoid Arthritis Patients?
Steffan Robstad Nilssen¹, Jintana B: Andersen¹, Hanne K. Vestaby¹, Glenn Haugeberg² and Brigitte Michelsen³, ¹Dept. of Rheumatology, Hospital of Southern Norway Trust, Kristiansand, Norway, ²Martina Hansens Hospital, Bærum, Norway, ³Dept. of Rheumatology, Hospital of Southern Norway Trust, kristiansand, Norway
Background/Purpose: The Maastricht Ankylosing Spondylitis Enthesitis Score (MASES) is an enthesitis index developed and validated as an outcome measure in ankylosing spondylitis (AS), but is…
Abstract Number: 2878 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety Results of Guselkumab in Patients with Active Psoriatic Arthritis over 56 Weeks from a Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study
Atul A. Deodhar¹, Alice B Gottlieb², Wolf-Henning Boehncke³, Bin Dong⁴, Yuhua Wang⁴, Yanli Zhuang⁴, William Barchuk⁵, Xie L. Xu⁵ and Elizabeth Hsia⁴, ¹Division of Arthritis & Rheumatic Diseases OP09, Oregon Health & Science University, Portland, OR, ²Department of Dermatology, New York Medical College, Valhalla, NY, ³Geneva University Hospital and University of Geneva, Geneva, Switzerland, ⁴Janssen Research & Development, LLC, Spring House, PA, ⁵Janssen Research & Development, LLC, San Diego, CA
Background/Purpose: Evaluate efficacy and safety of guselkumab (GUS) in patients (pts) with active psoriatic arthritis (PsA) over 56 weeks (wks). Methods: Pts w/active PsA (defined…