ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2398

Children with Enthesitis Have Worse Quality of Life, Function, and Pain, Irrespective of Their Juvenile Arthritis Category

Dax G. Rumsey1, Jaime Guzman2, Alan Rosenberg3, Adam Huber4, Rosie Scuccimarri5, Natalie J. Shiff6, Alessandra Bruns7, Brian M. Feldman8 and Dean Eurich9, 1Paediatrics, University of Alberta, Edmonton, AB, Canada, 2Rheumatology, BC Children's Hospital and University of British Columbia, Vancouver, BC, Canada, 3Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada, 4Dalhousie University, Halifax, NS, Canada, 5Department of Pediatrics, McGill University Health Centre, Montreal, QC, Canada, 6University of Florida, Gainesville, FL, 7Hospitalier de l’Universite de Sherbrooke, Sherbrooke, QC, Canada, 8Division of Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, 9University of Alberta, Edmonton, AB, Canada

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: , , ,

Session Information

Date: Tuesday, October 23, 2018

Title: Pediatric Rheumatology – Clinical Poster III: Juvenile Idiopathic Arthritis and Uveitis

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

To estimate the impact of enthesitis on patient reported outcomes (PROs) in children with juvenile idiopathic arthritis (JIA), irrespective of their JIA category.

Methods:

Children with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) cohort were studied. Entheseal tenderness by physician examination in 33 defined locations, Juvenile Arthritis Quality of life Questionnaire (JAQQ), Quality of My Life questionnaire (QoML), Childhood Health Assessment Questionnaire (CHAQ), and a pain severity visual analogue scale (VAS) were completed at enrolment, every six months for 2 years, and then yearly for up to 5 years. Analyses consisted of descriptive statistics, multivariate linear mixed models for longitudinal data, and ANCOVA.

Results:

Among 1371 patients followed for a median of 35.3 months (IQR 21.1, 49.1), 214 (16%) had enthesitis, of whom 137 (64%) were classified as having enthesitis-related arthritis (ERA). After adjusting for patient characteristics and JIA category, children with enthesitis reported higher JAQQ (0.41 points; 95% CI 0.22, 0.59; 1=no difficulties, 7=difficulties all the time), higher CHAQ (0.14 points; 95% CI 0.07, 0.22; 0 = without any difficulty, 3 = unable to do task), higher pain (0.94 points; 95% CI 0.64, 1.25; 0 = no pain, 10 = maximum pain) and lower QoML (-0.80 points; 95% CI -1.09, -0.51; 0=the worst, 10=the best) scores than children without enthesitis, and these differences persisted during the five years after diagnosis.

Conclusion:

Children with enthesitis, regardless of JIA category, report worse PROs than those without enthesitis. Physicians should assess for the presence of enthesitis in all children with JIA. Enthesitis should be considered as a criterion for classification and included in the assessment of treatment response in JIA.

Disclosure: D. G. Rumsey, None; J. Guzman, None; A. Rosenberg, None; A. Huber, None; R. Scuccimarri, None; N. J. Shiff, None; A. Bruns, None; B. M. Feldman, None; D. Eurich, None.

To cite this abstract in AMA style:

Rumsey DG, Guzman J, Rosenberg A, Huber A, Scuccimarri R, Shiff NJ, Bruns A, Feldman BM, Eurich D. Children with Enthesitis Have Worse Quality of Life, Function, and Pain, Irrespective of Their Juvenile Arthritis Category [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/children-with-enthesitis-have-worse-quality-of-life-function-and-pain-irrespective-of-their-juvenile-arthritis-category/. Accessed .

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/children-with-enthesitis-have-worse-quality-of-life-function-and-pain-irrespective-of-their-juvenile-arthritis-category/