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Abstracts tagged "Enthesitis"

  • Abstract Number: 110 • 2020 Pediatric Rheumatology Symposium

    Consequences and Predictors of Persisting Pain in Children with Juvenile Idiopathic Arthritis: A Case Control Study Nested in the ReACCh-Out Cohort

    Tara McGrath1, Jaime Guzman 2, Lori Tucker 3, Natalie Shiff 4, Maryna Yaskina 5, Susan Tupper 6 and Dax Rumsey 7, 1University of British Columbia, Vancouver, Canada, 2University of British Columbia and BC Children's Hospital, Vancouver, Canada, 3BC Children's Hospital, Vancouver, British Columbia, Canada, 4Florida, Gainesville, 5Women and Children's Research Institute, Edmonton, Canada, 6Saskatoon, Canada, 7University of Alberta, Edmonton, Canada

    Background/Purpose: Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease of childhood. Pain is a distressing and prevalent feature of JIA and can decrease…
  • Abstract Number: 2455 • 2019 ACR/ARP Annual Meeting

    Impact of Enthesitis on Patient Reported Outcomes and Physician Satisfaction with Treatment: Data from a Multinational Patient and Physician Survey

    Ana-Maria Orbai1, Birt Julie 2, Elizabeth Holdsworth 3, Nicola Booth 4, Matthew M. Hufford 2, Malatestinic William 2, Aubrey Trevelin Sprabery 2 and Anthony Reginato 5, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Eli Lilly and Company, Indianapolis, IN, 3Adelphi Real World, Manchester, England, United Kingdom, 4Adelphi Real World, Bollington, United Kingdom, 5Division of Rheumatology, Providence VAMC, Associate Professor in Medicine, The Warren Alpert School of Medicine, Providence

    Background/Purpose: Enthesitis, a characteristic clinical feature of psoriatic arthritis (PsA) [1], is a core outcome for PsA clinical trials. While enthesitis is considered important when…
  • Abstract Number: 2503 • 2019 ACR/ARP Annual Meeting

    Achilles Tendon Enthesitis and Disease Burden in Psoriatic Arthritis and Axial Spondyloarthritis: Baseline Results from a Randomized Controlled Trial

    Frank Behrens1, Philipp Sewerin 2, Eugenio de Miguel 3, Yusuf Patel 4, Anastas Batalov 5, Eva Dokoupilova 6, Christine Kleinmond 7, Effie Pournara 8, Ankita Shekhawat 9, Claudia Jentzsch 10, Annette Wiedon 10 and Xenofon Baraliakos 11, 1CIRI/Rheumatology and Fraunhofer TMP, Goethe-University, Frankfurt, Germany, 2Department of Rheumatology & Hiller Research Unit, University Hospital Düsseldorf,, Duesseldorf, Germany, 3Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 4Hull University Teaching Hospitals, Hull, United Kingdom, 5Medical University of Plovdiv, University Hospital Kaspela, Plovdiv, Bulgaria, 6MEDICAL PLUS s.r.o., Uherske Hradiste, University of Veterinary and Pharmaceutical sciences, Faculty of Pharmacy, Department of Pharmaceutics, Uherské Hradiště, Czech Republic, 7ClinProject GmbH, Eurasburg, Germany, 8Novartis Pharma AG, Basel, Basel-Stadt, Switzerland, 9Novartis Healthcare Pvt. Ltd., Hyderabad, India, 10Novartis Pharma GmbH, Nürnberg, Germany, 11Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany

    Background/Purpose: Enthesitis is a common feature of Spondyloarthritis (SpA)1. Enthesitis at the Achilles tendon is an important manifestation with impact on function which is often…
  • Abstract Number: 287 • 2019 ACR/ARP Annual Meeting

    Ultrasound Evaluation of the Achilles Enthesis in Inflammatory and Non-inflammatory Processes: A Systematic Review

    Nancy Desai1, Justin Bucci 1 and Eugene Kissin 2, 1Boston Medical Center, Boston, 2Boston University, Boston, MA

    Background/Purpose: Ultrasound (US) evaluation of the Achilles tendon has been utilized to assess involvement at the entheses in the setting various inflammatory, metabolic and mechanical…
  • Abstract Number: 1482 • 2019 ACR/ARP Annual Meeting

    Secukinumab Provides Sustained Improvement of Enthesitis in Ankylosing Spondylitis Patients: A Pooled Analysis of Four Pivotal Phase 3 Trials

    Georg Schett1, Xenofon Baraliakos 2, Filip Van den Bosch 3, Atul Deodhar 4, Lianne Gensler 5, Mikkel Østergaard 6, Shital Agawane 7, Ayan Das Gupta 7, Shephard Mpofu 8, Todd Fox 8, Adam Winseck 9, Brian Porter 9 and Abhijit Shete 8, 1Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, 2Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, 3Ghent University Hospital, Ghent, Belgium, 4Oregon Health & Science University, Portland, OR, 5University San Francisco California, San Francisco, CA, 6Copenhagen Center for Arthritis Research, University of Copenhagen, Copenhagen, Denmark, 7Novartis Healthcare Pvt Ltd, Hyderabad, India, 8Novartis Pharma AG, Basel, Switzerland, 9Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: Enthesitis can be a debilitating spondyloarthritis (SpA) manifestation and the cause of pain, reduced quality of life and impaired physical function.1,2 Herein, we evaluated…
  • Abstract Number: 1493 • 2019 ACR/ARP Annual Meeting

    Improvement in the Signs and Symptoms of Psoriatic Arthritis with Ixekizumab Compared to Adalimumab in Patient Subgroups Defined by Baseline Disease Characteristics

    Joseph Merola1, Aubrey Trevelin Sprabery 2, Amanda Gellett 2, Chen-Yen Lin 2 and Dennis McGonagle 3, 1Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 2Eli Lilly and Company, Indianapolis, IN, 3University of Leeds, Leeds, United Kingdom

    Background/Purpose: Multiple biologic DMARD (bDMARD) treatments are available for PsA, but there is limited research that compares the safety and efficacy of these treatments. Head-to-head…
  • Abstract Number: 1778 • 2019 ACR/ARP Annual Meeting

    Entheseal CD90+ SOX9+ Cartilage-like Cells Initiate Spinal Ankylosis in Ankylosing Spondylitis

    Sungsin Jo1, Young Lim Lee 1, Tae-Han Lee 1, Ye-Soo Park 2 and Tae-Hwan Kim 1, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 2Department of Orthopedic Surgery, Hanyang University Medical Center, Guri Hospital,, Guri, Republic of Korea

    Background/Purpose: Enthesitis is characterized by inflammation at the interface where tendon or ligament attaches to the bone and is a representative symptom of ankylosing spondylitis(AS).…
  • Abstract Number: 679 • 2018 ACR/ARHP Annual Meeting

    Ultrasonographic Research of the Relationship between Nail Disorders and Peripheral Arthritis or Enthesitis in Patients with Psoriasis and Psoriatic Arthritis

    Tadashi Okano1, Kentaro Inui2, Koji Mandai3, Yutaro Yamada4, Tatsuya Koike5 and Hiroaki Nakamura2, 1Orthopedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 2Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 3Orthopaedic surgery, Osaka City University Graduate School of Medicine, Osaka, Japan, 4Orthopedic surgery, Yodogawa Christian Hospital, Osaka, Japan, 5Center for Senile Degenerative Disorders, Osaka City University Graduate School of Medicine, Osaka, Japan

    Background/Purpose: Although skin lesion is the most typical findings in patients with psoriasis (PsO), nail psoriasis is also one of the important clinical manifestation. Moreover,…
  • Abstract Number: 1028 • 2018 ACR/ARHP Annual Meeting

    An Entheseal Innate Immune Cell Biological Basis for Differential Efficacy of PDE4 and IL-23 Pathway Blockade between Psoriatic Disease and Rheumatoid Arthritis

    Charlie Bridgewood1, Richard Cuthbert1, Abdulla Watad2, Tobias Russell1, Timothy Palmer3, Robert Dunsmuir4, Almas Khan4, Abhay Rao4, Miriam Wittmann5 and Dennis McGonagle1, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Department of Internal Medicine 'B', Sheba Medical Center, Ramat Gan, Ramat Gan, Israel, 3School of Pharmacy and Medical Sciences, University of Bradford, Bradford, United Kingdom, 4Department of Spinal Surgery, National Health Service, Leeds, United Kingdom, 5NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Background/Purpose: Both IL-23 and phosphodiesterase (PDE) 4 inhibition are ineffective in RA but show efficacy in PsA-related synovitis despite similar cytokine and molecular profiles between…
  • Abstract Number: 1207 • 2018 ACR/ARHP Annual Meeting

    Clinical Evaluation Correlates Poorly with Ultrasound and Magnetic Resonance Imaging of Joints and Entheses in Early Peripheral Spondyloarthritis

    Thomas Renson1, Ann-Sophie De Craemer1, Philippe Carron1, Simon Krabbe2, Lennart Jans3, Manouk de Hooge4, Peggy Jacques1, Mikkel Østergaard5, Dirk Elewaut1 and Filip van Den Bosch6, 1Department of Rheumatology, Ghent University Hospital, Ghent, 9000, Belgium, 2Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Centre for Head and Orthopaedics, Rigshospitalet, Glostrup, Denmark, 3Department of Radiology, Ghent University Hospital, Ghent, Belgium, 4Ghent University Hospital, Ghent, Belgium, 5Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, Copenhagen, Denmark, 6Department of Rheumatology, Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Enthesitis is a hallmark of spondyloarthritis (SpA), which occurs in 30 to 50% of psoriatic arthritis patients [1]. Evaluation of tenderness at the site…
  • Abstract Number: 1591 • 2018 ACR/ARHP Annual Meeting

    Is Enthesitis a Marker of Disease Severity in Early Psoriatic Arthritis?

    Lihi Eder1, Chandra Farrer2 and Dana Jerome3, 1Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada, 2Rheumatology, Women's College Hospital, Toronto, ON, Canada, 3University of Toronto, Women's College Hospital, Toronto, ON, Canada

    Background/Purpose: Enthesitis is a key feature in psoriatic arthritis (PsA) affecting approximately a third of the patients. Ultrasound improves the detection of enthesitis compared to…
  • Abstract Number: 1602 • 2018 ACR/ARHP Annual Meeting

    Disease Characteristics, Quality of Life, and Work Productivity By Enthesitis Sites: Real-World Data from the US Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry

    Philip J. Mease1, Mei Liu2, Sabrina Rebello3, Winnie Hua2, Robert R. McLean2, Peter Hur4 and Alexis Ogdie5, 1Swedish Medical Center and University of Washington, Seattle, WA, 2Corrona, LLC, Waltham, MA, 3Corrona, LLC, Southborough, MA, 4Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA, East Hanover, NJ, 5Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Prior studies showed psoriatic arthritis (PsA) patients with enthesitis had greater disease burden than patients without enthesitis, yet it is unknown whether the impact…
  • Abstract Number: 1614 • 2018 ACR/ARHP Annual Meeting

    Prevalence of Sonographic Enthesitis in Patients with Psoriasis without Arthritis and Its Association Risk Factors of Psoriatic Arthritis

    Anwar Albasri1, Justine Y. Ye2, Cheryl F. Rosen3, Vinod Chandran2, Dafna D Gladman4 and Lihi Eder5, 1Rheumatology, University of Toronto, Toronto, ON, Canada, 2Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 3University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 4Department of Medicine, Toronto Psoriatic Arthritis Research Program, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 5Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada

    Background/Purpose: Enthesitis is one of the hallmarks of psoriatic arthritis (PsA) and may be the initial site of musculoskeletal inflammation. Enthesitis affects up to 50…
  • Abstract Number: 1632 • 2018 ACR/ARHP Annual Meeting

    Ultrasonographic Evaluation of the Enthesis in Patients Affected By Entheropatic Spondiloarthritis. Focus on Distal Enthesis of the Patellar Tendon

    Alberto Batticciotto1, Giada Prato2, Marco Antivalle3, Maria Chiara Ditto4, Michele Agosti5, Enrico Cumbo2, Rossella Talotta2, Fabiola Atzeni6 and Piercarlo Sarzi-Puttini5, 1SS Reumatologia Ospedale di Circolo - fondazione Macchi ASST Settelaghi, Varese, Italy, 2Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milan, Italy, 3Rheumatology, Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, 4Department of Rheumatology, University Hospital Città Della Salute e della Scienza di Torino, Turin, Italy, 5Rheumatology Unit, ASST Fatebenefratelli - Sacco, L. Sacco University Hospital, Milano, Italy, 6Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Messina, Messina, Italy

    Background/Purpose: Enteropathic arthritis (EA) belongs to the spondyloarthritis (SpA) spectrum of diseases and occurs in patients affected by inflammatory bowel diseases (IBD). Several works demonstrated…
  • Abstract Number: 1657 • 2018 ACR/ARHP Annual Meeting

    The Effect of Guselkumab on Enthesitis: Results from a Phase 2 Study in Patients with Active Psoriatic Arthritis

    Philip Helliwell1, Alice B Gottlieb2, Atul A. Deodhar3, Wolf-Henning Boehncke4, Dennis McGonagle1, Xie L. Xu5, Stephen Xu5, Yuhua Wang5, Elizabeth C Hsia5,6, Chetan S Karyekar5 and Philip J. Mease7, 1U of Leeds, Leeds, United Kingdom, 2NY Medical College, Metropolitan Hospital, NY, NY, 3Oregon Health & Science U, Portland, OR, 4U of Geneva, Geneva, Switzerland, 5Janssen Research & Development, LLC, Spring House, PA, 6U Penn School of Medicine, Phila, PA, 7Swedish Medical Center & U of Wash, Seattle, WA

    Background/Purpose: In a Phase 2 study, Guselkumab (GUS) was shown to be safe & effective in pts w/active PsA w/meaningful improvements in enthesitis. To evaluate…
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