ACR Meeting Abstracts

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Abstracts tagged "endothelial cells"

  • Abstract Number: 477 • 2016 ACR/ARHP Annual Meeting

    Conventional Non-Steroidal Anti-Inflammatory Drugs, but Not COX2 Selective Inhibitors, Are Beneficial on Vascular Function in Arthritis: A Study in Adjuvant Induced Arthritis

    Frank Verhoeven1, Clément Prati2, Katy Maguin-Gaté1, Perle Totoson1, Daniel Wendling3 and Céline Demougeot1, 1EA 4267 FDE, FHU INCREASE, Université de Bourgogne Franche-Comté, Besançon, France, 2FDE EA4267, FHU INCREASE, Bourgogne Franche-Comté University, Besançon, France, 3Service de Rhumatologie, CHU Jean Minjoz, Besancon, France

    Background/Purpose: (RA) is associated with an increase in cardiovascular (CV) risk explained in part by an accelerated atherosclerosis as a consequence of endothelial dysfunction. Non-steroidal…
  • Abstract Number: 1127 • 2016 ACR/ARHP Annual Meeting

    Extracellular Macrophage Migration Inhibitory Factor Is Essential for Hypoxia-Induced Angiogenesis in a Hypoxia Inducible Factor Independent Manner

    Mathias Mursell1,2, Martin Hahne1,2,3, Peggy Kunath1,2, Cindy Strehl1,2, Paula Hoff1,2, Frank Buttgereit2 and Timo Gaber1,2, 1German Rheumatism Research Center (DRFZ), Berlin, Germany, 2Department of Rheumatology and Clinical Immunology, Charité – Universitätsmedizin Berlin, Berlin, Germany, 3Miltenyi Biotec GmbH, Bergisch Gladbach, Germany

    Background/Purpose: Angiogenesis is a hallmark of the pathogenesis of rheumatoid arthritis (RA) but also of other inflammatory processes, tissue regeneration and progressing tumors. In RA,…
  • Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting

    Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation

    Carlos Perez-Sanchez1, Maria Ángeles Aguirre Zamorano1, María Galindo2, Patricia Ruiz-Limon3, Ivan Arias de la Rosa3, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Pedro Segui1, Eduardo Collantes-Estévez1, Maria Jose Cuadrado4 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
  • Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting

    The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Thomas Dr. Umscheid3, Markus Prof. Dr. Schönburg4, Stefan Rehart5, Ulf Müller-Ladner2 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 3William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, 4Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 5Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
  • Abstract Number: 591 • 2015 ACR/ARHP Annual Meeting

    Rosuvastatin Improves Endothelial Function in Patients with Inflammatory Joint Diseases, Longitudinal Associations with Atherosclerosis and Arteriosclerosis

    Eirik Ikdahl1, Jonny Hisdal2, Silvia Rollefstad1, Inge C Olsen3, Tore K. Kvien4, Terje R. Pedersen5 and Anne Grete Semb6, 1Preventive Cardio-Rheuma Clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 2Section of Vascular Investigations, Oslo University Hospital Aker, Oslo, Norway, 3Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 4Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, 5Department of Preventive Cardiology, Ullevaal University Hospital, Oslo, Norway, 6Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

    Background/Purpose: Endothelial dysfunction is an early step in the formation of atherosclerotic lesions and can be quantified by the degree of flow mediated vasodilation (FMD)…
  • Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting

    Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype

    Robert Good1, Sarah L. Trinder2, Christopher P. Denton3, David Abraham4 and Alan M. Holmes1, 1Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 2Centre for Rheumatology and Connective Tissue Diseases, UCL, London, United Kingdom, 3Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 4Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom

    Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…
  • Abstract Number: 1880 • 2015 ACR/ARHP Annual Meeting

    Circulating Microparticle Populations May Differentiate Between Connective Tissue Diseases. 

    Eoghan M. McCarthy1,2, Daniel Moreno-Martinez3, Fiona Wilkinson4, Neil J McHugh5,6, Ian N. Bruce7,8, Yvonne Alexander3, John D. Pauling6,9 and Ben Parker7,8, 1The University of Manchester, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Mmanchester, United Kingdom, 2NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom, 3Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, 4School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, 5Rheumatology, Bath Institute of Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 6Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, 7Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, 8Stopford Building, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 9Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom

     Background/Purpose: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). Circulating MPs levels are altered…
  • Abstract Number: 1919 • 2015 ACR/ARHP Annual Meeting

    Genetic Deletion of Toll-like Receptor 4 (Tlr4) Abrogates TGF-β1-Induced Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells

    Peter J. Wermuth1 and Sergio A. Jimenez2, 1Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology whose pathogenesis involves the regulation of a diverse range of molecular pathways. The…
  • Abstract Number: 2934 • 2015 ACR/ARHP Annual Meeting

    Endothelial Dysfunction in SLE-the Role of Platelets and Type I Interferon

    Helena Tydén1, Christian Lood2, Birgitta Gullstrand3, Andreas Jönsen4 and Anders A. Bengtsson5, 1Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 2Department of Clinical Sciences, Division of Rheumatology, Lund University and Skane University Hospital Lund Sweden, Lund University, Lund, Sweden, 3Department of Clinical Sciences, Division of Rheumatology Lund University and Skane University Hospital, Lund University, Lund, Sweden, 4Department of Rheumatology, Lund University Hospital, Lund, Sweden, 5Rheumatology, Inst of Clinical sciences, Lund, Sweden

    Background/Purpose: Type I interferon (IFN) may affect endothelial progenitor cells leading to endothelial dysfunction in SLE. SLE patients have a type I IFN signature in…
  • Abstract Number: 3009 • 2015 ACR/ARHP Annual Meeting

    Fli1 Deficiency Contributes to the Downregulation of Endothelial Protein C Receptor in Systemic Sclerosis: A Possible Role in Pro-Thrombotic Condition

    Ryosuke Saigusa1, Yoshihide Asano2, Takashi Taniguchi2, Takashi Yamashita2, Takehiro Takahashi2, Yohei Ichimura2, Tetsuo Toyama2, Ayumi Yoshizaki2, Tomomitsu Miyagaki2, Makoto Sugaya2 and Shinichi Sato2, 17-3-1 Hongo, Bunkyo-ku, University of Tokyo Graduate School of Medicine, Tokyo, Japan, 2Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan

    Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by fibrosis of the skin and certain internal organs due to the constitutive activation…
  • Abstract Number: 3015 • 2015 ACR/ARHP Annual Meeting

    Characterization of the Profibrotic/Antifibrotic Profile of microRNA Contained in Exosomes Isolated from Cultured Normal Human Dermal and Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition in Vitro

    Sergio A. Jimenez1, Sonsoles Piera-Velazquez2, Peter J. Wermuth3 and Kerri Fasino4, 1Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, 3Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, 4Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Systemic Sclerosis (SSc) is characterized by progressive fibrosis of skin and multiple internal organs, severe alterations in the microvasculature, and numerous immunological abnormalities. Recently…
  • Abstract Number: 3018 • 2015 ACR/ARHP Annual Meeting

    Paracrine Effect of Proteins Secreted By Normal Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition on the Expression of Genes Associated with Tissue Fibrosis in Normal Human Lung Fibroblasts

    Sonsoles Piera-Velazquez1, Kerri Fasino2 and Sergio A. Jimenez3, 1Jefferson Institute of Molecular Medicine, Thomas Jefferson Univ, Philadelphia, PA, 2Jefferson Institute of Molecular Medicine and Division of Connective Tissue Diseases, Thomas Jefferson University, Philadelphia, PA, 3Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA

    Background/Purpose: Progressive tissue fibrosis and microvascular alterations are the hallmarks of Systemic Sclerosis (SSc). The mechanisms involved in SSc pathogenesis are complex and have not…
  • Abstract Number: 3085 • 2015 ACR/ARHP Annual Meeting

    Platelet Activation and Endothelial Reactivity in the Pathogenesis of Tissue Inflammation/Injury in Systemic Lupus Erythematosus

    Robert Clancy1, Sokha Nhek2, Jonathan Newman3, Janet Nwaukoni1, Sara Rasmussen4, Jill P. Buyon1, Maya Rubin5, Kristen Lee1 and Jeffrey Berger5, 1Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2New York University School of Medicine, New York, NY, 3Medicine, New York University School of Medicine, New York, NY, 4Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 5Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

    Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at increased risk for widespread endothelial dysfunction, vascular thromboses, and premature cardiovascular disease.  Enhanced platelet activation and…
  • Abstract Number: 774 • 2014 ACR/ARHP Annual Meeting

    Endothelin-1 Synergistically Increases TGF-β-Induced Hif1α Expression Under Normoxic Conditions during Endothelial-to-Mesenchymal Transition in Murine Endothelial Cells. a Novel Mechanism for the Fibrogenic Effects of Endothelin

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Tissue hypoxia is a consequence of vascular damage and Hif-1α accumulation is a major mechanism of hypoxia response pathways.  HIF-1α induces the transcriptional upregulation…
  • Abstract Number: 771 • 2014 ACR/ARHP Annual Meeting

    Development of a Bifluorescent Lineage Tracker Reporter Mouse Strain to Analyze the Phenotypic Conversion of Endothelial Cells into Myofibroblasts in Vivo. Application to Study the Synergistic Effects of Endothelin-1 on TGF-β1-Induced Endothelial-to-Mesenchymal Transition

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Endothelial-to-mesenchymal transition (EndoMT) may be a crucial pathway in generating activated myofibroblasts, cells that play a pivotal role in the development of tissue and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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