Abstract Number: 2700 • 2016 ACR/ARHP Annual Meeting
The Lymphatic System: A Gatekeeper for Migration of Pathogenic T-Cells Towards Synovial Joints and Entheses in Psoriasis
Background/Purpose: Psoriasis (PsO) is a common inflammatory skin disease that is characterized by acanthosis, impaired immune cell migration, and remodeling of the vascular and lymphatic…Abstract Number: 2836 • 2016 ACR/ARHP Annual Meeting
Microparticles of Endothelial Origin in Women with Systemic LUPUS Erythematosus UNDER Treatment
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an inflammatory and multisystem disease. Microparticles (MPs) are cell membrane-shedded fragments released during apoptosis and cell activation. Several diseases are…Abstract Number: 2876 • 2016 ACR/ARHP Annual Meeting
SLE Serum Impairs NO Production in Huvecs through Induction of eNOS Uncoupling
Background/Purpose: Systemic lupus erythematosus (SLE) induces endothelial cell dysfunction (ECD) that can manifest as glomerulonephritis or atherosclerosis. Lupus-prone mice lacking endothelial nitric oxide synthase (eNOS,…Abstract Number: 2934 • 2015 ACR/ARHP Annual Meeting
Endothelial Dysfunction in SLE-the Role of Platelets and Type I Interferon
Background/Purpose: Type I interferon (IFN) may affect endothelial progenitor cells leading to endothelial dysfunction in SLE. SLE patients have a type I IFN signature in…Abstract Number: 3009 • 2015 ACR/ARHP Annual Meeting
Fli1 Deficiency Contributes to the Downregulation of Endothelial Protein C Receptor in Systemic Sclerosis: A Possible Role in Pro-Thrombotic Condition
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by fibrosis of the skin and certain internal organs due to the constitutive activation…Abstract Number: 3015 • 2015 ACR/ARHP Annual Meeting
Characterization of the Profibrotic/Antifibrotic Profile of microRNA Contained in Exosomes Isolated from Cultured Normal Human Dermal and Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition in Vitro
Background/Purpose: Systemic Sclerosis (SSc) is characterized by progressive fibrosis of skin and multiple internal organs, severe alterations in the microvasculature, and numerous immunological abnormalities. Recently…Abstract Number: 3018 • 2015 ACR/ARHP Annual Meeting
Paracrine Effect of Proteins Secreted By Normal Lung Microvascular Endothelial Cells Undergoing Endothelial Mesenchymal Transition on the Expression of Genes Associated with Tissue Fibrosis in Normal Human Lung Fibroblasts
Background/Purpose: Progressive tissue fibrosis and microvascular alterations are the hallmarks of Systemic Sclerosis (SSc). The mechanisms involved in SSc pathogenesis are complex and have not…Abstract Number: 3085 • 2015 ACR/ARHP Annual Meeting
Platelet Activation and Endothelial Reactivity in the Pathogenesis of Tissue Inflammation/Injury in Systemic Lupus Erythematosus
Background/Purpose: Patients with systemic lupus erythematosus (SLE) are at increased risk for widespread endothelial dysfunction, vascular thromboses, and premature cardiovascular disease. Enhanced platelet activation and…Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting
The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells
Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…Abstract Number: 591 • 2015 ACR/ARHP Annual Meeting
Rosuvastatin Improves Endothelial Function in Patients with Inflammatory Joint Diseases, Longitudinal Associations with Atherosclerosis and Arteriosclerosis
Background/Purpose: Endothelial dysfunction is an early step in the formation of atherosclerotic lesions and can be quantified by the degree of flow mediated vasodilation (FMD)…Abstract Number: 1175 • 2015 ACR/ARHP Annual Meeting
Blood Outgrowth Endothelial Cells Isolated from Systemic Sclerosis Patients Exhibit a Pro-Inflammatory Phenotype
Background/Purpose: Vascular complications are a key pathological feature of systemic sclerosis (SSc) affecting the microcirculation and arterioles. Under normal circumstances the endothelium acts as a…Abstract Number: 1880 • 2015 ACR/ARHP Annual Meeting
Circulating Microparticle Populations May Differentiate Between Connective Tissue Diseases.
Background/Purpose: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). Circulating MPs levels are altered…Abstract Number: 1919 • 2015 ACR/ARHP Annual Meeting
Genetic Deletion of Toll-like Receptor 4 (Tlr4) Abrogates TGF-β1-Induced Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells
Background/Purpose: Systemic sclerosis (SSc) is a systemic autoimmune disease of unknown etiology whose pathogenesis involves the regulation of a diverse range of molecular pathways. The…Abstract Number: 3003 • 2014 ACR/ARHP Annual Meeting
Am80 Ameliorates Bleomycin-Induced Dermal Fibrosis By Suppressing the Pro-Fibrotic Phenotype of Fibroblasts, Endothelial Cells, and Immune Cells
Background/Purpose: Am80 is a synthetic retinoid serving as an agonist for retinoic acid receptor α/β with chemical and pharmacological advantages over all-trans retinoic acid, such…Abstract Number: 2445 • 2014 ACR/ARHP Annual Meeting
A Distinct Profile of Circulating Microparticles Is Associated with Disease Features in Rheumatoid Arthritis Patients and Impairs Endothelial Functionality in Vitro
Background/Purpose Cell-derived microparticles (MPs) could be considered biomarkers of cell damage and activation and they are thought to have a role in cardiovascular (CV) and inflammatory…
ACR Meeting Abstracts