ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2075

Vascular Endothelial and Inflammatory Differences in Psoriasis and Psoriatic Arthritis Patients

Michael Gashick1, Todd Wechter2, Tessa Barrett1, Sarah Azarchi2, Stuart Katz3, Andrea L. Neimann4, James Krueger5, Sanja Jelic6, Edward Fisher1, Jose U. Scher7 and Jeffrey S. Berger8, 1Medicine/Cardiology, New York University School of Medicine, New York City, NY, 2Dermatology, New York University School of Medicine, New York City, NY, 3Medicine/Cardiology, New York University School of Medicine, New York, NY, 4Department of Dermatology, New York University School of Medicine, New York, NY, 5The Rockefeller University, New York, NY, 6Medicine/Pulmonary, Columbia University Medical Center, New York City, NY, 7New York University School of Medicine, New York, NY, 8Medicine, Division of Cardiology, New York University School of Medicine, New York, NY

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: Cardiovascular disease, endothelial cells, Inflammation, psoriasis and psoriatic arthritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Date: Tuesday, October 23, 2018

Session Title: Spondyloarthritis Including Psoriatic Arthritis – Basic Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:

Psoriatic arthritis (PsA) and Psoriasis (PsO) are chronic inflammatory diseases associated with vascular inflammation and increased CVD risk. Few studies have examined vascular inflammatory differences between PsO and PsA and how these differences may impart a different CVD risk profile. We directly investigated the vascular endothelium of patients with PsA, PsO and compared to controls to better understand the inflammatory mechanism(s) that predispose psoriatic patients to CVD risk.

Methods:

Twenty patients with psoriatic disease (PD) (mean age 45 years, 55% male, 11.2 ± 19% body surface area (BSA) involvement) were first compared to 10 matched controls. Next, comparisons were made between PsO (n = 14, average age 50 years, 57% male, 11 ± 22% BSA) and active PsA (n = 6, average age 36 years, 50% male, 11 ± 10% BSA, average 2 – 3 tender/swollen joints per individual). To measure vascular endothelial health, venous endothelial cells were collected from the brachial vein using guidewires inserted through an angiocatheter and isolated with CD146-conjugated magnetic beads. Following collection, endothelial mRNA was isolated, converted to cDNA and inflammatory gene profiling performed by RT-qPCR with Taqman probes and primers. Transcripts were chosen based on in vitro gene arrays of human aortic endothelial cells co-stimulated with IL-17 and TNF-α.

Results:

PD patients compared to controls showed a trend towards higher levels of hs-CRP (2.4 ± 4 mg/dl vs. 0.8 ± 2 mg/dl, p = 0.08) with no overall difference noted between PsA and PsO patients (2.8 ± 2 mg/dl vs. 2.7 ± 4 mg/dl, p = 0.24). Transcriptomic profiling of venous endothelial cells comparing PD (PsO and PsA) to controls revealed upregulation of inflammatory cytokine- and chemokine- associated transcripts (lymphotoxin beta [4 – fold], CCL3 [11 – fold], CXCL10 [16 – fold], IL-8 [10 – fold] and IL-1β [4 – fold], P < 0.05 for all) and transcripts related to intracellular adhesion (ICAM1 [2.4 – fold] and inflammation COX-2 [3 – fold], P < 0.05). Increased expression of the chemokine fractalkine (CX3CL1 [2.8 – fold], p < 0.05) and lymphotoxin beta [2 – fold, p = 0.10] were found in patients with active PsA compared to PsO. No differences in CCL3, CXCL10, IL-8, IL-1B, ICAM1 and COX-2 where seen between PsA and PsO patients.

Conclusion:

Endothelial cell pro-inflammatory transcripts are upregulated in patients with active PD compared with controls. Levels of lymphotoxin beta and fractalkine, a chemokine present in inflamed arthritic synovial tissue, are greater in endothelial cells of patients with PsA than PsO. These findings may underlie increased CVD risk in patients with PD and highlight the inflammatory vascular differences between PsO and PsA.


Disclosure: M. Gashick, None; T. Wechter, None; T. Barrett, None; S. Azarchi, None; S. Katz, None; A. L. Neimann, None; J. Krueger, None; S. Jelic, None; E. Fisher, None; J. U. Scher, Janssen, 5,Novartis, 5,UCB, Inc., 5,AbbVie Inc., 5; J. S. Berger, Astra Zeneca, Janssen, 2.

To cite this abstract in AMA style:

Gashick M, Wechter T, Barrett T, Azarchi S, Katz S, Neimann AL, Krueger J, Jelic S, Fisher E, Scher JU, Berger JS. Vascular Endothelial and Inflammatory Differences in Psoriasis and Psoriatic Arthritis Patients [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 10). https://acrabstracts.org/abstract/vascular-endothelial-and-inflammatory-differences-in-psoriasis-and-psoriatic-arthritis-patients/. Accessed January 27, 2021.
  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2018 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/vascular-endothelial-and-inflammatory-differences-in-psoriasis-and-psoriatic-arthritis-patients/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.