ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Cognitive dysfunction"

  • Abstract Number: 041 • 2023 Pediatric Rheumatology Symposium

    Cognitive Performance Score of the Pediatric Automated Neuropsychological Assessment Metrics Software in a Brazilian Cohort

    Jaqueline De Amorim1, Simone Kishimoto1, Paula Fernandes1, Roberto Marini1, Lilian Costallat1, Zahi Touma2, Hermine Brunner3 and Simone Appenzelle4, 1UNICAMP, São Paulo, Brazil, 2University of Toronto, Toronto, ON, Canada, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4University of Campinas, Campinas, Sao Paulo, Brazil

    Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The…
  • Abstract Number: 1447 • ACR Convergence 2022

    Serum Cytokine Profiling Reveals Elevated Levels of S100A8/A9 and MMP-9 in Systemic Lupus Erythematosus Patients with Cognitive Impairment Independently of Disease Activity and Inflammatory Markers

    Carolina Munoz1, Michelle Barraclough2, Juan Pablo Diaz-Martinez1, Jiandong Su1, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, May Choi6, Dennisse Bonilla1, Simone Appenzeller7, Patricia Katz8, Dorcas Beaton9, Robin Green5, Joan Wither10 and Zahi Touma1, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 7Unicamp, Campinas, São Paulo, Brazil, 8UCSF, San Rafael, CA, 9Institute for Work & Health, Toronto, ON, Canada, 10Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is one of the most common manifestations of neuropsychiatric lupus(NPSLE), which may occur in the absence of active Systemic Lupus Erythematosus…
  • Abstract Number: 1458 • ACR Convergence 2022

    Systemic Lupus Erythematosus (SLE) Patients with Cognitive Impairment Experience More Fatigue Compared to Patients Without Impairment

    Delansie Lawrence1, Jiandong Su1, Andrea Knight2, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, Joan Wither6, May Choi7, Simone Appenzeller8, Nicole Anderson1, Dennisse Bonilla1, Patricia Katz9, Dorcas Beaton10, Robin Green5, Zahi Touma1 and Michelle Barraclough11, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 7Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 8Unicamp, Campinas, São Paulo, Brazil, 9UCSF, San Rafael, CA, 10Institute for Work & Health, Toronto, ON, Canada, 11Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is highly prevalent in patients with systemic lupus erythematosus (SLE). Objective prevalence rates are reported as 38% [range: 20% to 80%]…
  • Abstract Number: 1459 • ACR Convergence 2022

    Evolution of Subjective Cognitive Impairment Overtime in SLE Patients: Bayesian Longitudinal Item Response Theory Modelling

    Michelle Barraclough1, Juan Pablo Diaz-Martinez2, Andrea Knight3, Kathleen Bingham4, Jiandong Su2, Mahta Kakvan5, Carolina Munoz2, Maria Carmela Tartaglia6, Leslet Ruttan7, Joan Wither5, May Choi8, Nicole Anderson9, Dennisse Bonilla2, Simone Appenzeller10, Ben Parker11, Patricia Katz12, Dorcas Beaton13, Robin Green7, Ian N. Bruce14 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 5Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 6University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 7University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 8Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 9Schroeder Arthritis Institute, Krembil Research Institute and University Health Network, University of Toronto, Toronto, ON, Canada, 10Unicamp, Campinas, São Paulo, Brazil, 11Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 12UCSF, San Rafael, CA, 13Institute for Work & Health, Toronto, ON, Canada, 14Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Subjective cognitive impairment (SCI) is a significant problem in SLE and there are a lack of studies assessing change over time in SCI. The…
  • Abstract Number: 1468 • ACR Convergence 2022

    Apathy Measurement in a Cohort of Systemic Lupus Erythematosus

    Mike Putman1, David Gazeley2 and Ikechukwu Mbonu3, 1The Medical College of Wisconsin, Milwaukee, WI, 2Medical College of Wisconsin, Wauwatosa, WI, 3Medical College of Wisconsin, Milwaukee, WI

    Background/Purpose: Up to 40% of patients with systemic lupus erythematosus (SLE) have measurable cognitive dysfunction on neuropsychiatric testing. Around 83% of patients are nonadherent with…
  • Abstract Number: 1474 • ACR Convergence 2022

    Quinolinic Acid, a Kynurenine/Tryptophan Pathway Metabolite, Correlates with Abnormalities in Brain Structure and Function in SLE

    Erik Anderson, Chris Tang, An Vo, Cynthia Aranow, Bruce Volpe, Betty Diamond and Meggan Mackay, Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Stimulation of the kynurenine/tryptophan pathway by interferons alpha and gamma, both known contributors to SLE pathogenesis, leads to a potentially neurotoxic imbalance of pathway…
  • Abstract Number: 0062 • ACR Convergence 2022

    Comparing Alzheimer’s Disease Risk in Patients with Chronic Inflammatory Autoimmune Diseases: A Medicare Cohort Study

    Justin Levinson1, Jonathan Katz2, Yi Chen3, W. Ryan Powell4, Andrea Gilmore-Bykovskyi5, Amy J. Kind6 and Christie Bartels7, 1University of Wisconsin School of Medicine and Public Health, Department of Medicine, Rheumatology Division, Madison, WI, 2University of Wisconsin Hospitals and Clinics, Madison, WI, 3University of Wisconsin School of Medicine and Public Health, Department of Medicine, Department of Biostatistics and Informatics, Madison, WI, 4University of Wisconsin School of Medicine and Public Health, Center for Health Disparities Research, Thousand Oaks, CA, 5University of Wisconsin School of Medicine and Public Health, Department of Emergency Medicine; and the Center for Health Disparities Research, Madison, WI, 6University of Wisconsin School of Medicine and Public Health, Department of Medicine, Geriatrics Division & Center for Health Disparities Research, Madison, WI, 7University of Wisconsin School of Medicine and Public Health, Madison, WI

    Background/Purpose: Chronic inflammatory diseases have been associated with an increased risk of Alzheimer’s disease (AD), yet emerging research in rheumatoid arthritis (RA) and psoriasis suggests…
  • Abstract Number: 1708 • ACR Convergence 2022

    A Role for the RAGE Receptor in Chronic Neurotoxicity After Exposure to SLE Antibodies That Cross React with dsDNA and the NMDA Receptor

    Bahtiyar Toz1, Jeffrey C wingard2, Bruce Volpe2 and Betty Diamond2, 1Resident in Queens Hospital Center, Jamaica, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Neurologic dysfunction occurs in up to 80% of SLE patients. Cognitive impairment is one of the most frequent manifestations of neuropsychiatric SLE (NPSLE). There…
  • Abstract Number: 0322 • ACR Convergence 2022

    Are Virtual Cognitive Assessments Comparable to In-person Assessments in a Systemic Lupus Erythematosus Cohort?

    Michelle Barraclough1, Juan Pablo Diaz-Martinez2, Andrea Knight3, Kathleen Bingham4, Jiandong Su2, Mahta Kakvan2, Carolina Munoz2, Maria Carmela Tartaglia5, Leslet Ruttan6, Joan Wither7, May Choi8, Dennisse Bonilla2, Nicole Anderson2, Simone Appenzeller9, Ben Parker10, Patricia Katz11, Dorcas Beaton12, Robin Green6, Ian N. Bruce13 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 5University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 6University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 7Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 8Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 9Unicamp, Campinas, São Paulo, Brazil, 10Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, 11UCSF, San Rafael, CA, 12Institute for Work & Health, Toronto, ON, Canada, 13Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom

    Background/Purpose: Many in-person research studies, such as ours examining cognitive impairment (CI) in SLE, were paused for safety reasons during the COVID-19 pandemic. To restart…
  • Abstract Number: 1754 • ACR Convergence 2022

    Association of Cognitive Impairment and Symptomatic Lower Extremity Osteoarthritis by Level of Physical Activity: Preliminary Data from the Johnston County Health Study

    Kharma Foucher1, Amanda Nelson2, Leigh Callahan3 and Yvonne Golightly4, 1University of Illinois at Chicago, Chicago, IL, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, 3University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, 4University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: While osteoarthritis (OA) is associated with an increased risk of dementia,1 the frequency of milder cognitive impairment is unknown. Mild to moderate cognitive impairment…
  • Abstract Number: 0330 • ACR Convergence 2022

    Assessing the Utility of the Montreal Cognitive Assessment as a Screening Tool for Cognitive Impairment in Patients with SLE Using a Bayesian Item-Response Theory Model

    Juan Pablo Diaz-Martinez1, Michelle Barraclough2, Kimberley Yuen3, Oshrat Tayer-Shifman4, Andrea Knight5, Kathleen Bingham6, Jiandong Su1, Mahta Kakvan1, Carolina Munoz1, Maria Carmela Tartaglia7, Leslet Ruttan8, Joan Wither9, May Choi10, Dennisse Bonilla1, Simone Appenzeller11, Patricia Katz12, Dorcas Beaton13, Robin Green8 and Zahi Touma1, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 3Queen's University School of Medicine, Toronto, ON, Canada, 4Meir Medical Center, Kfar Saba, Israel, 5The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 6Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 7University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 8University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 9Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 10Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 11Unicamp, Campinas, São Paulo, Brazil, 12UCSF, San Rafael, CA, 13Institute for Work & Health, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is one of the most common manifestations of neuropsychiatric syndromes in patients with SLE, with a prevalence ranging from 20% to…
  • Abstract Number: 2058 • ACR Convergence 2022

    Evidence on the Construct Validity of the Perceived Deficits Questionnaire Among Adult Patients with Systemic Lupus Erythematosus

    Stefan Perera1, Jiandong Su2, Kathleen Bingham3, Mahta Kakvan1, Maria Carmela Tartaglia4, Leslet Ruttan5, Joan Wither1, May Choi6, Simone Appenzeller7, Dorcas Beaton8, Dennisse Bonilla2, Patricia Katz9, Robin Green5, Michelle Barraclough10 and Zahi Touma2, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 3Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, 5University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 6Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, 7Unicamp, Campinas, São Paulo, Brazil, 8Institute for Work & Health, Toronto, ON, Canada, 9UCSF, San Rafael, CA, 10Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is prevalent in SLE and negatively impacts social and occupational engagement. There is a need for a patient-reported outcome measure (PROM)…
  • Abstract Number: 0363 • ACR Convergence 2022

    Centrally-Acting Angiotensin Converting Enzyme Inhibitor (cACEi) and Angiotensin Receptor Blocker (cARB) Use and Cognitive Dysfunction in Patients with Systemic Lupus

    Chrisanna Dobrowolski1, Michelle Barraclough2, Jiandong Su3, Milica Tanic4, Kathleen Bingham5, Leslet Ruttan6, Dorcas Beaton7, Joan Wither8, Maria Carmela Tartaglia9, Mahta Kakvan3, Nicole Anderson3, Dennisse Bonilla3, Robin Green6 and Zahi Touma3, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 4McMaster University, Toronto, ON, Canada, 5Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 6University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, 7Institute for Work & Health, Toronto, ON, Canada, 8Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, 9University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada

    Background/Purpose: Cognitive dysfunction (CD) is detectable in 40% of patients with systemic lupus erythematosus (SLE). Despite this high prevalence, there are limited treatment options for…
  • Abstract Number: 2074 • ACR Convergence 2022

    Poor Executive Function Correlates with Increased Disease Damage and Impaired Patient-Reported Outcomes in Youth with Childhood-Onset Lupus: A Cross-Sectional Study

    Tala El Tal1, Santiago Arciniegas2, Sarah Mossad3, Ibrahim Mohamed4, Victoria Lishak5, Stephanie Fevrier6, Lawrence Ng3, Paris Moaf3, Joanna Law3, ashley Danguecan3, Linda Hiraki7, Deborah Levy8 and Andrea Knight1, 1The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 2University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 3The Hospital for Sick Children, Toronto, ON, Canada, 4The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 5The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 6The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 7The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive dysfunction affects up to 60% of youth with childhood-onset systemic lupus erythematosus (cSLE), particularly executive dysfunction (ED), with adverse effects on treatment adherence,…
  • Abstract Number: 0517 • ACR Convergence 2022

    Cortical Surface Area Correlates with Cognitive Efficiency and Disease Measures in Childhood-Onset Systemic Lupus Erythematosus

    Santiago Arciniegas1, Sarah Mossad2, Tala El Tal3, Victoria Lishak4, Stephanie Fevrier5, Ibrahim Mohamed6, Joanna Law2, Lawrence Ng2, Paris Moaf2, Helen Branson2, Adrienne Davis2, Linda Hiraki7, Deborah Levy8, ashley Danguecan2, George Ibrahim5 and Andrea Knight3, 1University of Toronto/Hospital for Sick Children, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 4The Hospital for Sick Children, Department of Psychology, University of Toronto, Toronto, ON, Canada, 5The Hospital for Sick Children/University of Toronto, Toronto, ON, Canada, 6The Hospital for Sick Children, Neurosciences and Mental Health, Research Institute, ON, Canada 3Institute of Biomedical Engineering, University of Toronto, Brampton, ON, Canada, 7The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Genetics and Genome Biology, SickKids Research Institute, Toronto, ON, Canada, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive difficulties are common in children with childhood-onset SLE (cSLE), but neuropsychiatric lupus (NPSLE) remains challenging to diagnose and treat. To increase understanding of…
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