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Abstracts tagged "Cognitive dysfunction"

  • Abstract Number: 1300 • ACR Convergence 2020

    Identifying Cognitive Impairment in Patients with Systemic Lupus Erythematosus Using Hidden Markov Models: A Bayesian Approach

    Juan Pablo Diaz-Martinez1, Kathleen Bingham2, Robin Green3, Dorcas Beaton4, Mahta Kakvan1, Lesley Ruttan3, Carmela Tartaglia5, Marvin Fritzler6, May Choi7, Jiandong Su1, Dennisse Bonilla1, Nicole Anderson1, Joan Wither1, Patricia Katz8 and Zahi Touma9, 1University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 2Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 3Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, 4Institute for Work & Health, Toronto, Canada, 5University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, 6Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 7Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 8University of California, San Francisco, Novato, CA, 9University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network; Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is usually operationalized on the American College of Rheumatology Neuropsychological Battery (ACR-NB) as a z-score of ≤-1.5 on ≥2 domains or…
  • Abstract Number: 1688 • ACR Convergence 2020

    Long-term Hearing Loss, Anxiety and Neurodevelopmental Outcomes Following Kawasaki Disease: A Population-based Cohort Study

    Cal Robinson1, Francis Lao2, Rahul Chanchlani1, Anastasia Gayowsky3, Sandeep Brar4, Elizabeth Darling5, Catherine Demers5, Tapas Mondal1, Rulan Parekh6, Hsien Seow5 and Michelle Batthish1, 1McMaster Children's Hospital, Hamilton, ON, Canada, 2Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada, 3ICES McMaster, Hamilton, ON, Canada, 4University of California, San Fransisco, 5McMaster University, Hamilton, ON, Canada, 6University of Toronto, Toronto, Canada

    Background/Purpose: The incidence of Kawasaki disease (KD) is increasing in Ontario. Cardiovascular sequelae following KD are well-described. However, there are limited and conflicting non-cardiovascular outcome…
  • Abstract Number: 1788 • ACR Convergence 2020

    Assessment of the Impact of Interferon Levels on Cognitive Dysfunction in Patients with SLE

    Andrew Kwan1, Joan Wither2, Juan Pablo Diaz-Martinez2, Robin Green3, Dorcas Beaton4, Mahta Kakvan2, Lesley Ruttan3, Carmela Tartaglia5, Marvin Fritzler6, May Choi7, Jiandong Su2, Dennisse Bonilla2, Nicole Anderson2, Patricia Katz8 and Zahi Touma9, 1University of Toronto, Department of Medicine, Toronto, ON, Canada, 2University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 3Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, 4Institute for Work & Health, Toronto, ON, Canada, 5University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, 6Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 7Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 8University of California, San Francisco, Novato, CA, 9University of Toronto, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is among the earliest and the most prevalent manifestations of SLE. Previous studies have demonstrated that the increased levels of interferon…
  • Abstract Number: 1804 • ACR Convergence 2020

    Impact of the Kynurenine/Tryptophan Pathway on Cognitive Dysfunction and Depression in Systemic Lupus Erythematosus

    Erik Anderson1, Joanna Fishbein2, Joseph Hong2, Julien Roeser3, Richard Furie4, Cynthia Aranow2, Bruce Volpe2, Betty Diamond5 and Meggan Mackay6, 1Feinstein Institutes for Medical Research, New York, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Charles River Laboratories, South San Francisco, CA, 4Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 5Northwell Health, Manhasset, NY, 6Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Tryptophan (TRP) is metabolized to kynurenine (KYN), quinolonic acid [QA, a N-methyl D-aspartate receptor (NMDAR) agonist] and kynurenic acid (KA, an NMDAR antagonist). KYN/TRP…
  • Abstract Number: 1806 • ACR Convergence 2020

    The Association of Interferon-α with Kynurenine/Tryptophan Pathway Activation in Systemic Lupus Erythematosus

    Erik Anderson1, Ying Jin2, Sara Goodwin2, Julien Roeser3, Richard Furie4, Cynthia Aranow5, Bruce Volpe5, Betty Diamond6 and Meggan Mackay7, 1Feinstein Institutes for Medical Research, New York, NY, 2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 3Charles River Laboratories, South San Francisco, CA, 4Zucker School of Medicine at Hofstra/Northwell, Great Neck, NY, 5Feinstein Institutes for Medical Research, Manhasset, NY, 6Northwell Health, Manhasset, NY, 7Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Type I IFN contributes to SLE pathogenesis and stimulates the kynurenine/tryptophan (KYN/TRP) pathway, producing elevated quinolinic acid (QA) levels relative to kynurenic acid (KA)…
  • Abstract Number: 1819 • ACR Convergence 2020

    Altered Brain Functional Connectivity in Systemic Lupus Erythematosus

    Michelle Barraclough1, Shane McKie2, Benjamin Parker1, Alan Jackson3, Rebecca Elliott4 and Ian Bruce5, 1Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2FBMH Platform Sciences, Enabling Technologies & Infrastructure, The University of Manchester, Manchester, 3Wolfson Molecular Imaging Centre, Institute of imaging and bioinformatics, The University of Manchester, Manchester, 4Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 5Centre for Epidemiology Versus Arthritis, The University of Manchester and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom

    Background/Purpose: Cognitive dysfunction (CD) is very prevalent in SLE and significantly affects quality of life. Altered functional brain mechanisms are associated with CD in SLE.…
  • Abstract Number: 0026 • ACR Convergence 2020

    A Modified Version of the 2016 ACR Fibromyalgia Criteria Cognitive Items Results in Stronger Correlation Between Subjective and Objective Measures of Cognitive Impairment

    Valerie Aloush1, Chen Yaalon2, Sheer Raev2, Noy Sobol2, Jacob Ablin1, Ran Shorer3 and Odelia Elkana2, 1Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 2Academic College Tel Aviv Jaffa, Tel Aviv, Israel, 3Tel Aviv Medical Center, Tel Aviv, Israel

    Background/Purpose: In a previous study, we showed that the subjective item assessing cognitive impairment (SSS-Cog) for fibromyalgia (FM) did not correlate with objective cognitive measures.…
  • Abstract Number: 0488 • ACR Convergence 2020

    Incidence of Dementia in Patients with Rheumatoid Arthritis and Association with DMARDs – Analysis of a National Claims Database

    Sebastian Sattui1, Iris Navarro-Millan2, Fenglong Xie3, Mangala Rajan2, Huifeng Yun4 and Jeffrey R Curtis4, 1Hospital for Special Surgery, New York, NY, 2Weill Cornell Medicine, New York, 3University of Alabama at Birmingham, Birmingham, AL, 4Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: There is growing interest regarding the role of neuroinflammation in the development of dementia and the potential role for anti-inflammatory therapy, including TNF-inhibitors (TNFi),…
  • Abstract Number: 1260 • ACR Convergence 2020

    Longitudinal Relationships Between Depression, Anxiety and Cognition in Lupus

    Kathleen Bingham1, Juan Pablo Diaz-Martinez2, Mahta Kakvan2, Robin Green3, Dorcas Beaton4, Lesley Ruttan3, Carmela Tartaglia5, Marvin Fritzler6, May Choi7, Jiandong Su2, Denisse Bonilla8, Nicole Anderson2, Joan Wither2, Patricia Katz9 and Zahi Touma10, 1Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 2University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 3Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, 4Institute for Work & Health, Toronto, ON, Canada, 5University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, 6Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 7Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 8University Health Network, Toronto, Canada, 9University of California, San Francisco, Novato, CA, 10University of Toronto, Toronto, ON, Canada

    Background/Purpose: There is a consistent relationship between cognition and depression and anxiety (affective symptoms) in lupus. Together, affective and cognitive symptoms represent among lupus’ most…
  • Abstract Number: 1268 • ACR Convergence 2020

    Structural Validity of a Comprehensive Neuropsychological Battery for Assessment of Cognitive Impairment in Systemic Lupus Erythematosus: Exploratory Factor Analysis Confirms Six Cognitive Domains

    Bahar Moghaddam1, Robin Green2, Dorcas Beaton3, Kathleen Bingham4, Mahta Kakvan5, Lesley Ruttan2, Carmela Tartaglia6, Marvin Fritzler7, May Choi8, Jiandong Su5, Juan Pablo Diaz-Martinez5, Dennisse Bonilla5, Nicole Anderson5, Joan Wither5, Patricia Katz9 and Zahi Touma1, 1University of Toronto, toronto, ON, Canada, 2Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, 3Institute for Work & Health, Toronto, ON, Canada, 4Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 5University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 6University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, 7Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 8Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 9University of California, San Francisco, Novato, CA

    Background/Purpose: Systemic Lupus Erythematosus (SLE) can lead to neuropsychiatric manifestations including cognitive impairment (CI). The gold standard for assessment of SLE cognitive function is the…
  • Abstract Number: 1276 • ACR Convergence 2020

    Using Classification and Regression Tree Analysis to Assess the Construct Validity of the Automated Neuropsychological Assessment Metrics in the Assessment of Cognitive Impairment in SLE Compared to the ACR Neuropsychological Battery

    Kimberley Yuen1, Dorcas Beaton2, Kathleen Bingham3, Jiandong Su4, Mahta Kakvan4, Juan Pablo Diaz-Martinez4, Carmela Tartaglia5, Lesley Ruttan6, Joan Wither4, Nicole Anderson4, Dennisse Bonilla4, May Choi7, Marvin Fritzler8, Patricia Katz9, Robin Green6 and Zahi Touma10, 1Queen's University School of Medicine; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Canada, 2Institute for Work & Health, Toronto, ON, Canada, 3Department of Psychiatry, University of Toronto, Toronto, ON, Canada, 4University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, 5University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, 6Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, 7Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 8Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 9University of California, San Francisco, Novato, CA, 10University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network; Krembil Research Institute, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is common in systemic lupus erythematosus (SLE) patients, however there is no standard screening tool available. The American College of Rheumatology…
  • Abstract Number: 122 • 2020 Pediatric Rheumatology Symposium

    Systemic Inflammation and Cognitive Dysfunction in jSLE Patients

    Sara Ganhão 1, Mariana Rodrigues2, Beatriz Silva 1, Francisca Aguiar 1, Margarida Figueiredo-Braga 1 and Iva Brito 1, 1Centro Hospitalar de São João, Oporto, Portugal, 2Porto, Portugal

    Background/Purpose: Neurocognitive dysfunction (NCD) is one of the most commonly reported neuropsychiatric symptoms in patients with juvenile systemic lupus erythematosus (SLE), even without overt CNS…
  • Abstract Number: 677 • 2019 ACR/ARP Annual Meeting

    Performance of Montreal Cognitive Assessment (MoCA) in Screening for Cognitive Impairment in Patients with Lupus Compared to the Neuropsychological Battery

    Mahta Kakvan 1, Robin Green 2, Lesley Ruttan 3, Maria Tartaglia 4, Joan Wither 5, Moe Zandy 1, Dennisse Bonilla 1, May Choi 6, Jiandong Su 1, Marvin Fritzler 6, Dorcas Beaton 7 and Zahi Touma1, 1University Health Network, University of Toronto, Toronto, ON, Canada, 2University Health Network, Toronto, ON, Canada, 3Toronto Rehabilitation Institute, Toronto, Canada, 4University Health Network, University of Toronto, Toronto, ON, Canada, 5University Health Network, Krembil Research Institute, Toronto, ON, Canada, 6Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 7St. Michael's Hospital, Toronto, ON, Canada

    Background/Purpose: Cognitive impairment (CI) is a common neuropsychological manifestation of Systemic Lupus Erythematosus (SLE) with a prevalence of 38% [95% confidence interval: 33,43%]. Previous studies,…
  • Abstract Number: 1612 • 2019 ACR/ARP Annual Meeting

    Disease Activity and Cognitive Function in Systemic Lupus Erythematosus

    Michelle Barraclough 1, Shane McKie 2, Benjamin Parker 1, Alan Jackson 3, Philip Pemberton 4, Rebecca Elliott 5 and Ian Bruce6, 1Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 2FBMH Platform Sciences, Enabling Technologies & Infrastructure, The University of Manchester, Manchester, United Kingdom, 3Wolfson Molecular Imaging Centre, Institute of imaging and bioinformatics, The University of Manchester, Manchester, United Kingdom, 4Manchester University NHS Foundation Trust, Manchester, 5Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, The University of Manchester; NIHR Manchester Biomedical Research Centre, Manchester University NHS FT, Manchester Academic Health Science Centre, Manchester, United Kingdom, 6University of Manchester, Manchester, United Kingdom, Manchester, England, United Kingdom

    Background/Purpose: Cognitive dysfunction (CD) is a common symptom in systemic lupus erythematosus (SLE), that significantly affects quality of life but there are limited treatment options…
  • Abstract Number: 1792 • 2019 ACR/ARP Annual Meeting

    Cognitive Dysfunction (CD) and Serum Levels of Brain-Derived Neurotrophic Factor (BDNF) in Primary Antiphospholipid Syndrome (PAPS)

    Renata Rosa1, Michelle Remião Ugolini-Lopes 2, Ana Paula Gandara 2, Kenia Campanholo 2, Livia Dutra 3 and Danieli Andrade 4, 1Faculdade de Medicina da Universidade de São Paulo (USP), Brazil., São Paulo, Sao Paulo, Brazil, 2Faculdade de Medicina da Universidade de São Paulo (USP), Brazil., São Paulo, Brazil, 3Escola Paulista de Medicina (EPM), Brazil, São Paulo, Brazil, 4Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil

    Background/Purpose: Cognition dysfunction (CD) is a poorly understood non-stroke central neurologic manifestation of antiphospholipid syndrome, whose diagnosis involves a specific neuropsychological (NP) evaluation. Brain-derived neurotrophic…
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