ACR Meeting Abstracts

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Abstracts tagged "Autoinflammatory Disease"

  • Abstract Number: 052 • 2023 Pediatric Rheumatology Symposium

    Extreme Periodic Fever, Aphthous Stomatitis, Pharyngitis, Adenitis (PFAPA): A Discrete Group of Patients

    Yoel Levinsky1, Rotem Tal2, Liora Harel2, Shoval Shoham3, Sabreen Abu Ahmad4, Yonatan Butbul Aviel5, Gil Amarilyo2 and Mor Broide3, 1Schneider Children's Medical Center of Israel, Petach Tikva, Israel, 2Pediatric rheumatology clinic, Schneider children's medical center of Israel, Petach Tikva, Israel, 3Schneider Children's Medical Center of Israel, Petach Tikva, Israel, 4Ruth Rappaport Children's Hospital, Rambam Health Care, Haifa, Israel, 5Rambam Medical center, Haifa, Israel

    Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children; by definition, episodes occur every…
  • Abstract Number: 053 • 2023 Pediatric Rheumatology Symposium

    Can Children with Colchicine Resistant FMF Be Treated with on Demand Canakinumab Regimen?– a Multicenter Study

    Katy shehadeh1, Yoel Levinsky2, rotem tal3, Neta Hana Aviran3, Yonatan Butbul Aviel4, Irit Tirosh5, Shelly Kagan6, Tarek Zoabi3, Shiri Spielman7, Adi Miller-Barmak4, Rotem Semo Oz8, Liora Harel9, Gabriel Chodick10 and Gil Amarilyo6, 1Tel Aviv University, Tel Aviv, Israel, 2Schneider Children's Medical Center of Israel, Tel Aviv University, Petach Tikva, Israel, 3Schneider Children's Medical Center of Israel, Petach Tikva, Israel, 4Rambam Medical center, Haifa, Israel, 5Sheba Medical Center, Savyon, Israel, 6Schneider Children's Medical Center of Israel, Petach Tikva, Israel, 7Sheba Tel-HaShomer Medical Center, Givataim, Israel, 8Sheba medical center, Herzelyia, Israel, 9Scheiders Children Medical Center of Israel, Petah-Tiqva, Israel, 10Maccabitech institute for research and innovation, Maccabi healthcare services, Tel Aviv, Israel

    Background/Purpose: Familial Mediterranean fever (FMF) is the most common autoinflammatory disease. Without therapy, it may lead to the development of secondary amyloidosis. Treatment with colchicine…
  • Abstract Number: 041 • 2020 Pediatric Rheumatology Symposium

    Ancestry, Demographic and Clinical Features of Israeli Periodic Fever Aphthous Stomatitis, Pharyngitis and Adenitis (PFAPA) Syndrome – a Multi-center Cohort

    Gil Amarilyo1, Liora Harel 2, Sabreen Abu Ahmad 3, Maryam Abu Rumi 3, Riva Brik 4, Nofar Hezkelo 5, Orly Ohana 6, Yoel Levinsky 7, Gabriel Chodick 5 and Yonatan Butbul Aviel 8, 1Schneider Hospital, Tel Aviv University, Kibbutz Magal, Israel, 2Schneider Hospital, Tel Aviv University, Petah-Tiqva, Israel, 3Ruth Rappaport Children's Hospital, Rambam Medical Center, Haifa, Israel, 4Haifa, Israel, 5Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Tel Aviv, Israel, 6Schneider Children's Medical Cener of Israel, Petach Tikva, Israel, 7Schneider Children's Medical Cnetr of Israel, Tel Aviv University, Petach Tikva, Israel, 8Rambam Medical center, Haifa, Hefa, Israel

    Background/Purpose: Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome is an autoinflammatory disease of unknown etiology. Recently, we showed that there may be a…
  • Abstract Number: 059 • 2020 Pediatric Rheumatology Symposium

    Challenges Faced by Families of Children with an Auto-inflammatory Disease

    Lori Tucker1, Maria Belen 2, Jenny Tekano 2, Iwona Niemietz 3, Martina Sundqvist 3 and Kelly Brown 3, 1BC Children's Hospital, Vancouver, British Columbia, Canada, 2BC CHildren's Hospital, Vancouver, Canada, 3BC Children's Hospital Research Institute, Vancouver, Canada

    Background/Purpose: Auto-inflammatory diseases (AIDs) are rare disorders that usually present in young children. Disease episodes, characterized by recurrent inflammation, are often frequent and unpredictable, and…
  • Abstract Number: 080 • 2020 Pediatric Rheumatology Symposium

    Therapeutic Interferon Gamma Neutralization with Emapalumab in Patients with NRLC4- and CDC42-Associated Diseases Characterized by Recurrent and Severe Hemophagocytic Lymphohistiocytosis

    Claudia Bracaglia1, Antonella Insalaco 1, Giulia Marucci 1, Manuela Pardeo 1, Emanuela Sacco 1, Virginia Messia 1, Giusi Prencipe 1, Ivan Caiello 1, Sarka Fingerhutova 2, Pavla Dolezalova 2, Veronica Asnaghi 3, Maria Ballabio 3, Cristina de Min 3 and Fabrizio De Benedetti 1, 1Division of Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, 2Paediatric Rheumatology and Autoinflammatory Diseases Unit, General University Hospital, Prague, Czech Republic, 3Swedish Orphan Biovitrum AG (Sobi), Basel, Switzerland

    Background/Purpose: Interferon gamma (IFNγ) is a pivotal mediator of HLH. Emapalumab (a fully human anti-IFNγ monoclonal antibody) is efficacious in patients with primary HLH. In…
  • Abstract Number: 087 • 2020 Pediatric Rheumatology Symposium

    Standardizing Care and Fostering Systemic Autoinflammatory Disease (SAID) Research Through the CARRA Autoinflammatory Disease Network

    Grant Schulert1, Julie Cherian 2, Theresa Wampler Muskardin 3, Marinka Twilt 4, Shoghik Akoghlanian 5, Gil Amarilyo 6, Dilan Dissanayake 7, Karen Durrant 8, Polly Ferguson 9, Maria Gutierrez 10, Liora Harel 11, Jonathan Hausmann 12, Merav Heshin Bekenstein 13, Ronald Laxer 7, Aleksander Lenert 9, Suzanne Li 14, Greg Licameli 15, Geraldina Lionetti 16, Ian Michelow 17, Lakshmi Moorthy 18, Evan Propst 19, Vivian Saper 20, Hemalatha Srinivasalu 21, Yuriy Stepanovskiy 22, Akaluck Thatayatikom 23, Lori Tucker 24, Peter Wright 25, Cagri Yildirim-Toruner 5, Fatma Dedeoglu 15 and Sivia Lapidus 26 for the CARRA investigators, 1Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, 2Stony Brook Children's Hospital, Stony Brook, 3Colton Center for Autoimmunity, NYU School of Medicine, New York, 4Alberta Children's Hospital, Calgary, Canada, 5Nationwide Children's Hospital, Columbus, 6Schneider Hospital, Tel Aviv University, Kibbutz Magal, Israel, 7The Hospital for Sick Children and University of Toronto, Toronto, Canada, 8Kaiser Permanente San Francisco Medical Center and Autoinflammatory Alliance, San Francisco, 9University of Iowa Carver College of Medicine, Iowa City, 10Johns Hopkins University School of Medicine, Baltimore, 11Schneider Hospital, Tel Aviv University, Petah-Tiqva, Israel, 12Division of Immunology, Boston Children's Hospital; Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 13Dana Children’s Hospital of Tel Aviv Medical Center, Binyamina, Israel, 14Joseph M. Sanzari Children's Hospital Hackensack Meridian Health, Hackensack, 15Boston Children's Hospital, Boston, 16UCSF Benioff Children’s Hospital, Oakland, 17Alpert Medical School, Brown University, Providence, 18Rutgers Robert Wood Johnson Medical School, Metuchen, 19The Hospital for Sick Children, University of Toronto, Toronto, Canada, 20Stanford University, Los Altos, 21Children's National Medical Center, Washington, 22Shupyk National Medical Academy of Postgraduate Education, Kiev, 23University of Florida, Gainesville, 24BC Children's Hospital, Vancouver, British Columbia, Canada, 25Dartmouth-Hitchcock Medical Center, Lebanon, 26The Joseph M. Sanzari Children's Hospital, Hackensack Meridian Health, Maplewood

    Background/Purpose: International registries have significantly enhanced the understanding of the genetics, phenotype, prognosis, and treatment of Systemic Autoinflammatory Diseases (SAIDs) that could be further augmented…
  • Abstract Number: 104 • 2020 Pediatric Rheumatology Symposium

    Patients Perspectives on Living with a Systemic Autoinflammatory Disease: Impact on Quality of Life

    Mariana Correia Marques1, Nicole Tennermann 2, Sivia Lapidus 3, Grant Schulert 4, Jennifer Tousseau 2, Rashmi Sinha 5, Karen Durrant 6, Saskya Angevare 7 and Fatma Dedeoglu 8, 1Boston Children's Hospital, Boston, Massachusetts, 2, 3The Joseph M. Sanzari Children's Hospital, Hackensack Meridian Health, Maplewood, 4Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, 5Systemic JIA Foundation, Cincinnati, 6Autoinflammatory Alliance, San Francisco, 7Amersfoort, Netherlands, 8Boston Children's Hospital, Boston

    Background/Purpose: Systemic autoinflammatory diseases (SAIDs) encompass multiple clinical entities in which spontaneous inflammation occurs due to dysregulation of the innate immune response.  The variability in…
  • Abstract Number: 026 • 2020 Pediatric Rheumatology Symposium

    Allogeneic Hematopoietic Cell Transplantation (HCT) in the National Institutes of Health (NIH)’s Deficiency of Adenosine Deaminase 2 (DADA2) Patient Cohort

    Michele Nehrebecky1, Jennifer Kanakry 1, Dimana Dimitrova 1, Deborah Stone 1, Patrycja Hoffmann 2, Tina Romeo 1, Anne Jones 3, Karyl Barron 4 and Amanda Ombrello 5, 1NIH, Bethesda, 2NIH, Vienna, 3Bethesda, 4National Institutes of Health, Bethesda, 5National Human Genome Research Institute/National Institutes of Health, Bethesda

    Background/Purpose: The deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disease caused by biallelic mutations in ADA2. The diagnosis of DADA2 is…
  • Abstract Number: 027 • 2020 Pediatric Rheumatology Symposium

    Clinical Features and Outcomes in Chronic Atypical Neutrophilic Dermatosis with Lipodystrophy and Elevated Temperature (CANDLE) Syndrome: Before and After JAK-inhibition

    Sofia Torreggiani1, Pascal Pillet 2, Fabiano de Oliveira Poswar 3, Anna Kozlova 4, Anna Shcherbina 4, Marietta De Guzman 5, Jacob Mitchell 6, Gina A. Montealegre Sanchez 7, Katherine Townsend 8, Kim Johnson 9, Adriana Almeida de Jesus 10 and Raphaela Goldbach-Mansky 11, 1National Institutes of Health, Bethesda, 2Bordeaux Cedex, France, 3Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil, 4Center for Pediatric Hematology, Oncology, Immunology, Moscow, Russia, 5Section of Rheumatology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, 6NIAID, NIH, Bethesda, 7NIH/ NIAID, Rockville, 8NIH, 9NIH, NIAID, Bethesda, 10NIAID, NIH, Silver Spring, 11NIH/NIAID, Potomac

    Background/Purpose: Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature (CANDLE) Syndrome is an autoinflammatory interferonopathy caused by mutations in the genes encoding for components…
  • Abstract Number: 772 • 2019 ACR/ARP Annual Meeting

    The Study of the Novel G87V Mutation in the TNFRSF1A Gene Identified in a Family with TNF Receptor-Associated Periodic Syndrome (TRAPS)

    Shoko Tsuji1, Hidenori Matsuzaki 2, Masanori Iseki 3, Akiko Nagasu 1, Hiroyasu Hirano 1, Katsuhiko Ishihara 4, Naoyasu Ueda 5, Yoshitaka Honda 6, Takahiko Horiuchi 7, Ryuta Nishikomori 8, Yoshitaka Morita 1 and Tomoyuki Mukai 9, 1Department of Rheumatology, Kawasaki Medical School, Kurashiki, Okayama, Japan, 2Department of Life Sciences, Faculty of Life and Environmental Sciences, Prefectural University of Hiroshima, shobara, Hiroshima, Japan, 3Department of Immunology and Molecular Genetics, Kawasaki Medical School, Kurashiki, Okayama, Japan, 4Department of Immunology and Molecular Genetics, Kurashiki, Okayama, Japan, 5Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan, 6Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan, 7Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, Beppu, Japan, 8Department of Pediatrics and Child Health, Kurume University School of Medicine, Kurume, Fukuoka, Japan, 9Department of Rheumatology, Kawasaki medical School, Kurashiki, Okayama, Okayama, Japan

    Background/Purpose: TNF Receptor-Associated Periodic Syndrome (TRAPS) is one of the autoinflammatory diseases. TRAPS is caused by heterozygous mutations in the TNFRSF1A gene. Although more than…
  • Abstract Number: 799 • 2019 ACR/ARP Annual Meeting

    Application of the Autoinflammatory Disease Activity Index (ADDI) to a Cohort of Patients in a Tertiary Hospital

    Mireia Lopez-corbeto1 and Estefania Moreno Ruzafa 1, 1Hospital Universitari Vall d'Hebron, Barcelona, Spain

    Background/Purpose: Autoinflammatory diseases (AIDs) cause chronic systemic inflammation that can damage multiple organs. Recently, the ADDI index has been developed and validated in the four…
  • Abstract Number: 810 • 2019 ACR/ARP Annual Meeting

    Small Vessel Vasculitis Syndrome with Autoinflammation Caused by De Novo Mutations in LYN Kinase

    Adriana de Jesus1, Gina Montealegre Sanchez 2, Helen Freeman 3, Neil Martin 4, Ebun Omoyinmi 5, Katherine Calvo 6, Richard Chyi-chia Lee 7, Murray Passo 8, Natasha Ruth 8, David Kleiner 7, Yan Huang 9, Nirali Shah 10, Paul Brogan 11, SuJin Hwang 12, HyeSun Kuehn 12, Sergio Rosenzweig 12, Zuoming Deng 13, Anna Huttenlocher 14, Susan Moir 15, Douglas Kuhns 16 and Raphaela Goldbach-Mansky 17, 1Translation Autoinflammatory Diseases Section/NIAID/NIH, Silver Spring, MD, 2Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, 3Raigmore Hospital, Inverness, United Kingdom, 4Royal Hospital for Children, Glasgow, United Kingdom, 5University College London Institute of Child Health, London, United Kingdom, 6Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, 7Laboratory of Pathology/NCI/NIH, Bethesda, MD, 8Medical University of South Carolina, Charleston, SC, 9Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, 10Pediatric Oncology Branch/NCI/NIH, Bethesda, MD, 11Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 12Immunology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, 13Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, 14Department of Pediatrics/University of Wisconsin, Madison, WI, 15Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, 16Collaborative Clinical Research Branch/NIAID/NIH, Bethesda, MD, 17Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD

    Background/Purpose: Lyn kinase is a member of the Src family of non-receptor tyrosine-protein kinases that modifies signals from various cell surface receptors and regulates innate…
  • Abstract Number: 903 • 2019 ACR/ARP Annual Meeting

    Prevalence of Atopic Features in Classic Autoinflammatory Diseases

    Brian Dizon1, Hirsch komarow 1, Deborah Stone 1, Patrycja Hoffmann 1, Anne Jones 1, Tina Romeo 1, Karyl Barron 1, Ivona Aksentijevich 2, Daniel Kastner 1, Amanda Ombrello 1, Joshua Milner 1 and Daniella Schwartz 1, 1National Institutes of Health, Bethesda, MD, 2National Institutes of Health, Bethesda

    Background/Purpose: Autoinflammatory diseases (AIDs), often caused by single gene mutations, are disorders in which aberrant activation of innate immune cells causes uncontrolled systemic inflammation. Because…
  • Abstract Number: 947 • 2019 ACR/ARP Annual Meeting

    TNF Inhibitor Treatment and Dramatic Stroke Risk Reduction in Patients with Deficiency of Adenosine Deaminase 2

    Ryan Laird1, Patrycja Hoffmann 2, Karyl Barron 2, Deborah Stone 2, Michele Nehrebecky 3, Anne Jones 2, Tina Romeo 2, Camilo Toro 3, Arianne Soldatos 4, Cornelia Cudrici 3, Daniel Kastner 2 and Amanda Ombrello 2, 1National Institues of Health, Bethesda, 2National Institutes of Health, Bethesda, MD, 3National Institutes of Health, Bethesda, 4NIH/NINDS, Bethesda

    Background/Purpose: Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive disease caused by biallelic loss-of-function mutations in the ADA2 gene . Over 60 pathogenic…
  • Abstract Number: 1244 • 2019 ACR/ARP Annual Meeting

    Tocilizumab – An Effective Rescue Therapy for Refractory Unclassified Autoinflammatory Diseases in Children

    Jasmin B. Kuemmerle-Deschner1, Daniel Sturm 1 and Susanne Benseler 2, 1University Hospital Tuebingen, Tuebingen, Germany, 2Alberta Children’s Hospital Research Institute, Calgary, Canada

    Background/Purpose: Evidence based treatment options for children and adults with unclassified autoinflammatory diseases (AID) are limited. Frequently, IL-1-inhibition is primarily tried to control the severe…
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