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Abstracts tagged "autoantibodies"

  • Abstract Number: 020 • 2020 Pediatric Rheumatology Symposium

    Murine Roseolovirus Induces Autoimmune Disease and Development of Autoantibodies

    Tarin Bigley1 and Wayne Yokoyama 2, 1Washington University in St. Louis, Saint Louis, Missouri, 2Washington University in St. Louis, St Louis, Missouri

    Background/Purpose: Murine roseolovirus (MRV) is a recently sequenced beta-herpesvirus that is a natural murine pathogen and is genetically highly related to HHV6 and HHV7. The…
  • Abstract Number: 054 • 2020 Pediatric Rheumatology Symposium

    Clinical and Laboratory Characteristics in Juvenile-onset Systemic Lupus Erythematosus Across Age Groups

    Joseph Massias 1, Eve Smith 1, Michael Beresford 1 and Christian Hedrich1, 1University of Liverpool, Liverpool, United Kingdom

    Background/Purpose: Systemic lupus erythematous (SLE) is a systemic autoimmune/inflammatory condition. Up to 20% of patients develop symptoms before their 18th birthday and are diagnosed with…
  • Abstract Number: 163 • 2020 Pediatric Rheumatology Symposium

    Anti-Dense Fine Speckled (DFS) Autoantibodies in Autoinflammatory Vasculopathies

    Asa Laestadius1, May Choi 1, Marvin Fritzler 1, Aurore Fifi-Mah 2, Susanne Benseler 3 and Joao Dantas 1, 1University of Calgary, Calgary, Canada, 2Calgary, Canada, 3Univeristy of Calgary, Calagry, Canada

    Background/Purpose: Autoantibodies to dense fine speckles 70 (DFS70) is now recognized to be more common among apparently healthy individuals compared to patients with ANA-related rheumatic…
  • Abstract Number: 881 • 2019 ACR/ARP Annual Meeting

    Auto-antibodies Targeting Components of Sarcolemma Repair: A Pathogenic Mechanism in Human Inflammatory Myopathies

    Kevin McElhanon1, Ana Capati 2, Nicholas Young 3, Brian Paleo 2, Eric Beck 2, Zarife Sahenk 4, Rohit Aggarwal 5, Chester Oddis 5, Noah Weisleder 1 and Wael Jarjour 6, 1Dorothy M. Davis Heart and Lung Research Institute & Dept. of Physiology & Cell Biology, The Ohio State University Wexner Medical Center, Columbus, OH, 2The Ohio State University Wexner Medical Center, Columbus, OH, 3The Ohio State University Wexner Medical Center, Division of Immunology and Rheumatology, Columbus, OH, 4Nationwide Children's Hospital, Columbus, OH, 5University of Pittsburgh Medical Center, Pittsburgh, PA, 6Ohio State College of Medicine, Columbus, OH

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) represent a group of disorders causing chronic inflammation and significant damage to skeletal muscle due to an unchecked autoimmune response. …
  • Abstract Number: 2425 • 2019 ACR/ARP Annual Meeting

    The anti-Ro52 Prevalence in the Sjögren’s Syndrome Picture: A Single Center Cross Sectional Study

    Larissa Valor1, Hannah Schenker 2, Johannes Knitza 3, Melanie Hagen 3, Jürgen Rech 4 and Georg Schett 5, 1Friedrich-Alexander-University Erlangen-Nürnberg. Department of Internal Medicine 3 - Rheumatology and Immunology. Erlangen., Erlangen, Germany, 2Friedrich-Alexander-University Erlangen-Nürnberg. Department of Internal Medicine 3 - Rheumatology and Immunology. Erlangen. Germany., Erlangen, Germany, 3Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, University Hospital Erlangen, Erlangen, Germany, Erlangen, Germany, 4Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, 5Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany

    Background/Purpose: Sjögren syndrome (SjS) is an autoimmune disorder characterized by inflammation and destruction of exocrine glands. The presence of autoantibodies (AA) against the Ro52/TRIM21, an…
  • Abstract Number: 893 • 2019 ACR/ARP Annual Meeting

    The Presence of Extractable Nuclear Antigens (ENA) Antibodies in a Large Population-based Cohort from the Netherlands and Their Association with Known Risk Factors for Systemic Lupus Erythematosus and Primary Sjögren Syndrome

    Petra Yntema-Eckenhaussen 1, Suzanne Arends 1, Elisabeth Brouwer 2, Caroline Roozendaal 3, Hendrika Bootsma 4, Johanna Westra 1 and Karina de Leeuw1, 1Dept. of Rheumatology and Clinical Immunology - University Medical Center Groningen (UMCG), University of Groningen, Groningen, Netherlands, 2Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Dept. of Laboratory Medicine - University Medical Center Groningen (UMCG), University of Groningen, Groningen, Netherlands, 4University of Groningen, Groningen, Netherlands

    Background/Purpose: Previous studies have demonstrated that years before clinical onset of auto-immune diseases, auto-antibodies can already be present. However, it is also known that some…
  • Abstract Number: 2429 • 2019 ACR/ARP Annual Meeting

    Zipcode-Binding Protein 1 (ZBP1) Facilitates Ro60 Surface Translocation, Cellular Growth and Autoimmune Sequelae

    Francis DiDonato1, Jill Buyon 1 and Robert Clancy 1, 1NYU School of Medicine, New York

    Background/Purpose: Despite the strong association of maternal anti-Ro60 autoantibodies in the development of SS, Neonatal Lupus (NL) and scLE, understanding causality is challenging given that…
  • Abstract Number: 959 • 2019 ACR/ARP Annual Meeting

    A Novel Image Analysis Program, “CytoSkaler”, Demonstrates That Anti-Vimentin Antibody Affinity Maturation in Lupus Tubulointerstitial Nephritis Also Results in More Selective Antigen Targeting

    Andrew Kinloch1, Aazam Mohsin 1, Yuta Asano 1, Carole Henry 1, Nirit Mor Vaknin 2, Maureen Legendre 2, Patrick Wilson 1, David Markovitz 2 and Marcus Clark 1, 1University of Chicago, Chicago, IL, 2University of Michigan, Ann Arbor, MI

    Background/Purpose: Vimentin is a dominant target of B-cells selected in lupus tubulointerstial inflammation (TII), a predictor of renal failure. The origins of anti-vimentin antibodies (AVA)…
  • Abstract Number: 2437 • 2019 ACR/ARP Annual Meeting

    Autoantibodies from Sjögren’s Syndrome Enhance NLRP3 Inflammasome Activation and IL-18 Production in Human Salivary Gland Cell Line A-253

    Cheng-Han Wu1, Ko Jen Li 2, Chia-Li Yu 3 and Song-Chou Hsieh 3, 1Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan (Republic of China), 2National Taiwan University Hospital, Taipei, Taiwan (Republic of China), 3Division of Immunology,Rheumatology and Allergy, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Taipei, Taiwan (Republic of China)

    Background/Purpose: Primary Sjögren's syndrome (SS) is a chronic autoimmune epithelitis characterized by the presence of autoantibodies against SS-related antigen A (SSA) and lymphocytic infiltration of…
  • Abstract Number: 982 • 2019 ACR/ARP Annual Meeting

    A Novel Role for Nod2 in Controlling Autoantibody Production and Arthritis in SKG Mice

    Ruth Napier1, Emily Vance 1, James O'Dell 2, Jill Poole 3, Bryant England 4, Michael Duryee 3, Ted Mikuls 2, Holly Rosenzweig 5 and Geoffrey Thiele 2, 1Oregon Health & Science University and Portland VA Hospital, Portland, OR, 2VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE, 4VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, 5Oregon Health & Science University and Portland VA Hospital, Oregon

    Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests in a chronic and debilitating polyarthritis. Although the etiology of RA is unknown pathogenic…
  • Abstract Number: 2733 • 2019 ACR/ARP Annual Meeting

    Inhibition of Neutrophil Elastase Reduces Autoantibody Levels and Renal Inflammation in Murine Lupus

    Gautam Sule1, Kristen Gilley 1, Andrew Fernandes 1, Srilakshmi Yalavarthi 1 and Jason Knight 2, 1University of Michigan, Ann Arbor, MI, 2Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI

    Background/Purpose: Dysregulated neutrophil extracellular trap (NET) release has been proposed as a source of autoantigens in lupus.  Furthermore, it has recently been shown that the…
  • Abstract Number: 1028 • 2019 ACR/ARP Annual Meeting

    Lupus Auto-antibodies Act as Positive Allosteric Modulators at GluN2A-containing NMDA Receptors to Induce Excitotoxicity and Spatial Memory Deficits

    Kelvin Chan1, Jacquelyn Nestor 2, Tomas Huerta 2, Czeslawa Kowal 2, Patricio Huerta 2, Bruce Volpe 2, Betty Diamond 3 and Lonnie Wollmuth 1, 1Stony Brook University School of Medicine, Stony Brook, NY, 2Feinstein Institutes for Medical Research, Manhasset, NY, 3Feinstein Institutes for Medical Research, Manhasset

    Background/Purpose: Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of auto-antibodies (DNRAbs) cross-react…
  • Abstract Number: 2739 • 2019 ACR/ARP Annual Meeting

    Skin Disease Activity and Autoantibody Phenotype Are Major Determinants of Blood Interferon Signatures in Dermatomyositis

    Mika Tabata1, Kavita Sarin 2, Karen Page 3, Christine Huard 3, Shanrong Zhao 3, Donald Bennett 3, Jillian Johnson 3, Kristen Johnson 3 and David Fiorentino 2, 1Stanford University School of Medicine, Stanford, CA, 2Department of Dermatology, Stanford University School of Medicine, Redwood City, CA, 3Pfizer, Boston

    Background/Purpose: Interferon (IFN) signaling is upregulated in dermatomyositis (DM) and thought to play a role in pathogenesis. An IFN gene signature in peripheral blood of…
  • Abstract Number: 1464 • 2019 ACR/ARP Annual Meeting

    The Oral Microbiome as a Risk Factor for Benign or Pathologic Autoimmunity Associated with Anti-SSA/Ro Positivity and Mimicry for Von Willebrand Factor Type a Domain Protein (vWFA) of L. Mirabilis

    Robert Clancy1, Miranda Marion 2, Peter Izmirly 1, Hannah Ainsworth 3, Timothy Howard 3, Mala Masson 1, Jill Buyon 1 and Carl Langefeld 3, 1NYU School of Medicine, New York, 2Wake Forest School of Medicine, Winston-Salem, NC, 3Wake Forest School of Medicine, Winston-Salem

    Background/Purpose: Autoantibody production precedes SLE or SS by years, including anti-Ro. Anti-Ro+ mothers of children with congenital heart block (CHB) are a unique population at…
  • Abstract Number: 2815 • 2019 ACR/ARP Annual Meeting

    Lower IL-4R in IgD+ Naïve B Cells Is a Pre-disposing Factor for Development of T-bet+ DN2 B Cells in Systemic Lupus Erythematosus

    John Mountz1, Min Gao 2, Qi Wu 3, PingAr Yang 2, Alex Essman 4, Oluwagbemiga Ojo 4, Shanrun Liu 2, Jake Chen 2, Iñaki Sanz 5, W. Winn Chatham 2 and Hui-Chen Hsu 2, 1University of Alabama at Birmingham and Birmingham VAMC, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, 3University of Alabama at Birmingham, Birmingham, AL, 4Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, 5Emory University, ATLANTA, GA

    Background/Purpose: Studies to date have primarily focused on stimulators that are overexpressed and activate B cells in SLE subjects.  Factors that can maintain B cells…
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ACR Pediatric Rheumatology Symposium 2020

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