ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 163

Anti-Dense Fine Speckled (DFS) Autoantibodies in Autoinflammatory Vasculopathies

Asa Laestadius1, May Choi 1, Marvin Fritzler 1, Aurore Fifi-Mah 2, Susanne Benseler 3 and Joao Dantas 1, 1University of Calgary, Calgary, Canada, 2Calgary, Canada, 3Univeristy of Calgary, Calagry, Canada

Meeting: 2020 Pediatric Rheumatology Symposium

Keywords: autoantibodies, Biomarkers, systemic vasculitides

  • Tweet
  • Email
  • Print
Session Information

The 2020 Pediatric Rheumatology Symposium, originally scheduled for April 29 – May 2, was postponed due to COVID-19; therefore, abstracts were not presented as scheduled.

Date: Saturday, May 2, 2020

Session Title: Poster Session 3

Session Type: ACR Abstract Session

Session Time: 4:15PM-5:15PM

Background/Purpose: Autoantibodies to dense fine speckles 70 (DFS70) is now recognized to be more common among apparently healthy individuals compared to patients with ANA-related rheumatic disease (AARD). DFS70 autoantibodies has also been associated with milder rheumatic autoimmune disease  and has a higher prevalence in young women implicating age-related hormonal alteration. Whether anti-DFS70 is a clinically relevant biomarker in autoinflammatory vasculopathies (AV) not well studied. The objective of this study was to determine the frequency of anti-DFS70 in a spectrum of AV’s and whether anti-DFS70 has a clinically relevant correlation to patient demographic and clinical characteristics.

Methods: Patients diagnosed with AV by a rheumatologist (AF-M) in Calgary, Alberta, were enrolled in the Southern Alberta Vasculitis Patient Registry. Antibodies to proteinase 3 (PR3), myeloperoxidase (MPO), and DFS70 were detected by a chemiluminescence immunoassay. The association between anti-DFS70, diagnosis, age, sex, disease activity as assessed by Birmingham Vasculitis Activity Score (BVAS) and disease duration was described.

Results: There were 146 AV patients, 7 (4.8%) of which had a positive anti-DFS70 antibody. This included 1/22 (4.5%) giant cell arteritis, 2/35 (5.7%) granulomatosis with polyangiitis, 1/10 (10.0%) Behçet disease, 1/7 (14.3%) microscopic polyangiitis, 1/1 (100%) eosinophilic granulomatosis with polyangiitis, 1/6 (16.7%) IgA vasculitis. The mean age of patients with positive anti-DFS70 antibody was 57 years (standard deviation 46-83) with 57% being younger than 55-years-old. All patients were female. Sampling from diagnosis of disease ranged between 0-10 years, and BVAS was 0 in 6/7 patients and 2 in one patient.

Conclusion: The prevalence of anti-DFS70 autoantibodies in AV was rare (5%), similar to the frequency seen in other AARDs. Although the number of DFS70 positive patients were few, all patients were female with low disease activity.


Disclosure: A. Laestadius, None; M. Choi, None; M. Fritzler, Inova Diagnostics Inc., 1; A. Fifi-Mah, None; S. Benseler, None; J. Dantas, None.

To cite this abstract in AMA style:

Laestadius A, Choi M, Fritzler M, Fifi-Mah A, Benseler S, Dantas J. Anti-Dense Fine Speckled (DFS) Autoantibodies in Autoinflammatory Vasculopathies [abstract]. Arthritis Rheumatol. 2020; 72 (suppl 4). https://acrabstracts.org/abstract/anti-dense-fine-speckled-dfs-autoantibodies-in-autoinflammatory-vasculopathies/. Accessed March 28, 2023.
  • Tweet
  • Email
  • Print

« Back to 2020 Pediatric Rheumatology Symposium

ACR Meeting Abstracts - https://acrabstracts.org/abstract/anti-dense-fine-speckled-dfs-autoantibodies-in-autoinflammatory-vasculopathies/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences